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Gene: ENSG00000152977

Summary for ZIC1

Gene summary

Gene information	Ensembl ID	ENSG00000152977
	Gene symbol	ZIC1
	Gene name	Zic family member 1
	HGNC	12872
	Entrez ID	7545
	Gene type	protein_coding
	Synonyms	ZIC1\|ZIC\|ZNF201
	UniProtAcc	Q15915

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for ZIC1

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Top

Sex-biased somatic mutation for ZIC1

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for ZIC1

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg00154357	chr3:147393493	CGI:chr3:147390724-147393916	promoter,exon,gene body	5.66e-01	7.17e-01	-2.27e+00	2.35e-02	3.72e-02	-1.51e-01
BRCA	cg27416372	chr3:147392442	CGI:chr3:147390724-147393916	promoter	3.41e-01	4.60e-01	-2.00e+00	4.57e-02	4.83e-02	-1.19e-01
BRCA	cg03900143	chr3:147393873	CGI:chr3:147390724-147393916	promoter,exon,gene body	4.61e-01	6.65e-01	-2.30e+00	2.16e-02	3.60e-02	-2.04e-01
BRCA	cg22796509	chr3:147392508	CGI:chr3:147390724-147393916	promoter	3.62e-01	5.00e-01	-2.27e+00	2.32e-02	3.70e-02	-1.38e-01
BRCA	cg08812189	chr3:147392580	CGI:chr3:147390724-147393916	promoter	4.06e-01	5.96e-01	-2.37e+00	1.76e-02	3.33e-02	-1.90e-01
BRCA	cg07850418	chr3:147392591	CGI:chr3:147390724-147393916	promoter	3.44e-01	4.96e-01	-2.11e+00	3.51e-02	4.36e-02	-1.52e-01
BRCA	cg01581018	chr3:147392808	CGI:chr3:147390724-147393916	promoter	4.27e-01	6.18e-01	-2.50e+00	1.23e-02	2.88e-02	-1.91e-01
BRCA	cg17003736	chr3:147393521	CGI:chr3:147390724-147393916	promoter,exon,gene body	4.31e-01	5.64e-01	-2.14e+00	3.21e-02	4.22e-02	-1.33e-01
KIRP	cg26014036	chr3:147394309	CGI:chr3:147390724-147393916	promoter,gene body	3.15e-01	1.98e-01	3.95e+00	7.76e-05	6.18e-04	1.17e-01
KIRP	cg25007283	chr3:147394356	CGI:chr3:147390724-147393916	promoter,gene body	5.65e-01	4.50e-01	3.54e+00	3.96e-04	2.39e-03	1.15e-01
GBM	cg12388007	chr3:147392712	CGI:chr3:147390724-147393916	promoter	1.80e-01	2.94e-01	-2.14e+00	3.24e-02	4.32e-02	-1.13e-01
KICH	cg25007283	chr3:147394356	CGI:chr3:147390724-147393916	promoter,gene body	3.54e-01	4.82e-01	-2.22e+00	2.62e-02	4.10e-02	-1.28e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
KIRC	cg02653559	chr3:147394294	CGI:chr3:147390724-147393916	promoter,gene body	1.63e-01	3.55e-02	6.08e+00	1.17e-09	1.35e-08	1.27e-01
KIRC	cg00235367	chr3:147392535	CGI:chr3:147390724-147393916	promoter	1.78e-01	6.97e-02	5.03e+00	4.93e-07	1.97e-06	1.09e-01
KIRC	cg01581018	chr3:147392808	CGI:chr3:147390724-147393916	promoter	2.85e-01	1.79e-01	2.89e+00	3.87e-03	5.13e-03	1.06e-01
KIRC	cg25007283	chr3:147394356	CGI:chr3:147390724-147393916	promoter,gene body	5.19e-01	3.70e-01	3.17e+00	1.51e-03	2.23e-03	1.49e-01
