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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000155760

Summary for FZD7

check button Gene summary

Gene informationEnsembl ID

ENSG00000155760

Gene symbol

FZD7

Gene namefrizzled class receptor 7
HGNC

4045

Entrez ID

8324

Gene typeprotein_coding
SynonymsFZD7|FzE3
UniProtAcc

O75084


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for FZD7

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
FZD72.20e+031.21e+004.98e-012.43e+001.49e-022.87e-02KICH
FZD74.47e+021.58e+006.69e-012.36e+001.80e-024.10e-02CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
FZD79.12e+02-1.20e+002.00e-01-6.00e+002.00e-091.10e-08KIRC
FZD73.49e+03-1.19e+001.08e-01-1.10e+014.86e-282.30e-27BRCA
FZD71.10e+03-1.07e+004.34e-01-2.47e+001.35e-023.20e-02READ

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Sex-biased somatic mutation for FZD7

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for FZD7

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg23246885chr2:202035154CGI:chr2:202032663-202036149promoter,exon,CDS,gene body9.95e-022.85e-01-2.57e+001.03e-022.70e-02-1.85e-01
BRCAcg02697649chr2:202036322CGI:chr2:202032663-202036149promoter,exon,CDS,gene body7.02e-018.12e-01-1.99e+004.62e-024.85e-02-1.10e-01
BRCAcg11613003chr2:202036565CGI:chr2:202032663-202036149UTR,promoter,exon,gene body6.25e-017.38e-01-2.20e+002.81e-023.99e-02-1.13e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg23246885chr2:202035154CGI:chr2:202032663-202036149promoter,exon,CDS,gene body1.50e-012.96e-023.59e+003.35e-045.92e-041.20e-01
LUSCcg11613003chr2:202036565CGI:chr2:202032663-202036149UTR,promoter,exon,gene body5.04e-016.32e-01-2.13e+003.29e-023.55e-02-1.28e-01
LIHCcg14239329chr2:202034576CGI:chr2:202032663-202036149promoter2.19e-016.20e-024.08e+004.55e-051.03e-041.57e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg08077337chr2:202035340CGI:chr2:202032663-202036149promoter,exon,CDS,gene body3.42e-017.98e-028.39e+004.87e-172.07e-162.63e-01
BRCAcg02697649chr2:202036322CGI:chr2:202032663-202036149promoter,exon,CDS,gene body7.02e-014.60e-011.15e+011.85e-302.85e-292.42e-01
BRCAcg11613003chr2:202036565CGI:chr2:202032663-202036149UTR,promoter,exon,gene body6.25e-014.12e-011.14e+013.07e-304.60e-292.13e-01
KIRCcg02697649chr2:202036322CGI:chr2:202032663-202036149promoter,exon,CDS,gene body7.28e-016.28e-012.17e+003.01e-023.55e-021.00e-01
HNSCcg11613003chr2:202036565CGI:chr2:202032663-202036149UTR,promoter,exon,gene body6.38e-015.03e-012.48e+001.32e-022.17e-021.35e-01
KIRPcg08077337chr2:202035340CGI:chr2:202032663-202036149promoter,exon,CDS,gene body3.45e-011.06e-012.18e+002.89e-023.43e-022.38e-01
KIRPcg23246885chr2:202035154CGI:chr2:202032663-202036149promoter,exon,CDS,gene body1.84e-013.33e-022.47e+001.35e-022.06e-021.50e-01

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Exon skipping events with PSI in TCGA for FZD7

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for FZD7

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for FZD7

check buttonTFs related to FZD7.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
GBMKLF3FZD73.25e+008.17e-034.39e+009.85e-01Female-biased
GBMZNF101FZD73.38e+001.21e-024.36e+009.80e-01Female-biased
GBMZNF141FZD73.37e+007.39e-034.54e+009.87e-01Female-biased
GBMZNF454FZD73.33e+001.06e-024.36e+009.82e-01Female-biased
GBMZNF816FZD73.29e+001.06e-024.32e+009.81e-01Female-biased
PCPGKLF17FZD72.80e+002.13e-033.94e+009.83e-01Female-biased
PCPGKLF3FZD72.96e+003.43e-033.99e+009.83e-01Female-biased
PCPGMBD2FZD73.27e+007.28e-034.14e+009.82e-01Female-biased
PCPGNR1H4FZD72.54e+009.42e-043.84e+009.81e-01Female-biased
PCPGPATZ1FZD72.80e+001.91e-033.96e+009.83e-01Female-biased
PCPGZFP64FZD73.09e+005.97e-034.00e+009.80e-01Female-biased
PCPGZNF101FZD72.87e+003.19e-033.92e+009.81e-01Female-biased
PCPGZNF141FZD72.88e+001.39e-034.11e+009.87e-01Female-biased
PCPGZNF225FZD73.96e+009.82e-012.80e+001.83e-03Male-biased
PCPGZNF23FZD73.10e+003.69e-034.12e+009.85e-01Female-biased
PCPGZNF281FZD72.89e+003.39e-033.92e+009.81e-01Female-biased
PCPGZNF454FZD72.68e+001.59e-033.87e+009.81e-01Female-biased
PCPGZNF468FZD73.19e+005.65e-034.12e+009.83e-01Female-biased
PCPGZNF530FZD72.75e+001.82e-033.92e+009.83e-01Female-biased
PCPGZNF543FZD73.39e+007.72e-034.24e+009.83e-01Female-biased
PCPGZNF605FZD72.74e+002.34e-033.85e+009.80e-01Female-biased
PCPGZNF611FZD73.24e+004.56e-034.22e+009.86e-01Female-biased
PCPGZNF619FZD72.96e+001.67e-034.15e+009.88e-01Female-biased
PCPGZNF740FZD72.92e+002.27e-034.04e+009.85e-01Female-biased
PCPGZNF816FZD72.85e+001.69e-034.04e+009.85e-01Female-biased
PCPGZSCAN22FZD73.27e+008.21e-034.11e+009.80e-01Female-biased

