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Gene: ENSG00000142230 |
Summary for SAE1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000142230 | Gene symbol | SAE1 |
| Gene name | SUMO1 activating enzyme subunit 1 | |
| HGNC | 30660 | |
| Entrez ID | 10055 | |
| Gene type | protein_coding | |
| Synonyms | SAE1|AOS1|FLJ3091|Sua1 | |
| UniProtAcc | Q9UBE0 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for SAE1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for SAE1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SAE1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| DLBC | cg24181914 | chr19:47114044 | CGI:chr19:47113417-47113844 | promoter,gene body | 1.93e-01 | 3.03e-01 | -2.11e+00 | 3.48e-02 | 4.46e-02 | -1.10e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg09137630 | chr19:47114760 | CGI:chr19:47113417-47113844 | promoter,gene body | 2.20e-01 | 3.43e-01 | -4.64e+00 | 3.49e-06 | 1.60e-05 | -1.24e-01 |
| LUSC | cg09137630 | chr19:47114760 | CGI:chr19:47113417-47113844 | promoter,gene body | 2.65e-01 | 5.58e-01 | -3.87e+00 | 1.08e-04 | 7.20e-04 | -2.94e-01 |
| ESCA | cg09137630 | chr19:47114760 | CGI:chr19:47113417-47113844 | promoter,gene body | 1.67e-01 | 4.01e-01 | -2.18e+00 | 2.90e-02 | 4.34e-02 | -2.34e-01 |
| CHOL | cg09137630 | chr19:47114760 | CGI:chr19:47113417-47113844 | promoter,gene body | 2.98e-01 | 5.32e-01 | -2.29e+00 | 2.23e-02 | 3.24e-02 | -2.34e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg09137630 | chr19:47114760 | CGI:chr19:47113417-47113844 | promoter,gene body | 2.26e-01 | 3.96e-01 | -1.15e+01 | 8.76e-31 | 1.41e-29 | -1.70e-01 |
| KIRC | cg09137630 | chr19:47114760 | CGI:chr19:47113417-47113844 | promoter,gene body | 1.73e-01 | 2.74e-01 | -2.71e+00 | 6.78e-03 | 1.33e-02 | -1.00e-01 |
| LIHC | cg09137630 | chr19:47114760 | CGI:chr19:47113417-47113844 | promoter,gene body | 3.66e-01 | 5.86e-01 | -3.46e+00 | 5.47e-04 | 1.41e-03 | -2.19e-01 |
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Exon skipping events with PSI in TCGA for SAE1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SAE1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | SAE1-005 | chr19_47191896_+ | 3.11e-01 | 4.56e-01 | -2.53e+00 | 1.14e-02 | 4.96e-02 | -1.45e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SAE1 |
| TFs related to SAE1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SAE1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SAE1 |
| RBPs related to ES in SAE1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUSC | CNOT4 | exon_skip_308630 | 1.03e+01 | 9.93e-01 | 9.86e+00 | 5.61e-03 | Male-biased |
| SAE1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs385349 | chr19:55838881:C:A | - | 0.231760672377263 | 0.0208527993638196 | GBM | Female-baised eQTL |
| rs373879 | chr19:55839707:A:G | - | 0.231760672377263 | 0.0208527993638196 | GBM | Female-baised eQTL |
| rs412812 | chr19:55842652:C:G | - | 0.231760672377263 | 0.0208527993638196 | GBM | Female-baised eQTL |
| rs8106416 | chr19:53685201:T:C | - | 0.0489775257037912 | 0.0237083060998244 | LUAD | Female-baised eQTL |
| rs383133 | chr19:43962944:T:G | - | 0.0581568184905664 | 0.0293135845496426 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs80252508 | chr19:52965435:A:C | - | 0.102159890329187 | 0.0190364210844273 | THCA | Male-baised eQTL |
| rs2616943 | chr19:55830208:G:A | - | -0.059588302277217 | 0.0163892338898384 | LGG | Male-baised eQTL |
| rs12983624 | chr19:51678028:T:C | - | -0.0973890684331643 | 0.0301265753500275 | LGG | Male-baised eQTL |
| rs347518 | chr19:43768036:G:A | - | -0.0541667498100558 | 0.0043361448190117 | KIRC | Male-baised eQTL |
