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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000142611

Summary for PRDM16

check button Gene summary

Gene informationEnsembl ID

ENSG00000142611

Gene symbol

PRDM16

Gene namePR/SET domain 16
HGNC

14000

Entrez ID

63976

Gene typeprotein_coding
SynonymsPRDM16|MEL1|PFM13|KIAA1675|MGC166915|KMT8F
UniProtAcc

Q9HAZ2


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for PRDM16

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
PRDM166.96e+02-1.05e+003.44e-01-3.06e+002.19e-034.41e-03LUAD
PRDM161.09e+03-2.30e+006.79e-01-3.39e+006.89e-044.73e-03ESCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
PRDM161.08e+03-1.32e+004.34e-01-3.03e+002.45e-031.13e-02STAD

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Sex-biased somatic mutation for PRDM16

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for PRDM16

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg05303132chr1:3068067CGI:chr1:3067361-3071398promoter3.09e-014.99e-01-2.17e+003.01e-024.10e-02-1.90e-01
BRCAcg17239558chr1:3070768CGI:chr1:3067361-3071398promoter,gene body2.52e-014.18e-01-2.23e+002.58e-023.86e-02-1.67e-01
BRCAcg17173498chr1:3068930CGI:chr1:3067361-3071398promoter1.68e-013.92e-01-2.47e+001.36e-023.00e-02-2.23e-01
BRCAcg26938364chr1:3068963CGI:chr1:3067361-3071398promoter1.42e-014.48e-01-1.99e+004.67e-024.87e-02-3.06e-01
BRCAcg25152368chr1:3069128CGI:chr1:3067361-3071398promoter1.69e-014.57e-01-2.18e+002.90e-024.04e-02-2.87e-01
BRCAcg12267948chr1:3070002CGI:chr1:3067361-3071398promoter,gene body1.17e-013.87e-01-2.30e+002.16e-023.60e-02-2.70e-01
BRCAcg10802480chr1:3067691CGI:chr1:3067361-3071398promoter3.86e-015.22e-01-1.97e+004.85e-024.94e-02-1.36e-01
BRCAcg07363855chr1:3067906CGI:chr1:3067361-3071398promoter4.61e-015.90e-01-2.32e+002.03e-023.52e-02-1.29e-01
BRCAcg08528984chr1:3068654CGI:chr1:3067361-3071398promoter3.91e-016.17e-01-2.41e+001.60e-023.21e-02-2.26e-01
BRCAcg04080595chr1:3069085CGI:chr1:3067361-3071398promoter2.76e-014.36e-01-2.74e+006.23e-032.22e-02-1.60e-01
BRCAcg08541612chr1:3069156CGI:chr1:3067361-3071398promoter1.86e-014.50e-01-2.07e+003.82e-024.51e-02-2.64e-01
BRCAcg08537652chr1:3069798CGI:chr1:3067361-3071398promoter,gene body1.25e-012.77e-01-2.16e+003.06e-024.14e-02-1.52e-01
BRCAcg07534194chr1:3070783CGI:chr1:3067361-3071398promoter,gene body3.98e-015.53e-01-2.20e+002.77e-023.97e-02-1.55e-01
LAMLcg12140144chr1:3067711CGI:chr1:3067361-3071398promoter2.27e-013.30e-01-2.04e+004.18e-024.69e-02-1.04e-01
CHOLcg12140144chr1:3067711CGI:chr1:3067361-3071398promoter5.09e-012.73e-012.99e+002.77e-038.11e-032.36e-01
CHOLcg04241652chr1:3068266CGI:chr1:3067361-3071398promoter2.82e-011.21e-011.97e+004.84e-024.84e-021.60e-01
CHOLcg07946633chr1:3067681CGI:chr1:3067361-3071398promoter6.06e-014.86e-012.39e+001.70e-022.98e-021.21e-01
CHOLcg10802480chr1:3067691CGI:chr1:3067361-3071398promoter5.12e-013.71e-012.48e+001.30e-022.54e-021.41e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg12140144chr1:3067711CGI:chr1:3067361-3071398promoter1.57e-013.20e-026.18e+006.26e-108.59e-091.25e-01
KIRCcg05303132chr1:3068067CGI:chr1:3067361-3071398promoter1.66e-015.15e-025.00e+005.64e-072.21e-061.15e-01