KIRC	cg02390329	chr3:147395305	CGI:chr3:147395821-147396692	promoter,gene body	4.71e-01	3.57e-01	2.55e+00	1.08e-02	1.28e-02	1.14e-01
LUAD	cg13340636	chr3:147392880	CGI:chr3:147390724-147393916	promoter	2.93e-01	1.83e-01	3.34e+00	8.29e-04	1.66e-03	1.10e-01
LUAD	cg02390329	chr3:147395305	CGI:chr3:147395821-147396692	promoter,gene body	4.83e-01	3.47e-01	2.76e+00	5.84e-03	8.52e-03	1.36e-01
THCA	cg00154357	chr3:147393493	CGI:chr3:147390724-147393916	promoter,exon,gene body	3.32e-01	2.05e-01	2.66e+00	7.72e-03	1.38e-02	1.27e-01
THCA	cg27606499	chr3:147393333	CGI:chr3:147390724-147393916	promoter	1.88e-01	7.39e-02	3.92e+00	8.97e-05	5.53e-04	1.14e-01
THCA	cg03900143	chr3:147393873	CGI:chr3:147390724-147393916	promoter,exon,gene body	1.95e-01	5.48e-02	3.57e+00	3.58e-04	1.49e-03	1.40e-01
THCA	cg20939084	chr3:147391997	CGI:chr3:147390724-147393916	promoter	3.24e-01	1.83e-01	2.89e+00	3.91e-03	8.40e-03	1.41e-01
LUSC	cg03881775	chr3:147393348	CGI:chr3:147390724-147393916	promoter	4.27e-01	1.19e-01	4.03e+00	5.64e-05	5.75e-04	3.08e-01
LUSC	cg00154357	chr3:147393493	CGI:chr3:147390724-147393916	promoter,exon,gene body	6.35e-01	3.14e-01	4.12e+00	3.76e-05	5.31e-04	3.21e-01
LUSC	cg27416372	chr3:147392442	CGI:chr3:147390724-147393916	promoter	4.25e-01	1.37e-01	4.04e+00	5.31e-05	5.65e-04	2.88e-01
LUSC	cg27606499	chr3:147393333	CGI:chr3:147390724-147393916	promoter	4.92e-01	1.23e-01	4.06e+00	5.00e-05	5.58e-04	3.69e-01
LUSC	cg03900143	chr3:147393873	CGI:chr3:147390724-147393916	promoter,exon,gene body	5.69e-01	1.02e-01	4.17e+00	3.07e-05	5.26e-04	4.67e-01
LUSC	cg02653559	chr3:147394294	CGI:chr3:147390724-147393916	promoter,gene body	4.30e-01	4.06e-02	3.98e+00	6.89e-05	6.07e-04	3.90e-01
LUSC	cg20939084	chr3:147391997	CGI:chr3:147390724-147393916	promoter	6.17e-01	2.51e-01	4.42e+00	9.95e-06	5.26e-04	3.66e-01
LUSC	cg22796509	chr3:147392508	CGI:chr3:147390724-147393916	promoter	4.41e-01	2.24e-01	3.82e+00	1.31e-04	7.87e-04	2.17e-01
LUSC	cg00235367	chr3:147392535	CGI:chr3:147390724-147393916	promoter	3.79e-01	8.98e-02	4.20e+00	2.71e-05	5.26e-04	2.89e-01
LUSC	cg08812189	chr3:147392580	CGI:chr3:147390724-147393916	promoter	5.17e-01	1.24e-01	4.18e+00	2.94e-05	5.26e-04	3.93e-01
LUSC	cg07850418	chr3:147392591	CGI:chr3:147390724-147393916	promoter	4.43e-01	1.21e-01	4.19e+00	2.82e-05	5.26e-04	3.22e-01
LUSC	cg12388007	chr3:147392712	CGI:chr3:147390724-147393916	promoter	3.26e-01	8.88e-02	3.96e+00	7.45e-05	6.23e-04	2.38e-01
LUSC	cg01581018	chr3:147392808	CGI:chr3:147390724-147393916	promoter	4.19e-01	2.06e-01	3.62e+00	2.92e-04	1.20e-03	2.13e-01
LUSC	cg13340636	chr3:147392880	CGI:chr3:147390724-147393916	promoter	3.95e-01	2.01e-01	3.17e+00	1.52e-03	3.46e-03	1.95e-01
LUSC	cg17003736	chr3:147393521	CGI:chr3:147390724-147393916	promoter,exon,gene body	4.83e-01	1.96e-01	4.21e+00	2.54e-05	5.26e-04	2.87e-01