| rs11083506 | chr19:39110997:G:A | - | 0.0352373121035306 | 0.00783596564140454 | KIRC | Male-baised eQTL |
| rs7258793 | chr19:39111268:C:G | - | 0.0352373121035306 | 0.00783596564140454 | KIRC | Male-baised eQTL |
| rs1865027 | chr19:39111823:G:T | - | 0.0349645569059298 | 0.00908160662299595 | KIRC | Male-baised eQTL |
| rs4803201 | chr19:39110552:C:T | - | 0.0341296011231982 | 0.0124355954573392 | KIRC | Male-baised eQTL |
| rs8108108 | chr19:39101663:C:T | - | 0.0324822891955442 | 0.0204379527687293 | KIRC | Male-baised eQTL |
| rs692364 | chr19:39115242:C:A | - | 0.0315559645673831 | 0.0216048912385563 | KIRC | Male-baised eQTL |
| rs12978685 | chr19:39121683:C:T | - | 0.0324537754194036 | 0.0240698305121433 | KIRC | Male-baised eQTL |
| rs774903 | chr19:39121926:C:T | - | 0.0306953490071541 | 0.030873209512825 | KIRC | Male-baised eQTL |
| rs149765705 | chr19:48039838:C:T | - | 0.044425467571187 | 0.0340049640690185 | KIRC | Male-baised eQTL |
| rs555132 | chr19:39122666:G:A | - | 0.0304298939281396 | 0.0340502608455527 | KIRC | Male-baised eQTL |
| rs111784716 | chr19:48037457:G:A | - | 0.0468415613047906 | 0.0343489898881251 | KIRC | Male-baised eQTL |
| rs774902 | chr19:39121916:C:T | - | 0.0304071389162459 | 0.0351139711166592 | KIRC | Male-baised eQTL |
| rs9749593 | chr19:39119112:G:A | - | 0.0302538714172992 | 0.0356500929368611 | KIRC | Male-baised eQTL |
| rs476508 | chr19:39121535:C:G | - | 0.0302538714172992 | 0.0356500929368611 | KIRC | Male-baised eQTL |
| rs79480967 | chr19:48036305:C:T | - | 0.0461848942380908 | 0.0393430380057834 | KIRC | Male-baised eQTL |
| rs376591693 | chr19:48040901:A:G | - | 0.0439045758059991 | 0.0414002552789004 | KIRC | Male-baised eQTL |
| rs34862923 | chr19:48040649:G:C | - | 0.0437635903001077 | 0.0418559225968695 | KIRC | Male-baised eQTL |
| rs117861443 | chr19:48040916:G:C | - | 0.0437239645416391 | 0.0434300012240376 | KIRC | Male-baised eQTL |
| rs79135781 | chr19:48040983:A:C | - | 0.0437239645416391 | 0.0434300012240376 | KIRC | Male-baised eQTL |
| rs78381043 | chr19:48040999:G:A | - | 0.0437239645416391 | 0.0434300012240376 | KIRC | Male-baised eQTL |
| rs113419610 | chr19:48041054:T:A | - | 0.0437239645416391 | 0.0434300012240376 | KIRC | Male-baised eQTL |
| rs112270137 | chr19:48041087:A:G | - | 0.0437239645416391 | 0.0434300012240376 | KIRC | Male-baised eQTL |
| rs76881010 | chr19:48036688:G:A | - | 0.0454482620431194 | 0.0444186247613039 | KIRC | Male-baised eQTL |
| rs736994 | chr19:57175987:G:A | - | -0.0550406849738185 | 0.00919890526970123 | COAD | Male-baised eQTL |
| rs999135 | chr19:57185017:G:A | - | -0.0529650520149206 | 0.0124773757160217 | COAD | Male-baised eQTL |
| rs11669518 | chr19:57180338:T:C | - | -0.0519387186842394 | 0.0174179568377839 | COAD | Male-baised eQTL |
| rs4801204 | chr19:57184686:A:G | - | -0.0517610197933096 | 0.0190081356483199 | COAD | Male-baised eQTL |
| rs9807896 | chr19:57206082:A:G | - | -0.0535708618204619 | 0.019424549087528 | COAD | Male-baised eQTL |
| rs2864096 | chr19:51488518:T:C | - | -0.0607827508695314 | 0.0260455382857571 | COAD | Male-baised eQTL |
| rs75205204 | chr19:53097498:T:A | - | -0.0756055319002958 | 0.0362659090461029 | COAD | Male-baised eQTL |
| rs77949198 | chr19:53097499:G:T | - | -0.0756055319002958 | 0.0362659090461029 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000142230 |
| CpG Site: cg13387235 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.366706011172976 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13387235 | chr19:47130507 | gene | -0.366706011172976 | 3.20675356147578e-05 | -0.322109530334832 | 1.446488567773588e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SAE1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