KIRCcg19356825chr1:3068748CGI:chr1:3067361-3071398promoter1.38e-019.37e-035.93e+003.04e-092.81e-081.28e-01
KIRCcg07946633chr1:3067681CGI:chr1:3067361-3071398promoter3.82e-012.66e-016.11e+009.96e-101.20e-081.16e-01
KIRCcg10802480chr1:3067691CGI:chr1:3067361-3071398promoter2.55e-011.26e-016.55e+005.79e-111.97e-091.29e-01
KIRCcg08528984chr1:3068654CGI:chr1:3067361-3071398promoter2.30e-011.19e-014.71e+002.50e-068.09e-061.11e-01
KIRCcg04080595chr1:3069085CGI:chr1:3067361-3071398promoter2.22e-011.17e-015.62e+001.92e-081.24e-071.05e-01
KIRCcg07534194chr1:3070783CGI:chr1:3067361-3071398promoter,gene body2.13e-018.88e-025.08e+003.69e-071.53e-061.25e-01
LUADcg04241652chr1:3068266CGI:chr1:3067361-3071398promoter1.49e-013.31e-024.35e+001.34e-055.35e-051.16e-01
LUADcg01908338chr1:3067961CGI:chr1:3067361-3071398promoter2.05e-019.86e-024.41e+001.02e-054.26e-051.07e-01
HNSCcg17239558chr1:3070768CGI:chr1:3067361-3071398promoter,gene body1.64e-014.27e-022.98e+002.87e-034.44e-031.21e-01
HNSCcg00945293chr1:3068305CGI:chr1:3067361-3071398promoter1.92e-012.37e-023.88e+001.04e-042.68e-041.69e-01
HNSCcg07534194chr1:3070783CGI:chr1:3067361-3071398promoter,gene body3.01e-011.71e-013.18e+001.47e-032.51e-031.30e-01
LUSCcg12140144chr1:3067711CGI:chr1:3067361-3071398promoter3.32e-014.09e-024.19e+002.82e-055.26e-042.91e-01
LUSCcg05303132chr1:3068067CGI:chr1:3067361-3071398promoter2.04e-014.91e-023.63e+002.87e-041.19e-031.55e-01
LUSCcg04241652chr1:3068266CGI:chr1:3067361-3071398promoter1.45e-012.58e-023.95e+007.91e-056.37e-041.19e-01
LUSCcg11229543chr1:3067881CGI:chr1:3067361-3071398promoter4.40e-018.50e-024.20e+002.65e-055.26e-043.55e-01
LUSCcg18381051chr1:3071081CGI:chr1:3067361-3071398promoter,gene body3.46e-012.90e-024.00e+006.36e-055.92e-043.17e-01
LUSCcg07946633chr1:3067681CGI:chr1:3067361-3071398promoter5.05e-013.24e-014.06e+005.00e-055.58e-041.81e-01
LUSCcg10802480chr1:3067691CGI:chr1:3067361-3071398promoter3.32e-011.55e-014.27e+001.98e-055.26e-041.77e-01
LUSCcg07363855chr1:3067906CGI:chr1:3067361-3071398promoter4.01e-011.47e-014.16e+003.19e-055.26e-042.54e-01
LUSCcg01908338chr1:3067961CGI:chr1:3067361-3071398promoter2.23e-019.44e-023.84e+001.21e-047.60e-041.29e-01
LUSCcg07534194chr1:3070783CGI:chr1:3067361-3071398promoter,gene body2.08e-019.20e-023.94e+008.07e-056.42e-041.16e-01
COADcg17239558chr1:3070768CGI:chr1:3067361-3071398promoter,gene body2.24e-013.44e-022.72e+006.62e-031.03e-021.89e-01
BLCAcg12140144chr1:3067711CGI:chr1:3067361-3071398promoter4.06e-018.66e-023.84e+001.25e-044.71e-043.20e-01
BLCAcg05303132chr1:3068067CGI:chr1:3067361-3071398promoter4.00e-011.33e-012.96e+003.04e-035.47e-032.68e-01
BLCAcg17239558chr1:3070768CGI:chr1:3067361-3071398promoter,gene body2.23e-014.40e-022.42e+001.57e-022.02e-021.79e-01
BLCAcg00945293chr1:3068305CGI:chr1:3067361-3071398promoter3.28e-014.83e-022.83e+004.72e-037.77e-032.80e-01
BLCAcg07946633chr1:3067681CGI:chr1:3067361-3071398promoter5.31e-013.67e-013.78e+001.55e-045.49e-041.64e-01
BLCAcg10802480chr1:3067691CGI:chr1:3067361-3071398promoter3.84e-011.95e-013.89e+009.98e-053.99e-041.89e-01
BLCAcg01908338chr1:3067961CGI:chr1:3067361-3071398promoter3.30e-011.54e-012.42e+001.54e-021.99e-021.76e-01
ESCAcg12140144chr1:3067711CGI:chr1:3067361-3071398promoter3.26e-011.07e-012.53e+001.14e-023.68e-022.19e-01
