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Gene: ENSG00000151632 |
Summary for AKR1C2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000151632 | Gene symbol | AKR1C2 |
| Gene name | aldo-keto reductase family 1 member C2 | |
| HGNC | 385 | |
| Entrez ID | 1646 | |
| Gene type | protein_coding | |
| Synonyms | AKR1C2|DD|BABP|DD2|HAKRD|MCDR2 | |
| UniProtAcc | P52895 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000151632 | AKR1C2 | DB00157 | NADH | SmallMoleculeDrug |
| ENSG00000151632 | AKR1C2 | DB01586 | Ursodeoxycholic acid | SmallMoleculeDrug |
| ENSG00000151632 | AKR1C2 | DB03461 | Nicotinamide adenine dinucleotide phosphate | SmallMoleculeDrug |
| ENSG00000151632 | AKR1C2 | DB06777 | Chenodeoxycholic acid | SmallMoleculeDrug |
| ENSG00000151632 | AKR1C2 | DB07768 | Epitestosterone | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for AKR1C2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AKR1C2 | 6.76e+02 | -1.65e+00 | 6.23e-01 | -2.65e+00 | 8.04e-03 | 4.97e-02 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AKR1C2 | 5.14e+02 | -1.10e+00 | 2.29e-01 | -4.81e+00 | 1.49e-06 | 2.97e-06 | KIRC |
| AKR1C2 | 1.78e+04 | 1.20e+00 | 2.91e-01 | 4.12e+00 | 3.80e-05 | 1.33e-04 | LIHC |
| AKR1C2 | 5.82e+03 | -1.57e+00 | 6.70e-01 | -2.34e+00 | 1.91e-02 | 4.29e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AKR1C2 | 5.57e+02 | -3.30e+00 | 4.93e-01 | -6.70e+00 | 2.12e-11 | 1.62e-10 | KICH |
| AKR1C2 | 1.68e+03 | -3.02e+00 | 2.30e-01 | -1.32e+01 | 1.39e-39 | 9.88e-39 | BRCA |
Top |
Sex-biased somatic mutation for AKR1C2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for AKR1C2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for AKR1C2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for AKR1C2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for AKR1C2 |
| TFs related to AKR1C2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | PRDM6 | AKR1C2 | 2.87e+00 | 1.67e-03 | 4.26e+00 | 9.89e-01 | Female-biased |
| DLBC | ZNF182 | AKR1C2 | 2.81e+00 | 2.84e-03 | 4.04e+00 | 9.83e-01 | Female-biased |
| DLBC | ZNF235 | AKR1C2 | 3.10e+00 | 1.24e-03 | 4.58e+00 | 9.93e-01 | Female-biased |
| DLBC | ZNF287 | AKR1C2 | 3.09e+00 | 1.20e-03 | 4.58e+00 | 9.93e-01 | Female-biased |
| DLBC | ZNF487 | AKR1C2 | 2.96e+00 | 1.63e-03 | 4.36e+00 | 9.90e-01 | Female-biased |
| DLBC | ZNF879 | AKR1C2 | 2.55e+00 | 1.02e-03 | 4.08e+00 | 9.86e-01 | Female-biased |
| UVM | FOXP3 | AKR1C2 | 4.69e+00 | 9.82e-01 | 3.17e+00 | 6.48e-03 | Male-biased |
| UVM | ZNF334 | AKR1C2 | 4.37e+00 | 9.81e-01 | 1.88e+00 | 6.28e-04 | Male-biased |
| AKR1C2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for AKR1C2 |
| RBPs related to ES in AKR1C2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| HNSC | ELAVL2 | exon_skip_46810 | 8.99e+00 | 2.45e-03 | 9.46e+00 | 9.95e-01 | Female-biased |
| AKR1C2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs111645179 | chr10:12802805:T:C | - | 0.218433810908593 | 0.0237644669829001 | HNSC | Female-baised eQTL |
| rs74115087 | chr10:627431:T:C | - | 0.0463385601416049 | 0.000220283104654039 | THCA | Female-baised eQTL |
| rs7913729 | chr10:7726393:C:T | - | 0.0462856325341564 | 0.000223693812215513 | THCA | Female-baised eQTL |