LUSC	cg26014036	chr3:147394309	CGI:chr3:147390724-147393916	promoter,gene body	5.24e-01	1.71e-01	3.82e+00	1.36e-04	8.00e-04	3.53e-01
LUSC	cg25007283	chr3:147394356	CGI:chr3:147390724-147393916	promoter,gene body	5.83e-01	4.35e-01	2.10e+00	3.61e-02	3.83e-02	1.48e-01
LUSC	cg22203776	chr3:147394529	CGI:chr3:147390724-147393916	promoter,gene body	3.30e-01	1.71e-01	3.06e+00	2.24e-03	4.52e-03	1.60e-01
LUSC	cg02126051	chr3:147394651	CGI:chr3:147390724-147393916	promoter,gene body	4.21e-01	1.92e-01	3.57e+00	3.57e-04	1.35e-03	2.28e-01
LUSC	cg18292434	chr3:147394754	CGI:chr3:147390724-147393916	promoter,gene body	5.59e-01	4.09e-01	2.95e+00	3.14e-03	5.79e-03	1.50e-01
LUSC	cg04557018	chr3:147394818	CGI:chr3:147390724-147393916	promoter,gene body	3.79e-01	1.48e-01	2.68e+00	7.36e-03	1.09e-02	2.31e-01
LUSC	cg02390329	chr3:147395305	CGI:chr3:147395821-147396692	promoter,gene body	6.22e-01	3.66e-01	3.28e+00	1.03e-03	2.64e-03	2.57e-01
COAD	cg22203776	chr3:147394529	CGI:chr3:147390724-147393916	promoter,gene body	3.35e-01	2.00e-01	2.33e+00	1.99e-02	2.46e-02	1.35e-01
BLCA	cg12388007	chr3:147392712	CGI:chr3:147390724-147393916	promoter	2.45e-01	8.60e-02	3.92e+00	8.82e-05	3.66e-04	1.59e-01
BLCA	cg13340636	chr3:147392880	CGI:chr3:147390724-147393916	promoter	3.59e-01	1.87e-01	2.94e+00	3.23e-03	5.74e-03	1.72e-01
BLCA	cg02126051	chr3:147394651	CGI:chr3:147390724-147393916	promoter,gene body	3.81e-01	1.76e-01	3.46e+00	5.35e-04	1.40e-03	2.05e-01
BLCA	cg18292434	chr3:147394754	CGI:chr3:147390724-147393916	promoter,gene body	5.18e-01	3.53e-01	3.17e+00	1.53e-03	3.18e-03	1.65e-01
LIHC	cg02390329	chr3:147395305	CGI:chr3:147395821-147396692	promoter,gene body	6.81e-01	5.34e-01	4.10e+00	4.19e-05	9.58e-05	1.46e-01
KIRP	cg18292434	chr3:147394754	CGI:chr3:147390724-147393916	promoter,gene body	2.01e-01	3.02e-01	-5.05e+00	4.48e-07	2.83e-06	-1.01e-01
ESCA	cg02390329	chr3:147395305	CGI:chr3:147395821-147396692	promoter,gene body	6.61e-01	4.86e-01	2.08e+00	3.71e-02	4.58e-02	1.75e-01
CHOL	cg03881775	chr3:147393348	CGI:chr3:147390724-147393916	promoter	4.31e-01	1.09e-01	2.65e+00	7.96e-03	1.92e-02	3.22e-01
CHOL	cg00154357	chr3:147393493	CGI:chr3:147390724-147393916	promoter,exon,gene body	6.21e-01	2.69e-01	2.88e+00	4.04e-03	1.47e-02	3.52e-01
CHOL	cg27606499	chr3:147393333	CGI:chr3:147390724-147393916	promoter	5.03e-01	9.49e-02	2.65e+00	7.96e-03	1.92e-02	4.08e-01
CHOL	cg03900143	chr3:147393873	CGI:chr3:147390724-147393916	promoter,exon,gene body	5.21e-01	4.24e-02	3.10e+00	1.96e-03	1.07e-02	4.78e-01
CHOL	cg20939084	chr3:147391997	CGI:chr3:147390724-147393916	promoter	5.77e-01	2.34e-01	3.54e+00	4.02e-04	8.32e-03	3.43e-01
CHOL	cg00235367	chr3:147392535	CGI:chr3:147390724-147393916	promoter	3.12e-01	9.92e-02	2.58e+00	9.87e-03	2.15e-02	2.12e-01