ESCAcg11229543chr1:3067881CGI:chr1:3067361-3071398promoter4.11e-011.84e-012.24e+002.49e-024.21e-022.27e-01
ESCAcg18381051chr1:3071081CGI:chr1:3067361-3071398promoter,gene body3.91e-011.74e-011.98e+004.82e-024.90e-022.17e-01
ESCAcg07946633chr1:3067681CGI:chr1:3067361-3071398promoter4.96e-013.60e-012.48e+001.31e-023.74e-021.36e-01
ESCAcg10802480chr1:3067691CGI:chr1:3067361-3071398promoter3.40e-012.20e-012.37e+001.77e-023.94e-021.20e-01
ESCAcg07363855chr1:3067906CGI:chr1:3067361-3071398promoter3.98e-012.23e-012.23e+002.55e-024.23e-021.74e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg12140144chr1:3067711CGI:chr1:3067361-3071398promoter3.90e-011.67e-019.21e+003.15e-201.74e-192.23e-01
BRCAcg05303132chr1:3068067CGI:chr1:3067361-3071398promoter3.09e-018.23e-029.44e+003.75e-212.24e-202.27e-01
BRCAcg04241652chr1:3068266CGI:chr1:3067361-3071398promoter3.09e-014.01e-021.13e+011.02e-291.43e-282.69e-01
BRCAcg17239558chr1:3070768CGI:chr1:3067361-3071398promoter,gene body2.52e-013.95e-021.09e+017.88e-288.92e-272.12e-01
BRCAcg11229543chr1:3067881CGI:chr1:3067361-3071398promoter4.37e-011.64e-011.06e+012.87e-262.76e-252.73e-01
BRCAcg00945293chr1:3068305CGI:chr1:3067361-3071398promoter2.49e-012.61e-029.75e+001.82e-221.22e-212.23e-01
BRCAcg19356825chr1:3068748CGI:chr1:3067361-3071398promoter2.76e-013.27e-029.87e+005.75e-234.04e-222.43e-01
BRCAcg17173498chr1:3068930CGI:chr1:3067361-3071398promoter1.68e-011.54e-028.99e+002.55e-191.30e-181.53e-01
BRCAcg26938364chr1:3068963CGI:chr1:3067361-3071398promoter1.42e-011.91e-028.02e+001.09e-154.19e-151.22e-01
BRCAcg07348009chr1:3069125CGI:chr1:3067361-3071398promoter2.10e-014.81e-029.82e+009.20e-236.34e-221.62e-01
BRCAcg25152368chr1:3069128CGI:chr1:3067361-3071398promoter1.69e-014.02e-026.08e+001.17e-092.84e-091.29e-01
BRCAcg12267948chr1:3070002CGI:chr1:3067361-3071398promoter,gene body1.17e-011.34e-029.05e+001.39e-197.24e-191.04e-01
BRCAcg10802480chr1:3067691CGI:chr1:3067361-3071398promoter3.86e-012.04e-011.11e+019.83e-291.23e-271.82e-01
BRCAcg07363855chr1:3067906CGI:chr1:3067361-3071398promoter4.61e-012.56e-011.06e+012.84e-262.74e-252.05e-01
BRCAcg01908338chr1:3067961CGI:chr1:3067361-3071398promoter2.42e-011.26e-016.51e+007.62e-112.02e-101.17e-01
BRCAcg08528984chr1:3068654CGI:chr1:3067361-3071398promoter3.91e-011.56e-011.05e+015.26e-264.93e-252.35e-01
BRCAcg04080595chr1:3069085CGI:chr1:3067361-3071398promoter2.76e-011.37e-017.97e+001.60e-156.06e-151.39e-01
BRCAcg08541612chr1:3069156CGI:chr1:3067361-3071398promoter1.86e-016.56e-026.87e+006.42e-121.85e-111.21e-01
BRCAcg13744917chr1:3069974CGI:chr1:3067361-3071398promoter,gene body1.57e-014.11e-027.69e+001.49e-145.25e-141.16e-01
BRCAcg07534194chr1:3070783CGI:chr1:3067361-3071398promoter,gene body3.98e-011.71e-011.06e+012.06e-262.01e-252.27e-01
COADcg25152368chr1:3069128CGI:chr1:3067361-3071398promoter1.66e-013.01e-023.46e+005.37e-041.93e-031.35e-01
COADcg12267948chr1:3070002CGI:chr1:3067361-3071398promoter,gene body1.23e-011.43e-022.14e+003.21e-023.64e-021.09e-01
LIHCcg07363855chr1:3067906CGI:chr1:3067361-3071398promoter4.16e-012.67e-012.52e+001.19e-021.59e-021.49e-01
KIRPcg07534194chr1:3070783CGI:chr1:3067361-3071398promoter,gene body2.04e-019.57e-022.22e+002.67e-023.25e-021.08e-01

