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Gene: ENSG00000153283 |
Summary for CD96 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000153283 | Gene symbol | CD96 |
| Gene name | CD96 molecule | |
| HGNC | 16892 | |
| Entrez ID | 10225 | |
| Gene type | protein_coding | |
| Synonyms | CD96|TACTILE | |
| UniProtAcc | P40200 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CD96 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CD96 | 5.18e+02 | -1.35e+00 | 4.36e-01 | -3.09e+00 | 1.98e-03 | 1.84e-02 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CD96 | 4.79e+02 | -1.12e+00 | 1.75e-01 | -6.38e+00 | 1.77e-10 | 9.43e-10 | THCA |
Top |
Sex-biased somatic mutation for CD96 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CD96 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for CD96 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for CD96 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for CD96 |
| TFs related to CD96. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | NFIB | CD96 | 3.49e+00 | 1.09e-02 | 4.67e+00 | 9.82e-01 | Female-biased |
| BRCA | ZNF616 | CD96 | 2.56e+00 | 2.30e-03 | 4.23e+00 | 9.81e-01 | Female-biased |
| CHOL | ZNF33B | CD96 | 4.44e+00 | 9.82e-01 | 3.52e+00 | 1.24e-02 | Male-biased |
| MESO | DMRTA1 | CD96 | 4.39e+00 | 1.66e-02 | 5.51e+00 | 9.82e-01 | Female-biased |
| MESO | FOXC2 | CD96 | 2.93e+00 | 7.25e-03 | 4.29e+00 | 9.83e-01 | Female-biased |
| MESO | FOXL1 | CD96 | 3.37e+00 | 4.51e-03 | 4.90e+00 | 9.92e-01 | Female-biased |
| MESO | ZKSCAN2 | CD96 | 3.90e+00 | 1.17e-02 | 5.13e+00 | 9.85e-01 | Female-biased |
| MESO | ZNF334 | CD96 | 3.35e+00 | 1.14e-03 | 5.25e+00 | 9.97e-01 | Female-biased |
| MESO | ZNF33B | CD96 | 3.81e+00 | 8.51e-03 | 5.14e+00 | 9.89e-01 | Female-biased |
| MESO | ZNF418 | CD96 | 2.77e+00 | 5.97e-04 | 4.83e+00 | 9.95e-01 | Female-biased |
| MESO | ZNF570 | CD96 | 2.95e+00 | 4.34e-03 | 4.47e+00 | 9.88e-01 | Female-biased |
| SARC | FOXC1 | CD96 | 3.91e+00 | 9.23e-03 | 4.56e+00 | 9.85e-01 | Female-biased |
| SARC | MBNL2 | CD96 | 3.56e+00 | 6.31e-03 | 4.28e+00 | 9.85e-01 | Female-biased |
| SARC | NR3C1 | CD96 | 4.90e+00 | 1.69e-02 | 5.45e+00 | 9.82e-01 | Female-biased |
| SARC | SOX14 | CD96 | 4.32e+00 | 1.03e-02 | 4.96e+00 | 9.87e-01 | Female-biased |
| SARC | ZNF33B | CD96 | 3.59e+00 | 5.25e-03 | 4.34e+00 | 9.87e-01 | Female-biased |
| SARC | ZSCAN16 | CD96 | 3.82e+00 | 1.19e-02 | 4.43e+00 | 9.81e-01 | Female-biased |
| SKCM | ZNF334 | CD96 | 3.56e+00 | 7.73e-03 | 4.61e+00 | 9.81e-01 | Female-biased |
| CD96 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CD96 |
| RBPs related to ES in CD96. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CD96 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000153283 | FAM30A,hsa-mir-150,CD96 | Tumor sex-biased ceRNA | TCGA-BRCA |
| ENSG00000153283 | AC009133.3,hsa-mir-150,CD96 | Female-specific ceRNA | TCGA-THCA |
| ENSG00000153283 | LINC01013,hsa-mir-150,CD96 | Female-specific ceRNA | TCGA-THCA |
| ENSG00000153283 | LINC02413,hsa-mir-150,CD96 | Female-specific ceRNA | TCGA-THCA |
| ENSG00000153283 | LINC01991,hsa-mir-150,CD96 | Female-specific ceRNA | TCGA-THCA |
| ENSG00000153283 | FAM30A,hsa-mir-150,CD96 | Female-specific ceRNA | TCGA-THCA |
| ENSG00000153283 | AC243960.1,hsa-mir-150,CD96 | Female-specific ceRNA | TCGA-THCA |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2683903 | chr3:112392952:T:C | - | -0.242335166972554 | 0.0276950339228078 | LUSC | Female-baised eQTL |
| rs626889 | chr3:107515656:T:A | - | -0.0889229017236103 | 0.0162812152696391 | LUAD | Female-baised eQTL |
