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Gene: ENSG00000154217 |
Summary for PITPNC1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000154217 | Gene symbol | PITPNC1 |
| Gene name | phosphatidylinositol transfer protein cytoplasmic 1 | |
| HGNC | 21045 | |
| Entrez ID | 26207 | |
| Gene type | protein_coding | |
| Synonyms | PITPNC1|RDGBB1|RDGBB|RDGB-BETA | |
| UniProtAcc | Q9UKF7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PITPNC1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PITPNC1 | 1.92e+03 | -1.06e+00 | 3.20e-01 | -3.30e+00 | 9.63e-04 | 6.05e-03 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PITPNC1 | 3.25e+03 | 1.16e+00 | 1.53e-01 | 7.57e+00 | 3.85e-14 | 4.05e-13 | KIRC |
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Sex-biased somatic mutation for PITPNC1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PITPNC1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg01599633 | chr17:67376336 | CGI:chr17:67377108-67379015 | promoter | 6.49e-01 | 4.56e-01 | 3.31e+00 | 9.26e-04 | 9.01e-03 | 1.93e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg01599633 | chr17:67376336 | CGI:chr17:67377108-67379015 | promoter | 5.38e-01 | 6.42e-01 | -2.63e+00 | 8.49e-03 | 1.24e-02 | -1.04e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg01599633 | chr17:67376336 | CGI:chr17:67377108-67379015 | promoter | 4.32e-01 | 5.83e-01 | -2.61e+00 | 9.07e-03 | 1.60e-02 | -1.50e-01 |
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Exon skipping events with PSI in TCGA for PITPNC1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PITPNC1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | PITPNC1-004 | chr17_67437989_+ | 4.68e-01 | 3.97e-01 | 2.23e+00 | 2.55e-02 | 4.96e-02 | 7.03e-02 |
| STAD | PITPNC1-002 | chr17_67654762_+ | 5.17e-01 | 3.22e-01 | 2.15e+00 | 3.12e-02 | 4.96e-02 | 1.95e-01 |
| ESCA | PITPNC1-002 | chr17_67678131_+ | 6.32e-01 | 4.16e-01 | 2.58e+00 | 1.00e-02 | 4.99e-02 | 2.16e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PITPNC1 |
| TFs related to PITPNC1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PITPNC1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PITPNC1 |
| RBPs related to ES in PITPNC1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | TARDBP | exon_skip_155396 | 9.32e+00 | 9.84e-01 | 9.02e+00 | 1.23e-02 | Male-biased |
| COAD | TARDBP | exon_skip_155396 | 8.77e+00 | 9.61e-03 | 9.10e+00 | 9.87e-01 | Female-biased |
| MESO | TARDBP | exon_skip_155396 | 8.98e+00 | 1.41e-02 | 9.30e+00 | 9.82e-01 | Female-biased |
| HNSC | FXR2 | exon_skip_155404 | 6.80e+00 | 3.87e-03 | 7.22e+00 | 9.84e-01 | Female-biased |
| PITPNC1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1562087 | chr17:76935544:A:G | - | -0.0407350121542871 | 0.0221763111241927 | THCA | Female-baised eQTL |
| rs4789376 | chr17:76933916:A:C | - | -0.0397164500965289 | 0.0315930629717085 | THCA | Female-baised eQTL |
| rs7217999 | chr17:76934592:T:C | - | -0.0395680763150802 | 0.0335244912230814 | THCA | Female-baised eQTL |
| rs4789378 | chr17:76934284:T:C | - | -0.0392430091557622 | 0.0346680835337186 | THCA | Female-baised eQTL |
| rs76552183 | chr17:71916185:G:A | - | 0.0837341659463648 | 0.0411460619411568 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4789411 | chr17:77052590:G:A | - | 0.0809586497056845 | 0.0469138585450181 | SARC | Male-baised eQTL |
| rs112615097 | chr17:68136795:C:T | - | 0.129417427698003 | 0.032090581987511 | LIHC | Male-baised eQTL |
| rs2687065 | chr17:59178449:C:T | - | 0.0939572842176024 | 0.0384091914839496 | LIHC | Male-baised eQTL |
| rs4366773 | chr17:59971086:C:T | - | 0.089793069082635 | 0.00709637651271994 | LUSC | Male-baised eQTL |
| rs4632189 | chr17:59971554:A:C | - | 0.0897617359991372 | 0.00717131760074984 | LUSC | Male-baised eQTL |
| rs56142307 | chr17:59800788:A:G | - | 0.0750350575299228 | 0.0268185419171046 | LUSC | Male-baised eQTL |
| rs7214032 | chr17:59808467:T:C | - | 0.0750350575299228 | 0.0268185419171046 | LUSC | Male-baised eQTL |
| rs73315252 | chr17:59777494:A:G | - | 0.0748420208337796 | 0.0273272632394748 | LUSC | Male-baised eQTL |
| rs8073489 | chr17:59784433:A:C | - | 0.0748420208337796 | 0.0273272632394748 | LUSC | Male-baised eQTL |
| rs111848007 | chr17:59794376:C:T | - | 0.0748420208337796 | 0.0273272632394748 | LUSC | Male-baised eQTL |
| rs7220187 | chr17:59820248:C:T | - | 0.0748420208337796 | 0.0273272632394748 | LUSC | Male-baised eQTL |
| rs7213697 | chr17:59825680:G:C | - | 0.0748420208337796 | 0.0273272632394748 | LUSC | Male-baised eQTL |
| rs62081818 | chr17:59813268:C:T | - | 0.0730323153632242 | 0.0359710396770519 | LUSC | Male-baised eQTL |
| rs59685433 | chr17:59813846:T:C | - | 0.0730323153632242 | 0.0359710396770519 | LUSC | Male-baised eQTL |
| rs62081820 | chr17:59816869:C:G | - | 0.0730323153632242 | 0.0359710396770519 | LUSC | Male-baised eQTL |
| rs7221646 | chr17:68157976:A:T | - | 0.0345501489913227 | 0.0294319700905479 | KIRC | Male-baised eQTL |
| rs6501318 | chr17:68123917:G:T | - | 0.0997420572506356 | 0.0172033858055577 | COAD | Male-baised eQTL |
| rs8075265 | chr17:68130748:A:G | - | 0.0997420572506356 | 0.0172033858055577 | COAD | Male-baised eQTL |
| rs17737934 | chr17:68141500:T:C | - | 0.0911813323966285 | 0.0293583371173361 | COAD | Male-baised eQTL |
| rs35863764 | chr17:68143091:A:C | - | 0.0911813323966285 | 0.0293583371173361 | COAD | Male-baised eQTL |
| rs35507398 | chr17:68144043:C:G | - | 0.0911813323966285 | 0.0293583371173361 | COAD | Male-baised eQTL |
| rs71382159 | chr17:68111196:A:G | - | 0.0924148497676833 | 0.0298533214318297 | COAD | Male-baised eQTL |
| rs34101723 | chr17:68118518:T:C | - | 0.0924148497676833 | 0.0298533214318297 | COAD | Male-baised eQTL |
| rs8069144 | chr17:68123171:C:T | - | 0.100359494711494 | 0.030437217191111 | COAD | Male-baised eQTL |
| rs34714600 | chr17:68128744:C:G | - | 0.100359494711494 | 0.030437217191111 | COAD | Male-baised eQTL |
| rs151063904 | chr17:68113988:C:T | - | 0.0921619036432347 | 0.0305303186334626 | COAD | Male-baised eQTL |
| rs146234068 | chr17:68114175:A:T | - | 0.0921619036432347 | 0.0305303186334626 | COAD | Male-baised eQTL |
| rs7211136 | chr17:68116502:G:T | - | 0.0921619036432347 | 0.0305303186334626 | COAD | Male-baised eQTL |
| rs8078366 | chr17:68121432:T:C | - | 0.0921619036432347 | 0.0305303186334626 | COAD | Male-baised eQTL |
| rs8077300 | chr17:68134503:G:A | - | 0.0921619036432347 | 0.0305303186334626 | COAD | Male-baised eQTL |
| rs1661745 | chr17:75651059:A:G | - | 0.0501816425289236 | 0.0495761999125211 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000154217 |
| CpG Site: cg18596621 | |
| Position to Gene: gene | |
| Male Effect: -0.450981286322238 | |
| Female Effect: - | |
 | Gene ID: ENSG00000154217 |
| CpG Site: cg06559756 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.426873866083011 | |
 | Gene ID: ENSG00000154217 |
| CpG Site: cg18596621 | |
| Position to Gene: gene | |
| Male Effect: -0.233769366638273 | |
| Female Effect: - | |
 | Gene ID: ENSG00000154217 |
| CpG Site: cg24613558 | |
| Position to Gene: gene | |
| Male Effect: -0.203279532597366 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg18596621 | chr17:67475205 | gene | -0.450981286322238 | 1.60777552263397e-07 | -0.4014899398739964 | 4.792482957809714e-10 | LUAD |
| cg18596621 | chr17:67475205 | gene | -0.233769366638273 | 5.99657078318392e-06 | -0.3367098732438308 | 1.0261910999672707e-08 | LUSC |
| cg24613558 | chr17:67475231 | gene | -0.203279532597366 | 1.43132902728331e-05 | -0.3288399333981158 | 2.3446898977476774e-08 | LUSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06559756 | chr17:67468181 | gene | -0.426873866083011 | 3.01388923927079e-09 | -0.5868396412708476 | 2.8794168067219964e-12 | STAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PITPNC1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