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Exon skipping events with PSI in TCGA for PRDM16

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for PRDM16

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for PRDM16

check buttonTFs related to PRDM16.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonPRDM16 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for PRDM16

check buttonRBPs related to ES in PRDM16.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonPRDM16 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000142611KCNQ1OT1,hsa-mir-133b,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611SNHG14,hsa-mir-133b,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611KCNQ1OT1,hsa-mir-296,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611SNHG14,hsa-mir-296,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611C5orf66-AS1,hsa-mir-296,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611KCNQ1OT1,hsa-mir-330,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611AC068790.5,hsa-mir-330,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611KCNQ1OT1,hsa-mir-409,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611KCNQ1OT1,hsa-mir-429,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611SNHG14,hsa-mir-429,PRDM16Female-specific ceRNATCGA-LIHC
ENSG00000142611Z95331.1,hsa-mir-429,PRDM16Female-specific ceRNATCGA-LIHC

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs11121559chr1:10395091:G:A-0.17217890937480.0130991318496581PAADFemale-baised eQTL
rs6702309chr1:7019197:G:T-0.2215643166721740.0405862995005246GBMFemale-baised eQTL
rs201613528chr1:7498838:G:A-0.1786379740875678.06441794476187e-15LGGFemale-baised eQTL
rs61772234chr1:7488601:T:C-0.1782168283723691.01254034046069e-14LGGFemale-baised eQTL
rs61111144chr1:7492374:G:C-0.1726011913809026.39456954209494e-14LGGFemale-baised eQTL
rs10864304chr1:7497092:A:G-0.127888726099911.93225209182721e-09LGGFemale-baised eQTL
rs4328022chr1:3477715:C:T-0.1128233564563256.11011156963283e-06LGGFemale-baised eQTL
rs61734742chr1:3478610:C:A-0.1128233564563256.11011156963283e-06LGGFemale-baised eQTL
rs2493315chr1:3483278:G:A-0.112746639232786.32291858897245e-06LGGFemale-baised eQTL
rs57077909chr1:7492441:A:T-0.09650889023253729.37037824476913e-06LGGFemale-baised eQTL
rs72644730chr1:5862070:C:T-0.1002434393432981.12272958389805e-05LGGFemale-baised eQTL
rs3931607chr1:3455668:C:T-0.09506172786139125.67740988741936e-05LGGFemale-baised eQTL
rs56293443chr1:5864821:G:A-0.09235042338238467.41503437684975e-05LGGFemale-baised eQTL
rs75368965chr1:3455298:T:A-0.08673988864068930.000323054701395076LGGFemale-baised eQTL
rs77136906chr1:3455299:C:A-0.08673988864068930.000323054701395076LGGFemale-baised eQTL
rs11121605chr1:5861525:T:A-0.08418842161643110.000478970509212789LGGFemale-baised eQTL
rs56127510chr1:5952130:A:G-0.08227826351973960.000638166284660174LGGFemale-baised eQTL
rs11121423chr1:9450467:T:C--0.08345693227532030.000931567805841008LGGFemale-baised eQTL
rs72630630chr1:5937622:C:T-0.07614744530694160.00120435406637632LGGFemale-baised eQTL
rs10864423chr1:9449961:A:G--0.07933439936410580.0018649105181201LGGFemale-baised eQTL
rs2062784chr1:5940069:T:C-0.07401822246670780.00201169785743932LGGFemale-baised eQTL
rs12409002chr1:5973271:T:C-0.07622211062157040.00218386809980491LGGFemale-baised eQTL
rs7522246chr1:5963559:T:C-0.07610149177202050.00219244606457718LGGFemale-baised eQTL
rs10157281chr1:5855602:G:A-0.0751510771684480.00266085090265123LGGFemale-baised eQTL
rs1220382chr1:9899690:C:T-0.06901902464725250.00403431060515623LGGFemale-baised eQTL
rs144096630chr1:4666965:C:T-0.122582695336770.00443440554685664LGGFemale-baised eQTL
rs76508223chr1:4667197:C:T-0.122582695336770.00443440554685664LGGFemale-baised eQTL
rs7225chr1:9848622:C:T-0.06932404639995440.00443790179297297LGGFemale-baised eQTL
rs1470160chr1:9870199:G:A-0.06804824521281460.00502456096270221LGGFemale-baised eQTL
rs1660735chr1:9885480:C:T-0.06804824521281460.00502456096270221LGGFemale-baised eQTL
rs1220413chr1:9867196:A:G-0.06823156804228180.0053846969423495LGGFemale-baised eQTL
rs935074chr1:9869909:G:A-0.06823156804228180.0053846969423495LGGFemale-baised eQTL
rs1220406chr1:9862372:C:T-0.06777373645702730.00568652439507486LGGFemale-baised eQTL
rs11588169chr1:4665568:C:T-0.1186328022586940.00594994863272307LGGFemale-baised eQTL
rs17455108chr1:4663988:A:G-0.1182240010254680.00630827331551423LGGFemale-baised eQTL
rs76789200chr1:4659026:C:T-0.1182031465809460.00634983786792636LGGFemale-baised eQTL
rs12733769chr1:3997342:T:A-0.06371328920886540.0106486701869746LGGFemale-baised eQTL
rs1220394chr1:9849448:G:A-0.06406799465024280.0114964452385166LGGFemale-baised eQTL
rs12404173chr1:4958018:C:T-0.09983563132371540.0119135595946886LGGFemale-baised eQTL
rs11576910chr1:5910205:G:A-0.06472548539924550.0121524716287493LGGFemale-baised eQTL
rs1220395chr1:9848211:C:T-0.0639451470048230.012513239610383LGGFemale-baised eQTL
rs1220418chr1:9878761:C:T-0.06393442195438150.0134653176609097LGGFemale-baised eQTL
rs935075chr1:9882060:C:T-0.06332340078049830.0151346560256289LGGFemale-baised eQTL
rs1220384chr1:9896127:C:A-0.06332340078049830.0151346560256289LGGFemale-baised eQTL
rs10797396chr1:3481361:G:A--0.06070388911855010.0186881816982485LGGFemale-baised eQTL
rs2821041chr1:3487663:C:T-0.05899205169334010.0231071992643538LGGFemale-baised eQTL
rs1051515chr1:3480891:G:A--0.05755676957694930.0321432161643924LGGFemale-baised eQTL
rs112449630chr1:4181027:G:A-0.1043347936775440.0336898017495957LGGFemale-baised eQTL
rs4281299chr1:4670900:T:C-0.09579343026282340.0372904830678067LGGFemale-baised eQTL
rs11588149chr1:4665436:C:T-0.09564314960569130.0377241124179731LGGFemale-baised eQTL
rs114168592chr1:4666933:C:T-0.09557668490530830.0379482256495462LGGFemale-baised eQTL