CHOL	cg08812189	chr3:147392580	CGI:chr3:147390724-147393916	promoter	4.23e-01	1.24e-01	2.58e+00	9.87e-03	2.15e-02	2.98e-01
CHOL	cg07850418	chr3:147392591	CGI:chr3:147390724-147393916	promoter	3.53e-01	1.11e-01	2.21e+00	2.70e-02	3.50e-02	2.42e-01
CHOL	cg12388007	chr3:147392712	CGI:chr3:147390724-147393916	promoter	3.30e-01	8.39e-02	1.99e+00	4.65e-02	4.65e-02	2.46e-01
CHOL	cg01581018	chr3:147392808	CGI:chr3:147390724-147393916	promoter	4.56e-01	1.52e-01	3.17e+00	1.52e-03	1.07e-02	3.04e-01
CHOL	cg13340636	chr3:147392880	CGI:chr3:147390724-147393916	promoter	4.19e-01	1.58e-01	3.02e+00	2.51e-03	1.19e-02	2.61e-01
CHOL	cg17003736	chr3:147393521	CGI:chr3:147390724-147393916	promoter,exon,gene body	4.93e-01	1.60e-01	2.65e+00	7.96e-03	1.92e-02	3.33e-01
CHOL	cg26014036	chr3:147394309	CGI:chr3:147390724-147393916	promoter,gene body	4.34e-01	1.27e-01	1.99e+00	4.65e-02	4.65e-02	3.07e-01
CHOL	cg02126051	chr3:147394651	CGI:chr3:147390724-147393916	promoter,gene body	2.63e-01	1.02e-01	2.14e+00	3.25e-02	3.87e-02	1.61e-01
CHOL	cg04557018	chr3:147394818	CGI:chr3:147390724-147393916	promoter,gene body	1.98e-01	7.01e-02	2.43e+00	1.50e-02	2.65e-02	1.27e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg03881775	chr3:147393348	CGI:chr3:147390724-147393916	promoter	3.94e-01	1.27e-01	1.14e+01	3.03e-30	4.54e-29	2.68e-01
BRCA	cg00154357	chr3:147393493	CGI:chr3:147390724-147393916	promoter,exon,gene body	5.66e-01	2.87e-01	1.15e+01	1.04e-30	1.66e-29	2.80e-01
BRCA	cg27416372	chr3:147392442	CGI:chr3:147390724-147393916	promoter	3.41e-01	1.53e-01	9.68e+00	3.69e-22	2.41e-21	1.88e-01
BRCA	cg27606499	chr3:147393333	CGI:chr3:147390724-147393916	promoter	4.58e-01	1.15e-01	1.22e+01	2.06e-34	5.48e-33	3.43e-01
BRCA	cg03900143	chr3:147393873	CGI:chr3:147390724-147393916	promoter,exon,gene body	4.61e-01	7.52e-02	1.18e+01	2.88e-32	5.60e-31	3.86e-01
BRCA	cg02653559	chr3:147394294	CGI:chr3:147390724-147393916	promoter,gene body	2.97e-01	8.07e-02	5.43e+00	5.61e-08	1.17e-07	2.16e-01
BRCA	cg20939084	chr3:147391997	CGI:chr3:147390724-147393916	promoter	5.12e-01	2.33e-01	1.04e+01	3.38e-25	2.93e-24	2.79e-01
BRCA	cg22796509	chr3:147392508	CGI:chr3:147390724-147393916	promoter	3.62e-01	2.48e-01	6.76e+00	1.41e-11	3.96e-11	1.14e-01
BRCA	cg00235367	chr3:147392535	CGI:chr3:147390724-147393916	promoter	2.72e-01	9.71e-02	9.64e+00	5.30e-22	3.41e-21	1.75e-01
BRCA	cg08812189	chr3:147392580	CGI:chr3:147390724-147393916	promoter	4.06e-01	1.11e-01	1.17e+01	1.36e-31	2.42e-30	2.94e-01
BRCA	cg07850418	chr3:147392591	CGI:chr3:147390724-147393916	promoter	3.44e-01	1.12e-01	1.10e+01	4.66e-28	5.40e-27	2.32e-01
BRCA	cg12388007	chr3:147392712	CGI:chr3:147390724-147393916	promoter	2.39e-01	9.90e-02	8.76e+00	1.90e-18	9.04e-18	1.40e-01