| rs74115089 | chr10:628594:C:T | - | 0.0453693879107428 | 0.000309601575236132 | THCA | Female-baised eQTL |
| rs74117336 | chr10:687996:A:C | - | 0.0416261095974208 | 0.00110114839501912 | THCA | Female-baised eQTL |
| rs74115308 | chr10:697915:C:T | - | 0.0416307223357949 | 0.00110768797536262 | THCA | Female-baised eQTL |
| rs74115099 | chr10:631057:C:T | - | 0.0416070733303327 | 0.00110965713147414 | THCA | Female-baised eQTL |
| rs74115100 | chr10:633186:T:C | - | 0.0416070733303327 | 0.00110965713147414 | THCA | Female-baised eQTL |
| rs74115307 | chr10:697087:C:G | - | 0.0416303106825131 | 0.00111270567557788 | THCA | Female-baised eQTL |
| rs61564811 | chr10:697300:C:G | - | 0.0416303106825131 | 0.00111270567557788 | THCA | Female-baised eQTL |
| rs1409873 | chr10:6607753:T:G | - | 0.0419016888941921 | 0.00116807216188145 | THCA | Female-baised eQTL |
| rs17159728 | chr10:598075:A:C | - | 0.0409640208124838 | 0.00138378904450609 | THCA | Female-baised eQTL |
| rs1409872 | chr10:6607751:G:C | - | 0.0411418439605895 | 0.00144145466508851 | THCA | Female-baised eQTL |
| rs58168774 | chr10:612485:A:C | - | 0.040474771695758 | 0.00171909720701103 | THCA | Female-baised eQTL |
| rs74115077 | chr10:613982:G:A | - | 0.040474771695758 | 0.00171909720701103 | THCA | Female-baised eQTL |
| rs17136375 | chr10:662353:G:A | - | 0.0400967642473974 | 0.00185968256733403 | THCA | Female-baised eQTL |
| rs17159707 | chr10:585726:G:C | - | 0.038852462136916 | 0.00275241686299223 | THCA | Female-baised eQTL |
| rs140168001 | chr10:671677:G:A | - | 0.0375043340155184 | 0.00448572948465648 | THCA | Female-baised eQTL |
| rs75374145 | chr10:6610181:T:C | - | 0.0370371626858723 | 0.00561458678584981 | THCA | Female-baised eQTL |
| rs10795567 | chr10:7730697:C:T | - | 0.0367260177639545 | 0.0065329044874693 | THCA | Female-baised eQTL |
| rs59939816 | chr10:626107:A:G | - | 0.035956403390074 | 0.00723859271208971 | THCA | Female-baised eQTL |
| rs74868109 | chr10:6613587:T:C | - | 0.035918068268048 | 0.0079937270493939 | THCA | Female-baised eQTL |
| rs7088809 | chr10:619541:G:A | - | 0.0357232459770119 | 0.00821567123879819 | THCA | Female-baised eQTL |
| rs2387587 | chr10:6611974:G:T | - | 0.0358471792424372 | 0.00825587731638144 | THCA | Female-baised eQTL |
| rs79555618 | chr10:6615356:G:A | - | 0.0353385531968737 | 0.00973197303439732 | THCA | Female-baised eQTL |
| rs61832966 | chr10:597518:T:C | - | 0.0347997056066791 | 0.0103414917833066 | THCA | Female-baised eQTL |
| rs55782929 | chr10:6613076:G:T | - | 0.0343089429435281 | 0.0134198005890943 | THCA | Female-baised eQTL |
| rs74115074 | chr10:603763:C:A | - | 0.0333260111968029 | 0.0163630053081842 | THCA | Female-baised eQTL |
| rs113997801 | chr10:619505:G:C | - | 0.033311537646639 | 0.0163630053081842 | THCA | Female-baised eQTL |
| rs74115079 | chr10:619659:C:T | - | 0.033311537646639 | 0.0163630053081842 | THCA | Female-baised eQTL |
| rs60702184 | chr10:621112:C:G | - | 0.033311537646639 | 0.0163630053081842 | THCA | Female-baised eQTL |
| rs55712957 | chr10:621231:T:C | - | 0.033311537646639 | 0.0163630053081842 | THCA | Female-baised eQTL |
