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Gene: ENSG00000155760 |
Summary for FZD7 |
Gene summary |
| Gene information | Ensembl ID | ENSG00000155760 | Gene symbol | FZD7 |
| Gene name | frizzled class receptor 7 | |
| HGNC | 4045 | |
| Entrez ID | 8324 | |
| Gene type | protein_coding | |
| Synonyms | FZD7|FzE3 | |
| UniProtAcc | O75084 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for FZD7 |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| FZD7 | 2.20e+03 | 1.21e+00 | 4.98e-01 | 2.43e+00 | 1.49e-02 | 2.87e-02 | KICH |
| FZD7 | 4.47e+02 | 1.58e+00 | 6.69e-01 | 2.36e+00 | 1.80e-02 | 4.10e-02 | CHOL |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| FZD7 | 9.12e+02 | -1.20e+00 | 2.00e-01 | -6.00e+00 | 2.00e-09 | 1.10e-08 | KIRC |
| FZD7 | 3.49e+03 | -1.19e+00 | 1.08e-01 | -1.10e+01 | 4.86e-28 | 2.30e-27 | BRCA |
| FZD7 | 1.10e+03 | -1.07e+00 | 4.34e-01 | -2.47e+00 | 1.35e-02 | 3.20e-02 | READ |
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Sex-biased somatic mutation for FZD7 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for FZD7 |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg23246885 | chr2:202035154 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 9.95e-02 | 2.85e-01 | -2.57e+00 | 1.03e-02 | 2.70e-02 | -1.85e-01 |
| BRCA | cg02697649 | chr2:202036322 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 7.02e-01 | 8.12e-01 | -1.99e+00 | 4.62e-02 | 4.85e-02 | -1.10e-01 |
| BRCA | cg11613003 | chr2:202036565 | CGI:chr2:202032663-202036149 | UTR,promoter,exon,gene body | 6.25e-01 | 7.38e-01 | -2.20e+00 | 2.81e-02 | 3.99e-02 | -1.13e-01 |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg23246885 | chr2:202035154 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 1.50e-01 | 2.96e-02 | 3.59e+00 | 3.35e-04 | 5.92e-04 | 1.20e-01 |
| LUSC | cg11613003 | chr2:202036565 | CGI:chr2:202032663-202036149 | UTR,promoter,exon,gene body | 5.04e-01 | 6.32e-01 | -2.13e+00 | 3.29e-02 | 3.55e-02 | -1.28e-01 |
| LIHC | cg14239329 | chr2:202034576 | CGI:chr2:202032663-202036149 | promoter | 2.19e-01 | 6.20e-02 | 4.08e+00 | 4.55e-05 | 1.03e-04 | 1.57e-01 |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg08077337 | chr2:202035340 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 3.42e-01 | 7.98e-02 | 8.39e+00 | 4.87e-17 | 2.07e-16 | 2.63e-01 |
| BRCA | cg02697649 | chr2:202036322 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 7.02e-01 | 4.60e-01 | 1.15e+01 | 1.85e-30 | 2.85e-29 | 2.42e-01 |
| BRCA | cg11613003 | chr2:202036565 | CGI:chr2:202032663-202036149 | UTR,promoter,exon,gene body | 6.25e-01 | 4.12e-01 | 1.14e+01 | 3.07e-30 | 4.60e-29 | 2.13e-01 |
| KIRC | cg02697649 | chr2:202036322 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 7.28e-01 | 6.28e-01 | 2.17e+00 | 3.01e-02 | 3.55e-02 | 1.00e-01 |
| HNSC | cg11613003 | chr2:202036565 | CGI:chr2:202032663-202036149 | UTR,promoter,exon,gene body | 6.38e-01 | 5.03e-01 | 2.48e+00 | 1.32e-02 | 2.17e-02 | 1.35e-01 |
| KIRP | cg08077337 | chr2:202035340 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 3.45e-01 | 1.06e-01 | 2.18e+00 | 2.89e-02 | 3.43e-02 | 2.38e-01 |
| KIRP | cg23246885 | chr2:202035154 | CGI:chr2:202032663-202036149 | promoter,exon,CDS,gene body | 1.84e-01 | 3.33e-02 | 2.47e+00 | 1.35e-02 | 2.06e-02 | 1.50e-01 |
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Exon skipping events with PSI in TCGA for FZD7 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for FZD7 |
| ∗Please access CAeditome for RNA editing annotation. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for FZD7 |
TFs related to FZD7.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | KLF3 | FZD7 | 3.25e+00 | 8.17e-03 | 4.39e+00 | 9.85e-01 | Female-biased |