BRCA	cg01581018	chr3:147392808	CGI:chr3:147390724-147393916	promoter	4.27e-01	2.62e-01	7.32e+00	2.56e-13	8.22e-13	1.65e-01
BRCA	cg13340636	chr3:147392880	CGI:chr3:147390724-147393916	promoter	3.18e-01	2.00e-01	5.78e+00	7.42e-09	1.68e-08	1.18e-01
BRCA	cg17003736	chr3:147393521	CGI:chr3:147390724-147393916	promoter,exon,gene body	4.31e-01	1.87e-01	1.18e+01	3.04e-32	5.90e-31	2.44e-01
BRCA	cg26014036	chr3:147394309	CGI:chr3:147390724-147393916	promoter,gene body	4.59e-01	2.51e-01	5.02e+00	5.23e-07	9.98e-07	2.08e-01
LIHC	cg03881775	chr3:147393348	CGI:chr3:147390724-147393916	promoter	2.81e-01	8.38e-02	3.26e+00	1.11e-03	2.44e-03	1.97e-01
LIHC	cg00154357	chr3:147393493	CGI:chr3:147390724-147393916	promoter,exon,gene body	4.72e-01	2.45e-01	3.34e+00	8.27e-04	1.95e-03	2.27e-01
LIHC	cg03900143	chr3:147393873	CGI:chr3:147390724-147393916	promoter,exon,gene body	3.34e-01	5.46e-02	3.49e+00	4.75e-04	1.27e-03	2.79e-01
LIHC	cg02653559	chr3:147394294	CGI:chr3:147390724-147393916	promoter,gene body	1.47e-01	3.98e-02	4.05e+00	5.07e-05	2.30e-04	1.07e-01
LIHC	cg20939084	chr3:147391997	CGI:chr3:147390724-147393916	promoter	4.64e-01	2.42e-01	3.29e+00	1.01e-03	2.28e-03	2.22e-01
LIHC	cg00235367	chr3:147392535	CGI:chr3:147390724-147393916	promoter	2.16e-01	8.38e-02	2.02e+00	4.34e-02	4.46e-02	1.32e-01
LIHC	cg08812189	chr3:147392580	CGI:chr3:147390724-147393916	promoter	2.82e-01	1.04e-01	2.62e+00	8.90e-03	1.27e-02	1.78e-01
LIHC	cg12388007	chr3:147392712	CGI:chr3:147390724-147393916	promoter	1.76e-01	7.06e-02	2.95e+00	3.19e-03	5.63e-03	1.05e-01
LIHC	cg17003736	chr3:147393521	CGI:chr3:147390724-147393916	promoter,exon,gene body	3.25e-01	1.65e-01	2.90e+00	3.75e-03	6.40e-03	1.60e-01
LIHC	cg26014036	chr3:147394309	CGI:chr3:147390724-147393916	promoter,gene body	2.40e-01	9.64e-02	2.29e+00	2.20e-02	2.60e-02	1.44e-01
LIHC	cg25007283	chr3:147394356	CGI:chr3:147390724-147393916	promoter,gene body	3.62e-01	1.83e-01	2.52e+00	1.19e-02	1.59e-02	1.79e-01
KIRP	cg03881775	chr3:147393348	CGI:chr3:147390724-147393916	promoter	1.92e-01	6.72e-02	2.61e+00	9.00e-03	1.57e-02	1.25e-01
KIRP	cg03900143	chr3:147393873	CGI:chr3:147390724-147393916	promoter,exon,gene body	2.23e-01	4.75e-02	2.33e+00	2.00e-02	2.67e-02	1.76e-01
KIRP	cg02653559	chr3:147394294	CGI:chr3:147390724-147393916	promoter,gene body	1.48e-01	3.60e-02	3.23e+00	1.24e-03	4.42e-03	1.12e-01
KIRP	cg08812189	chr3:147392580	CGI:chr3:147390724-147393916	promoter	2.04e-01	9.29e-02	2.15e+00	3.13e-02	3.63e-02	1.11e-01
KIRP	cg17003736	chr3:147393521	CGI:chr3:147390724-147393916	promoter,exon,gene body	2.83e-01	1.53e-01	2.66e+00	7.83e-03	1.43e-02	1.29e-01
KIRP	cg25007283	chr3:147394356	CGI:chr3:147390724-147393916	promoter,gene body	5.65e-01	4.11e-01	2.07e+00	3.81e-02	4.14e-02	1.55e-01