rs116056075chr1:4663721:A:G-0.09553982059582190.0380208730942416LGGFemale-baised eQTL
rs12083135chr1:4663782:G:A-0.09553982059582190.0380208730942416LGGFemale-baised eQTL
rs1531831chr1:4662387:G:A-0.09525489524173650.0393009937080818LGGFemale-baised eQTL
rs3748597chr1:953279:T:C--0.09745389944116350.0435752996097732LGGFemale-baised eQTL
rs3748596chr1:953259:T:C--0.09796521489682690.0486940019889807LGGFemale-baised eQTL
rs2298082chr1:3472709:T:C--0.05437286627618250.0494934782933006LGGFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs77495751chr1:5026311:T:A-0.06068576845391610.0289350661997327LGGMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg07946633
Position to Gene: promoter
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg01431482
Position to Gene: gene,enhancer
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg25618424
Position to Gene: gene,enhancer
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg11731671
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg25308086
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg00806481
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22506548
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg24490279
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg23273418
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg24642064
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg21299491
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg23609682
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg09321238
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg01104489
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg12096707
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg08110058
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg16265140
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg21401095
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg24679453
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22396632
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22796923
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg24612696
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg17445936
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg05354921
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg15619820
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg04022097
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22720392
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg23631759
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg09282201
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg03449456
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg12141662
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg19263228
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg17601209
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg20988960
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg26520908
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg13209113
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg17493795
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg26537941
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg25362585
Position to Gene: gene
Male Effect: -
Female Effect: -0.47009332434938
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22726349
Position to Gene: gene,enhancer
Male Effect: -
Female Effect: -0.231069937007169
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg01065697
Position to Gene: gene
Male Effect: -
Female Effect: -0.2339822838622
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg04509221
Position to Gene: gene
Male Effect: -
Female Effect: -0.171361186340709
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg04134748
Position to Gene: gene
Male Effect: -0.354451550058496
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg07946633
Position to Gene: promoter
Male Effect: -0.462849273223366
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg01431482
Position to Gene: gene,enhancer
Male Effect: -0.462849273223366
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22726349
Position to Gene: gene,enhancer
Male Effect: -0.462849273223366
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg24460544
Position to Gene: gene
Male Effect: -0.462849273223366
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg14966901
Position to Gene: gene
Male Effect: -0.462849273223366
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22729726
Position to Gene: gene
Male Effect: -0.462849273223366
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg22122862
Position to Gene: gene,enhancer
Male Effect: -0.304810994081099
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg01961086
Position to Gene: gene
Male Effect: -0.215021061760058
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg14380230
Position to Gene: gene
Male Effect: -0.248984900038863
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg27523417
Position to Gene: gene
Male Effect: -0.186443150771204
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg20699701
Position to Gene: gene
Male Effect: -0.0570925840855482
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg01647724
Position to Gene: gene
Male Effect: -0.244037687783124
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg10100424
Position to Gene: gene
Male Effect: -
Female Effect: -0.468498872073744
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg20671649
Position to Gene: gene
Male Effect: -
Female Effect: -0.468498872073744
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg21475097
Position to Gene: gene
Male Effect: -
Female Effect: -0.350613738126893
eQTM boxplot analysisGene ID: ENSG00000142611
CpG Site: cg10893986
Position to Gene: gene
Male Effect: -
Female Effect: -0.0833488626747736