| rs10905224 | chr10:7733007:A:G | - | 0.0332544188526825 | 0.0167422491065809 | THCA | Female-baised eQTL |
| rs2386709 | chr10:616253:A:C | - | 0.0328341339490823 | 0.0188210625907277 | THCA | Female-baised eQTL |
| rs6602270 | chr10:7732014:T:C | - | 0.0327813283233374 | 0.0193146836148381 | THCA | Female-baised eQTL |
| rs11253064 | chr10:537281:A:C | - | 0.0325567359833172 | 0.0221949760388805 | THCA | Female-baised eQTL |
| rs11255322 | chr10:7733203:A:G | - | 0.0316554726336115 | 0.0259182350586873 | THCA | Female-baised eQTL |
| rs17159756 | chr10:616748:G:A | - | 0.0314490308552122 | 0.0287710516413918 | THCA | Female-baised eQTL |
| rs61834653 | chr10:7287924:T:C | - | 0.0288268481044926 | 0.032941793126037 | THCA | Female-baised eQTL |
| rs11252919 | chr10:519891:C:A | - | 0.0307934579851538 | 0.0384580153823628 | THCA | Female-baised eQTL |
| rs7913021 | chr10:553792:C:T | - | 0.0305844982206438 | 0.0388389349712144 | THCA | Female-baised eQTL |
| rs74115086 | chr10:626947:C:T | - | 0.0299028738660096 | 0.042392431372096 | THCA | Female-baised eQTL |
| rs73581620 | chr10:528429:G:A | - | 0.0303830392902326 | 0.0430434579666132 | THCA | Female-baised eQTL |
| rs7893218 | chr10:531345:C:T | - | 0.0303885322362484 | 0.0430434579666132 | THCA | Female-baised eQTL |
| rs7912391 | chr10:531504:G:A | - | 0.0303885322362484 | 0.0430434579666132 | THCA | Female-baised eQTL |
| rs113210208 | chr10:530574:T:C | - | 0.030411525015919 | 0.0430434579666132 | THCA | Female-baised eQTL |
| rs2794955 | chr10:626458:A:G | - | 0.0298398539809161 | 0.0450109268570743 | THCA | Female-baised eQTL |
| rs77226461 | chr10:9739414:G:T | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs77371493 | chr10:9745627:G:A | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs74805176 | chr10:9748488:T:A | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs7896153 | chr10:9750378:A:G | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs76243386 | chr10:9750511:T:C | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs77702097 | chr10:9751881:A:G | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs7905035 | chr10:9752387:A:G | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs7909203 | chr10:9753143:A:G | - | 0.466480952067701 | 0.0276102326956014 | KIRP | Female-baised eQTL |
| rs79617759 | chr10:9708885:A:G | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs76281634 | chr10:9710740:T:C | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs79794020 | chr10:9711576:C:A | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs75389107 | chr10:9715086:G:A | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs79595174 | chr10:9719633:C:T | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs116240718 | chr10:9721404:C:T | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs78129622 | chr10:9731098:T:C | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs77670847 | chr10:9731362:A:G | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs2397855 | chr10:9731770:C:T | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs17146359 | chr10:9736232:T:C | - | 0.464983523303835 | 0.0291253950806863 | KIRP | Female-baised eQTL |
