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Gene: ENSG00000154175 |
Summary for ABI3BP |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000154175 | Gene symbol | ABI3BP |
| Gene name | ABI family member 3 binding protein | |
| HGNC | 17265 | |
| Entrez ID | 25890 | |
| Gene type | protein_coding | |
| Synonyms | ABI3BP|NESHBP|DKFZP586L2024|TARSH | |
| UniProtAcc | Q7Z7G0 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ABI3BP |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ABI3BP | 1.53e+03 | -1.50e+00 | 4.30e-01 | -3.48e+00 | 4.96e-04 | 6.76e-03 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ABI3BP | 7.78e+02 | -2.33e+00 | 3.36e-01 | -6.95e+00 | 3.59e-12 | 2.89e-11 | HNSC |
| ABI3BP | 3.70e+02 | -3.05e+00 | 3.37e-01 | -9.04e+00 | 1.50e-19 | 3.00e-18 | COAD |
| ABI3BP | 2.04e+03 | -3.18e+00 | 6.54e-01 | -4.86e+00 | 1.20e-06 | 2.80e-05 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ABI3BP | 2.02e+03 | -2.13e+00 | 1.44e-01 | -1.48e+01 | 2.86e-49 | 2.84e-48 | BRCA |
| ABI3BP | 4.30e+02 | -3.88e+00 | 5.17e-01 | -7.51e+00 | 6.02e-14 | 3.84e-12 | READ |
Top |
Sex-biased somatic mutation for ABI3BP |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ABI3BP |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| DLBC | cg21968765 | chr3:100993501 | CGI:chr3:100709225-100709825 | UTR,promoter,exon,gene body | 2.00e-01 | 3.19e-01 | -2.30e+00 | 2.16e-02 | 3.65e-02 | -1.19e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg23634451 | chr3:100994802 | CGI:chr3:100709225-100709825 | promoter | 8.20e-01 | 9.31e-01 | -2.93e+00 | 3.39e-03 | 6.12e-03 | -1.11e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg15028548 | chr3:100993478 | CGI:chr3:100709225-100709825 | UTR,promoter,exon,gene body | 6.18e-01 | 4.25e-01 | 9.79e+00 | 1.22e-22 | 8.30e-22 | 1.93e-01 |
| BRCA | cg16163419 | chr3:100993482 | CGI:chr3:100709225-100709825 | UTR,promoter,exon,gene body | 6.44e-01 | 4.49e-01 | 1.01e+01 | 6.55e-24 | 5.02e-23 | 1.95e-01 |
| BRCA | cg21968765 | chr3:100993501 | CGI:chr3:100709225-100709825 | UTR,promoter,exon,gene body | 3.56e-01 | 2.05e-01 | 8.61e+00 | 7.18e-18 | 3.27e-17 | 1.50e-01 |
| COAD | cg23634451 | chr3:100994802 | CGI:chr3:100709225-100709825 | promoter | 8.11e-01 | 9.16e-01 | -2.57e+00 | 1.01e-02 | 1.59e-02 | -1.06e-01 |
| BLCA | cg00569747 | chr3:100994728 | CGI:chr3:100709225-100709825 | promoter | 8.42e-01 | 9.42e-01 | -2.72e+00 | 6.50e-03 | 1.33e-02 | -1.00e-01 |
Top |
Exon skipping events with PSI in TCGA for ABI3BP |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| KIRP | exon_skip_385982 | 1.07e-01 | 4.51e-01 | -4.71e+00 | 2.46e-06 | 4.13e-05 | -3.43e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ABI3BP |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ABI3BP |
| TFs related to ABI3BP. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ABI3BP related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ABI3BP |
| RBPs related to ES in ABI3BP. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LGG | MATR3 | exon_skip_385972 | 8.64e+00 | 9.90e-01 | 8.22e+00 | 3.99e-03 | Male-biased |
| KIRC | RBM41 | exon_skip_386170 | 8.54e+00 | 9.82e-01 | 8.24e+00 | 1.14e-02 | Male-biased |
| SARC | BRUNOL6 | exon_skip_385971 | 8.78e+00 | 9.83e-01 | 8.42e+00 | 1.14e-02 | Male-biased |
| ABI3BP related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs28896543 | chr3:99159070:T:C | - | 0.122241761368036 | 0.0337128966134866 | STAD | Female-baised eQTL |
| rs67909117 | chr3:94265547:T:C | - | 0.181248967877268 | 0.0391667865059257 | BLCA | Female-baised eQTL |
| rs11721294 | chr3:98397257:A:G | - | 0.0924819321983016 | 0.00735002918665081 | LUAD | Female-baised eQTL |
| rs10433345 | chr3:98394962:C:T | - | 0.10436139082605 | 0.00890524635197962 | LUAD | Female-baised eQTL |