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Exon skipping events with PSI in TCGA for ZIC1

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for ZIC1

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for ZIC1

TFs related to ZIC1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

Target Gene

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

ZIC1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for ZIC1

RBPs related to ES in ZIC1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

ZIC1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID

ceRNA(lncRNA-miRNA-mRNA)

Group

Cancer Type

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs62287762	chr3:155927368:G:A	-	0.11716833922354	0.0174875066031715	LGG	Female-baised eQTL
rs142712555	chr3:155867549:C:T	-	0.100367630532188	0.0289666214923225	LGG	Female-baised eQTL
rs77388182	chr3:155856227:C:A	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs73873435	chr3:155856864:C:A	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs115045482	chr3:155857166:G:A	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs59255899	chr3:155860397:A:G	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs62286783	chr3:155861232:T:C	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs13088748	chr3:155862555:T:C	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs12493654	chr3:155863189:C:A	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs12493730	chr3:155863545:C:T	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs12487275	chr3:155863546:A:G	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs62286785	chr3:155864915:A:G	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs62286788	chr3:155867212:C:A	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs12496097	chr3:155868003:T:C	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs62286792	chr3:155869037:C:A	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs62286793	chr3:155869177:T:G	-	0.101466250769346	0.0301825960185242	LGG	Female-baised eQTL
rs3804769	chr3:155853486:T:C	-	0.0954699923525178	0.0455662398251829	LGG	Female-baised eQTL

Female-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000152977
	CpG Site: cg21776417
	Position to Gene: gene
	Male Effect: 0.399539026693415
	Female Effect: -
	Gene ID: ENSG00000152977
	CpG Site: cg27136844
	Position to Gene: gene
	Male Effect: 0.387564453149548
	Female Effect: -
	Gene ID: ENSG00000152977
	CpG Site: cg26224785
	Position to Gene: gene
	Male Effect: -0.288927530824662
	Female Effect: -
	Gene ID: ENSG00000152977
	CpG Site: cg06166523
	Position to Gene: gene
	Male Effect: -0.288927530824662
	Female Effect: -
	Gene ID: ENSG00000152977
	CpG Site: cg18297437
	Position to Gene: gene,exon,CDS
	Male Effect: -0.134362033995037
	Female Effect: -
	Gene ID: ENSG00000152977
	CpG Site: cg24620761
	Position to Gene: gene
	Male Effect: -0.268311666216307
	Female Effect: -
	Gene ID: ENSG00000152977
	CpG Site: cg06369327
	Position to Gene: gene
	Male Effect: 0.0392016186313403
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg21776417	chr3:147424628	gene	0.399539026693415	2.5956750344458e-07	0.3373918189363807	0.00018684807324815343	SARC
cg27136844	chr3:147424568	gene	0.387564453149548	4.87413569884011e-07	0.38228437194705644	1.784015842481075e-05	SARC
cg26224785	chr3:147404528	gene	-0.288927530824662	9.19416201610907e-09	-0.38133567311726696	1.94818867550758e-11	LGG
cg06166523	chr3:147404877	gene	-0.288927530824662	9.19416201610907e-09	-0.38133567311726696	1.94818867550758e-11	LGG
cg18297437	chr3:147413545	gene,exon,CDS	-0.134362033995037	2.22159460886356e-08	-0.36351582184707903	1.8620418833215236e-10	LGG
cg24620761	chr3:147405412	gene	-0.268311666216307	1.45850251754695e-07	-0.3510477077962354	8.335366479901419e-10	LGG
cg06369327	chr3:147406736	gene	0.0392016186313403	1.11508513192536e-05	0.3069530884727396	9.609132696609723e-08	SKCM

Female-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

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Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

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Related disease information of ZIC1

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000152977	ZIC1	C0010278	Craniosynostosis	1	CTD_human
ENSG00000152977	ZIC1	C0030044	Acrocephaly	1	CTD_human
ENSG00000152977	ZIC1	C0221356	Brachycephaly	1	CTD_human
ENSG00000152977	ZIC1	C0265534	Scaphycephaly	1	CTD_human
ENSG00000152977	ZIC1	C0265535	Trigonocephaly	1	CTD_human
ENSG00000152977	ZIC1	C1833340	Synostotic Posterior Plagiocephaly	1	CTD_human
ENSG00000152977	ZIC1	C1860819	Metopic synostosis	1	CTD_human
ENSG00000152977	ZIC1	C2931150	Synostotic Anterior Plagiocephaly	1	CTD_human
ENSG00000152977	ZIC1	C4551902	Craniosynostosis, Type 1	1	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene