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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000147443

Summary for DOK2

check button Gene summary

Gene informationEnsembl ID

ENSG00000147443

Gene symbol

DOK2

Gene namedocking protein 2
HGNC

2991

Entrez ID

9046

Gene typeprotein_coding
SynonymsDOK2|p56dok-2|Dok-2
UniProtAcc

O60496


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for DOK2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
DOK23.62e+021.13e+003.21e-013.51e+004.53e-041.38e-03THCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
DOK22.82e+021.10e+004.08e-012.71e+006.80e-032.37e-02KIRP

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Sex-biased somatic mutation for DOK2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for DOK2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LIHCcg03732056chr8:21913548CGI:chr8:21912183-21912569promoter,gene body,CDS,UTR,exon4.00e-012.91e-014.00e+006.39e-055.00e-041.09e-01
KICHcg03732056chr8:21913548CGI:chr8:21912183-21912569promoter,gene body,CDS,UTR,exon4.77e-013.50e-012.06e+003.92e-024.64e-021.27e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BLCAcg02837301chr8:21912184CGI:chr8:21912183-21912569promoter,gene body5.02e-016.17e-01-3.16e+001.59e-033.28e-03-1.15e-01
LIHCcg03732056chr8:21913548CGI:chr8:21912183-21912569promoter,gene body,CDS,UTR,exon2.91e-015.22e-01-5.71e+001.12e-088.70e-08-2.31e-01
LIHCcg09314421chr8:21913741CGI:chr8:21912183-21912569UTR,promoter,exon,gene body4.50e-015.93e-01-4.02e+005.88e-051.29e-04-1.43e-01
LIHCcg13292636chr8:21913747CGI:chr8:21912183-21912569UTR,promoter,exon,gene body4.93e-016.38e-01-3.99e+006.67e-051.45e-04-1.44e-01
LIHCcg21031128chr8:21913767CGI:chr8:21912183-21912569UTR,promoter,exon,gene body6.11e-017.39e-01-3.39e+006.92e-041.14e-03-1.28e-01
LIHCcg08288130chr8:21914029CGI:chr8:21912183-21912569promoter6.30e-017.35e-01-2.28e+002.25e-022.48e-02-1.05e-01
ESCAcg03732056chr8:21913548CGI:chr8:21912183-21912569promoter,gene body,CDS,UTR,exon3.85e-015.17e-01-2.16e+003.05e-024.39e-02-1.32e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg15316716chr8:21912286CGI:chr8:21912183-21912569promoter,exon,CDS,gene body6.92e-018.18e-01-8.91e+005.10e-192.54e-18-1.26e-01
KIRCcg15316716chr8:21912286CGI:chr8:21912183-21912569promoter,exon,CDS,gene body6.51e-017.54e-01-2.65e+008.15e-031.50e-02-1.03e-01
LUADcg15316716chr8:21912286CGI:chr8:21912183-21912569promoter,exon,CDS,gene body6.39e-017.44e-01-2.99e+002.81e-036.43e-03-1.05e-01
LUADcg08288130chr8:21914029CGI:chr8:21912183-21912569promoter5.75e-017.14e-01-2.45e+001.44e-022.04e-02-1.39e-01
LUADcg16476235chr8:21914157CGI:chr8:21912183-21912569promoter7.29e-018.69e-01-2.18e+002.90e-023.37e-02-1.40e-01

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Exon skipping events with PSI in TCGA for DOK2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for DOK2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for DOK2

check buttonTFs related to DOK2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
READPLAGL2DOK24.30e+009.87e-013.08e+002.05e-03Male-biased