| rs6439826 | chr3:98384238:T:C | - | 0.0908938585392906 | 0.0100895972196238 | LUAD | Female-baised eQTL |
| rs6439824 | chr3:98384127:A:G | - | 0.0894234619008838 | 0.012244242315654 | LUAD | Female-baised eQTL |
| rs66692191 | chr3:98387418:A:C | - | 0.0859265162419904 | 0.0191734590577858 | LUAD | Female-baised eQTL |
| rs6791981 | chr3:98385778:T:C | - | 0.0884812743634566 | 0.0204497787234353 | LUAD | Female-baised eQTL |
| rs6439823 | chr3:98383957:G:T | - | 0.087780822278307 | 0.0216524847700767 | LUAD | Female-baised eQTL |
| rs6439827 | chr3:98384239:G:A | - | 0.087780822278307 | 0.0216524847700767 | LUAD | Female-baised eQTL |
| rs7646920 | chr3:98386158:G:C | - | 0.0884333862836679 | 0.0217488962421683 | LUAD | Female-baised eQTL |
| rs13086478 | chr3:98386547:G:A | - | 0.0884333862836679 | 0.0217488962421683 | LUAD | Female-baised eQTL |
| rs7621233 | chr3:95120920:T:G | - | -0.0649626629165405 | 0.037408247743661 | LUAD | Female-baised eQTL |
| rs4857022 | chr3:95136235:T:G | - | -0.06486328157566 | 0.0382775112314826 | LUAD | Female-baised eQTL |
| rs9859961 | chr3:95137373:T:A | - | -0.06486328157566 | 0.0382775112314826 | LUAD | Female-baised eQTL |
| rs7620908 | chr3:95123082:G:A | - | -0.064111763288598 | 0.0402971150573603 | LUAD | Female-baised eQTL |
| rs7643795 | chr3:95123191:C:T | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs9855703 | chr3:95123848:G:A | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs9842570 | chr3:95123852:T:C | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs11708909 | chr3:95124766:C:G | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs11712965 | chr3:95124927:A:G | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs11713846 | chr3:95125212:A:G | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs67828560 | chr3:95125440:T:A | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs9288845 | chr3:95128096:G:A | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs9288846 | chr3:95128224:A:G | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs9845130 | chr3:95129098:T:C | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs11712473 | chr3:95129422:A:G | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs11708513 | chr3:95129518:C:A | - | -0.0627534712248331 | 0.0481264194741481 | LUAD | Female-baised eQTL |
| rs4106684 | chr3:95147226:T:A | - | -0.061426842026162 | 0.0495176417264869 | LUAD | Female-baised eQTL |
| rs9810121 | chr3:95147596:T:C | - | -0.061426842026162 | 0.0495176417264869 | LUAD | Female-baised eQTL |
| rs10933903 | chr3:95151265:T:A | - | -0.061426842026162 | 0.0495176417264869 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4257580 | chr3:106422888:A:C | - | 0.0519281232083131 | 0.0335497550929975 | LGG | Male-baised eQTL |
| rs12489523 | chr3:106416096:G:A | - | 0.0513663504376596 | 0.0395418096718692 | LGG | Male-baised eQTL |
| rs9853125 | chr3:97615055:A:G | - | 0.0509286502788878 | 0.0253087214847304 | KIRC | Male-baised eQTL |
| rs9841964 | chr3:97612545:T:A | - | 0.0491121192891574 | 0.0314916893142537 | KIRC | Male-baised eQTL |
| rs6808580 | chr3:96714933:T:C | - | -0.0821769312332541 | 0.00178474185837226 | BLCA | Male-baised eQTL |
| rs6798644 | chr3:96816009:C:T | - | -0.0791513067485847 | 0.00275262554887819 | BLCA | Male-baised eQTL |
| rs9834252 | chr3:98502809:A:G | - | 0.102528467349979 | 0.00241387376884854 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_385984 | chr3:100796408:100796468 | In-frame | rs9842968 | chr3:100782016:A:G | Distant downstream | -0.0606176529170328 | 0.0190050704067901 | KIRP | Female-baised sQTL |
| exon_skip_385984 | chr3:100796408:100796468 | In-frame | rs983474 | chr3:100786744:C:A | Distant downstream | -0.0606176529170328 | 0.0190050704067901 | KIRP | Female-baised sQTL |