| rs2244035 | chr3:112384453:G:A | - | 0.0814411523328803 | 0.025162744638816 | LUAD | Female-baised eQTL |
| rs1683976 | chr3:120956039:A:G | - | -0.0677609569324835 | 0.0397511447009764 | LUAD | Female-baised eQTL |
| rs836926 | chr3:107483170:G:A | - | -0.0699925750458147 | 0.0469519041320913 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9814086 | chr3:116939490:C:T | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs3972692 | chr3:116940018:C:T | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs3972691 | chr3:116940090:G:C | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs11709956 | chr3:116942021:C:G | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs116790645 | chr3:116944217:A:G | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs13059181 | chr3:116945982:C:T | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs34662557 | chr3:116947502:C:A | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs35843048 | chr3:116947617:C:T | - | 0.133111704033476 | 0.00853781782623486 | PAAD | Male-baised eQTL |
| rs2140344 | chr3:116942743:C:T | - | 0.132452736883566 | 0.0092495383258529 | PAAD | Male-baised eQTL |
| rs9835156 | chr3:116943400:C:T | - | 0.132452736883566 | 0.0092495383258529 | PAAD | Male-baised eQTL |
| rs6781792 | chr3:116944234:T:C | - | 0.130846679754613 | 0.0115680914958955 | PAAD | Male-baised eQTL |
| rs9289064 | chr3:116931013:G:A | - | 0.130154252983129 | 0.0130985797677141 | PAAD | Male-baised eQTL |
| rs9880161 | chr3:116932396:C:A | - | 0.130154252983129 | 0.0130985797677141 | PAAD | Male-baised eQTL |
| rs10049335 | chr3:116929173:C:T | - | 0.12998444230498 | 0.0133640107124753 | PAAD | Male-baised eQTL |
| rs58059953 | chr3:116930716:T:A | - | 0.129828608221031 | 0.014487272023475 | PAAD | Male-baised eQTL |
| rs9870308 | chr3:116930724:G:T | - | 0.129828608221031 | 0.014487272023475 | PAAD | Male-baised eQTL |
| rs28709185 | chr3:116893256:C:A | - | 0.127431573321162 | 0.0199983483496079 | PAAD | Male-baised eQTL |
| rs1980081 | chr3:116915275:T:C | - | 0.125885249640989 | 0.0231015838241015 | PAAD | Male-baised eQTL |
| rs7427341 | chr3:116896175:A:G | - | 0.125652676531986 | 0.0232340385273846 | PAAD | Male-baised eQTL |
| rs7430708 | chr3:116895342:C:G | - | 0.125673008052314 | 0.0240211092076616 | PAAD | Male-baised eQTL |
| rs7428839 | chr3:116911128:C:T | - | 0.125673008052314 | 0.0240211092076616 | PAAD | Male-baised eQTL |
| rs2037008 | chr3:116909887:T:C | - | 0.123585155978686 | 0.0309581717749594 | PAAD | Male-baised eQTL |
| rs7620372 | chr3:111189548:T:C | - | 0.049332704629383 | 0.00348297973945571 | LUAD | Male-baised eQTL |
| rs7610754 | chr3:111195125:G:A | - | 0.0448997333425687 | 0.00966081704008576 | LUAD | Male-baised eQTL |
| rs12635328 | chr3:115742620:G:A | - | 0.0532346701862229 | 0.0104968085624328 | LUAD | Male-baised eQTL |
| rs2712994 | chr3:110270173:G:A | - | 0.0492915197096808 | 0.0287046151799309 | LUAD | Male-baised eQTL |
| rs13069411 | chr3:115785309:C:T | - | 0.0461564890914814 | 0.0360633804379066 | LUAD | Male-baised eQTL |
| rs13061169 | chr3:115787456:A:G | - | 0.0461564890914814 | 0.0360633804379066 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000153283 |
| CpG Site: cg05655806 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.116509614181591 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg05655806 | chr3:111541909 | gene | -0.116509614181591 | 1.25108315551284e-07 | -0.40876178747915154 | 9.675438249746342e-10 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CD96 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000153283 | CD96 | C0796095 | Opitz trigonocephaly syndrome | 1 | CTD_human |
