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Gene: ENSG00000143379 |
Summary for SETDB1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000143379 | Gene symbol | SETDB1 |
| Gene name | SET domain bifurcated histone lysine methyltransferase 1 | |
| HGNC | 10761 | |
| Entrez ID | 9869 | |
| Gene type | protein_coding | |
| Synonyms | SETDB1|KG1T|KIAA0067|ESET|KMT1E|TDRD21 | |
| UniProtAcc | Q15047 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SETDB1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SETDB1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| TCGA-BLCA |
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| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
| ENSG00000143379 | BLCA | SETDB1 | 4 | 7 | 9.84e-03 | 1.97e-01 | 7.93e-01 | 4.13e-02 | 1.00e+00 |
Top |
DNA methylation with beta values for SETDB1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg15448220 | chr1:150925380 | CGI:chr1:150926143-150926363 | promoter | 7.20e-01 | 6.11e-01 | 3.89e+00 | 1.02e-04 | 6.33e-04 | 1.09e-01 |
| ESCA | cg15448220 | chr1:150925380 | CGI:chr1:150926143-150926363 | promoter | 7.61e-01 | 5.96e-01 | 3.06e+00 | 2.18e-03 | 8.81e-03 | 1.66e-01 |
| ESCA | cg10589385 | chr1:150925961 | CGI:chr1:150926143-150926363 | promoter | 4.35e-01 | 3.10e-01 | 2.98e+00 | 2.86e-03 | 1.10e-02 | 1.25e-01 |
| THYM | cg10589385 | chr1:150925961 | CGI:chr1:150926143-150926363 | promoter | 6.76e-01 | 5.67e-01 | 3.62e+00 | 2.98e-04 | 8.62e-04 | 1.09e-01 |
| CHOL | cg15448220 | chr1:150925380 | CGI:chr1:150926143-150926363 | promoter | 8.39e-01 | 7.03e-01 | 2.01e+00 | 4.49e-02 | 4.72e-02 | 1.36e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg10589385 | chr1:150925961 | CGI:chr1:150926143-150926363 | promoter | 4.14e-01 | 5.52e-01 | -3.34e+00 | 8.41e-04 | 1.68e-03 | -1.38e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg15448220 | chr1:150925380 | CGI:chr1:150926143-150926363 | promoter | 7.00e-01 | 9.02e-01 | -2.33e+00 | 1.97e-02 | 2.68e-02 | -2.01e-01 |
Top |
Exon skipping events with PSI in TCGA for SETDB1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SETDB1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUSC | SETDB1-013 | chr1_150931180_+ | 2.93e-01 | 3.58e-01 | -2.01e+00 | 4.46e-02 | 4.91e-02 | -6.51e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SETDB1 |
| TFs related to SETDB1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | ZNF235 | SETDB1 | 4.06e+00 | 9.81e-01 | 3.01e+00 | 3.95e-03 | Male-biased |
| PAAD | ZNF225 | SETDB1 | 4.16e+00 | 9.81e-01 | 3.26e+00 | 7.17e-03 | Male-biased |
| PAAD | ZNF418 | SETDB1 | 4.22e+00 | 9.89e-01 | 2.79e+00 | 4.49e-04 | Male-biased |
| PAAD | ZNF879 | SETDB1 | 4.25e+00 | 9.87e-01 | 3.15e+00 | 2.48e-03 | Male-biased |
| SARC | ZNF418 | SETDB1 | 4.06e+00 | 9.82e-01 | 3.33e+00 | 3.55e-03 | Male-biased |
| SARC | ZNF571 | SETDB1 | 3.15e+00 | 3.36e-03 | 3.99e+00 | 9.82e-01 | Female-biased |
| SETDB1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SETDB1 |
| RBPs related to ES in SETDB1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | RBM46 | exon_skip_9876 | 1.03e+01 | 9.83e-01 | 1.00e+01 | 1.56e-02 | Male-biased |
| COAD | SAMD4A | exon_skip_9898 | 6.67e+00 | 9.82e-01 | 6.15e+00 | 1.57e-03 | Male-biased |
| DLBC | FMR1 | exon_skip_9898 | 6.44e+00 | 3.54e-03 | 6.87e+00 | 9.81e-01 | Female-biased |
| THCA | FMR1 | exon_skip_9898 | 6.54e+00 | 8.17e-04 | 7.06e+00 | 9.86e-01 | Female-biased |
| THCA | SAMD4A | exon_skip_9898 | 6.51e+00 | 7.50e-04 | 7.04e+00 | 9.86e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_9898 | 6.74e+00 | 9.83e-01 | 6.22e+00 | 1.40e-03 | Male-biased |
| KICH | RBM28 | exon_skip_9876 | 1.00e+01 | 9.84e-01 | 9.74e+00 | 1.44e-02 | Male-biased |
| BLCA | SAMD4A | exon_skip_9898 | 6.09e+00 | 1.79e-03 | 6.61e+00 | 9.81e-01 | Female-biased |
| SETDB1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs13375287 | chr1:158811898:G:A | - | 0.113214489767397 | 0.00156610571911562 | LUSC | Female-baised eQTL |
| rs79825227 | chr1:158812675:C:G | - | 0.111909566609506 | 0.00200352843176699 | LUSC | Female-baised eQTL |
| rs76848939 | chr1:158812910:A:T | - | 0.111909566609506 | 0.00200352843176699 | LUSC | Female-baised eQTL |
| rs79236187 | chr1:158813155:T:A | - | 0.11007232014355 | 0.00226426084212738 | LUSC | Female-baised eQTL |
| rs77085007 | chr1:158819869:C:T | - | 0.11007232014355 | 0.00226426084212738 | LUSC | Female-baised eQTL |
| rs75699174 | chr1:158820990:T:C | - | 0.109844893222125 | 0.00234022953060916 | LUSC | Female-baised eQTL |
