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Gene: ENSG00000144535 |
Summary for DIS3L2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000144535 | Gene symbol | DIS3L2 |
| Gene name | DIS3 like 3'-5' exoribonuclease 2 | |
| HGNC | 28648 | |
| Entrez ID | 129563 | |
| Gene type | protein_coding | |
| Synonyms | DIS3L2|FLJ36974|MGC42174 | |
| UniProtAcc | Q8IYB7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for DIS3L2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for DIS3L2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for DIS3L2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg02002619 | chr2:231960041 | CGI:chr2:231961367-231962126 | promoter | 8.45e-01 | 9.47e-01 | -2.69e+00 | 7.05e-03 | 1.06e-02 | -1.02e-01 |
| COAD | cg18427905 | chr2:231961248 | CGI:chr2:231961367-231962126 | UTR,promoter,exon,gene body | 3.12e-01 | 4.27e-01 | -3.99e+00 | 6.60e-05 | 2.52e-04 | -1.15e-01 |
| ESCA | cg02002619 | chr2:231960041 | CGI:chr2:231961367-231962126 | promoter | 8.25e-01 | 9.36e-01 | -2.22e+00 | 2.62e-02 | 4.25e-02 | -1.11e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for DIS3L2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for DIS3L2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for DIS3L2 |
| TFs related to DIS3L2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | ZNF287 | DIS3L2 | 4.03e+00 | 9.80e-01 | 2.83e+00 | 2.15e-03 | Male-biased |
| DIS3L2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for DIS3L2 |
| RBPs related to ES in DIS3L2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | HNRNPH2 | exon_skip_334821 | 8.72e+00 | 9.88e-01 | 8.38e+00 | 6.10e-03 | Male-biased |
| UVM | IGF2BP1 | exon_skip_334825 | 9.93e+00 | 8.88e-03 | 1.02e+01 | 9.89e-01 | Female-biased |
| THYM | IGF2BP1 | exon_skip_334825 | 9.88e+00 | 5.59e-03 | 1.02e+01 | 9.93e-01 | Female-biased |
| THYM | KHDRBS1 | exon_skip_334806 | 7.49e+00 | 9.51e-03 | 7.81e+00 | 9.81e-01 | Female-biased |
| THYM | QKI | exon_skip_334803 | 1.32e+01 | 9.99e-01 | 1.27e+01 | 8.80e-04 | Male-biased |
| THYM | SRSF2 | exon_skip_334810 | 8.84e+00 | 8.83e-03 | 9.17e+00 | 9.87e-01 | Female-biased |
| LIHC | HNRNPH2 | exon_skip_334821 | 8.25e+00 | 7.93e-03 | 8.66e+00 | 9.86e-01 | Female-biased |
| LUSC | LIN28A | exon_skip_334797 | 8.54e+00 | 4.94e-03 | 8.96e+00 | 9.91e-01 | Female-biased |
| LUSC | QKI | exon_skip_334803 | 1.20e+01 | 3.38e-03 | 1.25e+01 | 9.96e-01 | Female-biased |
| COAD | IGF2BP1 | exon_skip_334825 | 9.87e+00 | 4.87e-03 | 1.03e+01 | 9.94e-01 | Female-biased |
| COAD | U2AF2 | exon_skip_334799 | 6.70e+00 | 9.81e-01 | 6.25e+00 | 2.94e-03 | Male-biased |
| DLBC | MBNL1 | exon_skip_334815 | 1.04e+01 | 9.96e-01 | 9.95e+00 | 2.93e-03 | Male-biased |
| CHOL | HNRNPH2 | exon_skip_334821 | 7.65e+00 | 4.81e-04 | 8.52e+00 | 9.93e-01 | Female-biased |
| KIRP | LIN28A | exon_skip_334797 | 8.96e+00 | 9.93e-01 | 8.50e+00 | 2.60e-03 | Male-biased |
| KIRP | QKI | exon_skip_334803 | 1.29e+01 | 2.87e-03 | 1.33e+01 | 9.97e-01 | Female-biased |
| ESCA | IGF2BP1 | exon_skip_334825 | 9.83e+00 | 1.21e-02 | 1.03e+01 | 9.87e-01 | Female-biased |
| ESCA | QKI | exon_skip_334803 | 1.19e+01 | 8.60e-03 | 1.24e+01 | 9.91e-01 | Female-biased |