| rs17146401 | chr10:9761467:G:A | - | 0.464190480540039 | 0.0300062511905231 | KIRP | Female-baised eQTL |
| rs878300 | chr10:9762846:T:C | - | 0.464190480540039 | 0.0300062511905231 | KIRP | Female-baised eQTL |
| rs17146434 | chr10:9765164:T:C | - | 0.464190480540039 | 0.0300062511905231 | KIRP | Female-baised eQTL |
| rs7903194 | chr10:9766537:G:C | - | 0.464190480540039 | 0.0300062511905231 | KIRP | Female-baised eQTL |
| rs115380015 | chr10:9772638:C:A | - | 0.464190480540039 | 0.0300062511905231 | KIRP | Female-baised eQTL |
| rs80355144 | chr10:9775115:A:G | - | 0.464190480540039 | 0.0300062511905231 | KIRP | Female-baised eQTL |
| rs12572396 | chr10:1824557:T:C | - | 0.100504286916408 | 0.00628054918157237 | STAD | Female-baised eQTL |
| rs79296515 | chr10:1800565:T:G | - | 0.0955139270628671 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs4075097 | chr10:1801182:T:C | - | 0.0955139270628671 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs79530533 | chr10:1803869:C:G | - | 0.0955139270628671 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs17156989 | chr10:1804437:C:T | - | 0.0955139270628671 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs77002657 | chr10:1807269:G:A | - | 0.0955139270628671 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs118158223 | chr10:1807460:C:A | - | 0.0955139270628671 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs191448520 | chr10:1809997:G:A | - | 0.0955139270628671 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs73592636 | chr10:1796173:G:A | - | 0.0954798365538512 | 0.0109098029877328 | STAD | Female-baised eQTL |
| rs12570407 | chr10:1812579:C:T | - | 0.0912791866695353 | 0.0166011209866416 | STAD | Female-baised eQTL |
| rs4360625 | chr10:1816246:T:A | - | 0.0912791866695353 | 0.0166011209866416 | STAD | Female-baised eQTL |
| rs12573506 | chr10:1818020:C:T | - | 0.0912791866695353 | 0.0166011209866416 | STAD | Female-baised eQTL |
| rs72773820 | chr10:7114428:G:T | - | 0.0892937431277712 | 0.0169201756556805 | STAD | Female-baised eQTL |
| rs11255030 | chr10:5610855:G:A | - | 0.089583867822224 | 0.0228387756528203 | STAD | Female-baised eQTL |
| rs11255035 | chr10:7188286:T:C | - | 0.0905548070300408 | 0.00112913100636588 | KIRC | Female-baised eQTL |
| rs6560840 | chr10:443716:A:G | - | 0.0735551216389662 | 0.00184837489663599 | KIRC | Female-baised eQTL |
| rs2244699 | chr10:1322136:G:T | - | 0.0774723585487723 | 0.00291696639126789 | KIRC | Female-baised eQTL |
| rs7917096 | chr10:4338101:G:A | - | 0.0795692177316738 | 0.0114072946708311 | KIRC | Female-baised eQTL |
| rs7074740 | chr10:550830:C:T | - | 0.0621965337611936 | 0.018895156553465 | KIRC | Female-baised eQTL |
| rs17155336 | chr10:14463214:T:C | - | 0.0722743823725787 | 0.0190371759386193 | KIRC | Female-baised eQTL |
| rs7917823 | chr10:550153:G:A | - | 0.061020699763301 | 0.0219296463181999 | KIRC | Female-baised eQTL |
| rs7917949 | chr10:550230:G:A | - | 0.061020699763301 | 0.0219296463181999 | KIRC | Female-baised eQTL |
| rs7914425 | chr10:549937:G:A | - | 0.0587927300900783 | 0.0303328808757982 | KIRC | Female-baised eQTL |
| rs7917694 | chr10:1636994:C:A | - | -0.0470784122539999 | 0.0318612973140175 | KIRC | Female-baised eQTL |
