|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000151790 |
Summary for TDO2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000151790 | Gene symbol | TDO2 |
| Gene name | tryptophan 2,3-dioxygenase | |
| HGNC | 11708 | |
| Entrez ID | 6999 | |
| Gene type | protein_coding | |
| Synonyms | TDO2|TDO|TPH2 | |
| UniProtAcc | P48775 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TDO2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TDO2 | 1.27e+04 | -5.33e+00 | 7.46e-01 | -7.14e+00 | 9.61e-13 | 2.49e-11 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TDO2 | 4.55e+02 | 1.70e+00 | 3.37e-01 | 5.06e+00 | 4.26e-07 | 1.81e-06 | LUSC |
Top |
Sex-biased somatic mutation for TDO2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TDO2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg15736994 | chr4:155854789 | CGI:chr4:155758943-155760234 | UTR,promoter,exon,gene body | 6.00e-01 | 2.93e-01 | 3.32e+00 | 9.08e-04 | 1.01e-02 | 3.08e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg15736994 | chr4:155854789 | CGI:chr4:155758943-155760234 | UTR,promoter,exon,gene body | 5.57e-01 | 6.99e-01 | -7.03e+00 | 2.08e-12 | 6.23e-12 | -1.42e-01 |
Top |
Exon skipping events with PSI in TCGA for TDO2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TDO2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for TDO2 |
| TFs related to TDO2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | FOXL1 | TDO2 | 3.47e+00 | 7.95e-03 | 4.38e+00 | 9.83e-01 | Female-biased |
| BLCA | FOXR2 | TDO2 | 3.64e+00 | 7.38e-03 | 4.57e+00 | 9.86e-01 | Female-biased |
| BLCA | POU3F3 | TDO2 | 4.37e+00 | 1.65e-02 | 5.10e+00 | 9.81e-01 | Female-biased |
| BLCA | ZNF25 | TDO2 | 3.61e+00 | 9.10e-03 | 4.48e+00 | 9.83e-01 | Female-biased |
| BLCA | ZNF334 | TDO2 | 3.59e+00 | 4.49e-03 | 4.64e+00 | 9.89e-01 | Female-biased |
| BLCA | ZNF418 | TDO2 | 2.53e+00 | 6.94e-04 | 4.05e+00 | 9.84e-01 | Female-biased |
| DLBC | FOXR2 | TDO2 | 3.48e+00 | 9.70e-03 | 4.38e+00 | 9.82e-01 | Female-biased |
| DLBC | ZNF334 | TDO2 | 3.42e+00 | 8.02e-03 | 4.38e+00 | 9.84e-01 | Female-biased |
| LAML | ZNF418 | TDO2 | 4.76e+00 | 9.81e-01 | 3.92e+00 | 1.35e-02 | Male-biased |
| TDO2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for TDO2 |
| RBPs related to ES in TDO2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TDO2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs28368475 | chr4:147569190:G:A | - | 0.16821905727387 | 0.000367065266954484 | LUAD | Female-baised eQTL |
| rs35177831 | chr4:147571793:C:T | - | 0.16350870761842 | 0.000855785930588437 | LUAD | Female-baised eQTL |
| rs9996163 | chr4:147561453:A:G | - | 0.172143837709746 | 0.00100687568891674 | LUAD | Female-baised eQTL |
| rs10032177 | chr4:147560467:C:T | - | 0.165316847271685 | 0.00180858832075154 | LUAD | Female-baised eQTL |
| rs17675332 | chr4:147564984:C:A | - | 0.154583271005243 | 0.00340562900969625 | LUAD | Female-baised eQTL |
| rs9997196 | chr4:147556588:A:G | - | 0.156982717668446 | 0.00374340006991258 | LUAD | Female-baised eQTL |
| rs2090422 | chr4:147567393:C:T | - | 0.145412064754359 | 0.00449984360720086 | LUAD | Female-baised eQTL |
| rs28696845 | chr4:155278326:T:G | - | 0.0890247262489092 | 0.0169605365136245 | LUAD | Female-baised eQTL |
| rs72690669 | chr4:155286219:G:A | - | 0.13638233953397 | 0.0189903925421958 | LUAD | Female-baised eQTL |
| rs35125259 | chr4:155279357:G:A | - | 0.088113430650422 | 0.0193739258163771 | LUAD | Female-baised eQTL |
| rs55856578 | chr4:155279950:G:C | - | 0.088113430650422 | 0.0193739258163771 | LUAD | Female-baised eQTL |
| rs17025307 | chr4:148842160:C:G | - | 0.104650187020571 | 0.0202453716197851 | LUAD | Female-baised eQTL |
| rs7656771 | chr4:151104817:T:C | - | 0.148725360458396 | 0.0217019515838494 | LUAD | Female-baised eQTL |
| rs6847518 | chr4:151088855:C:T | - | 0.14787855075428 | 0.0230615150146704 | LUAD | Female-baised eQTL |
| rs75997360 | chr4:151094836:C:T | - | 0.14787855075428 | 0.0230615150146704 | LUAD | Female-baised eQTL |
| rs59945218 | chr4:148822859:G:A | - | 0.111278958069652 | 0.0239837223463186 | LUAD | Female-baised eQTL |
| rs72737827 | chr4:148831731:G:A | - | 0.107198827150985 | 0.0316234291785727 | LUAD | Female-baised eQTL |
| rs6813451 | chr4:155301596:A:G | - | 0.0818816896008844 | 0.0319614524839085 | LUAD | Female-baised eQTL |
| rs7680281 | chr4:155381075:C:G | - | 0.0805270109939139 | 0.0329004021760734 | LUAD | Female-baised eQTL |
| rs77113754 | chr4:151073002:A:G | - | 0.146787132931782 | 0.0334279079935496 | LUAD | Female-baised eQTL |
| rs6536068 | chr4:155305152:G:T | - | 0.0813485387687021 | 0.0336517720110158 | LUAD | Female-baised eQTL |
| rs11723326 | chr4:155383959:G:T | - | 0.0894230129872039 | 0.0346809077484059 | LUAD | Female-baised eQTL |
| rs62325754 | chr4:155279376:C:T | - | 0.0875797373477434 | 0.0356352667825686 | LUAD | Female-baised eQTL |
| rs62325755 | chr4:155279461:T:C | - | 0.0878132653809684 | 0.0367382864850356 | LUAD | Female-baised eQTL |
| rs986416 | chr4:155375716:T:A | - | 0.0807762844351812 | 0.0370057633915953 | LUAD | Female-baised eQTL |
| rs17032793 | chr4:155306072:C:T | - | 0.0787093007047892 | 0.0413232206347191 | LUAD | Female-baised eQTL |
| rs11929964 | chr4:155306871:C:T | - | 0.0787093007047892 | 0.0413232206347191 | LUAD | Female-baised eQTL |
| rs983146 | chr4:155292557:A:C | - | 0.0816368475388033 | 0.0416278281093423 | LUAD | Female-baised eQTL |
| rs3733392 | chr4:155368880:G:C | - | 0.0772003698526781 | 0.0422717082034216 | LUAD | Female-baised eQTL |
| rs1078276 | chr4:155295533:G:T | - | 0.0840665382615313 | 0.0453553852624496 | LUAD | Female-baised eQTL |
| rs10000860 | chr4:146158574:T:C | - | 0.0946428966778058 | 0.00116146505787728 | COAD | Female-baised eQTL |
| rs10000865 | chr4:146158589:T:C | - | 0.0946428966778058 | 0.00116146505787728 | COAD | Female-baised eQTL |
| rs10029293 | chr4:146170008:G:A | - | 0.0932685138289318 | 0.00155741250405151 | COAD | Female-baised eQTL |
| rs76680787 | chr4:146159732:T:C | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs76672439 | chr4:146159734:T:G | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs17021150 | chr4:146160186:A:G | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs10015161 | chr4:146160638:G:A | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs28495089 | chr4:146160906:T:C | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs7671076 | chr4:146162521:C:T | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs11932480 | chr4:146163352:A:G | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs13435847 | chr4:146163912:C:T | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs13435855 | chr4:146164071:C:A | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs28602879 | chr4:146165024:G:A | - | 0.0932027760347125 | 0.00158999042230467 | COAD | Female-baised eQTL |
| rs73862948 | chr4:162458745:G:A | - | 0.096868769424903 | 0.00285328620661392 | COAD | Female-baised eQTL |
| rs72635105 | chr4:165666330:T:C | - | 0.0773341679678422 | 0.00762457514308611 | COAD | Female-baised eQTL |
| rs9997106 | chr4:146171899:C:A | - | 0.101638694586831 | 0.00830952155929213 | COAD | Female-baised eQTL |
| rs6847941 | chr4:156822275:C:T | - | 0.0763572253973527 | 0.0110815369457948 | COAD | Female-baised eQTL |
| rs2115788 | chr4:146172817:A:T | - | 0.0952071595707935 | 0.0117041638691574 | COAD | Female-baised eQTL |
| rs7340934 | chr4:146173416:T:C | - | 0.0952071595707935 | 0.0117041638691574 | COAD | Female-baised eQTL |
| rs10000880 | chr4:146173545:C:T | - | 0.0952071595707935 | 0.0117041638691574 | COAD | Female-baised eQTL |
| rs6844452 | chr4:146173804:A:G | - | 0.0952071595707935 | 0.0117041638691574 | COAD | Female-baised eQTL |
| rs6844462 | chr4:146173821:A:T | - | 0.0952071595707935 | 0.0117041638691574 | COAD | Female-baised eQTL |
| rs10519778 | chr4:146170753:C:A | - | 0.0950173282856758 | 0.0119957206641135 | COAD | Female-baised eQTL |
| rs11931059 | chr4:146170859:C:A | - | 0.0950173282856758 | 0.0119957206641135 | COAD | Female-baised eQTL |
| rs28703313 | chr4:146171370:C:T | - | 0.0950173282856758 | 0.0119957206641135 | COAD | Female-baised eQTL |
| rs10009000 | chr4:146172237:A:T | - | 0.0950173282856758 | 0.0119957206641135 | COAD | Female-baised eQTL |
| rs10000861 | chr4:146158577:T:A | - | 0.0737929511151666 | 0.0126960617091545 | COAD | Female-baised eQTL |
| rs7680354 | chr4:146166823:T:C | - | 0.0733020010578886 | 0.0156524597751745 | COAD | Female-baised eQTL |
| rs77586809 | chr4:146168235:G:A | - | 0.0725782783350405 | 0.0157499332557973 | COAD | Female-baised eQTL |
| rs10013229 | chr4:146168292:A:G | - | 0.0725782783350405 | 0.0157499332557973 | COAD | Female-baised eQTL |
| rs7356451 | chr4:146169059:A:G | - | 0.0725782783350405 | 0.0157499332557973 | COAD | Female-baised eQTL |
| rs7356484 | chr4:146169166:T:C | - | 0.0725782783350405 | 0.0157499332557973 | COAD | Female-baised eQTL |
| rs10029288 | chr4:146169999:G:A | - | 0.0725782783350405 | 0.0157499332557973 | COAD | Female-baised eQTL |
| rs10021707 | chr4:146170151:T:A | - | 0.0725782783350405 | 0.0157499332557973 | COAD | Female-baised eQTL |
| rs11946104 | chr4:146163557:C:G | - | 0.0732381396013177 | 0.0158932571630657 | COAD | Female-baised eQTL |
| rs17021149 | chr4:146159552:G:T | - | 0.0725139393279255 | 0.0159947166079084 | COAD | Female-baised eQTL |
| rs17021152 | chr4:146160554:A:C | - | 0.0725139393279255 | 0.0159947166079084 | COAD | Female-baised eQTL |
| rs7663853 | chr4:146161260:C:T | - | 0.0725139393279255 | 0.0159947166079084 | COAD | Female-baised eQTL |
| rs11936772 | chr4:146163584:G:C | - | 0.0725139393279255 | 0.0159947166079084 | COAD | Female-baised eQTL |
| rs10010356 | chr4:146163943:G:A | - | 0.0725139393279255 | 0.0159947166079084 | COAD | Female-baised eQTL |
| rs28862630 | chr4:146164354:G:A | - | 0.0725139393279255 | 0.0159947166079084 | COAD | Female-baised eQTL |
| rs10029930 | chr4:162455091:C:T | - | 0.0805645156923771 | 0.0168384644863222 | COAD | Female-baised eQTL |
| rs6826518 | chr4:162455342:G:T | - | 0.0805645156923771 | 0.0168384644863222 | COAD | Female-baised eQTL |
| rs6827305 | chr4:162455939:A:G | - | 0.0805645156923771 | 0.0168384644863222 | COAD | Female-baised eQTL |
| rs60125380 | chr4:162455996:G:A | - | 0.0805645156923771 | 0.0168384644863222 | COAD | Female-baised eQTL |
| rs6827845 | chr4:162456088:C:T | - | 0.0805645156923771 | 0.0168384644863222 | COAD | Female-baised eQTL |
| rs28377735 | chr4:162451919:A:T | - | 0.0775515942889948 | 0.0235397628814434 | COAD | Female-baised eQTL |
