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Gene: ENSG00000143631 |
Summary for FLG |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000143631 | Gene symbol | FLG |
| Gene name | filaggrin | |
| HGNC | 3748 | |
| Entrez ID | 2312 | |
| Gene type | protein_coding | |
| Synonyms | FLG| | |
| UniProtAcc | P20930 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for FLG |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| FLG | 1.41e+03 | -1.40e+00 | 4.70e-01 | -3.00e+00 | 2.60e-03 | 5.30e-03 | HNSC |
| FLG | 6.42e+02 | 2.97e+00 | 8.14e-01 | 3.65e+00 | 2.58e-04 | 2.14e-03 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for FLG |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for FLG |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg26390526 | chr1:152326602 | CGI:chr1:152216384-152216597 | promoter | 5.83e-01 | 4.15e-01 | 2.20e+00 | 2.80e-02 | 3.98e-02 | 1.69e-01 |
| DLBC | cg19855573 | chr1:152325397 | CGI:chr1:152216384-152216597 | promoter | 5.39e-01 | 7.53e-01 | 1.97e+00 | 4.93e-02 | 4.93e-02 | -2.14e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13447818 | chr1:152326408 | CGI:chr1:152216384-152216597 | promoter | 6.36e-01 | 9.30e-01 | -1.27e+01 | 5.12e-37 | 2.14e-35 | -2.94e-01 |
| BRCA | cg26390526 | chr1:152326602 | CGI:chr1:152216384-152216597 | promoter | 5.83e-01 | 9.34e-01 | -1.29e+01 | 6.44e-38 | 3.20e-36 | -3.50e-01 |
| LUAD | cg19855573 | chr1:152325397 | CGI:chr1:152216384-152216597 | promoter | 6.32e-01 | 8.63e-01 | -2.02e+00 | 4.34e-02 | 4.50e-02 | -2.31e-01 |
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Exon skipping events with PSI in TCGA for FLG |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for FLG |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for FLG |
| TFs related to FLG. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF334 | FLG | 6.08e+00 | 1.51e-02 | 6.82e+00 | 9.85e-01 | Female-biased |
| DLBC | ZNF287 | FLG | 4.79e+00 | 1.01e-02 | 5.69e+00 | 9.89e-01 | Female-biased |
| DLBC | ZNF487 | FLG | 5.10e+00 | 1.26e-02 | 5.94e+00 | 9.86e-01 | Female-biased |
| GBM | ELF3 | FLG | 6.44e+00 | 9.83e-01 | 5.49e+00 | 1.64e-02 | Male-biased |
| GBM | HOXC10 | FLG | 6.75e+00 | 9.83e-01 | 5.80e+00 | 1.62e-02 | Male-biased |
| GBM | POU4F2 | FLG | 6.86e+00 | 9.84e-01 | 5.91e+00 | 1.59e-02 | Male-biased |
| GBM | ZFP69B | FLG | 4.42e+00 | 6.18e-03 | 5.69e+00 | 9.93e-01 | Female-biased |
| GBM | ZFX | FLG | 3.78e+00 | 2.42e-03 | 5.41e+00 | 9.96e-01 | Female-biased |
| GBM | ZNF132 | FLG | 3.57e+00 | 1.06e-02 | 4.61e+00 | 9.84e-01 | Female-biased |
| GBM | ZNF157 | FLG | 5.08e+00 | 1.20e-02 | 6.09e+00 | 9.87e-01 | Female-biased |
| GBM | ZNF287 | FLG | 4.20e+00 | 9.82e-01 | 2.94e+00 | 5.70e-03 | Male-biased |
| GBM | ZNF329 | FLG | 4.80e+00 | 5.18e-03 | 6.14e+00 | 9.94e-01 | Female-biased |
| GBM | ZNF334 | FLG | 6.46e+00 | 9.96e-01 | 4.98e+00 | 3.29e-03 | Male-biased |
| GBM | ZNF343 | FLG | 5.07e+00 | 1.55e-02 | 5.98e+00 | 9.84e-01 | Female-biased |
| LGG | TOPORS | FLG | 4.29e+00 | 9.87e-01 | 3.55e+00 | 2.27e-03 | Male-biased |
| LGG | ZFP69B | FLG | 4.76e+00 | 1.14e-02 | 5.24e+00 | 9.86e-01 | Female-biased |
| LGG | ZFX | FLG | 4.05e+00 | 7.52e-03 | 4.59e+00 | 9.86e-01 | Female-biased |
| LGG | ZNF157 | FLG | 5.21e+00 | 3.33e-03 | 5.91e+00 | 9.96e-01 | Female-biased |
| LGG | ZNF182 | FLG | 4.49e+00 | 9.92e-01 | 3.12e+00 | 1.21e-04 | Male-biased |
| LGG | ZNF22 | FLG | 4.45e+00 | 9.92e-01 | 3.02e+00 | 8.22e-05 | Male-biased |
| LGG | ZNF287 | FLG | 4.13e+00 | 9.86e-01 | 2.62e+00 | 5.39e-05 | Male-biased |
| LGG | ZNF329 | FLG | 5.15e+00 | 7.22e-03 | 5.71e+00 | 9.92e-01 | Female-biased |
| LGG | ZNF334 | FLG | 6.38e+00 | 9.97e-01 | 5.66e+00 | 2.56e-03 | Male-biased |
| LGG | ZNF343 | FLG | 5.16e+00 | 4.55e-03 | 5.81e+00 | 9.94e-01 | Female-biased |
| LGG | ZNF487 | FLG | 4.38e+00 | 9.91e-01 | 2.92e+00 | 6.89e-05 | Male-biased |
| PAAD | ZNF182 | FLG | 5.21e+00 | 9.94e-01 | 4.18e+00 | 3.73e-03 | Male-biased |
| PAAD | ZNF22 | FLG | 5.20e+00 | 9.95e-01 | 4.10e+00 | 2.65e-03 | Male-biased |
| PAAD | ZNF287 | FLG | 4.76e+00 | 9.92e-01 | 3.71e+00 | 3.34e-03 | Male-biased |
| PAAD | ZNF334 | FLG | 7.25e+00 | 9.89e-01 | 6.42e+00 | 1.03e-02 | Male-biased |
| PAAD | ZNF487 | FLG | 5.10e+00 | 9.92e-01 | 4.14e+00 | 5.30e-03 | Male-biased |
| READ | ZNF334 | FLG | 6.69e+00 | 9.82e-01 | 6.01e+00 | 1.77e-02 | Male-biased |
| SARC | ZNF334 | FLG | 7.18e+00 | 9.94e-01 | 6.53e+00 | 5.80e-03 | Male-biased |
| SARC | ZNF487 | FLG | 5.66e+00 | 9.82e-01 | 5.18e+00 | 1.67e-02 | Male-biased |
| UVM | ELF3 | FLG | 4.22e+00 | 7.44e-03 | 5.69e+00 | 9.90e-01 | Female-biased |
| UVM | FOXP2 | FLG | 4.70e+00 | 1.34e-02 | 5.87e+00 | 9.85e-01 | Female-biased |
| UVM | HOXC10 | FLG | 4.70e+00 | 9.06e-03 | 6.08e+00 | 9.90e-01 | Female-biased |
| UVM | KLF15 | FLG | 4.93e+00 | 9.86e-01 | 3.33e+00 | 5.63e-03 | Male-biased |
| UVM | LHX2 | FLG | 5.86e+00 | 1.30e-02 | 7.05e+00 | 9.87e-01 | Female-biased |
| UVM | POU4F2 | FLG | 4.75e+00 | 8.99e-03 | 6.13e+00 | 9.90e-01 | Female-biased |
| UVM | TBP | FLG | 4.81e+00 | 1.19e-02 | 6.04e+00 | 9.87e-01 | Female-biased |
| UVM | ZFP69B | FLG | 5.96e+00 | 9.86e-01 | 4.75e+00 | 1.27e-02 | Male-biased |
| UVM | ZFX | FLG | 6.33e+00 | 9.95e-01 | 4.56e+00 | 4.12e-03 | Male-biased |
| UVM | ZNF132 | FLG | 5.57e+00 | 9.92e-01 | 3.94e+00 | 5.34e-03 | Male-biased |
| UVM | ZNF334 | FLG | 3.39e+00 | 1.67e-03 | 5.53e+00 | 9.96e-01 | Female-biased |
| FLG related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for FLG |
| RBPs related to ES in FLG. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| FLG related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12063310 | chr1:159906666:G:A | - | 0.148561947863839 | 0.021678614387835 | HNSC | Female-baised eQTL |
| rs72700678 | chr1:159907182:T:A | - | 0.148171730217727 | 0.0229995264122233 | HNSC | Female-baised eQTL |
| rs72696880 | chr1:150435120:G:A | - | 0.155821679879419 | 0.02980623007781 | HNSC | Female-baised eQTL |
| rs74857275 | chr1:150803647:G:A | - | 0.149534124491555 | 0.0376755944575103 | HNSC | Female-baised eQTL |
| rs12134719 | chr1:154714753:A:C | - | 0.21595823724549 | 0.0432646587810432 | HNSC | Female-baised eQTL |
| rs72700829 | chr1:150567705:C:T | - | 0.14763473148021 | 0.0449132573899755 | HNSC | Female-baised eQTL |
| rs11264245 | chr1:154710300:C:T | - | 0.214558616273226 | 0.0469204331674682 | HNSC | Female-baised eQTL |
| rs11264247 | chr1:154713131:G:A | - | 0.214558616273226 | 0.0469204331674682 | HNSC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of FLG |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000143631 | FLG | C0011603 | Dermatitis | 1 | CTD_human |
| ENSG00000143631 | FLG | C0011615 | Dermatitis, Atopic | 4 | CTD_human |
| ENSG00000143631 | FLG | C0011616 | Contact Dermatitis | 1 | CTD_human |
| ENSG00000143631 | FLG | C0013595 | Eczema | 1 | CTD_human |
| ENSG00000143631 | FLG | C0079584 | Ichthyosis Vulgaris | 2 | CTD_human |
| ENSG00000143631 | FLG | C0086196 | Eczema, Infantile | 4 | CTD_human |
| ENSG00000143631 | FLG | C0162351 | Contact hypersensitivity | 1 | CTD_human |
| ENSG00000143631 | FLG | C0678306 | alcohol sensitivity | 1 | PSYGENET |
| ENSG00000143631 | FLG | C1853965 | Dermatitis, Atopic, 2 | 1 | CTD_human |