check buttonDOK2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for DOK2

check buttonRBPs related to ES in DOK2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonDOK2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs78693232chr8:13985068:A:G-0.138564036744030.0351843943235668KIRPFemale-baised eQTL
rs73212385chr8:13987670:C:T-0.2287066576980360.0465499719548626KIRPFemale-baised eQTL
rs75225172chr8:13999815:G:A-0.2287066576980360.0465499719548626KIRPFemale-baised eQTL
rs10888102chr8:15067985:C:A--0.1995029920167650.000335864560405232BLCAFemale-baised eQTL
rs75357232chr8:20583937:A:G-0.200208946063210.00221882353142075BLCAFemale-baised eQTL
rs75694429chr8:20589004:G:A-0.1841376803227190.00458126533989688BLCAFemale-baised eQTL
rs1871659chr8:20592498:G:A-0.1748357509310540.00966484964519917BLCAFemale-baised eQTL
rs76394190chr8:20569056:C:T-0.1733675538978860.00976692943440517BLCAFemale-baised eQTL
rs289511chr8:13383749:A:T--0.1385119128072880.0112171063100198BLCAFemale-baised eQTL
rs2722895chr8:28314879:C:T--0.133871390034790.0128504761036542BLCAFemale-baised eQTL
rs2722896chr8:28315105:A:G--0.133871390034790.0128504761036542BLCAFemale-baised eQTL
rs62502292chr8:16050012:A:G-0.2673195284288180.0129615604751407BLCAFemale-baised eQTL
rs2614083chr8:28313363:G:T--0.1335215836008630.0129685846976706BLCAFemale-baised eQTL
rs2614084chr8:28313413:A:G--0.1335215836008630.0129685846976706BLCAFemale-baised eQTL
rs2722894chr8:28314022:A:T--0.1335215836008630.0129685846976706BLCAFemale-baised eQTL
rs2614085chr8:28314060:G:A--0.1335215836008630.0129685846976706BLCAFemale-baised eQTL
rs62492373chr8:16064468:T:C-0.2664728600374390.01379696156588BLCAFemale-baised eQTL
rs75280450chr8:16066563:A:G-0.2664728600374390.01379696156588BLCAFemale-baised eQTL
rs12543496chr8:29112406:C:G-0.1540970080383520.0151612631239406BLCAFemale-baised eQTL
rs17215039chr8:13374204:T:A-0.1947263916140050.021241158106529BLCAFemale-baised eQTL
rs17215195chr8:13376067:A:G-0.1947263916140050.021241158106529BLCAFemale-baised eQTL
rs73205736chr8:13376609:A:G-0.1947263916140050.021241158106529BLCAFemale-baised eQTL
rs12550612chr8:23109256:G:A--0.1255067933380970.022600990007525BLCAFemale-baised eQTL
rs167042chr8:13384552:C:T--0.2039991763589240.0226595051804783BLCAFemale-baised eQTL
rs73665366chr8:15011065:C:T-0.1603608843824310.0331303486501955BLCAFemale-baised eQTL
rs11203675chr8:15011606:C:A--0.1603608843824310.0331303486501955BLCAFemale-baised eQTL
rs6992611chr8:15011977:G:A-0.1603608843824310.0331303486501955BLCAFemale-baised eQTL
rs9918919chr8:23109777:G:C--0.1213803927066330.0364076557934767BLCAFemale-baised eQTL
rs7002838chr8:27900874:C:G-0.2122160128817750.0367180918355633BLCAFemale-baised eQTL
rs10111172chr8:23111578:T:C--0.1201784289738480.0394544928059824BLCAFemale-baised eQTL
rs1484768chr8:16045452:G:C-0.2267731752436140.0396132334871248BLCAFemale-baised eQTL
rs11574276chr8:31101484:T:A-0.1441409450264950.0418374762843546BLCAFemale-baised eQTL
rs73228694chr8:31104902:G:A-0.1441409450264950.0418374762843546BLCAFemale-baised eQTL
rs17650903chr8:31104903:C:A-0.1441409450264950.0418374762843546BLCAFemale-baised eQTL
rs62506090chr8:31106090:A:T-0.1441409450264950.0418374762843546BLCAFemale-baised eQTL
rs17651080chr8:31110157:A:C-0.1441409450264950.0418374762843546BLCAFemale-baised eQTL
rs62502290chr8:16048142:C:A-0.225787547796960.0422869636491653BLCAFemale-baised eQTL
rs62502316chr8:16050032:G:A-0.225787547796960.0422869636491653BLCAFemale-baised eQTL
rs62492405chr8:16094286:A:C-0.2368145636427780.0443302424023668BLCAFemale-baised eQTL
rs62492406chr8:16095054:A:T-0.2368145636427780.0443302424023668BLCAFemale-baised eQTL
rs118111862chr8:13395479:T:C-0.2445437348951230.0451849124930191BLCAFemale-baised eQTL
rs11988785chr8:16093369:C:T-0.2362667388093550.0459863421678606BLCAFemale-baised eQTL
rs79382796chr8:16086662:T:C-0.2358850377554840.0468371546162508BLCAFemale-baised eQTL
