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Gene: ENSG00000143537 |
Summary for ADAM15 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000143537 | Gene symbol | ADAM15 |
| Gene name | ADAM metallopeptidase domain 15 | |
| HGNC | 193 | |
| Entrez ID | 8751 | |
| Gene type | protein_coding | |
| Synonyms | ADAM15|MDC15 | |
| UniProtAcc | Q13444 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ADAM15 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ADAM15 | 9.12e+03 | 1.04e+00 | 2.49e-01 | 4.19e+00 | 2.83e-05 | 1.49e-04 | BLCA |
| ADAM15 | 4.15e+03 | 1.12e+00 | 3.40e-01 | 3.30e+00 | 9.51e-04 | 3.24e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for ADAM15 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ADAM15 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRP | cg24935121 | chr1:155050159 | CGI:chr1:155050512-155051856 | promoter | 2.86e-01 | 3.91e-01 | -2.97e+00 | 2.94e-03 | 4.54e-03 | -1.05e-01 |
| KIRP | cg03379131 | chr1:155051805 | CGI:chr1:155050512-155051856 | promoter,exon,gene body | 7.92e-02 | 1.82e-01 | -6.19e+00 | 5.99e-10 | 5.01e-08 | -1.03e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg24935121 | chr1:155050159 | CGI:chr1:155050512-155051856 | promoter | 2.25e-01 | 1.07e-01 | 2.23e+00 | 2.59e-02 | 2.97e-02 | 1.18e-01 |
Top |
Exon skipping events with PSI in TCGA for ADAM15 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| GBM | exon_skip_11187 | 8.77e-01 | 7.55e-01 | 3.00e+00 | 2.68e-03 | 4.91e-02 | 1.22e-01 |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BLCA | exon_skip_11263 | 4.73e-01 | 6.53e-01 | -4.16e+00 | 3.22e-05 | 1.11e-03 | -1.81e-01 |
| ESCA | exon_skip_11256 | 4.64e-01 | 6.89e-01 | -3.20e+00 | 1.36e-03 | 1.12e-02 | -2.25e-01 |
| ESCA | exon_skip_11263 | 4.84e-01 | 6.74e-01 | -3.00e+00 | 2.70e-03 | 1.45e-02 | -1.90e-01 |
| CHOL | exon_skip_11256 | 5.03e-01 | 8.57e-01 | -3.35e+00 | 8.15e-04 | 7.36e-03 | -3.54e-01 |
| CHOL | exon_skip_11263 | 4.78e-01 | 8.66e-01 | -3.19e+00 | 1.41e-03 | 1.03e-02 | -3.87e-01 |
| CHOL | exon_skip_11286 | 2.65e-01 | 4.74e-02 | 2.72e+00 | 6.44e-03 | 1.65e-02 | 2.18e-01 |
| CHOL | exon_skip_11349 | 3.45e-01 | 8.00e-01 | -3.50e+00 | 4.60e-04 | 5.30e-03 | -4.55e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BRCA | exon_skip_11259 | 2.60e-01 | 1.35e-01 | 1.18e+01 | 2.27e-32 | 1.55e-30 | 1.25e-01 |
| BRCA | exon_skip_11286 | 3.03e-01 | 9.80e-02 | 1.41e+01 | 2.61e-45 | 7.87e-43 | 2.05e-01 |
| BRCA | exon_skip_11346 | 8.07e-01 | 6.85e-01 | 9.16e+00 | 5.32e-20 | 1.19e-18 | 1.22e-01 |
| STAD | exon_skip_11256 | 5.10e-01 | 6.45e-01 | -2.98e+00 | 2.91e-03 | 1.31e-02 | -1.35e-01 |
| STAD | exon_skip_11263 | 5.34e-01 | 6.67e-01 | -2.91e+00 | 3.59e-03 | 1.47e-02 | -1.33e-01 |
| READ | exon_skip_11286 | 2.54e-01 | 4.10e-01 | -2.66e+00 | 7.83e-03 | 1.95e-02 | -1.56e-01 |
| READ | exon_skip_11346 | 7.34e-01 | 8.82e-01 | -3.02e+00 | 2.54e-03 | 1.13e-02 | -1.49e-01 |
Top |
RNA A-to-I editing events in TCGA for ADAM15 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | ADAM15-026 | chr1_155054790_+ | 2.06e-01 | 3.00e-01 | -2.37e+00 | 1.76e-02 | 3.62e-02 | -9.40e-02 |
| LUAD | ADAM15-026 | chr1_155054833_+ | 3.28e-01 | 4.52e-01 | -2.67e+00 | 7.57e-03 | 2.59e-02 | -1.24e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| BRCA | ADAM15-026 | chr1_155054743_+ | 6.01e-01 | 4.12e-01 | 2.92e+00 | 3.52e-03 | 5.77e-03 | 1.89e-01 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ADAM15 |