| ESCA | SART3 | exon_skip_334793 | 8.81e+00 | 9.81e-01 | 8.41e+00 | 1.40e-02 | Male-biased |
| READ | FXR1 | exon_skip_334794 | 9.57e+00 | 1.47e-03 | 1.01e+01 | 9.97e-01 | Female-biased |
| READ | HNRNPH2 | exon_skip_334821 | 8.06e+00 | 9.65e-03 | 8.40e+00 | 9.83e-01 | Female-biased |
| READ | NCL | exon_skip_334794 | 7.80e+00 | 7.94e-03 | 8.15e+00 | 9.84e-01 | Female-biased |
| READ | QKI | exon_skip_334803 | 1.18e+01 | 1.50e-03 | 1.23e+01 | 9.98e-01 | Female-biased |
| READ | SART3 | exon_skip_334793 | 8.89e+00 | 9.82e-01 | 8.59e+00 | 1.32e-02 | Male-biased |
| THCA | IGF2BP1 | exon_skip_334797 | 7.58e+00 | 9.82e-01 | 7.27e+00 | 7.92e-03 | Male-biased |
| THCA | KHDRBS3 | exon_skip_334797 | 8.24e+00 | 9.86e-01 | 7.91e+00 | 6.23e-03 | Male-biased |
| THCA | QKI | exon_skip_334803 | 1.26e+01 | 9.99e-01 | 1.21e+01 | 8.06e-04 | Male-biased |
| PCPG | FXR1 | exon_skip_334794 | 9.94e+00 | 2.73e-03 | 1.04e+01 | 9.96e-01 | Female-biased |
| PCPG | KHDRBS3 | exon_skip_334797 | 7.91e+00 | 4.40e-03 | 8.30e+00 | 9.88e-01 | Female-biased |
| PCPG | LIN28A | exon_skip_334797 | 8.52e+00 | 2.35e-03 | 8.97e+00 | 9.93e-01 | Female-biased |
| MESO | HNRNPH2 | exon_skip_334821 | 8.55e+00 | 9.85e-01 | 8.19e+00 | 8.75e-03 | Male-biased |
| LGG | LIN28A | exon_skip_334797 | 8.56e+00 | 8.76e-03 | 8.91e+00 | 9.87e-01 | Female-biased |
| PAAD | FXR1 | exon_skip_334794 | 9.74e+00 | 3.84e-03 | 1.01e+01 | 9.94e-01 | Female-biased |
| PAAD | IGF2BP1 | exon_skip_334797 | 7.63e+00 | 9.80e-01 | 7.33e+00 | 9.90e-03 | Male-biased |
| PAAD | KHDRBS3 | exon_skip_334797 | 8.26e+00 | 9.82e-01 | 7.97e+00 | 1.08e-02 | Male-biased |
| PAAD | LIN28A | exon_skip_334797 | 8.93e+00 | 9.84e-01 | 8.64e+00 | 1.09e-02 | Male-biased |
| PAAD | QKI | exon_skip_334803 | 1.31e+01 | 9.98e-01 | 1.27e+01 | 1.60e-03 | Male-biased |
| KICH | BRUNOL4 | exon_skip_334822 | 7.38e+00 | 1.01e-02 | 7.70e+00 | 9.80e-01 | Female-biased |
| KICH | BRUNOL5 | exon_skip_334822 | 7.39e+00 | 1.00e-02 | 7.71e+00 | 9.80e-01 | Female-biased |
| KICH | HNRNPH2 | exon_skip_334821 | 8.26e+00 | 9.81e-01 | 7.94e+00 | 1.11e-02 | Male-biased |
| KICH | SRSF2 | exon_skip_334810 | 9.12e+00 | 9.91e-01 | 8.73e+00 | 4.96e-03 | Male-biased |
| SKCM | QKI | exon_skip_334803 | 1.21e+01 | 4.51e-03 | 1.26e+01 | 9.95e-01 | Female-biased |
| SARC | QKI | exon_skip_334803 | 1.25e+01 | 1.71e-03 | 1.31e+01 | 9.98e-01 | Female-biased |
| DIS3L2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1837238 | chr2:222126865:A:G | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs2395845 | chr2:222128596:C:A | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs62185697 | chr2:222129177:C:T | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs62185698 | chr2:222130314:A:C | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs16863436 | chr2:222130772:A:G | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs12988357 | chr2:222132522:A:G | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs34651858 | chr2:222132860:A:G | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs12995566 | chr2:222133353:G:A | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs16863449 | chr2:222134193:A:G | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs71432695 | chr2:222134255:G:A | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs62185700 | chr2:222134417:G:T | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs62185701 | chr2:222134424:C:G | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs62185702 | chr2:222135863:G:T | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs35003070 | chr2:222136625:C:G | - | 0.0853420633343087 | 0.0269101954723141 | LUAD | Female-baised eQTL |
