|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000143753 |
Summary for DEGS1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000143753 | Gene symbol | DEGS1 |
| Gene name | delta 4-desaturase, sphingolipid 1 | |
| HGNC | 13709 | |
| Entrez ID | 8560 | |
| Gene type | protein_coding | |
| Synonyms | DEGS1|MLD|Des-1|DES1|FADS7|DEGS-1 | |
| UniProtAcc | O15121 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for DEGS1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for DEGS1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for DEGS1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| GBM | cg10502231 | chr1:224175747 | CGI:chr1:224182883-224184053 | promoter | 8.71e-02 | 1.87e-01 | -3.18e+00 | 1.47e-03 | 5.63e-03 | -1.00e-01 |
| GBM | cg17239057 | chr1:224175873 | CGI:chr1:224182883-224184053 | UTR,promoter,exon,gene body | 1.74e-01 | 3.30e-01 | -2.99e+00 | 2.83e-03 | 9.78e-03 | -1.57e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg10502231 | chr1:224175747 | CGI:chr1:224182883-224184053 | promoter | 4.31e-01 | 3.28e-01 | 2.50e+00 | 1.24e-02 | 1.44e-02 | 1.03e-01 |
| LUSC | cg10502231 | chr1:224175747 | CGI:chr1:224182883-224184053 | promoter | 6.11e-01 | 3.28e-01 | 4.04e+00 | 5.42e-05 | 5.68e-04 | 2.83e-01 |
| LUSC | cg17239057 | chr1:224175873 | CGI:chr1:224182883-224184053 | UTR,promoter,exon,gene body | 7.85e-01 | 5.06e-01 | 3.97e+00 | 7.31e-05 | 6.20e-04 | 2.79e-01 |
| CHOL | cg10502231 | chr1:224175747 | CGI:chr1:224182883-224184053 | promoter | 7.29e-01 | 5.91e-01 | 2.58e+00 | 9.87e-03 | 2.15e-02 | 1.38e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg10502231 | chr1:224175747 | CGI:chr1:224182883-224184053 | promoter | 5.60e-01 | 1.36e-01 | 1.33e+01 | 2.74e-40 | 2.32e-38 | 4.24e-01 |
| BRCA | cg17239057 | chr1:224175873 | CGI:chr1:224182883-224184053 | UTR,promoter,exon,gene body | 7.10e-01 | 2.24e-01 | 1.33e+01 | 2.34e-40 | 2.01e-38 | 4.86e-01 |
Top |
Exon skipping events with PSI in TCGA for DEGS1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for DEGS1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for DEGS1 |
| TFs related to DEGS1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DEGS1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for DEGS1 |
| RBPs related to ES in DEGS1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | HNRNPH2 | exon_skip_18381 | 7.97e+00 | 1.56e-03 | 8.52e+00 | 9.92e-01 | Female-biased |
| CHOL | HNRNPH2 | exon_skip_18381 | 8.04e+00 | 1.01e-02 | 8.44e+00 | 9.83e-01 | Female-biased |
| PCPG | HNRNPH2 | exon_skip_18381 | 8.22e+00 | 7.13e-03 | 8.57e+00 | 9.87e-01 | Female-biased |
| DEGS1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs141216261 | chr1:225104992:G:A | - | 0.102284682487679 | 0.0357822644921206 | LGG | Female-baised eQTL |
| rs549355 | chr1:214934812:C:T | - | 0.117596569154081 | 0.0146859105708758 | BLCA | Female-baised eQTL |
| rs474540 | chr1:214936385:T:C | - | 0.117251703921104 | 0.0156970660528956 | BLCA | Female-baised eQTL |
| rs1963938 | chr1:214937655:G:A | - | 0.117251703921104 | 0.0156970660528956 | BLCA | Female-baised eQTL |
| rs498942 | chr1:214943604:T:C | - | 0.115112864515742 | 0.0177034705077284 | BLCA | Female-baised eQTL |
| rs10864140 | chr1:214939581:T:C | - | 0.111300761389481 | 0.0260572696429578 | BLCA | Female-baised eQTL |
| rs486282 | chr1:214940749:T:G | - | 0.111300761389481 | 0.0260572696429578 | BLCA | Female-baised eQTL |
| rs73076218 | chr1:214926120:G:C | - | 0.194760912104416 | 0.043058726763935 | BLCA | Female-baised eQTL |
| rs12027044 | chr1:219899052:C:A | - | 0.178463219391652 | 0.0479680535038563 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9431947 | chr1:231166610:T:C | - | -0.200351501570981 | 0.0332375943508428 | THCA | Male-baised eQTL |
| rs1752185 | chr1:230578872:G:T | - | 0.0634283436782924 | 0.0171241721547486 | LIHC | Male-baised eQTL |
| rs56173830 | chr1:230577407:C:T | - | -0.0625856290859838 | 0.0208431744083008 | LIHC | Male-baised eQTL |
| rs740492 | chr1:230575689:C:T | - | 0.0611708371947864 | 0.0291169946486945 | LIHC | Male-baised eQTL |
| rs1637936 | chr1:230574685:G:A | - | 0.0593062562573822 | 0.0451155152745353 | LIHC | Male-baised eQTL |
| rs6541154 | chr1:220584473:G:A | - | 0.0454230519610958 | 0.0285311789327329 | KIRC | Male-baised eQTL |
| rs60122995 | chr1:230173518:G:A | - | 0.0591884370390416 | 0.00186650679104463 | BLCA | Male-baised eQTL |
| rs76753937 | chr1:230175759:C:T | - | 0.0627652556685867 | 0.00266324904962003 | BLCA | Male-baised eQTL |
| rs79249024 | chr1:230175003:G:A | - | 0.0608277271380803 | 0.00308573813210231 | BLCA | Male-baised eQTL |
| rs73111985 | chr1:230184592:G:A | - | 0.0583925186388317 | 0.00565635468120895 | BLCA | Male-baised eQTL |
| rs66815418 | chr1:230186321:C:T | - | 0.0583592497510569 | 0.00579919351900895 | BLCA | Male-baised eQTL |
| rs114901413 | chr1:232314862:C:T | - | 0.0598677562524105 | 0.016165525226321 | BLCA | Male-baised eQTL |
| rs17835545 | chr1:232317066:C:G | - | 0.0598677562524105 | 0.016165525226321 | BLCA | Male-baised eQTL |
| rs57111749 | chr1:225367000:C:T | - | 0.0794474409370391 | 0.0204869754773175 | BLCA | Male-baised eQTL |
| rs28406861 | chr1:225374092:G:C | - | 0.0706706838048858 | 0.0365271442656902 | BLCA | Male-baised eQTL |
| rs3789628 | chr1:230250876:C:G | - | 0.0434183654230842 | 0.0407215879370339 | BLCA | Male-baised eQTL |
| rs116731598 | chr1:224648594:C:T | - | 0.0617284281933012 | 0.045152393768481 | BLCA | Male-baised eQTL |
| rs56311342 | chr1:224648541:G:A | - | 0.0595549331647748 | 0.045152393768481 | BLCA | Male-baised eQTL |
| rs75890787 | chr1:230199557:A:G | - | 0.0418096974992578 | 0.0484340434879653 | BLCA | Male-baised eQTL |
| rs698279 | chr1:224545364:G:T | - | -0.120574090226748 | 0.0101275115893502 | COAD | Male-baised eQTL |
| rs61836866 | chr1:231555725:G:A | - | 0.131379804765877 | 0.0138871484266317 | COAD | Male-baised eQTL |
| rs10863446 | chr1:219313647:G:A | - | 0.0929205549936565 | 0.0245853083804113 | COAD | Male-baised eQTL |
| rs12084621 | chr1:233062960:G:A | - | -0.0930881618140336 | 0.028141098268743 | COAD | Male-baised eQTL |
| rs6697647 | chr1:218986492:A:G | - | -0.139070298627205 | 0.029798426981711 | COAD | Male-baised eQTL |
| rs7545152 | chr1:219125197:G:A | - | -0.0993222321460043 | 0.0299235528222082 | COAD | Male-baised eQTL |
| rs629222 | chr1:218970256:T:G | - | 0.0678954098410847 | 0.0330381014284245 | COAD | Male-baised eQTL |
| rs1890071 | chr1:222455327:A:T | - | -0.0686674853614694 | 0.0367049608386177 | COAD | Male-baised eQTL |
| rs2786562 | chr1:224554266:G:T | - | -0.112423066394793 | 0.0390403364937597 | COAD | Male-baised eQTL |
| rs1499295 | chr1:224558091:A:G | - | -0.112049823627669 | 0.0403762676806062 | COAD | Male-baised eQTL |
| rs77702728 | chr1:231427440:A:G | - | 0.108456793902513 | 0.0435310967239982 | COAD | Male-baised eQTL |
| rs12058065 | chr1:219116156:A:G | - | -0.0977221184447502 | 0.0438190087609424 | COAD | Male-baised eQTL |
| rs12068797 | chr1:219116645:C:T | - | -0.0977221184447502 | 0.0438190087609424 | COAD | Male-baised eQTL |
| rs12070184 | chr1:219117360:C:G | - | -0.0977221184447502 | 0.0438190087609424 | COAD | Male-baised eQTL |
| rs6689395 | chr1:219118870:G:A | - | -0.0977221184447502 | 0.0438190087609424 | COAD | Male-baised eQTL |
| rs74138160 | chr1:219120154:G:A | - | -0.0977221184447502 | 0.0438190087609424 | COAD | Male-baised eQTL |
| rs6688817 | chr1:219124301:G:A | - | -0.0977221184447502 | 0.0438190087609424 | COAD | Male-baised eQTL |
| rs8179452 | chr1:219320997:G:A | - | 0.0906298803543858 | 0.0456163943183463 | COAD | Male-baised eQTL |
| rs6687738 | chr1:218982447:G:A | - | -0.0676103161608377 | 0.0456766297946814 | COAD | Male-baised eQTL |
| rs190814059 | chr1:219102734:G:A | - | -0.097077761281802 | 0.0460768507495913 | COAD | Male-baised eQTL |
| rs57870885 | chr1:218982903:G:A | - | -0.0694779956703817 | 0.046669713553878 | COAD | Male-baised eQTL |
| rs3885898 | chr1:218953428:T:C | - | -0.124451990503752 | 0.0496791722567361 | COAD | Male-baised eQTL |
| rs715685 | chr1:218953695:G:C | - | -0.124451990503752 | 0.0496791722567361 | COAD | Male-baised eQTL |
| rs6691014 | chr1:218953996:T:C | - | -0.124451990503752 | 0.0496791722567361 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000143753 |
| CpG Site: cg09502069 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.392125676751461 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09502069 | chr1:224184856 | gene | -0.392125676751461 | 3.10444723364436e-13 | -0.5075488118263737 | 4.2166585205315976e-18 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of DEGS1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000143753 | DEGS1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000143753 | DEGS1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