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg04134748chr1:3135611gene-0.3544515500584962.78661725483303e-37-0.68234971630870826.103918925634674e-41LGG
cg07946633chr1:3067681promoter-0.4628492732233665.37077708964226e-30-0.63045652939078051.9819572250953887e-33LGG
cg01431482chr1:3072521gene,enhancer-0.4628492732233665.37077708964226e-30-0.63045652939078051.9819572250953887e-33LGG
cg22726349chr1:3074114gene,enhancer-0.4628492732233665.37077708964226e-30-0.63045652939078051.9819572250953887e-33LGG
cg24460544chr1:3168882gene-0.4628492732233665.37077708964226e-30-0.63045652939078051.9819572250953887e-33LGG
cg14966901chr1:3183579gene-0.4628492732233665.37077708964226e-30-0.63045652939078051.9819572250953887e-33LGG
cg22729726chr1:3207290gene-0.4628492732233665.37077708964226e-30-0.63045652939078051.9819572250953887e-33LGG
cg22122862chr1:3071350gene,enhancer-0.3048109940810995.51362455776039e-25-0.58690612073746343.8312181715622294e-28LGG
cg01961086chr1:3169923gene-0.2150210617600582.52001456736094e-17-0.50735376544991983.027753487913819e-20LGG
cg14380230chr1:3198745gene-0.2489849000388632.84121257139161e-15-0.479962788465171154.660769722922112e-18LGG
cg27523417chr1:3101460gene-0.1864431507712041.68298677078746e-12-0.4395243580612694.424802361960567e-15LGG
cg20699701chr1:3173198gene-0.05709258408554822.62997235594318e-08-0.35477399276686455.362130203563567e-10LGG
cg01647724chr1:3140207gene-0.2440376877831245.83838017166664e-07-0.33285491011124516.622101638340722e-09LGG

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg07946633chr1:3067681promoter-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg01431482chr1:3072521gene,enhancer-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg25618424chr1:3072743gene,enhancer-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg11731671chr1:3079040gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg25308086chr1:3079456gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg00806481chr1:3080086gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg22506548chr1:3080385gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg24490279chr1:3080796gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg23273418chr1:3125895gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg24642064chr1:3140387gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg21299491chr1:3140802gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg23609682chr1:3154222gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg09321238chr1:3155437gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg01104489chr1:3155671gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg12096707chr1:3157150gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg08110058chr1:3157242gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg16265140chr1:3161642gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg21401095chr1:3162275gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg24679453chr1:3162505gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg22396632chr1:3162648gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg22796923chr1:3169945gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg24612696chr1:3173327gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg17445936chr1:3173781gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg05354921chr1:3183933gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg15619820chr1:3217199gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg04022097chr1:3217247gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg22720392chr1:3217293gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg23631759chr1:3227118gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg09282201chr1:3238597gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg03449456chr1:3274655gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg12141662chr1:3274674gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg19263228chr1:3275096gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg17601209chr1:3275114gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg20988960chr1:3275251gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg26520908chr1:3275312gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg13209113chr1:3356168gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg17493795chr1:3356843gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg26537941chr1:3380598gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg25362585chr1:3403867gene-0.470093324349383.63946773859047e-31-0.92915804532322841.888997549282651e-35PAAD
cg22726349chr1:3074114gene,enhancer-0.2310699370071694.16508379508992e-08-0.65418745973827014.6925491419391215e-11PAAD
cg01065697chr1:3404174gene-0.23398228386222.03191876323906e-07-0.6176619594205951.0409302867325397e-09PAAD
cg04509221chr1:3238748gene-0.1713611863407091.07151507689541e-05-0.3433370949268951.8261181853595297e-08LUAD
cg10100424chr1:3261820gene-0.4684988720737449.86720152166095e-71-0.86881670924487772.653695675088983e-74LGG
cg20671649chr1:3393300gene-0.4684988720737449.86720152166095e-71-0.86881670924487772.653695675088983e-74LGG
cg21475097chr1:3248078gene-0.3506137381268932.20061490180351e-40-0.74884210245067923.147401088287485e-44LGG
cg10893986chr1:3313175gene-0.08334886267477362.73518344175949e-09-0.412542214560499553.083846859679776e-11LGG

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of PRDM16

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000142611PRDM16C0007852Cervical Migraine Syndrome1CTD_human
ENSG00000142611PRDM16C0018984Hemicrania migraine1CTD_human
ENSG00000142611PRDM16C0149931Migraine Disorders1CTD_human
ENSG00000142611PRDM16C0270858Abdominal Migraine1CTD_human
ENSG00000142611PRDM16C0338489Status Migrainosus1CTD_human
ENSG00000142611PRDM16C0521664Acute Confusional Migraine1CTD_human
ENSG00000142611PRDM16C0700438Sick Headaches1CTD_human
ENSG00000142611PRDM16C3809288LEFT VENTRICULAR NONCOMPACTION 81CTD_human