| rs6746265 | chr2:222123010:G:A | - | 0.0860881143273168 | 0.027099152618694 | LUAD | Female-baised eQTL |
| rs71432696 | chr2:222137081:G:C | - | 0.0854932237539266 | 0.0276986223904136 | LUAD | Female-baised eQTL |
| rs34912405 | chr2:222137426:T:A | - | 0.0854932237539266 | 0.0276986223904136 | LUAD | Female-baised eQTL |
| rs10498247 | chr2:230313107:G:A | - | 0.107276568036316 | 0.0369101272548531 | LUAD | Female-baised eQTL |
| rs16863460 | chr2:222138317:T:C | - | 0.0810966542230142 | 0.0377976519939449 | LUAD | Female-baised eQTL |
| rs62185705 | chr2:222139851:T:C | - | 0.0810966542230142 | 0.0377976519939449 | LUAD | Female-baised eQTL |
| rs6751789 | chr2:222142277:A:G | - | 0.0810966542230142 | 0.0377976519939449 | LUAD | Female-baised eQTL |
| rs72620826 | chr2:237476176:C:T | - | -0.106355498348691 | 0.0453208671760082 | LUAD | Female-baised eQTL |
| rs7426128 | chr2:222144308:A:T | - | 0.0795098186994801 | 0.0475641571395098 | LUAD | Female-baised eQTL |
| rs62185728 | chr2:222145068:G:T | - | 0.0795098186994801 | 0.0475641571395098 | LUAD | Female-baised eQTL |
| rs34561817 | chr2:222185957:A:G | - | 0.0924554422758647 | 0.0487579508175437 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7564278 | chr2:230863587:T:G | - | 0.0584123530813147 | 0.00229538584600656 | HNSC | Male-baised eQTL |
| rs7603371 | chr2:230863595:G:C | - | 0.0584123530813147 | 0.00229538584600656 | HNSC | Male-baised eQTL |
| rs72987428 | chr2:235028928:A:T | - | 0.0897264650073838 | 3.12663602862425e-05 | KIRC | Male-baised eQTL |
| rs55705244 | chr2:235027522:T:G | - | 0.0789372665718207 | 0.000430031338834081 | KIRC | Male-baised eQTL |
| rs11675405 | chr2:235020904:A:G | - | 0.0785586940585352 | 0.000435271690030917 | KIRC | Male-baised eQTL |
| rs11690481 | chr2:235011469:A:G | - | 0.0756484082474473 | 0.000494183978166168 | KIRC | Male-baised eQTL |
| rs11690620 | chr2:235011756:A:G | - | 0.0756484082474473 | 0.000494183978166168 | KIRC | Male-baised eQTL |
| rs4663537 | chr2:235022648:A:G | - | 0.0779552870147996 | 0.000519585595630703 | KIRC | Male-baised eQTL |
| rs72987417 | chr2:235019259:G:A | - | 0.0740790903535287 | 0.000791752472554264 | KIRC | Male-baised eQTL |
| rs11695279 | chr2:235023150:C:T | - | 0.0704301438435872 | 0.0063243009694567 | KIRC | Male-baised eQTL |
| rs56394744 | chr2:235027850:C:T | - | 0.0710630403102124 | 0.00638453896287062 | KIRC | Male-baised eQTL |
| rs1901813 | chr2:233600122:A:G | - | 0.0467089933978912 | 0.0188753713025631 | KIRC | Male-baised eQTL |
| rs10194249 | chr2:235013109:C:A | - | 0.0462113215499792 | 0.0279555523536805 | KIRC | Male-baised eQTL |
| rs7602940 | chr2:224343710:G:A | - | 0.0835395666798079 | 0.0387355622796028 | KIRC | Male-baised eQTL |
| rs630143 | chr2:223910025:C:T | - | -0.0731303753880498 | 0.00610565687980071 | BLCA | Male-baised eQTL |
