SexAnnoDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structure and Gene expression level

leaf

Sex-biased somatic mutation

leaf

DNA methylation with beta values in gene

leaf

Exon skipping events with PSI in TCGA

leaf

RNA A-to-I editing events in TCGA

leaf

Sex-biased TF-Gene network of gene

leaf

Sex-biased RBP-ES network of gene

leaf

Sex-biased CeRNA regulation of gene

leaf

Sex-biased eQTL regulation of gene

leaf

Sex-biased eQTM regulation of gene

leaf

Sex-biased sQTL regulation of gene

leaf

Sex-biased sQTM regulation of gene

leaf

Related disease information of gene

Gene: ENSG00000152556

Summary for PFKM

check button Gene summary

Gene informationEnsembl ID

ENSG00000152556

Gene symbol

PFKM

Gene namephosphofructokinase, muscle
HGNC

8877

Entrez ID

5213

Gene typeprotein_coding
SynonymsPFKM|PFK-1|PPP1R122
UniProtAcc

P08237


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

Top

Structure and expression level for PFKM

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
PFKM4.42e+03-1.00e+001.13e-01-8.86e+008.30e-193.76e-18KIRC
PFKM4.29e+03-2.28e+001.74e-01-1.32e+011.46e-393.16e-37HNSC
PFKM2.37e+03-1.07e+002.39e-01-4.49e+007.07e-064.35e-05BLCA
PFKM1.38e+031.51e+004.45e-013.39e+006.92e-042.44e-03CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

Top

Sex-biased somatic mutation for PFKM

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

Top

DNA methylation with beta values for PFKM

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

Top

Exon skipping events with PSI in TCGA for PFKM

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI
BRCAexon_skip_817498.14e-017.10e-012.39e+001.69e-024.90e-021.04e-01

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI
KICHexon_skip_817498.00e-019.02e-01-2.33e+001.97e-022.96e-02-1.02e-01

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI
LUSCexon_skip_817498.88e-017.62e-014.42e+001.00e-057.43e-051.26e-01
READexon_skip_817496.78e-018.19e-01-2.21e+002.70e-023.69e-02-1.41e-01

Top

RNA A-to-I editing events in TCGA for PFKM

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

Top

Sex-biased TF-Gene network for PFKM

check buttonTFs related to PFKM.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
MESOZNF79PFKM2.78e+006.33e-034.18e+009.82e-01Female-biased

check buttonPFKM related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

Top

Sex-biased RBP-ES network for PFKM

check buttonRBPs related to ES in PFKM.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
STADHNRNPH2exon_skip_817446.57e+009.81e-016.04e+002.16e-03Male-biased
STADRBM42exon_skip_817511.36e+019.99e-011.29e+011.10e-03Male-biased
STADSAMD4Aexon_skip_817556.78e+009.81e-016.32e+003.64e-03Male-biased
ACCSAMD4Aexon_skip_817557.24e+009.82e-016.74e+005.78e-03Male-biased
UVMHNRNPH2exon_skip_817446.31e+003.14e-036.71e+009.81e-01Female-biased
THYMHNRNPH2exon_skip_817446.69e+009.84e-015.91e+008.55e-05Male-biased
THYMRBM42exon_skip_817511.37e+019.96e-011.33e+013.60e-03Male-biased
LUSCSAMD4Aexon_skip_817556.90e+009.81e-016.42e+003.87e-03Male-biased
DLBCRBM42exon_skip_817511.39e+019.97e-011.35e+013.20e-03Male-biased
LUADRBM42exon_skip_817511.30e+017.06e-041.36e+019.99e-01Female-biased
BRCASAMD4Aexon_skip_817556.62e+001.53e-037.87e+009.89e-01Female-biased
ESCARBM42exon_skip_817511.28e+018.28e-031.33e+019.91e-01Female-biased
THCAHNRNPH2exon_skip_817446.28e+006.20e-046.83e+009.84e-01Female-biased
PCPGKHDRBS3exon_skip_817558.64e+001.27e-028.94e+009.83e-01Female-biased
LGGRBM42exon_skip_817511.28e+011.88e-021.31e+019.81e-01Female-biased
PAADDAZAP1exon_skip_817471.21e+019.99e-011.16e+018.39e-04Male-biased
PAADHNRNPA1L2exon_skip_817479.95e+009.95e-019.56e+003.03e-03Male-biased
PAADRBM42exon_skip_817511.34e+019.93e-011.31e+016.28e-03Male-biased
KIRCSAMD4Aexon_skip_817557.08e+009.87e-016.54e+006.34e-04Male-biased
KICHFXR2exon_skip_817447.40e+001.02e-027.72e+009.80e-01Female-biased
KICHRBM42exon_skip_817511.35e+019.99e-011.28e+013.36e-04Male-biased
BLCARBM42exon_skip_817511.32e+011.37e-031.38e+019.98e-01Female-biased
HNSCRBM42exon_skip_817511.31e+011.50e-031.36e+019.98e-01Female-biased

check buttonPFKM related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

Top

Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000152556AC011632.1,hsa-mir-142,PFKMMale-specific ceRNATCGA-BLCA
ENSG00000152556DUBR,hsa-mir-142,PFKMMale-specific ceRNATCGA-BLCA
ENSG00000152556NNT-AS1,hsa-mir-142,PFKMMale-specific ceRNATCGA-HNSC
ENSG00000152556AL161757.4,hsa-mir-142,PFKMMale-specific ceRNATCGA-HNSC
ENSG00000152556MAGI2-AS3,hsa-mir-142,PFKMMale-specific ceRNATCGA-HNSC

Top

Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs73104190chr12:47716040:G:A-0.1045151590923740.0477451768512301LUSCFemale-baised eQTL
rs73104197chr12:47717273:T:G-0.1045151590923740.0477451768512301LUSCFemale-baised eQTL
rs12228838chr12:52860733:A:G-0.09681007991547440.0407070416600777KIRCFemale-baised eQTL
rs78319805chr12:40841790:G:A-0.08860682891972630.0160382550211489LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs11181634chr12:42675501:G:T-0.07962114745260390.0150668012391623KIRCMale-baised eQTL
rs2730903chr12:38606153:T:C--0.06065668077631680.0360974091098556BLCAMale-baised eQTL
rs12297619chr12:38576289:T:C--0.05937834610340230.046779189251922BLCAMale-baised eQTL
rs2653726chr12:38577704:C:T--0.05937834610340230.046779189251922BLCAMale-baised eQTL
rs2730911chr12:38594048:T:C--0.05937834610340230.046779189251922BLCAMale-baised eQTL
rs10491995chr12:41860571:C:G-0.1046302043094230.00232563830396023LUADMale-baised eQTL
rs7953773chr12:42889633:A:C-0.1003004655208440.00806406295019081LUADMale-baised eQTL
rs11181204chr12:41864612:G:A-0.0922047312165760.01461346480351LUADMale-baised eQTL
rs11532503chr12:41872732:A:G-0.0922047312165760.01461346480351LUADMale-baised eQTL
rs11536158chr12:41872996:G:A-0.0922047312165760.01461346480351LUADMale-baised eQTL
rs60743130chr12:41873780:T:C-0.0922047312165760.01461346480351LUADMale-baised eQTL
rs12581985chr12:41877133:A:C-0.0922047312165760.01461346480351LUADMale-baised eQTL
rs11181215chr12:41879395:A:G-0.0922047312165760.01461346480351LUADMale-baised eQTL
rs11181224chr12:41889540:C:T-0.09902748658997190.0146270049714605LUADMale-baised eQTL
rs11831722chr12:42886064:A:G-0.08582991231102590.0322402997739848LUADMale-baised eQTL
rs11835318chr12:42888814:G:A-0.08562836010415230.0332946099874603LUADMale-baised eQTL
rs4344537chr12:48498668:T:C-0.07476376194822570.0366156164770909LUADMale-baised eQTL
rs12316395chr12:43563846:A:C--0.05754645008461710.0250773495126132COADMale-baised eQTL
rs10880528chr12:43565685:G:T--0.05754645008461710.0250773495126132COADMale-baised eQTL
rs7358551chr12:43563959:G:A--0.05700519736609020.0292252972980795COADMale-baised eQTL
rs7358701chr12:43564790:A:G--0.05608709943928670.0351059896469329COADMale-baised eQTL
rs58826621chr12:51735879:A:G-0.1122176333402280.0375905586134868COADMale-baised eQTL
rs58595992chr12:51730007:A:G-0.1130525294496390.0398390461560388COADMale-baised eQTL
rs57792817chr12:51734320:A:G-0.1130525294496390.0398390461560388COADMale-baised eQTL
rs7959233chr12:51742247:A:G-0.1130525294496390.0398390461560388COADMale-baised eQTL
rs34621434chr12:51743789:G:T-0.1130525294496390.0398390461560388COADMale-baised eQTL
rs11169692chr12:51064782:G:A-0.0652194327776640.0447275890669528COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

Top

Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

Top

Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_81749chr12:48135290:48135383In-framers3741632chr12:48693180:G:ADistant downstream-0.03628463033121410.0382568557112675LUADFemale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers2705130chr12:48494191:T:CDistant downstream0.01988546438649240.0394549105497484THCAFemale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers2731108chr12:48493578:G:ADistant downstream0.0196242412957770.0429165739869417THCAFemale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers2731099chr12:48490143:C:TDistant downstream0.01928683077377030.0468702044846351THCAFemale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers2731100chr12:48490375:G:CDistant downstream0.01928683077377030.0468702044846351THCAFemale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers2731103chr12:48490973:C:ADistant downstream0.01928683077377030.0468702044846351THCAFemale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers2731106chr12:48492701:C:TDistant downstream0.01928683077377030.0468702044846351THCAFemale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers10875713chr12:47970680:A:TDistant upstream0.125155290401090.0274336449657384KIRPFemale-baised sQTL

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_81749chr12:48135290:48135383In-framers12827401chr12:47916072:A:TDistant upstream0.03547179992104240.0211855810238606KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers35609792chr12:47916189:G:ADistant upstream0.03547179992104240.0211855810238606KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers11568820chr12:47908762:C:TDistant upstream0.03722396727341690.0221608446595275KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers7976091chr12:47910769:C:TDistant upstream0.03716616085906640.0230467665600169KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers12304110chr12:47914100:A:GDistant upstream0.03445209827130070.0290463184060282KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers11168311chr12:47934726:C:ADistant upstream0.0438202020261220.033613565590347KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers2130095chr12:48244972:G:ADistant downstream0.03431480221389920.0354286468089KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers11168308chr12:47926137:G:TDistant upstream0.03605857982535350.037924237666831KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers10783243chr12:48259220:G:ADistant downstream0.03391089680680280.0388021244008192KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers9645811chr12:48285453:A:GDistant downstream0.03361994476080810.0424137957409202KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers7303966chr12:47926326:C:TDistant upstream0.0374587807394740.0429453843559574KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers7315992chr12:47925542:T:CDistant upstream0.03707025638287030.0471272933464453KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers7300301chr12:47925800:G:ADistant upstream0.03707025638287030.0471272933464453KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers7300088chr12:47925811:A:GDistant upstream0.03707025638287030.0471272933464453KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers10875703chr12:47925919:A:TDistant upstream0.03707025638287030.0471272933464453KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers12316950chr12:47926077:A:GDistant upstream0.03707025638287030.0471272933464453KIRCMale-baised sQTL
exon_skip_81749chr12:48135290:48135383In-framers11168318chr12:47938746:G:ADistant upstream0.04187742063658970.0486631537016387KIRCMale-baised sQTL

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

Top

Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

Top

Related disease information of PFKM

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000152556PFKMC0002152Alloxan Diabetes1CTD_human
ENSG00000152556PFKMC0011853Diabetes Mellitus, Experimental1CTD_human
ENSG00000152556PFKMC0017926Glycogen Storage Disease Type VII2CTD_human
ENSG00000152556PFKMC0038433Streptozotocin Diabetes1CTD_human
ENSG00000152556PFKMC0151744Myocardial Ischemia1CTD_human