| rs75784551 | chr4:163809017:T:C | - | 0.0777489532834921 | 0.0352543000511721 | COAD | Female-baised eQTL |
| rs74438330 | chr4:164195079:C:T | - | 0.0664912639400535 | 0.0390847381640462 | COAD | Female-baised eQTL |
| rs2163394 | chr4:164195278:A:T | - | 0.0664912639400535 | 0.0390847381640462 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72953970 | chr4:148431963:T:C | - | 0.121551461786216 | 0.000385806554164627 | BLCA | Male-baised eQTL |
| rs10006794 | chr4:156301751:A:T | - | -0.0816010825813633 | 0.000402621659941707 | BLCA | Male-baised eQTL |
| rs3051803 | chr4:156310999:G:T | - | -0.0799064239444427 | 0.000587134451596572 | BLCA | Male-baised eQTL |
| rs17036867 | chr4:157946446:C:T | - | 0.138186727030307 | 0.00113985033724801 | BLCA | Male-baised eQTL |
| rs7666630 | chr4:156327215:T:C | - | -0.0738720054498305 | 0.00177993612395579 | BLCA | Male-baised eQTL |
| rs6536168 | chr4:156340286:G:C | - | -0.063665722206682 | 0.00450721234790057 | BLCA | Male-baised eQTL |
| rs1490556 | chr4:156330825:C:A | - | -0.0618125304396706 | 0.00622674043587151 | BLCA | Male-baised eQTL |
| rs1873358 | chr4:156330980:G:A | - | -0.0618125304396706 | 0.00622674043587151 | BLCA | Male-baised eQTL |
| rs870569 | chr4:156353149:T:C | - | -0.0599427227566091 | 0.00835095921174844 | BLCA | Male-baised eQTL |
| rs2029512 | chr4:156341122:C:T | - | -0.0583705792013166 | 0.0116798320016825 | BLCA | Male-baised eQTL |
| rs3933881 | chr4:156340786:C:G | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs1388015 | chr4:156341686:T:A | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs10008868 | chr4:156342437:A:G | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs1388017 | chr4:156342673:A:G | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs10517638 | chr4:156343316:A:G | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs2046875 | chr4:156343374:A:G | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs2046876 | chr4:156343473:C:A | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs11725600 | chr4:156347033:C:T | - | -0.0580609262805669 | 0.0119852641389461 | BLCA | Male-baised eQTL |
| rs111229111 | chr4:162634946:G:A | - | 0.0930166985018141 | 0.0161804728136141 | BLCA | Male-baised eQTL |
| rs10024133 | chr4:158134893:A:T | - | -0.107048978196284 | 0.0176073879334973 | BLCA | Male-baised eQTL |
| rs6536170 | chr4:156383655:C:T | - | -0.0614529613185474 | 0.020140032025276 | BLCA | Male-baised eQTL |
| rs1490555 | chr4:156330764:C:T | - | -0.055071205850623 | 0.0335820376389728 | BLCA | Male-baised eQTL |
| rs2168826 | chr4:162736480:T:A | - | 0.0828467512898356 | 0.0338203550334586 | BLCA | Male-baised eQTL |
| rs4498175 | chr4:156378743:A:C | - | -0.0571304742908086 | 0.0345344984534742 | BLCA | Male-baised eQTL |
| rs1352697 | chr4:156332992:G:A | - | -0.0552463249488975 | 0.0419366716718611 | BLCA | Male-baised eQTL |
| rs937065 | chr4:156336267:C:T | - | -0.0552463249488975 | 0.0419366716718611 | BLCA | Male-baised eQTL |
| rs2043701 | chr4:147023656:C:T | - | 0.100177950780428 | 0.0466804838831113 | BLCA | Male-baised eQTL |
| rs6845909 | chr4:147023657:T:C | - | 0.100177950780428 | 0.0466804838831113 | BLCA | Male-baised eQTL |
| rs6858001 | chr4:152292255:C:T | - | 0.0674718009708155 | 0.000517731514869707 | LUAD | Male-baised eQTL |
| rs72719955 | chr4:152295442:G:A | - | 0.0615105082865031 | 0.00158887199697457 | LUAD | Male-baised eQTL |
| rs7664527 | chr4:152297440:T:C | - | 0.0588526624967289 | 0.00198600557790978 | LUAD | Male-baised eQTL |
| rs72719954 | chr4:152295357:G:T | - | 0.0595115563591186 | 0.00247690599638544 | LUAD | Male-baised eQTL |
| rs74594497 | chr4:164830259:T:C | - | 0.0671566827928681 | 0.00396881178221128 | LUAD | Male-baised eQTL |
| rs4416456 | chr4:152298079:T:G | - | 0.055479255985966 | 0.00507561583239595 | LUAD | Male-baised eQTL |
| rs57116134 | chr4:152300205:T:C | - | 0.0560025920308143 | 0.00632579593031503 | LUAD | Male-baised eQTL |
| rs57225805 | chr4:152300417:G:A | - | 0.0560025920308143 | 0.00632579593031503 | LUAD | Male-baised eQTL |
| rs17583892 | chr4:164841366:C:G | - | 0.0566495648584264 | 0.0103157004808427 | LUAD | Male-baised eQTL |
| rs59614155 | chr4:163796165:T:C | - | 0.0516537117052916 | 0.0103222926223545 | LUAD | Male-baised eQTL |
| rs7672184 | chr4:164832280:G:C | - | 0.0582103396302486 | 0.0184758058952014 | LUAD | Male-baised eQTL |
| rs7672008 | chr4:164832323:C:T | - | 0.0582103396302486 | 0.0184758058952014 | LUAD | Male-baised eQTL |
| rs7671850 | chr4:164832336:A:G | - | 0.0582103396302486 | 0.0184758058952014 | LUAD | Male-baised eQTL |
| rs7696630 | chr4:164832391:T:A | - | 0.0582103396302486 | 0.0184758058952014 | LUAD | Male-baised eQTL |
| rs7696671 | chr4:164832455:T:C | - | 0.0582103396302486 | 0.0184758058952014 | LUAD | Male-baised eQTL |
| rs77653743 | chr4:164831498:T:C | - | 0.0581113858215072 | 0.0189547929707543 | LUAD | Male-baised eQTL |
| rs79865055 | chr4:164831674:C:T | - | 0.0581113858215072 | 0.0189547929707543 | LUAD | Male-baised eQTL |
| rs7691415 | chr4:164832077:T:C | - | 0.0581113858215072 | 0.0189547929707543 | LUAD | Male-baised eQTL |
| rs7691196 | chr4:164831913:T:C | - | 0.0581273155511364 | 0.0189964910179134 | LUAD | Male-baised eQTL |
| rs114524421 | chr4:164834766:A:C | - | 0.0580041882329969 | 0.0193337495395305 | LUAD | Male-baised eQTL |
| rs77098237 | chr4:164834906:A:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs10007994 | chr4:164835112:T:A | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs9996412 | chr4:164835476:C:A | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs28594454 | chr4:164835530:C:T | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs28539448 | chr4:164835689:C:A | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs28454472 | chr4:164835692:G:T | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs28754460 | chr4:164835799:A:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs28579487 | chr4:164836039:G:T | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs28433285 | chr4:164836091:A:C | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs79956003 | chr4:164836856:C:T | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs78301943 | chr4:164837182:A:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs10002729 | chr4:164837308:G:T | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs10014632 | chr4:164837346:T:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs80150267 | chr4:164837560:A:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs75686834 | chr4:164837700:A:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs79829629 | chr4:164837794:G:A | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs78370877 | chr4:164837957:C:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs74588752 | chr4:164837969:A:G | - | 0.055667844066541 | 0.022853318873208 | LUAD | Male-baised eQTL |
| rs10034282 | chr4:164833089:C:T | - | 0.056139824763802 | 0.0244836661955047 | LUAD | Male-baised eQTL |
| rs28481651 | chr4:164833218:G:A | - | 0.056139824763802 | 0.0244836661955047 | LUAD | Male-baised eQTL |
| rs7679273 | chr4:164833553:G:C | - | 0.056139824763802 | 0.0244836661955047 | LUAD | Male-baised eQTL |
| rs7678940 | chr4:164833592:A:G | - | 0.056139824763802 | 0.0244836661955047 | LUAD | Male-baised eQTL |
| rs7679373 | chr4:164833852:A:G | - | 0.056139824763802 | 0.0244836661955047 | LUAD | Male-baised eQTL |
| rs7657848 | chr4:164833890:T:G | - | 0.056139824763802 | 0.0244836661955047 | LUAD | Male-baised eQTL |
| rs7679551 | chr4:164833929:A:G | - | 0.056139824763802 | 0.0244836661955047 | LUAD | Male-baised eQTL |
| rs77263159 | chr4:164838051:T:C | - | 0.0544400545263651 | 0.025609953157889 | LUAD | Male-baised eQTL |
| rs372207903 | chr4:164838356:C:T | - | 0.0544400545263651 | 0.025609953157889 | LUAD | Male-baised eQTL |
| rs191033661 | chr4:164838403:G:A | - | 0.0544400545263651 | 0.025609953157889 | LUAD | Male-baised eQTL |
| rs10030832 | chr4:164838951:A:G | - | 0.0544400545263651 | 0.025609953157889 | LUAD | Male-baised eQTL |
| rs28670245 | chr4:164839490:A:G | - | 0.0544400545263651 | 0.025609953157889 | LUAD | Male-baised eQTL |
| rs10012694 | chr4:164840662:G:T | - | 0.0544400545263651 | 0.025609953157889 | LUAD | Male-baised eQTL |
| rs10010003 | chr4:164840819:T:C | - | 0.0544400545263651 | 0.025609953157889 | LUAD | Male-baised eQTL |
| rs111715804 | chr4:153859108:G:A | - | 0.0467946118200606 | 0.0283623379725132 | LUAD | Male-baised eQTL |
| rs80060151 | chr4:153864261:T:C | - | 0.0467946118200606 | 0.0283623379725132 | LUAD | Male-baised eQTL |
| rs79518828 | chr4:153865562:T:C | - | 0.0467946118200606 | 0.0283623379725132 | LUAD | Male-baised eQTL |
| rs76732887 | chr4:153866584:T:C | - | 0.0467946118200606 | 0.0283623379725132 | LUAD | Male-baised eQTL |
| rs141855914 | chr4:153868187:A:C | - | 0.0467946118200606 | 0.0283623379725132 | LUAD | Male-baised eQTL |
| rs76908478 | chr4:153871309:T:A | - | 0.0467946118200606 | 0.0283623379725132 | LUAD | Male-baised eQTL |
| rs10020422 | chr4:164840864:A:G | - | 0.0524674833720122 | 0.0347958303370281 | LUAD | Male-baised eQTL |
| rs112659364 | chr4:153894626:A:G | - | 0.0454674051379514 | 0.0357957400066957 | LUAD | Male-baised eQTL |
| rs75678546 | chr4:153895065:A:G | - | 0.0454674051379514 | 0.0357957400066957 | LUAD | Male-baised eQTL |
| rs79052710 | chr4:153895963:G:A | - | 0.0454674051379514 | 0.0357957400066957 | LUAD | Male-baised eQTL |
| rs4499686 | chr4:153896765:A:G | - | 0.0454378077066905 | 0.0362104535803337 | LUAD | Male-baised eQTL |
| rs78205019 | chr4:153898921:A:G | - | 0.0454378077066905 | 0.0362104535803337 | LUAD | Male-baised eQTL |
| rs78267621 | chr4:152293348:G:A | - | 0.0379078701534678 | 0.0373830541174268 | LUAD | Male-baised eQTL |
| rs112378984 | chr4:153868829:G:A | - | 0.0452933602261058 | 0.0376312057817007 | LUAD | Male-baised eQTL |
| rs77863564 | chr4:153919894:C:A | - | 0.04520105478376 | 0.0380265501443709 | LUAD | Male-baised eQTL |
| rs78390850 | chr4:153912256:T:A | - | 0.045127632337821 | 0.0390298208918476 | LUAD | Male-baised eQTL |
| rs79740475 | chr4:153913515:G:T | - | 0.045127632337821 | 0.0390298208918476 | LUAD | Male-baised eQTL |
| rs11933412 | chr4:153917664:G:A | - | 0.045127632337821 | 0.0390298208918476 | LUAD | Male-baised eQTL |
| rs76896174 | chr4:153925652:T:C | - | 0.0464571961700486 | 0.0422447663445497 | LUAD | Male-baised eQTL |
| rs76131536 | chr4:153925785:C:A | - | 0.0464571961700486 | 0.0422447663445497 | LUAD | Male-baised eQTL |
| rs1020703 | chr4:153901451:C:T | - | 0.0443865408810909 | 0.0428181130207788 | LUAD | Male-baised eQTL |
| rs1375136 | chr4:157967750:G:C | - | 0.0664735791730906 | 0.000651699361570687 | COAD | Male-baised eQTL |
| rs4569796 | chr4:158062328:T:C | - | 0.0657634481322466 | 0.000805570689751142 | COAD | Male-baised eQTL |
| rs36069561 | chr4:158063425:C:A | - | 0.0657634481322466 | 0.000805570689751142 | COAD | Male-baised eQTL |
| rs28593016 | chr4:151126213:C:T | - | 0.0520092690277572 | 0.00159015745985475 | COAD | Male-baised eQTL |
| rs11931905 | chr4:163630846:A:G | - | 0.0511508100662795 | 0.00166790461975848 | COAD | Male-baised eQTL |
| rs6846661 | chr4:158027644:A:G | - | 0.0586941788293974 | 0.00282919211803175 | COAD | Male-baised eQTL |
| rs7664258 | chr4:158041427:A:G | - | 0.0531937992464164 | 0.00625743646872919 | COAD | Male-baised eQTL |
| rs28672085 | chr4:151659526:T:C | - | 0.0369420193172147 | 0.013571701395691 | COAD | Male-baised eQTL |
| rs17045969 | chr4:165109706:C:T | - | 0.0469292665517753 | 0.0169943531825549 | COAD | Male-baised eQTL |
| rs28498882 | chr4:151666212:G:C | - | 0.0349279113840091 | 0.0196509237089267 | COAD | Male-baised eQTL |
| rs6858573 | chr4:151667977:C:T | - | 0.0349279113840091 | 0.0196509237089267 | COAD | Male-baised eQTL |
| rs12054502 | chr4:151665270:T:C | - | 0.0348621513917162 | 0.01989825317976 | COAD | Male-baised eQTL |
| rs28463438 | chr4:151669013:C:T | - | 0.0345620980221909 | 0.0209167556906925 | COAD | Male-baised eQTL |
| rs3172567 | chr4:151670235:G:A | - | 0.0345319656898266 | 0.0211164536605561 | COAD | Male-baised eQTL |
| rs28715753 | chr4:151668519:T:C | - | 0.0345202478682042 | 0.0213677148673484 | COAD | Male-baised eQTL |
| rs17027780 | chr4:151669185:G:T | - | 0.0340190746453762 | 0.0237318196746244 | COAD | Male-baised eQTL |
| rs28447105 | chr4:151669020:G:A | - | 0.0340340717365675 | 0.0238137294373006 | COAD | Male-baised eQTL |
| rs68094736 | chr4:155323231:T:A | - | 0.0372292281176235 | 0.037811487820556 | COAD | Male-baised eQTL |
| rs17032828 | chr4:155336550:C:T | - | 0.0372292281176235 | 0.037811487820556 | COAD | Male-baised eQTL |
| rs75801343 | chr4:155349656:G:A | - | 0.0372141041179492 | 0.0380895626943363 | COAD | Male-baised eQTL |
| rs7655236 | chr4:147821806:C:G | - | -0.0383423351185869 | 0.0482814159858232 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000151790 |
| CpG Site: cg15736994 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.077143928123394 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15736994 | chr4:155854789 | gene,exon,promoter,UTR | -0.077143928123394 | 3.9471963472653e-05 | -0.3394714588928072 | 2.0359453997556957e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TDO2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000151790 | TDO2 | C0004352 | Autistic Disorder | 1 | CTD_human |
| ENSG00000151790 | TDO2 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| ENSG00000151790 | TDO2 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| ENSG00000151790 | TDO2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| ENSG00000151790 | TDO2 | C0038187 | Starvation | 1 | CTD_human |
| ENSG00000151790 | TDO2 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| ENSG00000151790 | TDO2 | C0220702 | SCHIZOPHRENIA 1 (disorder) | 1 | PSYGENET |
| ENSG00000151790 | TDO2 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| ENSG00000151790 | TDO2 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