rs112681058chr8:16090564:T:C-0.2350160272643970.0493831188498045BLCAFemale-baised eQTL
rs2722911chr8:28311334:C:T--0.1150553727826310.0494246162422011BLCAFemale-baised eQTL
rs2614080chr8:28311606:G:A--0.1150553727826310.0494246162422011BLCAFemale-baised eQTL
rs2722908chr8:28311713:A:G--0.1150553727826310.0494246162422011BLCAFemale-baised eQTL
rs1026353chr8:15092024:A:G--0.06149817508687650.0116351081350842LUADFemale-baised eQTL
rs5006988chr8:16422975:A:G-0.07352815586369330.0339730680912056LUADFemale-baised eQTL
rs62504215chr8:15571336:C:G-0.07655583744504870.0360160418025484LUADFemale-baised eQTL
rs76060711chr8:16334865:T:G-0.0822269615735850.0425672632521789LUADFemale-baised eQTL
rs79514829chr8:16319247:C:A-0.08495329055763460.0433518893750885LUADFemale-baised eQTL
rs62504194chr8:15562005:T:G-0.04790398297958520.0468653896547257LUADFemale-baised eQTL
rs62504195chr8:15562349:C:T-0.04790398297958520.0468653896547257LUADFemale-baised eQTL
rs1366957chr8:16317662:T:C-0.08086901843014140.0499715475486879LUADFemale-baised eQTL
rs78454631chr8:15258110:C:T-0.07243984640695240.0295691025863392COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs7812583chr8:20483857:C:T-0.04511802089080470.0462113131139773LIHCMale-baised eQTL
rs80207740chr8:21922426:C:G-0.1002210804416140.02129454267749KIRCMale-baised eQTL
rs58141407chr8:21934261:C:T-0.09359388300666410.0267388365198416KIRCMale-baised eQTL
rs17581959chr8:21950246:A:G-0.09233221442703370.0332236219440769KIRCMale-baised eQTL
rs76008177chr8:21944761:C:T-0.08865500885011620.0454284623533059KIRCMale-baised eQTL
rs12679696chr8:17383207:C:T-0.04929080595703650.00930937909924533COADMale-baised eQTL
rs725949chr8:17387002:T:C-0.04533270650577340.0220179618124862COADMale-baised eQTL
rs9325882chr8:21406467:G:A-0.04585158937952430.0248964383725657COADMale-baised eQTL
rs2321847chr8:26242212:G:C-0.09069199412579190.0295458612669505COADMale-baised eQTL
rs6994023chr8:21422813:G:A-0.04905236029872610.0296744696645706COADMale-baised eQTL
rs10089703chr8:21418887:G:T-0.04672274117260040.0296917968344175COADMale-baised eQTL
rs2912243chr8:21388289:C:A--0.04490027614363120.0299458125558936COADMale-baised eQTL
rs13269262chr8:21419849:C:T-0.04801250549539690.0315553480348249COADMale-baised eQTL
rs10503641chr8:18973778:G:A-0.05242000382546690.0343910556105553COADMale-baised eQTL
rs7831273chr8:21424258:C:T-0.04737503676421040.0360583037950061COADMale-baised eQTL
rs2410686chr8:21393504:A:C--0.0441359570777480.0368018206449606COADMale-baised eQTL
rs2912241chr8:21385874:G:A--0.05321932330019470.037299028184161COADMale-baised eQTL
rs9644576chr8:21406819:G:C-0.04347497490352310.0373092705784324COADMale-baised eQTL
rs13263769chr8:21416265:G:A-0.04658427336426080.0379955903081874COADMale-baised eQTL
rs1002833chr8:21417424:A:T-0.04658427336426080.0379955903081874COADMale-baised eQTL
rs13273582chr8:21415960:T:C-0.04651287273932860.0393303514820017COADMale-baised eQTL
rs1834531chr8:21391610:G:A--0.04328551013770020.0425671093927848COADMale-baised eQTL
rs752619chr8:21393833:A:G--0.0431565476169270.0438971466703075COADMale-baised eQTL
rs17245234chr8:26230610:A:G-0.08548375810293290.0454967715491729COADMale-baised eQTL
rs55638656chr8:21393505:T:A--0.04278281038051940.0458276535436742COADMale-baised eQTL
rs4501588chr8:27112174:A:T-0.04271222311681050.0493245411163984COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000147443
CpG Site: cg00255726
Position to Gene: gene
Male Effect: -0.319967297311051
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg00255726chr8:21911603gene-0.3199672973110511.8860071399336e-05-0.351336938464886347.049379709423995e-08LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of DOK2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000147443DOK2C0024121Lung Neoplasms1CTD_human
ENSG00000147443DOK2C0242379Malignant neoplasm of lung1CTD_human