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Gene: ENSG00000149243 |
Summary for KLHL35 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000149243 | Gene symbol | KLHL35 |
| Gene name | kelch like family member 35 | |
| HGNC | 26597 | |
| Entrez ID | 283212 | |
| Gene type | protein_coding | |
| Synonyms | KLHL35|FLJ33790 | |
| UniProtAcc | Q6PF15 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for KLHL35 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| KLHL35 | 3.45e+02 | 2.13e+00 | 4.77e-01 | 4.46e+00 | 8.31e-06 | 1.20e-04 | STAD |
| KLHL35 | 4.45e+02 | 1.86e+00 | 1.29e-01 | 1.44e+01 | 5.25e-47 | 4.84e-46 | BRCA |
| KLHL35 | 1.92e+02 | 3.62e+00 | 4.74e-01 | 7.64e+00 | 2.11e-14 | 1.55e-12 | READ |
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Sex-biased somatic mutation for KLHL35 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for KLHL35 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg04231094 | chr11:75428635 | CGI:chr11:75428409-75428772 | promoter,exon,gene body | 6.27e-01 | 5.00e-01 | 2.31e+00 | 2.08e-02 | 3.55e-02 | 1.27e-01 |
| BRCA | cg20787146 | chr11:75431404 | CGI:chr11:75429692-75430804 | promoter | 5.23e-01 | 3.25e-01 | 3.55e+00 | 3.87e-04 | 5.02e-03 | 1.98e-01 |
| BLCA | cg10909185 | chr11:75428691 | CGI:chr11:75428409-75428772 | promoter,gene body | 6.49e-01 | 5.30e-01 | 3.42e+00 | 6.21e-04 | 3.49e-03 | 1.20e-01 |
| KIRP | cg10909185 | chr11:75428691 | CGI:chr11:75428409-75428772 | promoter,gene body | 3.50e-01 | 2.34e-01 | 3.00e+00 | 2.66e-03 | 9.31e-03 | 1.17e-01 |
| SARC | cg10909185 | chr11:75428691 | CGI:chr11:75428409-75428772 | promoter,gene body | 3.82e-01 | 2.80e-01 | 2.68e+00 | 7.31e-03 | 1.49e-02 | 1.02e-01 |
| PAAD | cg10909185 | chr11:75428691 | CGI:chr11:75428409-75428772 | promoter,gene body | 4.60e-01 | 3.18e-01 | 3.50e+00 | 4.70e-04 | 2.37e-03 | 1.42e-01 |
| ACC | cg04231094 | chr11:75428635 | CGI:chr11:75428409-75428772 | promoter,exon,gene body | 4.21e-01 | 5.76e-01 | -2.20e+00 | 2.79e-02 | 4.03e-02 | -1.55e-01 |
| KICH | cg05456789 | chr11:75430922 | CGI:chr11:75429692-75430804 | promoter | 4.60e-01 | 6.32e-01 | -2.80e+00 | 5.13e-03 | 1.83e-02 | -1.72e-01 |
| CHOL | cg08160331 | chr11:75429820 | CGI:chr11:75429692-75430804 | promoter,exon,CDS,gene body | 6.22e-01 | 5.06e-01 | 2.45e+00 | 1.42e-02 | 2.68e-02 | 1.16e-01 |
| CHOL | cg19149691 | chr11:75429496 | CGI:chr11:75429692-75430804 | promoter,gene body | 9.23e-01 | 8.09e-01 | 3.85e+00 | 1.17e-04 | 5.93e-04 | 1.14e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg12001148 | chr11:75430770 | CGI:chr11:75429692-75430804 | promoter | 1.86e-01 | 6.70e-02 | 4.86e+00 | 1.20e-06 | 4.26e-06 | 1.19e-01 |
| LUAD | cg16547529 | chr11:75429636 | CGI:chr11:75429692-75430804 | promoter,gene body | 6.82e-01 | 5.63e-01 | 4.76e+00 | 1.98e-06 | 1.15e-05 | 1.19e-01 |
| THCA | cg08160331 | chr11:75429820 | CGI:chr11:75429692-75430804 | promoter,exon,CDS,gene body | 4.38e-01 | 3.35e-01 | 2.51e+00 | 1.22e-02 | 1.91e-02 | 1.03e-01 |
| THCA | cg16547529 | chr11:75429636 | CGI:chr11:75429692-75430804 | promoter,gene body | 5.99e-01 | 4.75e-01 | 3.85e+00 | 1.16e-04 | 6.65e-04 | 1.25e-01 |
| LUSC | cg10909185 | chr11:75428691 | CGI:chr11:75428409-75428772 | promoter,gene body | 4.42e-01 | 1.23e-01 | 2.63e+00 | 8.58e-03 | 1.23e-02 | 3.19e-01 |
| LUSC | cg04231094 | chr11:75428635 | CGI:chr11:75428409-75428772 | promoter,exon,gene body | 5.58e-01 | 4.37e-01 | 2.26e+00 | 2.38e-02 | 2.74e-02 | 1.21e-01 |
| LUSC | cg20787146 | chr11:75431404 | CGI:chr11:75429692-75430804 | promoter | 5.25e-01 | 6.68e-01 | -3.17e+00 | 1.50e-03 | 3.42e-03 | -1.43e-01 |
| COAD | cg04231094 | chr11:75428635 | CGI:chr11:75428409-75428772 | promoter,exon,gene body | 5.86e-01 | 4.48e-01 | 2.65e+00 | 8.07e-03 | 1.21e-02 | 1.38e-01 |
| BLCA | cg16547529 | chr11:75429636 | CGI:chr11:75429692-75430804 | promoter,gene body | 6.81e-01 | 5.48e-01 | 3.54e+00 | 4.04e-04 | 1.13e-03 | 1.34e-01 |
| BLCA | cg20787146 | chr11:75431404 | CGI:chr11:75429692-75430804 | promoter | 4.28e-01 | 5.80e-01 | -3.47e+00 | 5.20e-04 | 1.37e-03 | -1.52e-01 |
| LIHC | cg23567562 | chr11:75430690 | CGI:chr11:75429692-75430804 | promoter | 2.49e-01 | 1.20e-01 | 2.46e+00 | 1.38e-02 | 1.62e-02 | 1.29e-01 |
| LIHC | cg04231094 | chr11:75428635 | CGI:chr11:75428409-75428772 | promoter,exon,gene body | 6.20e-01 | 4.99e-01 | 3.70e+00 | 2.12e-04 | 4.02e-04 | 1.21e-01 |
| KIRP | cg19149691 | chr11:75429496 | CGI:chr11:75429692-75430804 | promoter,gene body | 8.69e-01 | 7.57e-01 | 4.24e+00 | 2.26e-05 | 7.39e-05 | 1.12e-01 |
| ESCA | cg20787146 | chr11:75431404 | CGI:chr11:75429692-75430804 | promoter | 4.99e-01 | 6.06e-01 | -2.22e+00 | 2.62e-02 | 4.25e-02 | -1.07e-01 |
| CHOL | cg21555796 | chr11:75430748 | CGI:chr11:75429692-75430804 | promoter | 3.05e-01 | 4.56e-02 | 1.99e+00 | 4.65e-02 | 4.65e-02 | 2.59e-01 |
| CHOL | cg16547529 | chr11:75429636 | CGI:chr11:75429692-75430804 | promoter,gene body | 6.79e-01 | 5.55e-01 | 2.51e+00 | 1.22e-02 | 2.39e-02 | 1.24e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg08160331 | chr11:75429820 | CGI:chr11:75429692-75430804 | promoter,exon,CDS,gene body | 5.56e-01 | 4.15e-01 | 9.29e+00 | 1.48e-20 | 8.40e-20 | 1.41e-01 |
| BRCA | cg10909185 | chr11:75428691 | CGI:chr11:75428409-75428772 | promoter,gene body | 5.93e-01 | 3.19e-01 | 5.79e+00 | 7.24e-09 | 1.64e-08 | 2.74e-01 |
| BRCA | cg04231094 | chr11:75428635 | CGI:chr11:75428409-75428772 | promoter,exon,gene body | 6.27e-01 | 5.21e-01 | 6.20e+00 | 5.77e-10 | 1.43e-09 | 1.06e-01 |
| BRCA | cg16547529 | chr11:75429636 | CGI:chr11:75429692-75430804 | promoter,gene body | 7.31e-01 | 6.00e-01 | 1.13e+01 | 1.92e-29 | 2.62e-28 | 1.31e-01 |
| BRCA | cg20787146 | chr11:75431404 | CGI:chr11:75429692-75430804 | promoter | 5.23e-01 | 6.60e-01 | -8.97e+00 | 3.05e-19 | 1.55e-18 | -1.37e-01 |
| HNSC | cg21555796 | chr11:75430748 | CGI:chr11:75429692-75430804 | promoter | 1.27e-01 | 2.64e-02 | 2.02e+00 | 4.29e-02 | 4.48e-02 | 1.01e-01 |
| BLCA | cg04231094 | chr11:75428635 | CGI:chr11:75428409-75428772 | promoter,exon,gene body | 6.54e-01 | 5.09e-01 | 2.92e+00 | 3.55e-03 | 9.35e-03 | 1.45e-01 |
| LIHC | cg08160331 | chr11:75429820 | CGI:chr11:75429692-75430804 | promoter,exon,CDS,gene body | 5.63e-01 | 4.22e-01 | 4.85e+00 | 1.24e-06 | 1.54e-05 | 1.41e-01 |
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Exon skipping events with PSI in TCGA for KLHL35 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for KLHL35 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for KLHL35 |
| TFs related to KLHL35. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KLHL35 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for KLHL35 |
| RBPs related to ES in KLHL35. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KLHL35 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11820255 | chr11:81110964:T:C | - | 0.132511255762561 | 0.0261022458038137 | LUAD | Male-baised eQTL |
| rs12796196 | chr11:68953663:C:T | - | -0.0499787554997693 | 0.0278678859463435 | COAD | Male-baised eQTL |
| rs2846198 | chr11:68994131:C:T | - | 0.0617788844746566 | 0.0343323533185957 | COAD | Male-baised eQTL |
| rs4354693 | chr11:68951875:A:G | - | -0.0476613594871409 | 0.0387692606679863 | COAD | Male-baised eQTL |
| rs654797 | chr11:68918811:C:G | - | -0.0472280403472571 | 0.0404988809260486 | COAD | Male-baised eQTL |
| rs531991 | chr11:68921828:G:A | - | -0.0472280403472571 | 0.0404988809260486 | COAD | Male-baised eQTL |
| rs655915 | chr11:68932891:C:T | - | -0.0472280403472571 | 0.0404988809260486 | COAD | Male-baised eQTL |
| rs598255 | chr11:68935541:C:G | - | -0.0472280403472571 | 0.0404988809260486 | COAD | Male-baised eQTL |
| rs564244 | chr11:68939986:T:C | - | -0.0471117153077801 | 0.0417120681541094 | COAD | Male-baised eQTL |
| rs673711 | chr11:68945598:T:G | - | -0.0471117153077801 | 0.0417120681541094 | COAD | Male-baised eQTL |
| rs516510 | chr11:68948177:A:C | - | -0.0471117153077801 | 0.0417120681541094 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000149243 |
| CpG Site: cg16547529 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.455993970541188 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16547529 | chr11:75429636 | gene,promoter | -0.455993970541188 | 8.81945162095667e-13 | -0.5060559669248739 | 6.643577989557045e-16 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of KLHL35 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