| rs7076628 | chr10:1636025:T:A | - | -0.0470085553453247 | 0.0330108732932824 | KIRC | Female-baised eQTL |
| rs61673541 | chr10:1642996:C:T | - | 0.0588761059582026 | 0.03408308469527 | KIRC | Female-baised eQTL |
| rs7920777 | chr10:1634222:A:G | - | 0.0597400603132516 | 0.0345832757369802 | KIRC | Female-baised eQTL |
| rs7909592 | chr10:1635597:C:A | - | 0.059670431828639 | 0.0354409166755542 | KIRC | Female-baised eQTL |
| rs73574227 | chr10:545367:G:A | - | 0.0581277037826268 | 0.0357008916511807 | KIRC | Female-baised eQTL |
| rs12266646 | chr10:544142:G:T | - | 0.0568164862930801 | 0.0436763370206354 | KIRC | Female-baised eQTL |
| rs7100363 | chr10:547442:A:G | - | 0.0547273357747194 | 0.0471638110268807 | KIRC | Female-baised eQTL |
| rs4880893 | chr10:1640651:A:C | - | -0.0447875817685711 | 0.0476913122198906 | KIRC | Female-baised eQTL |
| rs7092480 | chr10:14423575:G:A | - | 0.341250453485883 | 0.0110290810572824 | BLCA | Female-baised eQTL |
| rs7077023 | chr10:14423598:A:G | - | 0.341250453485883 | 0.0110290810572824 | BLCA | Female-baised eQTL |
| rs7092613 | chr10:14423671:G:A | - | 0.341250453485883 | 0.0110290810572824 | BLCA | Female-baised eQTL |
| rs11259083 | chr10:14423943:A:C | - | 0.341250453485883 | 0.0110290810572824 | BLCA | Female-baised eQTL |
| rs11259084 | chr10:14423980:A:G | - | 0.341250453485883 | 0.0110290810572824 | BLCA | Female-baised eQTL |
| rs11259085 | chr10:14423988:T:C | - | 0.341250453485883 | 0.0110290810572824 | BLCA | Female-baised eQTL |
| rs7092054 | chr10:14423276:G:A | - | 0.330991044331882 | 0.0180446809937464 | BLCA | Female-baised eQTL |
| rs10904196 | chr10:4126848:G:T | - | -0.078272032049235 | 0.000211239262386631 | LUAD | Female-baised eQTL |
| rs1923392 | chr10:4129073:T:A | - | -0.0782145062578688 | 0.000216033102307507 | LUAD | Female-baised eQTL |
| rs11252367 | chr10:4129559:A:G | - | 0.0711680447508526 | 0.00203064744480944 | LUAD | Female-baised eQTL |
| rs7087085 | chr10:4126467:T:G | - | 0.071061151074307 | 0.00211135118899052 | LUAD | Female-baised eQTL |
| rs7101224 | chr10:4122139:T:C | - | 0.0709889570052927 | 0.00215846471792827 | LUAD | Female-baised eQTL |
| rs1291830 | chr10:11055051:G:A | - | 0.0631296900919362 | 0.00376915631290357 | LUAD | Female-baised eQTL |
| rs1011072 | chr10:12718382:G:C | - | 0.0672886101977296 | 0.01695789842702 | LUAD | Female-baised eQTL |
| rs7091265 | chr10:5331497:T:C | - | 0.0605035463763694 | 0.0173561769520417 | LUAD | Female-baised eQTL |
| rs9787415 | chr10:13661217:A:G | - | -0.041018556455779 | 0.0179581773286229 | LUAD | Female-baised eQTL |
| rs7090372 | chr10:11033170:T:C | - | -0.0453405054836482 | 0.0205796415490097 | LUAD | Female-baised eQTL |
| rs6602273 | chr10:7832026:A:G | - | 0.0614961546767471 | 0.0276195701022828 | LUAD | Female-baised eQTL |
| rs145769934 | chr10:9934404:C:T | - | 0.0665734147841947 | 0.0296847641792053 | LUAD | Female-baised eQTL |
| rs17146795 | chr10:9935074:A:G | - | 0.0665734147841947 | 0.0296847641792053 | LUAD | Female-baised eQTL |
| rs9787504 | chr10:13661605:G:A | - | -0.0389362816123465 | 0.0330612364332838 | LUAD | Female-baised eQTL |
| rs10737076 | chr10:13662056:C:T | - | -0.0385461183783778 | 0.0357752041254407 | LUAD | Female-baised eQTL |
| rs10906444 | chr10:13662583:G:A | - | -0.0385461183783778 | 0.0357752041254407 | LUAD | Female-baised eQTL |
| rs12220069 | chr10:7837708:G:A | - | 0.059523607891844 | 0.0384075272250175 | LUAD | Female-baised eQTL |
| rs66738509 | chr10:7839619:A:G | - | 0.059523607891844 | 0.0384075272250175 | LUAD | Female-baised eQTL |
| rs11255388 | chr10:7827409:G:A | - | 0.0594324731492689 | 0.0390801204083708 | LUAD | Female-baised eQTL |
| rs10906443 | chr10:13662228:A:G | - | -0.0381043325709339 | 0.0394811007418978 | LUAD | Female-baised eQTL |
| rs11817002 | chr10:9538866:A:C | - | 0.0455562364867287 | 0.0467021477764049 | LUAD | Female-baised eQTL |
| rs1291815 | chr10:11089175:G:A | - | 0.0398174761211731 | 0.0491315798929487 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72478233 | chr10:959968:C:T | - | 0.239319701146835 | 0.00117095114251411 | PAAD | Male-baised eQTL |
| rs11253536 | chr10:962687:A:G | - | -0.230206939614797 | 0.00201588451685369 | PAAD | Male-baised eQTL |
| rs3763720 | chr10:999159:C:T | - | 0.226381464868688 | 0.0202911426813953 | PAAD | Male-baised eQTL |
| rs61836975 | chr10:2742789:G:C | - | 0.110580899858924 | 0.00100512047713607 | THCA | Male-baised eQTL |
| rs61836568 | chr10:2771448:C:T | - | 0.110571898237118 | 0.00102189682633268 | THCA | Male-baised eQTL |
| rs12250892 | chr10:2744955:C:A | - | 0.11046103605933 | 0.00102238512344184 | THCA | Male-baised eQTL |
| rs57602059 | chr10:2755944:C:T | - | 0.110544656134713 | 0.00102884233523446 | THCA | Male-baised eQTL |
| rs61834752 | chr10:2746224:G:T | - | 0.105281313195722 | 0.00213827495133031 | THCA | Male-baised eQTL |
| rs78107021 | chr10:2749341:T:A | - | 0.105281313195722 | 0.00213827495133031 | THCA | Male-baised eQTL |
| rs140838735 | chr10:2750046:G:A | - | 0.105281313195722 | 0.00213827495133031 | THCA | Male-baised eQTL |
| rs74871141 | chr10:2750815:G:A | - | 0.105281313195722 | 0.00213827495133031 | THCA | Male-baised eQTL |
| rs61834754 | chr10:2753107:A:T | - | 0.105281313195722 | 0.00213827495133031 | THCA | Male-baised eQTL |
| rs61834758 | chr10:2757738:G:A | - | 0.105281313195722 | 0.00213827495133031 | THCA | Male-baised eQTL |
| rs7095226 | chr10:2767087:T:G | - | 0.100803103555636 | 0.00414050975232342 | THCA | Male-baised eQTL |
| rs7100748 | chr10:2760827:C:G | - | 0.100678799642874 | 0.00415160197439663 | THCA | Male-baised eQTL |
| rs61836566 | chr10:2761578:G:A | - | 0.100678799642874 | 0.00415160197439663 | THCA | Male-baised eQTL |
| rs148112573 | chr10:2768829:G:T | - | 0.100678799642874 | 0.00415160197439663 | THCA | Male-baised eQTL |
| rs61856091 | chr10:5010620:C:T | gene,exon | 0.0907090162056825 | 0.0141983661100071 | THCA | Male-baised eQTL |
| rs61856092 | chr10:5010870:T:C | gene | 0.0907090162056825 | 0.0141983661100071 | THCA | Male-baised eQTL |
| rs61856093 | chr10:5011235:C:T | gene | 0.0907090162056825 | 0.0141983661100071 | THCA | Male-baised eQTL |
| rs111864068 | chr10:5009619:C:T | gene | 0.0906860913672029 | 0.0142849762094438 | THCA | Male-baised eQTL |
| rs61836567 | chr10:2762908:T:C | - | 0.0897652278375242 | 0.0161638670593802 | THCA | Male-baised eQTL |
| rs113194281 | chr10:5008160:C:T | gene | 0.0839762488623758 | 0.0325331515859552 | THCA | Male-baised eQTL |
| rs10794944 | chr10:2762297:T:C | - | -0.0835878676483582 | 0.0348266156282055 | THCA | Male-baised eQTL |
| rs2152000 | chr10:2763047:T:G | - | -0.0835878676483582 | 0.0348266156282055 | THCA | Male-baised eQTL |
| rs11255660 | chr10:8366906:C:T | - | 0.0485725245097772 | 0.0190461099063019 | STAD | Male-baised eQTL |
| rs11255661 | chr10:8367111:C:T | - | 0.0485170765373008 | 0.0197082308601516 | STAD | Male-baised eQTL |
| rs78476053 | chr10:2451115:G:A | - | 0.0667984850184546 | 0.020894311065267 | STAD | Male-baised eQTL |
| rs11255659 | chr10:8366666:C:A | - | 0.0477508153250377 | 0.0226144084852975 | STAD | Male-baised eQTL |
| rs7350448 | chr10:8367754:T:G | - | 0.0477495552827646 | 0.0227446065753516 | STAD | Male-baised eQTL |
| rs7908949 | chr10:9920546:C:T | - | 0.0667291999557271 | 0.0251111840234048 | STAD | Male-baised eQTL |
| rs6602298 | chr10:8367506:G:C | - | 0.0467417008013139 | 0.0267294992590343 | STAD | Male-baised eQTL |
| rs11255654 | chr10:8364565:C:G | - | 0.0434913994737767 | 0.0385701285337926 | STAD | Male-baised eQTL |
| rs11255655 | chr10:8364770:A:G | - | 0.0427574307088775 | 0.0448590173464089 | STAD | Male-baised eQTL |
| rs12772460 | chr10:5001904:A:G | gene | 0.0394791005955818 | 0.0392076590531612 | BLCA | Male-baised eQTL |
| rs12357650 | chr10:4991040:T:C | gene | 0.0386842717494137 | 0.0460168898573643 | BLCA | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000151632 |
| CpG Site: cg19648686 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.489401460607637 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19648686 | chr10:5002800 | gene | -0.489401460607637 | 1.022849963405e-30 | -0.6922526440155469 | 2.7583724295100017e-36 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of AKR1C2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000151632 | AKR1C2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0011616 | Contact Dermatitis | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0014175 | Endometriosis | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0019269 | Hermaphroditism | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0027661 | Neoplasms, Hormone-Dependent | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0033804 | Pseudohermaphroditism | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0036875 | Disorders of Sex Development | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0043094 | Weight Gain | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0162351 | Contact hypersensitivity | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0266362 | Ambiguous Genitalia | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C0269102 | Endometrioma | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C1839840 | MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C2239176 | Liver carcinoma | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C2930618 | Intersex Conditions | 1 | CTD_human |
| ENSG00000151632 | AKR1C2 | C2930619 | Sex Differentiation Disorders | 1 | CTD_human |