| TFs related to ADAM15. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAML | TCF3 | ADAM15 | 4.18e+00 | 9.80e-01 | 3.11e+00 | 5.42e-03 | Male-biased |
| LAML | ZIC2 | ADAM15 | 4.08e+00 | 9.80e-01 | 2.83e+00 | 2.70e-03 | Male-biased |
| ADAM15 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ADAM15 |
| RBPs related to ES in ADAM15. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | BRUNOL6 | exon_skip_11349 | 9.10e+00 | 9.83e-01 | 8.78e+00 | 1.36e-02 | Male-biased |
| STAD | SAMD4A | exon_skip_11294 | 8.62e+00 | 9.90e-01 | 8.16e+00 | 3.86e-03 | Male-biased |
| ACC | SAMD4A | exon_skip_11294 | 9.08e+00 | 9.90e-01 | 8.58e+00 | 6.02e-03 | Male-biased |
| LIHC | BRUNOL6 | exon_skip_11289 | 8.87e+00 | 9.91e-01 | 8.36e+00 | 3.79e-03 | Male-biased |
| LIHC | SAMD4A | exon_skip_11125 | 7.10e+00 | 9.86e-01 | 6.08e+00 | 1.87e-04 | Male-biased |
| LUSC | SAMD4A | exon_skip_11294 | 9.42e+00 | 9.96e-01 | 8.84e+00 | 1.64e-03 | Male-biased |
| DLBC | SAMD4A | exon_skip_11294 | 8.18e+00 | 9.57e-03 | 8.53e+00 | 9.84e-01 | Female-biased |
| LUAD | SAMD4A | exon_skip_11125 | 7.01e+00 | 2.56e-03 | 7.49e+00 | 9.87e-01 | Female-biased |
| LUAD | SAMD4A | exon_skip_11147 | 8.69e+00 | 9.94e-01 | 8.09e+00 | 6.89e-04 | Male-biased |
| BRCA | BRUNOL6 | exon_skip_11289 | 8.63e+00 | 8.82e-03 | 9.31e+00 | 9.88e-01 | Female-biased |
| BRCA | BRUNOL6 | exon_skip_11349 | 8.64e+00 | 5.21e-03 | 9.47e+00 | 9.92e-01 | Female-biased |
| BRCA | SAMD4A | exon_skip_11125 | 6.77e+00 | 2.68e-03 | 7.81e+00 | 9.88e-01 | Female-biased |
| BRCA | SAMD4A | exon_skip_11294 | 8.61e+00 | 9.58e-04 | 1.00e+01 | 9.97e-01 | Female-biased |
| READ | SAMD4A | exon_skip_11294 | 8.74e+00 | 9.93e-01 | 8.26e+00 | 1.99e-03 | Male-biased |
| MESO | BRUNOL6 | exon_skip_11289 | 8.22e+00 | 6.67e-04 | 8.85e+00 | 9.94e-01 | Female-biased |
| MESO | BRUNOL6 | exon_skip_11349 | 8.39e+00 | 2.02e-03 | 8.90e+00 | 9.93e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_11125 | 6.46e+00 | 4.30e-03 | 6.87e+00 | 9.81e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_11147 | 8.48e+00 | 9.90e-01 | 8.03e+00 | 3.10e-03 | Male-biased |
| GBM | BRUNOL6 | exon_skip_11289 | 8.66e+00 | 9.91e-01 | 8.21e+00 | 2.89e-03 | Male-biased |
| GBM | SAMD4A | exon_skip_11147 | 8.24e+00 | 9.85e-01 | 7.86e+00 | 6.92e-03 | Male-biased |
| KIRC | BRUNOL6 | exon_skip_11289 | 8.34e+00 | 5.22e-03 | 8.72e+00 | 9.89e-01 | Female-biased |
| SKCM | SAMD4A | exon_skip_11294 | 8.86e+00 | 9.94e-01 | 8.26e+00 | 1.12e-03 | Male-biased |
| HNSC | SAMD4A | exon_skip_11125 | 7.31e+00 | 9.88e-01 | 6.57e+00 | 3.37e-04 | Male-biased |
| HNSC | SAMD4A | exon_skip_11294 | 9.03e+00 | 9.94e-01 | 8.51e+00 | 1.91e-03 | Male-biased |
| SARC | BRUNOL6 | exon_skip_11349 | 8.86e+00 | 9.81e-01 | 8.53e+00 | 1.41e-02 | Male-biased |
| SARC | SAMD4A | exon_skip_11294 | 8.54e+00 | 2.82e-03 | 9.04e+00 | 9.93e-01 | Female-biased |
| ADAM15 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs34550741 | chr1:161403998:G:A | - | 0.106298984681793 | 7.28814896954283e-05 | LGG | Female-baised eQTL |
| rs16841132 | chr1:158814000:A:G | - | 0.139827942874652 | 0.000199112976855444 | LGG | Female-baised eQTL |
| rs12029724 | chr1:163952319:G:T | - | 0.100358918612487 | 0.0234269301938923 | LGG | Female-baised eQTL |
| rs114756787 | chr1:163953191:C:G | - | 0.100358918612487 | 0.0234269301938923 | LGG | Female-baised eQTL |
| rs6702510 | chr1:163955504:A:C | - | 0.100358918612487 | 0.0234269301938923 | LGG | Female-baised eQTL |
| rs4657320 | chr1:163958117:C:T | - | 0.100358918612487 | 0.0234269301938923 | LGG | Female-baised eQTL |
| rs6673191 | chr1:163960598:T:C | - | 0.100358918612487 | 0.0234269301938923 | LGG | Female-baised eQTL |
| rs115549691 | chr1:163936027:G:C | - | 0.098801448682053 | 0.0255551713805299 | LGG | Female-baised eQTL |
| rs2341480 | chr1:161926148:G:T | - | -0.05487463214765 | 0.0260539587804364 | LGG | Female-baised eQTL |
| rs6656937 | chr1:161924302:G:C | - | -0.0522097541034363 | 0.0366404169289411 | LGG | Female-baised eQTL |
| rs10800109 | chr1:161927216:G:A | - | -0.0522097541034363 | 0.0366404169289411 | LGG | Female-baised eQTL |
| rs7516104 | chr1:161932855:T:G | - | -0.0522097541034363 | 0.0366404169289411 | LGG | Female-baised eQTL |
| rs16827987 | chr1:161936002:T:C | - | -0.0522097541034363 | 0.0366404169289411 | LGG | Female-baised eQTL |
| rs10737517 | chr1:161938548:G:A | - | -0.0522097541034363 | 0.0366404169289411 | LGG | Female-baised eQTL |
| rs4657127 | chr1:161941965:C:T | - | -0.0522097541034363 | 0.0366404169289411 | LGG | Female-baised eQTL |
| rs1822706 | chr1:163973306:T:A | - | 0.094214987615668 | 0.0405508565917397 | LGG | Female-baised eQTL |
| rs4845770 | chr1:152451191:G:A | - | 0.0872429207918726 | 0.0171052489581128 | LUAD | Female-baised eQTL |
| rs4845436 | chr1:152451483:T:C | - | 0.0872429207918726 | 0.0171052489581128 | LUAD | Female-baised eQTL |
| rs1923496 | chr1:152452372:C:T | - | 0.0872429207918726 | 0.0171052489581128 | LUAD | Female-baised eQTL |
| rs4845437 | chr1:152455539:T:C | - | 0.0872429207918726 | 0.0171052489581128 | LUAD | Female-baised eQTL |
| rs4845771 | chr1:152458204:C:T | - | 0.087127037146262 | 0.0175169982542487 | LUAD | Female-baised eQTL |
| rs6587674 | chr1:152460870:C:T | - | 0.0853650979934752 | 0.0201231831219135 | LUAD | Female-baised eQTL |
| rs7529997 | chr1:152458670:C:G | - | 0.0843997902097414 | 0.0227990887169175 | LUAD | Female-baised eQTL |
| rs7531606 | chr1:152454394:C:A | - | 0.0832710994801796 | 0.0270037967811544 | LUAD | Female-baised eQTL |
| rs7548609 | chr1:152457705:G:C | - | 0.0831560902577872 | 0.0275502142861477 | LUAD | Female-baised eQTL |
| rs4845438 | chr1:152458037:G:T | - | 0.0831560902577872 | 0.0275502142861477 | LUAD | Female-baised eQTL |
| rs16834090 | chr1:152460428:A:G | - | 0.0822716620693404 | 0.0285152369076386 | LUAD | Female-baised eQTL |
| rs7552436 | chr1:147890473:C:T | - | -0.104133960257137 | 0.0376730281117957 | LUAD | Female-baised eQTL |
| rs6694145 | chr1:152452349:G:T | - | 0.0784106208189993 | 0.0380502032896267 | LUAD | Female-baised eQTL |
| rs4845767 | chr1:152442832:G:A | - | 0.0762340289749514 | 0.0414750220018501 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76832302 | chr1:164894503:G:A | - | 0.13932189521993 | 0.0218369375262608 | STAD | Male-baised eQTL |
| rs6658647 | chr1:158706932:A:G | - | 0.0742324392237959 | 0.0136225322959825 | LGG | Male-baised eQTL |
| rs12145128 | chr1:158707756:A:C | - | 0.0723479856408047 | 0.0206318864338165 | LGG | Male-baised eQTL |
| rs6703837 | chr1:158705693:T:C | - | 0.0708661331006862 | 0.0244610380759956 | LGG | Male-baised eQTL |
| rs326012 | chr1:158736639:T:C | - | 0.0671941354834396 | 0.0268293374868075 | LGG | Male-baised eQTL |
| rs6698568 | chr1:158708989:T:C | - | 0.0672550115329989 | 0.0472755468305713 | LGG | Male-baised eQTL |
| rs56391817 | chr1:158709511:A:G | - | 0.0672550115329989 | 0.0472755468305713 | LGG | Male-baised eQTL |
| rs12087593 | chr1:160424383:A:G | - | -0.0868698077749009 | 0.00134077510134119 | COAD | Male-baised eQTL |
| rs4845600 | chr1:154133218:C:G | - | 0.0671570933384679 | 0.0149437090579364 | COAD | Male-baised eQTL |
| rs72696220 | chr1:154131849:G:C | - | 0.069538925712823 | 0.0151021526834199 | COAD | Male-baised eQTL |
| rs150788702 | chr1:162362408:T:C | - | 0.142850195057025 | 0.0167797067891598 | COAD | Male-baised eQTL |
| rs4845601 | chr1:154137275:G:A | - | 0.0688244126657175 | 0.0186729603833105 | COAD | Male-baised eQTL |
| rs6667928 | chr1:154142229:C:T | - | 0.0688244126657175 | 0.0186729603833105 | COAD | Male-baised eQTL |
| rs6659053 | chr1:154138445:A:G | - | 0.0684850576185439 | 0.0200320509437147 | COAD | Male-baised eQTL |
| rs111804060 | chr1:154114036:G:A | - | 0.0699949499963327 | 0.0201338493979327 | COAD | Male-baised eQTL |
| rs4845363 | chr1:154132540:T:C | - | 0.0669521060229339 | 0.0241879679895935 | COAD | Male-baised eQTL |
| rs11265122 | chr1:154114557:C:T | - | 0.0678166200765287 | 0.0256327478989153 | COAD | Male-baised eQTL |
| rs6661101 | chr1:154118541:G:C | - | 0.067427380845909 | 0.0269503104208038 | COAD | Male-baised eQTL |
| rs6678826 | chr1:154119300:A:C | - | 0.067427380845909 | 0.0269503104208038 | COAD | Male-baised eQTL |
| rs12128052 | chr1:162432185:T:C | - | -0.112054885136477 | 0.0273739921818401 | COAD | Male-baised eQTL |
| rs6664278 | chr1:154119254:G:A | - | 0.0670737516834307 | 0.0288077673967501 | COAD | Male-baised eQTL |
| rs6691826 | chr1:154122731:A:G | - | 0.0668844334313651 | 0.0302821643491571 | COAD | Male-baised eQTL |
| rs6692026 | chr1:154122896:A:C | - | 0.0668844334313651 | 0.0302821643491571 | COAD | Male-baised eQTL |
| rs6692035 | chr1:154122904:A:T | - | 0.0668844334313651 | 0.0302821643491571 | COAD | Male-baised eQTL |
| rs12407062 | chr1:154124551:T:G | - | 0.0668844334313651 | 0.0302821643491571 | COAD | Male-baised eQTL |
| rs6671166 | chr1:154121349:G:A | - | 0.0666896132039602 | 0.0305038681984287 | COAD | Male-baised eQTL |
| rs703123 | chr1:158679639:A:G | - | 0.0621842163815262 | 0.0311182506789823 | COAD | Male-baised eQTL |
| rs6691825 | chr1:154122720:A:T | - | 0.0665400905872971 | 0.0322290438117563 | COAD | Male-baised eQTL |
| rs6693620 | chr1:154130429:C:T | - | 0.0665400905872971 | 0.0322290438117563 | COAD | Male-baised eQTL |
| rs4845597 | chr1:154116962:T:C | - | 0.0649991673330341 | 0.03984400281778 | COAD | Male-baised eQTL |
| rs12408170 | chr1:154143159:G:C | - | 0.0640336084040946 | 0.0401086744922658 | COAD | Male-baised eQTL |
| rs12405309 | chr1:154124632:G:T | - | 0.0652981352998924 | 0.0421537329196662 | COAD | Male-baised eQTL |
| rs1213291 | chr1:164891017:C:T | - | 0.0623120389089863 | 0.0436748377614372 | COAD | Male-baised eQTL |
| rs199958719 | chr1:154125820:C:T | - | 0.0642764695080482 | 0.0444378645372729 | COAD | Male-baised eQTL |
| rs72696208 | chr1:154123621:C:T | - | 0.0641522345363376 | 0.0457495655824403 | COAD | Male-baised eQTL |
| rs78039055 | chr1:154125500:C:T | - | 0.0641522345363376 | 0.0457495655824403 | COAD | Male-baised eQTL |
| rs55677228 | chr1:154128742:A:G | - | 0.0641522345363376 | 0.0457495655824403 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000143537 |
| CpG Site: cg13069100 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: 0.3568496658508 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13069100 | chr1:155062532 | gene,exon,UTR | 0.3568496658508 | 3.78124232366482e-06 | 0.3413793838458328 | 2.822317490349991e-05 | SARC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
 | EX ID: exon_skip_11182 |
| SNP ID: rs16836580 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0793651527490033 | |
| Female Effect: - |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_11256 | chr1:155061414:155061489 | In-frame | rs906280 | chr1:154746302:G:A | Distant upstream | -0.0869127090057958 | 0.0256265437315531 | LUSC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs74554503 | chr1:155662262:G:A | Distant downstream | -0.0562687403215808 | 0.0158370988089122 | LUAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7414254 | chr1:155728634:C:T | Distant downstream | -0.0541208775814699 | 0.0181362379223207 | LUAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs16836580 | chr1:154972571:G:A | Distant upstream | -0.0793651527490033 | 8.18530909291133e-07 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2990245 | chr1:155227671:C:T | Distant downstream | 0.0324723206739488 | 6.6649665883188e-05 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2974930 | chr1:155226926:A:G | Distant downstream | 0.0322516583520149 | 0.00012961664992551 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs497829 | chr1:155223741:C:G | Distant downstream | 0.0318663053021846 | 0.00015875520792496 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2049805 | chr1:155225189:T:C | Distant downstream | 0.0318663053021846 | 0.00015875520792496 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2974931 | chr1:155225424:C:G | Distant downstream | 0.0318663053021846 | 0.00015875520792496 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2974929 | chr1:155227477:T:C | Distant downstream | 0.0314300453770984 | 0.000180491811754553 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7535144 | chr1:154992637:G:T | Distant upstream | -0.0609209855110887 | 0.00121320447585241 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2089248 | chr1:154989230:A:G | Distant upstream | -0.0573168115243411 | 0.00263101207678179 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs59519769 | chr1:154991186:A:G | Distant upstream | -0.0573168115243411 | 0.00263101207678179 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs28851228 | chr1:154991470:A:G | Distant upstream | -0.0573168115243411 | 0.00263101207678179 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4246529 | chr1:155142784:T:C | Distant downstream | 0.0259646068878349 | 0.0048083407819686 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12025371 | chr1:155146851:A:T | Distant downstream | 0.0259317357524912 | 0.00498979365332873 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11799962 | chr1:155149251:T:C | Distant downstream | 0.0259434342474801 | 0.00574452173419529 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7364524 | chr1:155149446:A:G | Distant downstream | 0.0259434342474801 | 0.00574452173419529 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4644481 | chr1:155158424:C:T | Distant downstream | 0.0260436013914443 | 0.00739972792132964 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12124306 | chr1:155161323:A:G | Distant downstream | 0.025235765016582 | 0.00902087930605262 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11264333 | chr1:155135811:G:A | Distant downstream | 0.0248528412809142 | 0.00964469620293723 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs9297 | chr1:155134074:A:G | Distant downstream | 0.0244249992690079 | 0.012050768174678 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12904 | chr1:155134221:G:A | Distant downstream | 0.0244249992690079 | 0.012050768174678 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971078 | chr1:155156547:A:G | Distant downstream | 0.0245987170255453 | 0.013301908300779 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12028043 | chr1:155160360:A:G | Distant downstream | 0.0243243035362445 | 0.0138601476370486 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12127609 | chr1:155161015:G:C | Distant downstream | 0.0243306040378718 | 0.0153912188608315 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12096640 | chr1:154985591:C:T | Distant upstream | -0.0477463232342283 | 0.0172844874846289 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7525580 | chr1:154987406:A:G | Distant upstream | -0.0477463232342283 | 0.0172844874846289 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971054 | chr1:155157782:T:G | Distant downstream | 0.0236277697667589 | 0.0235571776810149 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs34257409 | chr1:155158918:G:T | Distant downstream | 0.0232522489764768 | 0.0273929838527354 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7528060 | chr1:154987543:T:G | Distant upstream | -0.0451829405341339 | 0.0282749913298343 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4276913 | chr1:155159197:A:G | Distant downstream | 0.0230611138570196 | 0.0298966429432446 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12036859 | chr1:154887464:C:A | Distant upstream | -0.023012978265232 | 0.0463884389012785 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7534795 | chr1:155305762:C:T | Distant downstream | 0.0236424774160021 | 0.0483122727084503 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971073 | chr1:155140628:G:T | Distant downstream | 0.0221845411539998 | 0.0493336203740011 | HNSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs1001848 | chr1:155074903:C:A | Distant downstream | 0.0346939840052033 | 0.00019164176517759 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11264293 | chr1:154974041:A:G | Distant upstream | -0.0818255495787525 | 0.000286162748184714 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11264307 | chr1:155075243:C:T | Distant downstream | 0.0344951980754041 | 0.000424000655227474 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs1131397 | chr1:154965759:G:C | Distant upstream | -0.0792455248597549 | 0.000443590053955329 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12075984 | chr1:154971405:A:G | Distant upstream | -0.0792455248597549 | 0.000443590053955329 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12076073 | chr1:154971680:A:G | Distant upstream | -0.0792455248597549 | 0.000443590053955329 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11585145 | chr1:154975020:A:T | Distant upstream | -0.0792455248597549 | 0.000443590053955329 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7513082 | chr1:156031555:G:A | Distant downstream | -0.051013550795836 | 0.000881541675540496 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs10908456 | chr1:155113672:G:A | Distant downstream | 0.0328608070492346 | 0.00185968246576453 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12039316 | chr1:155100745:C:T | Distant downstream | 0.0317984809832786 | 0.00375508023135844 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12025371 | chr1:155146851:A:T | Distant downstream | 0.0316825280824408 | 0.00390662161078132 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4246529 | chr1:155142784:T:C | Distant downstream | 0.0314024557323959 | 0.0049870515794156 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs35200356 | chr1:156026470:T:C | Distant downstream | -0.046154185293502 | 0.00651849669613197 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7367207 | chr1:155107001:C:T | Distant downstream | 0.0307251844593113 | 0.0067338346984109 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7367897 | chr1:155110813:A:T | Distant downstream | 0.0306749992558498 | 0.0068965747050653 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11264322 | chr1:155115457:G:A | Distant downstream | 0.0306725719145959 | 0.00712275849909114 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4361977 | chr1:155103603:C:T | Distant downstream | 0.0308930429380241 | 0.00717840212077811 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11264321 | chr1:155113422:C:A | Distant downstream | 0.030289192950124 | 0.00742850800222427 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11799962 | chr1:155149251:T:C | Distant downstream | 0.0303877666962432 | 0.00753428109368155 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7364524 | chr1:155149446:A:G | Distant downstream | 0.0303877666962432 | 0.00753428109368155 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4303067 | chr1:155114095:C:T | Distant downstream | 0.0300577034894427 | 0.00809054206630903 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12124306 | chr1:155161323:A:G | Distant downstream | 0.0295512617950173 | 0.0122052662955078 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971076 | chr1:155152296:C:A | Distant downstream | 0.0293410352020056 | 0.0128991366662108 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs6668815 | chr1:155152509:A:G | Distant downstream | 0.0294303948506339 | 0.0129868938021571 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971078 | chr1:155156547:A:G | Distant downstream | 0.0292915159357345 | 0.013449992216655 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971052 | chr1:155153542:C:T | Distant downstream | 0.0292159975935104 | 0.0140216841158923 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11264334 | chr1:155154123:T:C | Distant downstream | 0.0292159975935104 | 0.0140216841158923 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs11264335 | chr1:155154222:A:G | Distant downstream | 0.0292159975935104 | 0.0140216841158923 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs10908458 | chr1:155154472:T:C | Distant downstream | 0.0292159975935104 | 0.0140216841158923 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12028043 | chr1:155160360:A:G | Distant downstream | 0.0291410539128487 | 0.0141099810655486 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12127609 | chr1:155161015:G:C | Distant downstream | 0.0291410539128487 | 0.0141099810655486 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971054 | chr1:155157782:T:G | Distant downstream | 0.0289938741428078 | 0.0149984376680842 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs34257409 | chr1:155158918:G:T | Distant downstream | 0.0287666143194993 | 0.0166620493866529 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4276913 | chr1:155159197:A:G | Distant downstream | 0.0286309190267614 | 0.0175071904171771 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs10908454 | chr1:155093940:G:A | Distant downstream | 0.0290620185749545 | 0.0175196830772377 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12904 | chr1:155134221:G:A | Distant downstream | 0.0279791383425394 | 0.0249765260099169 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs9297 | chr1:155134074:A:G | Distant downstream | 0.0278039365114863 | 0.0264668624341447 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs12023499 | chr1:155058900:C:T | Distant upstream | 0.0303593732847503 | 0.0303010614045823 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs17385169 | chr1:156014078:T:C | Distant downstream | -0.0416914198136289 | 0.0356822123240087 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs4971073 | chr1:155140628:G:T | Distant downstream | 0.0267649092130624 | 0.0363532943675725 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs7543209 | chr1:156021607:G:A | Distant downstream | -0.0410332908447043 | 0.0408265549751668 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs10908455 | chr1:155094807:T:C | Distant downstream | 0.0265550943311291 | 0.0412630705020028 | LUSC | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs1760796 | chr1:154335188:A:G | Distant upstream | 0.0454010914205671 | 0.000741557394602644 | COAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2483710 | chr1:154333704:G:A | Distant upstream | 0.0438221238929864 | 0.00109848664384781 | COAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2633438 | chr1:154336032:G:A | Distant upstream | 0.0438221238929864 | 0.00109848664384781 | COAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs1352333 | chr1:154338201:C:A | Distant upstream | 0.0435949348130414 | 0.0013091810972783 | COAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs1626035 | chr1:154338668:C:T | Distant upstream | 0.0435949348130414 | 0.0013091810972783 | COAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2483711 | chr1:154336968:T:A | Distant upstream | 0.0428222910599362 | 0.00177358149583212 | COAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2481064 | chr1:154336998:G:A | Distant upstream | 0.0428222910599362 | 0.00177358149583212 | COAD | Male-baised sQTL |
| exon_skip_11182 | chr1:155060762:155060832 | Frame-shift | rs2988721 | chr1:154336165:A:C | Distant upstream | 0.0423722592730859 | 0.00197213372084857 | COAD | Male-baised sQTL |
| exon_skip_11256 | chr1:155061414:155061489 | In-frame | rs77350683 | chr1:155514639:T:C | Distant downstream | 0.166344801703506 | 0.0481217672000096 | PAAD | Male-baised sQTL |
| exon_skip_11256 | chr1:155061414:155061489 | In-frame | rs113129002 | chr1:155539771:T:C | Distant downstream | 0.166344801703506 | 0.0481217672000096 | PAAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_11346 |
| CpG Site: cg22509057 | |
| Position to EX: Distant upstream | |
| Male Effect: 0.295323789579451 | |
| Female Effect: - | |
 | EX ID: exon_skip_11346 |
| CpG Site: cg26833883 | |
| Position to EX: Distant upstream | |
| Male Effect: 0.295323789579451 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_11346 | chr1:155061903:155061975 | cg22509057 | chr1:154544241 | Distant upstream | 0.295323789579451 | 3.99479668912545e-06 | 0.38329608927335684 | 0.00013718904834118074 | In-frame | PAAD |
| exon_skip_11346 | chr1:155061903:155061975 | cg26833883 | chr1:154993096 | Distant upstream | 0.295323789579451 | 3.99479668912545e-06 | 0.4139492164822084 | 3.363889648228732e-05 | In-frame | PAAD |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ADAM15 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