| GBM | ZNF101 | FZD7 | 3.38e+00 | 1.21e-02 | 4.36e+00 | 9.80e-01 | Female-biased |
| GBM | ZNF141 | FZD7 | 3.37e+00 | 7.39e-03 | 4.54e+00 | 9.87e-01 | Female-biased |
| GBM | ZNF454 | FZD7 | 3.33e+00 | 1.06e-02 | 4.36e+00 | 9.82e-01 | Female-biased |
| GBM | ZNF816 | FZD7 | 3.29e+00 | 1.06e-02 | 4.32e+00 | 9.81e-01 | Female-biased |
| PCPG | KLF17 | FZD7 | 2.80e+00 | 2.13e-03 | 3.94e+00 | 9.83e-01 | Female-biased |
| PCPG | KLF3 | FZD7 | 2.96e+00 | 3.43e-03 | 3.99e+00 | 9.83e-01 | Female-biased |
| PCPG | MBD2 | FZD7 | 3.27e+00 | 7.28e-03 | 4.14e+00 | 9.82e-01 | Female-biased |
| PCPG | NR1H4 | FZD7 | 2.54e+00 | 9.42e-04 | 3.84e+00 | 9.81e-01 | Female-biased |
| PCPG | PATZ1 | FZD7 | 2.80e+00 | 1.91e-03 | 3.96e+00 | 9.83e-01 | Female-biased |
| PCPG | ZFP64 | FZD7 | 3.09e+00 | 5.97e-03 | 4.00e+00 | 9.80e-01 | Female-biased |
| PCPG | ZNF101 | FZD7 | 2.87e+00 | 3.19e-03 | 3.92e+00 | 9.81e-01 | Female-biased |
| PCPG | ZNF141 | FZD7 | 2.88e+00 | 1.39e-03 | 4.11e+00 | 9.87e-01 | Female-biased |
| PCPG | ZNF225 | FZD7 | 3.96e+00 | 9.82e-01 | 2.80e+00 | 1.83e-03 | Male-biased |
| PCPG | ZNF23 | FZD7 | 3.10e+00 | 3.69e-03 | 4.12e+00 | 9.85e-01 | Female-biased |
| PCPG | ZNF281 | FZD7 | 2.89e+00 | 3.39e-03 | 3.92e+00 | 9.81e-01 | Female-biased |
| PCPG | ZNF454 | FZD7 | 2.68e+00 | 1.59e-03 | 3.87e+00 | 9.81e-01 | Female-biased |
| PCPG | ZNF468 | FZD7 | 3.19e+00 | 5.65e-03 | 4.12e+00 | 9.83e-01 | Female-biased |
| PCPG | ZNF530 | FZD7 | 2.75e+00 | 1.82e-03 | 3.92e+00 | 9.83e-01 | Female-biased |
| PCPG | ZNF543 | FZD7 | 3.39e+00 | 7.72e-03 | 4.24e+00 | 9.83e-01 | Female-biased |
| PCPG | ZNF605 | FZD7 | 2.74e+00 | 2.34e-03 | 3.85e+00 | 9.80e-01 | Female-biased |
| PCPG | ZNF611 | FZD7 | 3.24e+00 | 4.56e-03 | 4.22e+00 | 9.86e-01 | Female-biased |
| PCPG | ZNF619 | FZD7 | 2.96e+00 | 1.67e-03 | 4.15e+00 | 9.88e-01 | Female-biased |
| PCPG | ZNF740 | FZD7 | 2.92e+00 | 2.27e-03 | 4.04e+00 | 9.85e-01 | Female-biased |
| PCPG | ZNF816 | FZD7 | 2.85e+00 | 1.69e-03 | 4.04e+00 | 9.85e-01 | Female-biased |
| PCPG | ZSCAN22 | FZD7 | 3.27e+00 | 8.21e-03 | 4.11e+00 | 9.80e-01 | Female-biased |
FZD7 related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for FZD7 |
RBPs related to ES in FZD7.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
FZD7 related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10932413 | chr2:211977181:G:T | - | 0.206637185728799 | 1.99544353077235e-06 | HNSC | Female-baised eQTL |
| rs4850364 | chr2:195394536:G:A | - | 0.05086670899583 | 0.029356606816061 | THCA | Female-baised eQTL |
| rs13417594 | chr2:194636883:T:C | - | 0.161427853727716 | 0.0195855876914455 | STAD | Female-baised eQTL |
| rs7605446 | chr2:194637650:C:T | - | 0.161427853727716 | 0.0195855876914455 | STAD | Female-baised eQTL |
| rs140264386 | chr2:194474232:A:G | - | -0.124168734262895 | 0.0271044968127391 | STAD | Female-baised eQTL |
| rs1406017 | chr2:194477185:T:C | - | -0.13737308334578 | 0.0321726029502919 | STAD | Female-baised eQTL |
| rs12623833 | chr2:194479568:C:G | - | -0.13737308334578 | 0.0321726029502919 | STAD | Female-baised eQTL |
| rs2360091 | chr2:194479778:G:A | - | -0.13737308334578 | 0.0321726029502919 | STAD | Female-baised eQTL |
| rs10166194 | chr2:194480646:G:A | - | -0.13737308334578 | 0.0321726029502919 | STAD | Female-baised eQTL |
| rs10169076 | chr2:194481147:G:A | - | -0.13737308334578 | 0.0321726029502919 | STAD | Female-baised eQTL |
| rs1590050 | chr2:194483498:A:G | - | -0.13737308334578 | 0.0321726029502919 | STAD | Female-baised eQTL |
| rs4328652 | chr2:194483868:C:T | - | -0.13737308334578 | 0.0321726029502919 | STAD | Female-baised eQTL |