| exon_skip_385984 | chr3:100796408:100796468 | In-frame | rs7613610 | chr3:100780477:C:A | Distant downstream | -0.0683944828430669 | 0.0427266831866133 | KIRP | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1144112 | chr3:100666933:C:T | Distant downstream | -0.0207809540148494 | 0.0131738897114912 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs7653531 | chr3:100714953:T:C | Distant downstream | 0.0211675155864954 | 0.0150898992325488 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs6775161 | chr3:100719048:A:G | Distant downstream | 0.0211675155864954 | 0.0150898992325488 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1165534 | chr3:100664458:C:G | Distant downstream | -0.02427322537606 | 0.0150909628880688 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs989795 | chr3:100792602:T:A | Proximal downstream | 0.0212739156251337 | 0.015456980787796 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs9824346 | chr3:100798467:G:C | Distant upstream | 0.0205068124421898 | 0.0177798662384429 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs13062677 | chr3:101586234:G:A | Distant upstream | -0.0204336918365941 | 0.0189059720376876 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1165536 | chr3:100663664:C:G | Distant downstream | -0.01980932104321 | 0.0207990076029295 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs989794 | chr3:100792535:G:A | Proximal downstream | 0.0205240018648827 | 0.0211540122992556 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs989793 | chr3:100792584:G:A | Proximal downstream | 0.0205240018648827 | 0.0211540122992556 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs4586787 | chr3:101604794:C:T | Distant upstream | -0.0198245688757753 | 0.0227272799765398 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs10936708 | chr3:101605530:C:G | Distant upstream | -0.0198245688757753 | 0.0227272799765398 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1476123 | chr3:101594569:C:G | Distant upstream | -0.020114406467416 | 0.0238297688811563 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1145335 | chr3:100670188:T:A | Distant downstream | -0.0204980087122889 | 0.0240105476848891 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs12496951 | chr3:100797475:A:G | Distant upstream | 0.0203316505196272 | 0.0255489279676233 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1503845 | chr3:100807026:A:G | Distant upstream | 0.0193246318632652 | 0.0320235449829838 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1144108 | chr3:100702565:T:C | Distant downstream | -0.0223649548766971 | 0.035750159985614 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs1143776 | chr3:100709274:G:A | Distant downstream | -0.0221576727980679 | 0.0392489668089986 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs591728 | chr3:100714748:T:C | Distant downstream | -0.0219118551786525 | 0.0446776633805143 | KIRC | Male-baised sQTL |
| exon_skip_385976 | chr3:100792690:100792768 | In-frame | rs12638134 | chr3:101615765:G:T | Distant upstream | -0.0181717335820158 | 0.0493926973066922 | KIRC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_385976 |
| CpG Site: cg10507762 | |
| Position to EX: Distant upstream | |
| Male Effect: 0.448609921645702 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_385976 | chr3:100792690:100792768 | cg10507762 | chr3:101566031 | Distant upstream | 0.448609921645702 | 2.54874145809079e-14 | 0.6477595103236692 | 5.186401597683912e-12 | In-frame | SARC |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ABI3BP |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000154175 | ABI3BP | C0014175 | Endometriosis | 1 | CTD_human |
| ENSG00000154175 | ABI3BP | C0041696 | Unipolar Depression | 1 | PSYGENET |
| ENSG00000154175 | ABI3BP | C0269102 | Endometrioma | 1 | CTD_human |
| ENSG00000154175 | ABI3BP | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