| rs58608164 | chr1:158825602:T:A | - | 0.109844893222125 | 0.00234022953060916 | LUSC | Female-baised eQTL |
| rs201638960 | chr1:158827556:T:C | - | 0.109844893222125 | 0.00234022953060916 | LUSC | Female-baised eQTL |
| rs78176648 | chr1:158828991:C:T | - | 0.109844893222125 | 0.00234022953060916 | LUSC | Female-baised eQTL |
| rs6690446 | chr1:158829663:G:A | - | 0.109844893222125 | 0.00234022953060916 | LUSC | Female-baised eQTL |
| rs6684629 | chr1:158829813:T:C | - | 0.109844893222125 | 0.00234022953060916 | LUSC | Female-baised eQTL |
| rs16841138 | chr1:158830693:T:C | - | 0.109844893222125 | 0.00234022953060916 | LUSC | Female-baised eQTL |
| rs13375162 | chr1:158813754:A:G | - | 0.107832722104472 | 0.00276257025316873 | LUSC | Female-baised eQTL |
| rs76820111 | chr1:158813856:G:A | - | 0.107832722104472 | 0.00276257025316873 | LUSC | Female-baised eQTL |
| rs6679412 | chr1:158829577:A:T | - | 0.120931079793353 | 0.00534523783683425 | LUSC | Female-baised eQTL |
| rs59769927 | chr1:158841677:T:C | - | 0.106909333965138 | 0.00657287426146988 | LUSC | Female-baised eQTL |
| rs13376489 | chr1:158815857:C:A | - | 0.0664618421748072 | 0.024326681158515 | LUSC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12128578 | chr1:151501748:C:T | - | -0.12890176346237 | 0.0165287072427343 | SARC | Male-baised eQTL |
| rs2297752 | chr1:147293770:C:G | - | 0.132239800945789 | 0.0392290790095535 | SARC | Male-baised eQTL |
| rs7516430 | chr1:147295381:A:G | - | 0.132239800945789 | 0.0392290790095535 | SARC | Male-baised eQTL |
| rs57388899 | chr1:147301733:T:C | - | 0.132239800945789 | 0.0392290790095535 | SARC | Male-baised eQTL |
| rs143520797 | chr1:152552441:A:G | - | 0.119076713619034 | 0.0141252165736676 | LIHC | Male-baised eQTL |
| rs2297760 | chr1:152514558:T:C | - | 0.108575546392676 | 0.0336693415930074 | LIHC | Male-baised eQTL |
| rs6667498 | chr1:147236381:G:C | - | -0.0868360168071206 | 5.04705794266569e-06 | LUAD | Male-baised eQTL |
| rs4354587 | chr1:147229438:G:A | - | -0.0757019447040192 | 7.64935646198848e-05 | LUAD | Male-baised eQTL |
| rs4245679 | chr1:147238855:C:A | - | -0.0792199970316648 | 0.00235158778579115 | LUAD | Male-baised eQTL |
| rs1846858 | chr1:153167201:G:C | - | 0.0728177639519372 | 0.00502963750713822 | LUAD | Male-baised eQTL |
| rs12068238 | chr1:153163879:T:C | - | 0.0693942927607577 | 0.00900899254211321 | LUAD | Male-baised eQTL |
| rs12086522 | chr1:153166693:C:A | - | 0.0693942927607577 | 0.00900899254211321 | LUAD | Male-baised eQTL |
| rs1392803 | chr1:153155956:T:C | - | 0.0697256058280929 | 0.0103891042804678 | LUAD | Male-baised eQTL |
| rs12075011 | chr1:153158890:C:A | - | 0.0697256058280929 | 0.0103891042804678 | LUAD | Male-baised eQTL |
| rs7529179 | chr1:158517818:C:T | - | 0.0419916722368319 | 0.011016022398681 | LUAD | Male-baised eQTL |
| rs12068265 | chr1:153148830:C:T | - | 0.0649736443528511 | 0.0122695080660541 | LUAD | Male-baised eQTL |
| rs12057517 | chr1:153135930:T:G | - | 0.0656452781139441 | 0.0290409888307711 | LUAD | Male-baised eQTL |
| rs10796942 | chr1:155405032:A:T | - | -0.101217759891896 | 0.00855187092495944 | COAD | Male-baised eQTL |
| rs56228539 | chr1:147246274:A:G | - | 0.0730551995730897 | 0.0117176465453767 | COAD | Male-baised eQTL |
| rs61246702 | chr1:147250925:A:G | - | 0.0730551995730897 | 0.0117176465453767 | COAD | Male-baised eQTL |
| rs7514759 | chr1:147253708:G:C | - | 0.0730551995730897 | 0.0117176465453767 | COAD | Male-baised eQTL |
| rs7548980 | chr1:147255322:G:A | - | 0.0730551995730897 | 0.0117176465453767 | COAD | Male-baised eQTL |
| rs11584787 | chr1:147156900:C:G | - | -0.0596705584764417 | 0.0355357085921263 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000143379 |
| CpG Site: cg15448220 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.17413935716166 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15448220 | chr1:150925380 | promoter | -0.17413935716166 | 1.03602790744424e-06 | -0.3744025251077986 | 6.598647891460911e-10 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SETDB1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000143379 | SETDB1 | C0025202 | melanoma | 1 | CTD_human |
| ENSG00000143379 | SETDB1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000143379 | SETDB1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| ENSG00000143379 | SETDB1 | C0178417 | Anhedonia | 1 | PSYGENET |
| ENSG00000143379 | SETDB1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| ENSG00000143379 | SETDB1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