| rs10196648 | chr2:194628469:A:T | - | 0.146268794126031 | 0.0472919354770749 | STAD | Female-baised eQTL |
| rs7422905 | chr2:211718818:C:G | - | -0.09347911882335 | 0.00580602848571471 | LGG | Female-baised eQTL |
| rs13393587 | chr2:211715993:C:T | - | -0.0933169625575251 | 0.00615849259397556 | LGG | Female-baised eQTL |
| rs7419310 | chr2:211718838:A:G | - | -0.0929895556147348 | 0.00621294086609904 | LGG | Female-baised eQTL |
| rs12162287 | chr2:211715172:A:C | - | -0.0932353630205213 | 0.00629886097185823 | LGG | Female-baised eQTL |
| rs6435664 | chr2:211720340:G:C | - | -0.081630750766612 | 0.0220550530997058 | LGG | Female-baised eQTL |
| rs7563762 | chr2:211720186:A:T | - | -0.0769069656653482 | 0.0463548982494954 | LGG | Female-baised eQTL |
| rs7604206 | chr2:211720055:T:G | - | -0.0760175793978537 | 0.0471036263999467 | LGG | Female-baised eQTL |
| rs75472863 | chr2:211909895:T:A | - | 0.0929825210871573 | 0.0103553849542888 | LUAD | Female-baised eQTL |
| rs75556861 | chr2:211903042:A:G | - | 0.090182346472315 | 0.0131273910290788 | LUAD | Female-baised eQTL |
| rs77680578 | chr2:211904990:T:G | - | 0.090182346472315 | 0.0131273910290788 | LUAD | Female-baised eQTL |
| rs114788702 | chr2:211905523:T:A | - | 0.090182346472315 | 0.0131273910290788 | LUAD | Female-baised eQTL |
| rs114792967 | chr2:211907114:T:G | - | 0.090182346472315 | 0.0131273910290788 | LUAD | Female-baised eQTL |
| rs73066823 | chr2:196979430:G:T | - | 0.0817908718124111 | 0.0350093570765284 | LUAD | Female-baised eQTL |
| rs17384622 | chr2:196986182:C:G | - | 0.0799902539554924 | 0.0434771431705297 | LUAD | Female-baised eQTL |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs113769655 | chr2:197748381:C:G | - | 0.206576705590341 | 0.0323973885257533 | PCPG | Male-baised eQTL |
| rs13425988 | chr2:197757654:C:T | - | 0.206576705590341 | 0.0323973885257533 | PCPG | Male-baised eQTL |
| rs62277919 | chr2:198162466:T:C | - | 0.0580452220145782 | 0.0191325001449796 | BLCA | Male-baised eQTL |
| rs10204645 | chr2:198176616:G:A | - | 0.0525578182323661 | 0.0275536244043066 | BLCA | Male-baised eQTL |
| rs263680 | chr2:210202677:G:A | - | 0.0603351473057251 | 0.0310560149613013 | BLCA | Male-baised eQTL |
| rs73055628 | chr2:201771414:G:A | - | 0.071272958950226 | 0.0333739949532929 | LUAD | Male-baised eQTL |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg03345454 | chr2:202036705 | gene,exon,enhancer,UTR | -0.407160241635208 | 6.25894179376657e-07 | -0.4655182485295923 | 2.314188093544292e-10 | COAD |
| cg02697649 | chr2:202036322 | gene,exon,CDS,promoter | -0.235967023592689 | 1.40518256302834e-12 | -0.40793207039934887 | 3.4517058042706103e-16 | HNSC |
| cg10634136 | chr2:202036747 | gene,exon,enhancer,UTR | -0.203168922455945 | 2.04623316161104e-11 | -0.3943125468333397 | 3.866039246057099e-15 | HNSC |
| cg27638615 | chr2:202036629 | gene,exon,enhancer,UTR | -0.124627310935467 | 3.38006682416043e-09 | -0.3550254590811325 | 2.2619719467692016e-12 | HNSC |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg02697649 | chr2:202036322 | gene,exon,CDS,promoter | -0.43125044398873 | 7.42469350136173e-11 | -0.44549998728876095 | 7.768049750642097e-14 | LUAD |
| cg27638615 | chr2:202036629 | gene,exon,enhancer,UTR | -0.43125044398873 | 7.42469350136173e-11 | -0.44549998728876095 | 7.768049750642097e-14 | LUAD |
| cg03345454 | chr2:202036705 | gene,exon,enhancer,UTR | -0.276796026415412 | 1.58190117923293e-08 | -0.39497886381446107 | 5.975615867103789e-11 | LUAD |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of FZD7 |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |