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Gene: ENSG00000148660 |
Summary for CAMK2G |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000148660 | Gene symbol | CAMK2G |
| Gene name | calcium/calmodulin dependent protein kinase II gamma | |
| HGNC | 1463 | |
| Entrez ID | 818 | |
| Gene type | protein_coding | |
| Synonyms | CAMK2G| | |
| UniProtAcc | Q13555 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000148660 | CAMK2G | DB06616 | Bosutinib | SmallMoleculeDrug |
| ENSG00000148660 | CAMK2G | DB08699 | 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | SmallMoleculeDrug |
| ENSG00000148660 | CAMK2G | DB12010 | Fostamatinib | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
| ENSG00000148660 | CAMK2G | DB06616 | Bosutinib | SmallMoleculeDrug | Chronic Myelogenous Leukemia (CML) |
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Structure and expression level for CAMK2G |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CAMK2G | 3.98e+03 | -1.16e+00 | 2.56e-01 | -4.51e+00 | 6.62e-06 | 4.10e-05 | BLCA |
| CAMK2G | 4.01e+03 | -1.07e+00 | 1.69e-01 | -6.33e+00 | 2.38e-10 | 3.14e-09 | STAD |
| CAMK2G | 1.78e+03 | -1.06e+00 | 9.25e-02 | -1.14e+01 | 2.54e-30 | 1.57e-28 | COAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CAMK2G | 1.99e+03 | -1.26e+00 | 1.61e-01 | -7.81e+00 | 5.71e-15 | 4.66e-13 | READ |
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Sex-biased somatic mutation for CAMK2G |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CAMK2G |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| SARC | cg04717534 | chr10:73873294 | CGI:chr10:73874028-73875038 | promoter,gene body | 7.14e-01 | 8.18e-01 | -2.87e+00 | 4.13e-03 | 1.00e-02 | -1.04e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg04717534 | chr10:73873294 | CGI:chr10:73874028-73875038 | promoter,gene body | 8.68e-01 | 7.08e-01 | 1.19e+01 | 9.63e-33 | 2.00e-31 | 1.60e-01 |
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Exon skipping events with PSI in TCGA for CAMK2G |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| ESCA | exon_skip_51233 | 4.47e-01 | 2.53e-01 | 2.50e+00 | 1.25e-02 | 2.67e-02 | 1.95e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| LUSC | exon_skip_51216 | 2.15e-01 | 3.16e-01 | -4.23e+00 | 2.36e-05 | 1.46e-04 | -1.01e-01 |
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RNA A-to-I editing events in TCGA for CAMK2G |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CAMK2G |
| TFs related to CAMK2G. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CAMK2G related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CAMK2G |
| RBPs related to ES in CAMK2G. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | ELAVL2 | exon_skip_51211 | 9.09e+00 | 5.33e-03 | 9.48e+00 | 9.92e-01 | Female-biased |
| THCA | PABPC3 | exon_skip_51247 | 8.47e+00 | 9.89e-01 | 8.13e+00 | 4.69e-03 | Male-biased |
| MESO | ELAVL2 | exon_skip_51211 | 9.11e+00 | 2.19e-03 | 9.61e+00 | 9.95e-01 | Female-biased |
| LGG | RBM4 | exon_skip_51230 | 1.08e+01 | 1.25e-02 | 1.11e+01 | 9.87e-01 | Female-biased |
| KICH | SNRNP70 | exon_skip_51239 | 7.79e+00 | 3.71e-03 | 8.19e+00 | 9.88e-01 | Female-biased |
| KICH | SRSF1 | exon_skip_51215 | 8.97e+00 | 9.85e-01 | 8.65e+00 | 1.03e-02 | Male-biased |
| KICH | SRSF1 | exon_skip_51216 | 9.08e+00 | 9.89e-01 | 8.74e+00 | 7.41e-03 | Male-biased |
| HNSC | RBM4 | exon_skip_51230 | 1.10e+01 | 9.85e-01 | 1.07e+01 | 1.44e-02 | Male-biased |
| CAMK2G related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72805108 | chr10:69798552:A:C | - | 0.172160852624286 | 0.00344746284375676 | READ | Female-baised eQTL |
| rs72803101 | chr10:69793163:C:T | - | 0.154773226261462 | 0.0162999288116686 | READ | Female-baised eQTL |
| rs7903372 | chr10:71404293:A:G | - | 0.147043282201607 | 0.0271858726482876 | KIRP | Female-baised eQTL |
| rs1739770 | chr10:82125457:G:C | - | -0.158278526940066 | 0.0425025958178542 | KIRP | Female-baised eQTL |
| rs10999922 | chr10:71627604:G:A | - | 0.109590702112015 | 0.0429422160300636 | STAD | Female-baised eQTL |
| rs375448941 | chr10:82647664:C:T | - | 0.0617433702893601 | 0.0192913130683763 | COAD | Female-baised eQTL |
| rs2253530 | chr10:77593348:T:G | - | -0.0658835749302557 | 0.0237870386565011 | COAD | Female-baised eQTL |
| rs1464111 | chr10:77583168:T:C | - | -0.0656896676007727 | 0.0285481706388678 | COAD | Female-baised eQTL |
| rs2243681 | chr10:77583403:C:T | - | -0.0656896676007727 | 0.0285481706388678 | COAD | Female-baised eQTL |
| rs2673429 | chr10:77591040:A:G | - | -0.0656896676007727 | 0.0285481706388678 | COAD | Female-baised eQTL |
| rs1649940 | chr10:82193867:C:T | - | -0.0415075945940737 | 0.035941267015044 | COAD | Female-baised eQTL |
| rs60950762 | chr10:82650289:G:A | - | 0.0631360204894815 | 0.0396986118775764 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11199741 | chr10:83649324:A:G | - | 0.268729692205181 | 0.0383598161403875 | SARC | Male-baised eQTL |
| rs12261331 | chr10:80527771:C:T | - | 0.0827243359411482 | 0.033852151615082 | BLCA | Male-baised eQTL |
| rs7097610 | chr10:80544406:C:T | - | 0.0745157248924634 | 0.0495332006093619 | BLCA | Male-baised eQTL |
| rs55754636 | chr10:65442618:T:G | - | 0.0649881067284142 | 0.0183487844215838 | LUAD | Male-baised eQTL |
| rs10996565 | chr10:65645600:C:T | - | 0.0779283542316491 | 0.0202983099715684 | LUAD | Male-baised eQTL |
| rs12263974 | chr10:65594458:T:A | - | 0.0774189891166462 | 0.0443274458490813 | LUAD | Male-baised eQTL |
| rs7101097 | chr10:70362053:T:C | - | -0.0679847308594152 | 0.048851767854757 | LUAD | Male-baised eQTL |
| rs7914680 | chr10:66205252:T:G | - | 0.0559819963072094 | 0.0458063782013131 | COAD | Male-baised eQTL |
| rs505079 | chr10:82863871:C:T | - | 0.0537828655807829 | 0.0486981021837622 | COAD | Male-baised eQTL |
| rs504006 | chr10:82864019:G:A | - | 0.0537828655807829 | 0.0486981021837622 | COAD | Male-baised eQTL |
| rs509377 | chr10:82864273:T:C | - | 0.0537828655807829 | 0.0486981021837622 | COAD | Male-baised eQTL |
| rs10733846 | chr10:68653126:G:T | - | -0.0598865362993649 | 0.04884446136635 | COAD | Male-baised eQTL |
| rs7913568 | chr10:68650873:C:T | - | -0.0591715876191736 | 0.0495021640305683 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000148660 |
| CpG Site: cg07481027 | |
| Position to Gene: gene | |
| Male Effect: -0.375045444248837 | |
| Female Effect: - | |
 | Gene ID: ENSG00000148660 |
| CpG Site: cg05395156 | |
| Position to Gene: gene | |
| Male Effect: -0.375045444248837 | |
| Female Effect: - | |
 | Gene ID: ENSG00000148660 |
| CpG Site: cg05395156 | |
| Position to Gene: gene | |
| Male Effect: -0.201163504416814 | |
| Female Effect: - | |
 | Gene ID: ENSG00000148660 |
| CpG Site: cg02227879 | |
| Position to Gene: gene,exon | |
| Male Effect: -0.22940106684111 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg07481027 | chr10:73871830 | gene | -0.375045444248837 | 2.06911360377503e-05 | -0.34860333969744134 | 3.9474911691825003e-07 | KIRP |
| cg05395156 | chr10:73871943 | gene | -0.375045444248837 | 2.06911360377503e-05 | -0.34860333969744134 | 3.9474911691825003e-07 | KIRP |
| cg05395156 | chr10:73871943 | gene | -0.201163504416814 | 5.76644880742136e-12 | -0.4854785714664803 | 1.3749882408639449e-14 | LUAD |
| cg02227879 | chr10:73816434 | gene,exon | -0.22940106684111 | 5.33250784471009e-11 | -0.4768308150338989 | 7.823616147763081e-14 | STAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CAMK2G |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