| rs662190 | chr2:223924427:A:G | - | -0.0731303753880498 | 0.00610565687980071 | BLCA | Male-baised eQTL |
| rs12619790 | chr2:223926651:C:T | - | -0.077332891311564 | 0.00722460472510621 | BLCA | Male-baised eQTL |
| rs2055710 | chr2:224901446:G:A | - | -0.0662913503356465 | 0.00826126820583958 | BLCA | Male-baised eQTL |
| rs4350743 | chr2:223937546:C:T | - | -0.0715202070958163 | 0.00887564460630998 | BLCA | Male-baised eQTL |
| rs2272319 | chr2:223941828:G:A | - | -0.067908349817164 | 0.0154022859406946 | BLCA | Male-baised eQTL |
| rs11679791 | chr2:233247890:G:T | - | -0.0444140221452969 | 0.0190339627201302 | BLCA | Male-baised eQTL |
| rs13431103 | chr2:236752316:G:A | - | -0.110754046318921 | 0.0198429062133075 | BLCA | Male-baised eQTL |
| rs863965 | chr2:223864544:C:T | - | -0.0730675256386842 | 0.0223636843650028 | BLCA | Male-baised eQTL |
| rs840357 | chr2:223866176:T:G | - | -0.0730675256386842 | 0.0223636843650028 | BLCA | Male-baised eQTL |
| rs10191252 | chr2:238635606:C:T | - | 0.0631871813464841 | 0.0231677281931116 | BLCA | Male-baised eQTL |
| rs10164737 | chr2:233261176:C:T | - | -0.0418137305338844 | 0.0380960411203509 | BLCA | Male-baised eQTL |
| rs72990366 | chr2:238633820:G:A | - | 0.0624710456662908 | 0.0412236616253224 | BLCA | Male-baised eQTL |
| rs561264 | chr2:238421338:G:T | - | -0.0591933352801254 | 0.0282508420792014 | LUAD | Male-baised eQTL |
| rs13391650 | chr2:236899255:A:G | - | 0.170738648388126 | 0.000253615580824456 | COAD | Male-baised eQTL |
| rs13432103 | chr2:236935483:C:T | - | 0.14384909030602 | 0.000356093353302588 | COAD | Male-baised eQTL |
| rs10176706 | chr2:236932635:G:A | - | 0.159771416264167 | 0.000376436595773471 | COAD | Male-baised eQTL |
| rs13426398 | chr2:236928880:C:T | - | 0.151346055613178 | 0.00112654337333085 | COAD | Male-baised eQTL |
| rs72986770 | chr2:236929434:A:T | - | 0.151344451980995 | 0.00149006969981063 | COAD | Male-baised eQTL |
| rs58830632 | chr2:236932161:G:A | - | 0.150113225108858 | 0.00170779222155973 | COAD | Male-baised eQTL |
| rs55999919 | chr2:236929154:A:G | - | 0.158805009426139 | 0.00258623007595661 | COAD | Male-baised eQTL |
| rs9287606 | chr2:236890778:T:C | - | 0.159410301284488 | 0.00375504848605018 | COAD | Male-baised eQTL |
| rs9287607 | chr2:236891148:G:T | - | 0.159410301284488 | 0.00375504848605018 | COAD | Male-baised eQTL |
| rs58871070 | chr2:236894520:C:T | - | 0.159410301284488 | 0.00375504848605018 | COAD | Male-baised eQTL |
| rs10169105 | chr2:236897227:T:C | - | 0.159410301284488 | 0.00375504848605018 | COAD | Male-baised eQTL |
| rs4380174 | chr2:236934337:A:G | - | 0.135127007340512 | 0.00421201224337079 | COAD | Male-baised eQTL |
| rs920400 | chr2:231853147:A:G | - | 0.0810255716464774 | 0.00567080922149396 | COAD | Male-baised eQTL |
| rs4555339 | chr2:231804368:G:C | - | 0.0779434125682038 | 0.00774154573856913 | COAD | Male-baised eQTL |
| rs13391812 | chr2:232082473:A:T | gene | 0.153169240412833 | 0.00784871956816082 | COAD | Male-baised eQTL |
| rs3856543 | chr2:231849821:T:C | - | 0.0776074170347358 | 0.00799206827122924 | COAD | Male-baised eQTL |
| rs4040722 | chr2:231849927:G:C | - | 0.0776074170347358 | 0.00799206827122924 | COAD | Male-baised eQTL |
| rs7570882 | chr2:237526443:G:A | - | 0.082748964500162 | 0.00871293312555475 | COAD | Male-baised eQTL |
| rs1464976 | chr2:231767136:A:G | - | 0.0771229767550441 | 0.0100379840270512 | COAD | Male-baised eQTL |
| rs1979762 | chr2:237527859:T:C | - | 0.0816337727020966 | 0.0103990971526309 | COAD | Male-baised eQTL |
| rs6437035 | chr2:231771734:G:A | - | 0.0778047108478453 | 0.0106169086796887 | COAD | Male-baised eQTL |
| rs10186470 | chr2:237528437:A:G | - | 0.0814327222555433 | 0.0107797402529617 | COAD | Male-baised eQTL |
| rs11886562 | chr2:234406769:G:A | - | 0.149883641162156 | 0.0108441508330902 | COAD | Male-baised eQTL |
| rs57076878 | chr2:231751133:A:T | - | 0.078855166795568 | 0.0112013123088685 | COAD | Male-baised eQTL |
| rs4482426 | chr2:236934207:G:A | - | 0.146303569787759 | 0.0138981402696404 | COAD | Male-baised eQTL |
| rs10179202 | chr2:224821009:A:G | - | 0.105538796198196 | 0.0147314614875961 | COAD | Male-baised eQTL |
| rs4527189 | chr2:224821669:C:T | - | 0.105538796198196 | 0.0147314614875961 | COAD | Male-baised eQTL |
| rs7609087 | chr2:237529160:C:G | - | 0.078939427613668 | 0.0149383561491575 | COAD | Male-baised eQTL |
| rs13409241 | chr2:237529192:A:G | - | 0.078939427613668 | 0.0149383561491575 | COAD | Male-baised eQTL |
| rs2741023 | chr2:233608068:G:A | - | -0.0793245632109788 | 0.0170937267431902 | COAD | Male-baised eQTL |
| rs62186315 | chr2:224799778:C:T | - | 0.121877279983352 | 0.0181917656914994 | COAD | Male-baised eQTL |
| rs1246073 | chr2:231740799:A:T | - | 0.0763400157518558 | 0.0183353560571285 | COAD | Male-baised eQTL |
| rs838448 | chr2:231742746:T:C | - | 0.0763400157518558 | 0.0183353560571285 | COAD | Male-baised eQTL |
| rs2570991 | chr2:231743584:C:T | - | 0.0763400157518558 | 0.0183353560571285 | COAD | Male-baised eQTL |
| rs838445 | chr2:231745248:A:G | - | 0.0763400157518558 | 0.0183353560571285 | COAD | Male-baised eQTL |
| rs838442 | chr2:231747668:A:C | - | 0.0763400157518558 | 0.0183353560571285 | COAD | Male-baised eQTL |
| rs34089848 | chr2:231751134:A:T | - | 0.0763400157518558 | 0.0183353560571285 | COAD | Male-baised eQTL |
| rs6719408 | chr2:231752495:A:G | - | 0.0763400157518558 | 0.0183353560571285 | COAD | Male-baised eQTL |
| rs6728151 | chr2:224815905:A:T | - | 0.105342443127169 | 0.0200406225504308 | COAD | Male-baised eQTL |
| rs740393 | chr2:241126083:A:G | - | 0.0926554347794655 | 0.0202117863823891 | COAD | Male-baised eQTL |
| rs13414359 | chr2:226812877:A:G | - | 0.103009234313628 | 0.0202580295428285 | COAD | Male-baised eQTL |
| rs13391416 | chr2:234385866:A:T | - | 0.14692873770089 | 0.0218729927027457 | COAD | Male-baised eQTL |
| rs10929029 | chr2:234387054:G:A | - | 0.14692873770089 | 0.0218729927027457 | COAD | Male-baised eQTL |
| rs11884761 | chr2:234387546:C:T | - | 0.14692873770089 | 0.0218729927027457 | COAD | Male-baised eQTL |
| rs11678287 | chr2:234389768:C:T | - | 0.14692873770089 | 0.0218729927027457 | COAD | Male-baised eQTL |
| rs11887188 | chr2:234394166:C:T | - | 0.14692873770089 | 0.0218729927027457 | COAD | Male-baised eQTL |
| rs28447502 | chr2:234375421:G:A | - | 0.148600537642908 | 0.0222852559091096 | COAD | Male-baised eQTL |
| rs2741034 | chr2:233640168:A:G | - | -0.0776646025792535 | 0.0227458049888419 | COAD | Male-baised eQTL |
| rs13406583 | chr2:224816837:G:C | - | 0.106491495209832 | 0.0263983725083143 | COAD | Male-baised eQTL |
| rs6714121 | chr2:224817432:A:G | - | 0.106491495209832 | 0.0263983725083143 | COAD | Male-baised eQTL |
| rs2161892 | chr2:231100351:G:A | - | 0.0904245475804466 | 0.0307751123393731 | COAD | Male-baised eQTL |
| rs3768950 | chr2:236045890:A:T | - | 0.127786401448284 | 0.0335229612850053 | COAD | Male-baised eQTL |
| rs12621280 | chr2:231268271:C:G | - | 0.0744085455113622 | 0.033948833491308 | COAD | Male-baised eQTL |
| rs77741070 | chr2:236890061:G:A | - | 0.144056820038701 | 0.034597326288233 | COAD | Male-baised eQTL |
| rs2240541 | chr2:241126209:A:G | - | 0.105737478732189 | 0.0350448672916808 | COAD | Male-baised eQTL |
| rs7562498 | chr2:227325286:C:G | - | -0.0791997634864166 | 0.0353538548851039 | COAD | Male-baised eQTL |
| rs956115 | chr2:226809848:C:G | - | 0.0978548946687895 | 0.036309078478658 | COAD | Male-baised eQTL |
| rs838443 | chr2:231746432:A:G | - | 0.0704781872128033 | 0.0367524634286292 | COAD | Male-baised eQTL |
| rs3768951 | chr2:236045826:G:A | - | 0.125138338625124 | 0.0371169556293018 | COAD | Male-baised eQTL |
| rs7599243 | chr2:241125891:G:A | - | 0.0786905724902165 | 0.0376915528146161 | COAD | Male-baised eQTL |
| rs2363989 | chr2:234399186:G:A | - | 0.137540449722008 | 0.0380844962848503 | COAD | Male-baised eQTL |
| rs11692463 | chr2:234399474:T:C | - | 0.137540449722008 | 0.0380844962848503 | COAD | Male-baised eQTL |
| rs6735160 | chr2:231935874:T:A | - | 0.0965332330215289 | 0.0382617930338606 | COAD | Male-baised eQTL |
| rs878444 | chr2:231862453:G:C | - | 0.0742201656767812 | 0.0385298044390555 | COAD | Male-baised eQTL |
| rs2741038 | chr2:233655352:G:A | - | -0.0759444946829378 | 0.0401284235368641 | COAD | Male-baised eQTL |
| rs11896232 | chr2:237529481:T:C | - | 0.0742677586254007 | 0.0407855875650667 | COAD | Male-baised eQTL |
| rs72971678 | chr2:234400068:G:A | - | 0.135541608882567 | 0.0431493699429342 | COAD | Male-baised eQTL |
| rs10195796 | chr2:236707821:G:T | - | 0.0913330296347086 | 0.0495256237260075 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs4973008 | chr2:231575364:G:A | Distant upstream | 0.0451069743886075 | 0.0386464525649305 | KIRC | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs78680200 | chr2:232978888:C:T | Distant downstream | -0.0373629395672102 | 0.0079895927810072 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs2675967 | chr2:232871423:G:C | Distant downstream | 0.0180980703984341 | 0.0202647635827019 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs79471082 | chr2:232974005:C:T | Distant downstream | -0.0313934416770629 | 0.0217273435363463 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs75758173 | chr2:232975000:A:C | Distant downstream | -0.0313934416770629 | 0.0217273435363463 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs75713621 | chr2:232972278:A:C | Distant downstream | -0.0311735409863492 | 0.0236618860012841 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs78210025 | chr2:232977606:A:G | Distant downstream | -0.0318915688150153 | 0.0303436007485278 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs778368 | chr2:232880623:G:C | Distant downstream | 0.0175367346140135 | 0.0343078467268052 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs112083946 | chr2:232969703:A:G | Distant downstream | -0.0304711994032736 | 0.0379514746997204 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs111958950 | chr2:232969741:T:C | Distant downstream | -0.0304711994032736 | 0.0379514746997204 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs76479792 | chr2:232969936:T:C | Distant downstream | -0.0304711994032736 | 0.0379514746997204 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs113984112 | chr2:232970096:A:G | Distant downstream | -0.0304711994032736 | 0.0379514746997204 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs76603378 | chr2:232970110:T:C | Distant downstream | -0.0304711994032736 | 0.0379514746997204 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs78336991 | chr2:232970378:T:C | Distant downstream | -0.0304711994032736 | 0.0379514746997204 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs75687703 | chr2:232970440:A:C | Distant downstream | -0.0304711994032736 | 0.0379514746997204 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs778340 | chr2:232869373:G:A | Distant downstream | 0.0172070017935809 | 0.0382654746029093 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs111792921 | chr2:232973046:T:A | Distant downstream | -0.0303201357663178 | 0.0445599974919743 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs2675966 | chr2:232870833:T:C | Distant downstream | 0.0167634432937995 | 0.0476816546348671 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs2592117 | chr2:232870983:C:T | Distant downstream | 0.0167634432937995 | 0.0476816546348671 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs2592116 | chr2:232870999:G:A | Distant downstream | 0.0167634432937995 | 0.0476816546348671 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs2592115 | chr2:232871639:G:A | Distant downstream | 0.0167634432937995 | 0.0476816546348671 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs78664189 | chr2:232969049:G:A | Distant downstream | -0.0309565297736828 | 0.047724132352046 | LUAD | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs3439 | chr2:232586227:G:T | Distant downstream | -0.0180188689413661 | 0.0149718005712299 | LGG | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs3791711 | chr2:232568173:A:G | Distant downstream | -0.0171222440350793 | 0.0350242731384809 | LGG | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs6437068 | chr2:232582111:A:G | Distant downstream | -0.0168895346767239 | 0.0389861311206081 | LGG | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs3791712 | chr2:232567923:A:T | Distant downstream | -0.0168247057053948 | 0.0446823979771472 | LGG | Female-baised sQTL |
| exon_skip_334799 | chr2:232136471:232136719 | Frame-shift | rs3440 | chr2:232586296:C:G | Distant downstream | -0.0167034705767542 | 0.0454856364594458 | LGG | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of DIS3L2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000144535 | DIS3L2 | C0796113 | Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor | 1 | CTD_human |