check buttonFZD7 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for FZD7

check buttonRBPs related to ES in FZD7.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonFZD7 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10932413chr2:211977181:G:T-0.2066371857287991.99544353077235e-06HNSCFemale-baised eQTL
rs4850364chr2:195394536:G:A-0.050866708995830.029356606816061THCAFemale-baised eQTL
rs13417594chr2:194636883:T:C-0.1614278537277160.0195855876914455STADFemale-baised eQTL
rs7605446chr2:194637650:C:T-0.1614278537277160.0195855876914455STADFemale-baised eQTL
rs140264386chr2:194474232:A:G--0.1241687342628950.0271044968127391STADFemale-baised eQTL
rs1406017chr2:194477185:T:C--0.137373083345780.0321726029502919STADFemale-baised eQTL
rs12623833chr2:194479568:C:G--0.137373083345780.0321726029502919STADFemale-baised eQTL
rs2360091chr2:194479778:G:A--0.137373083345780.0321726029502919STADFemale-baised eQTL
rs10166194chr2:194480646:G:A--0.137373083345780.0321726029502919STADFemale-baised eQTL
rs10169076chr2:194481147:G:A--0.137373083345780.0321726029502919STADFemale-baised eQTL
rs1590050chr2:194483498:A:G--0.137373083345780.0321726029502919STADFemale-baised eQTL
rs4328652chr2:194483868:C:T--0.137373083345780.0321726029502919STADFemale-baised eQTL
rs10196648chr2:194628469:A:T-0.1462687941260310.0472919354770749STADFemale-baised eQTL
rs7422905chr2:211718818:C:G--0.093479118823350.00580602848571471LGGFemale-baised eQTL
rs13393587chr2:211715993:C:T--0.09331696255752510.00615849259397556LGGFemale-baised eQTL
rs7419310chr2:211718838:A:G--0.09298955561473480.00621294086609904LGGFemale-baised eQTL
rs12162287chr2:211715172:A:C--0.09323536302052130.00629886097185823LGGFemale-baised eQTL
rs6435664chr2:211720340:G:C--0.0816307507666120.0220550530997058LGGFemale-baised eQTL
rs7563762chr2:211720186:A:T--0.07690696566534820.0463548982494954LGGFemale-baised eQTL
rs7604206chr2:211720055:T:G--0.07601757939785370.0471036263999467LGGFemale-baised eQTL
rs75472863chr2:211909895:T:A-0.09298252108715730.0103553849542888LUADFemale-baised eQTL
rs75556861chr2:211903042:A:G-0.0901823464723150.0131273910290788LUADFemale-baised eQTL
rs77680578chr2:211904990:T:G-0.0901823464723150.0131273910290788LUADFemale-baised eQTL
rs114788702chr2:211905523:T:A-0.0901823464723150.0131273910290788LUADFemale-baised eQTL
rs114792967chr2:211907114:T:G-0.0901823464723150.0131273910290788LUADFemale-baised eQTL
rs73066823chr2:196979430:G:T-0.08179087181241110.0350093570765284LUADFemale-baised eQTL
rs17384622chr2:196986182:C:G-0.07999025395549240.0434771431705297LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs113769655chr2:197748381:C:G-0.2065767055903410.0323973885257533PCPGMale-baised eQTL
rs13425988chr2:197757654:C:T-0.2065767055903410.0323973885257533PCPGMale-baised eQTL
rs62277919chr2:198162466:T:C-0.05804522201457820.0191325001449796BLCAMale-baised eQTL
rs10204645chr2:198176616:G:A-0.05255781823236610.0275536244043066BLCAMale-baised eQTL
rs263680chr2:210202677:G:A-0.06033514730572510.0310560149613013BLCAMale-baised eQTL
rs73055628chr2:201771414:G:A-0.0712729589502260.0333739949532929LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000155760
CpG Site: cg03345454
Position to Gene: gene,exon,enhancer,UTR
Male Effect: -0.407160241635208
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000155760
CpG Site: cg02697649
Position to Gene: gene,exon,CDS,promoter
Male Effect: -
Female Effect: -0.43125044398873
eQTM boxplot analysisGene ID: ENSG00000155760
CpG Site: cg27638615
Position to Gene: gene,exon,enhancer,UTR
Male Effect: -
Female Effect: -0.43125044398873
eQTM boxplot analysisGene ID: ENSG00000155760
CpG Site: cg03345454
Position to Gene: gene,exon,enhancer,UTR
Male Effect: -
Female Effect: -0.276796026415412
eQTM boxplot analysisGene ID: ENSG00000155760
CpG Site: cg02697649
Position to Gene: gene,exon,CDS,promoter
Male Effect: -0.235967023592689
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000155760
CpG Site: cg10634136
Position to Gene: gene,exon,enhancer,UTR
Male Effect: -0.203168922455945
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000155760
CpG Site: cg27638615
Position to Gene: gene,exon,enhancer,UTR
Male Effect: -0.124627310935467
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg03345454chr2:202036705gene,exon,enhancer,UTR-0.4071602416352086.25894179376657e-07-0.46551824852959232.314188093544292e-10COAD
cg02697649chr2:202036322gene,exon,CDS,promoter-0.2359670235926891.40518256302834e-12-0.407932070399348873.4517058042706103e-16HNSC
cg10634136chr2:202036747gene,exon,enhancer,UTR-0.2031689224559452.04623316161104e-11-0.39431254683333973.866039246057099e-15HNSC
cg27638615chr2:202036629gene,exon,enhancer,UTR-0.1246273109354673.38006682416043e-09-0.35502545908113252.2619719467692016e-12HNSC

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg02697649chr2:202036322gene,exon,CDS,promoter-0.431250443988737.42469350136173e-11-0.445499987288760957.768049750642097e-14LUAD
cg27638615chr2:202036629gene,exon,enhancer,UTR-0.431250443988737.42469350136173e-11-0.445499987288760957.768049750642097e-14LUAD
cg03345454chr2:202036705gene,exon,enhancer,UTR-0.2767960264154121.58190117923293e-08-0.394978863814461075.975615867103789e-11LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of FZD7

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource