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Gene: ENSG00000141510 |
Summary for TP53 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000141510 | Gene symbol | TP53 |
| Gene name | tumor protein p53 | |
| HGNC | 11998 | |
| Entrez ID | 7157 | |
| Gene type | protein_coding | |
| Synonyms | TP53|p53|LFS1 | |
| UniProtAcc | P04637 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000141510 | TP53 | DB00945 | Acetylsalicylic acid | SmallMoleculeDrug |
| ENSG00000141510 | TP53 | DB01593 | Zinc | SmallMoleculeDrug |
| ENSG00000141510 | TP53 | DB03347 | Triethyl phosphate | SmallMoleculeDrug |
| ENSG00000141510 | TP53 | DB05404 | AZD 3355 | SmallMoleculeDrug |
| ENSG00000141510 | TP53 | DB08363 | 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine | SmallMoleculeDrug |
| ENSG00000141510 | TP53 | DB14487 | Zinc acetate | SmallMoleculeDrug |
| ENSG00000141510 | TP53 | DB14533 | Zinc chloride | SmallMoleculeDrug |
| ENSG00000141510 | TP53 | DB14548 | Zinc sulfate, unspecified form | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TP53 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TP53 | 2.70e+03 | 1.08e+00 | 3.88e-01 | 2.78e+00 | 5.43e-03 | 1.48e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TP53 | 3.94e+03 | 1.03e+00 | 4.02e-01 | 2.55e+00 | 1.07e-02 | 2.62e-02 | READ |
Top |
Sex-biased somatic mutation for TP53 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| TCGA-BRCA |
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| TCGA-LIHC |
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| TCGA-LUSC |
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| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
| ENSG00000141510 | BRCA | TP53 | 0 | 328 | 1.98e-02 | 0.00e+00 | 7.58e-01 | 0.00e+00 | 1.00e+00 |
| ENSG00000141510 | LIHC | TP53 | 81 | 22 | 4.25e-03 | 2.18e+00 | 3.92e+00 | 1.25e+00 | 6.19e-01 |
| ENSG00000141510 | LUSC | TP53 | 290 | 88 | 3.76e-02 | 1.74e+00 | 2.96e+00 | 1.00e+00 | 9.90e-01 |
Top |
DNA methylation with beta values for TP53 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for TP53 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TP53 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| GBM | TP53-018 | chr17_7666770_- | 4.66e-01 | 3.50e-01 | 2.07e+00 | 3.88e-02 | 4.96e-02 | 1.16e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for TP53 |
| TFs related to TP53. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TP53 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Top |
Sex-biased RBP-ES network for TP53 |
| RBPs related to ES in TP53. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | PCBP2 | exon_skip_286384 | 6.49e+00 | 9.81e-01 | 5.94e+00 | 5.11e-04 | Male-biased |
| THYM | PCBP2 | exon_skip_286384 | 5.92e+00 | 4.43e-04 | 6.53e+00 | 9.82e-01 | Female-biased |
| LIHC | YBX2 | exon_skip_286388 | 1.40e+01 | 1.86e-03 | 1.47e+01 | 9.98e-01 | Female-biased |
| LUSC | YBX2 | exon_skip_286388 | 1.38e+01 | 2.34e-03 | 1.43e+01 | 9.98e-01 | Female-biased |
| LUAD | YBX2 | exon_skip_286388 | 1.38e+01 | 4.01e-03 | 1.42e+01 | 9.96e-01 | Female-biased |
| KIRP | YBX2 | exon_skip_286388 | 1.38e+01 | 1.10e-03 | 1.44e+01 | 9.99e-01 | Female-biased |
| READ | YBX2 | exon_skip_286388 | 1.39e+01 | 5.65e-04 | 1.45e+01 | 9.99e-01 | Female-biased |
| THCA | YBX2 | exon_skip_286388 | 1.44e+01 | 1.00e+00 | 1.38e+01 | 2.18e-04 | Male-biased |
| GBM | PCBP2 | exon_skip_286384 | 6.63e+00 | 9.80e-01 | 6.18e+00 | 2.84e-03 | Male-biased |
| KIRC | YBX2 | exon_skip_286388 | 1.39e+01 | 1.66e-03 | 1.44e+01 | 9.98e-01 | Female-biased |
| KICH | PABPC5 | exon_skip_286367 | 9.10e+00 | 9.42e-03 | 9.43e+00 | 9.88e-01 | Female-biased |
| KICH | YBX2 | exon_skip_286388 | 1.46e+01 | 9.99e-01 | 1.40e+01 | 1.24e-03 | Male-biased |
| BLCA | YBX2 | exon_skip_286388 | 1.40e+01 | 2.98e-03 | 1.45e+01 | 9.97e-01 | Female-biased |
| HNSC | ESRP2 | exon_skip_286371 | 8.38e+00 | 2.71e-03 | 8.84e+00 | 9.92e-01 | Female-biased |
| HNSC | YBX2 | exon_skip_286388 | 1.39e+01 | 2.93e-03 | 1.43e+01 | 9.97e-01 | Female-biased |
| SARC | PCBP2 | exon_skip_286384 | 6.90e+00 | 9.84e-01 | 6.27e+00 | 1.10e-03 | Male-biased |
| TP53 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9897496 | chr17:10784575:A:G | - | -0.061620544914703 | 0.0114484671680242 | LUAD | Female-baised eQTL |
| rs28455468 | chr17:10868015:G:A | - | 0.0548389231475425 | 0.0321586154804776 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76116797 | chr17:12836779:A:G | - | 0.0653049570238222 | 0.0499338178661313 | LGG | Male-baised eQTL |
| rs7209078 | chr17:9428291:T:A | - | -0.0485850274963945 | 0.00932059356041898 | KIRC | Male-baised eQTL |
| rs9904459 | chr17:9435415:A:G | - | -0.04752597606881 | 0.0126995132289115 | KIRC | Male-baised eQTL |
| rs9908951 | chr17:9428790:G:A | - | -0.045731379438056 | 0.0189435120755064 | KIRC | Male-baised eQTL |
| rs9909211 | chr17:9428890:G:T | - | -0.0431667611365356 | 0.0354298890095772 | KIRC | Male-baised eQTL |
| rs12450050 | chr17:5535093:A:G | - | -0.0440537611497293 | 0.0458328117007087 | KIRC | Male-baised eQTL |
| rs34081014 | chr17:3712859:C:G | - | 0.111772843145262 | 0.0464763282076492 | LUAD | Male-baised eQTL |
| rs2013868 | chr17:12209077:G:A | - | 0.0935307244803184 | 0.0399193648679557 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_286371 | chr17:7673534:7673608 | Frame-shift | rs72841789 | chr17:8450754:C:T | Distant upstream | -0.0773693841746655 | 0.00113784808462508 | LUSC | Female-baised sQTL |
| exon_skip_286371 | chr17:7673534:7673608 | Frame-shift | rs72841791 | chr17:8451003:C:T | Distant upstream | -0.0773693841746655 | 0.00113784808462508 | LUSC | Female-baised sQTL |
| exon_skip_286371 | chr17:7673534:7673608 | Frame-shift | rs56005127 | chr17:8451558:C:T | Distant upstream | -0.0773693841746655 | 0.00113784808462508 | LUSC | Female-baised sQTL |
| exon_skip_286371 | chr17:7673534:7673608 | Frame-shift | rs166563 | chr17:8498643:T:G | Distant upstream | -0.0732188546327666 | 0.00222310936302541 | LUSC | Female-baised sQTL |
| exon_skip_286371 | chr17:7673534:7673608 | Frame-shift | rs111981244 | chr17:8498623:G:A | Distant upstream | -0.0731435942676414 | 0.00229187752414525 | LUSC | Female-baised sQTL |
| exon_skip_286371 | chr17:7673534:7673608 | Frame-shift | rs4128516 | chr17:8610945:A:T | Distant upstream | 0.0650808314960494 | 0.00784599903214376 | LUSC | Female-baised sQTL |
| exon_skip_286371 | chr17:7673534:7673608 | Frame-shift | rs166563 | chr17:8498643:T:C | Distant upstream | 0.0551933977281598 | 0.0308809023539419 | LUSC | Female-baised sQTL |
| exon_skip_286384 | chr17:7675993:7676272 | In-frame | rs17807161 | chr17:7868478:A:G | Distant upstream | -0.154585996150759 | 0.0489441031612062 | BLCA | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TP53 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000141510 | TP53 | C0001418 | Adenocarcinoma | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0001430 | Adenoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0001969 | Alcoholic Intoxication | 2 | PSYGENET |
| ENSG00000141510 | TP53 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| ENSG00000141510 | TP53 | C0002152 | Alloxan Diabetes | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0004698 | Balkan Nephropathy | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0005684 | Malignant neoplasm of urinary bladder | 5 | CTD_human |
| ENSG00000141510 | TP53 | C0005695 | Bladder Neoplasm | 5 | CTD_human |
| ENSG00000141510 | TP53 | C0006142 | Malignant neoplasm of breast | 6 | CTD_human |
| ENSG00000141510 | TP53 | C0006663 | Calcinosis | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0007097 | Carcinoma | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0007102 | Malignant tumor of colon | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0007114 | Malignant neoplasm of skin | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human |
| ENSG00000141510 | TP53 | C0007134 | Renal Cell Carcinoma | 4 | CTD_human |
| ENSG00000141510 | TP53 | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0007273 | Carotid Artery Diseases | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0007786 | Brain Ischemia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0009375 | Colonic Neoplasms | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0009402 | Colorectal Carcinoma | 8 | CTD_human |
| ENSG00000141510 | TP53 | C0009404 | Colorectal Neoplasms | 8 | CTD_human |
| ENSG00000141510 | TP53 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0011303 | Demyelinating Diseases | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0011304 | Demyelination | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0014859 | Esophageal Neoplasms | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0016978 | gallbladder neoplasm | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0017638 | Glioma | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0018923 | Hemangiosarcoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0019207 | Hepatoma, Morris | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0019208 | Hepatoma, Novikoff | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0020538 | Hypertensive disease | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0021361 | Female infertility | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0021364 | Male infertility | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0022116 | Ischemia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0022593 | Keratosis | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0022594 | Keratosis Blennorrhagica | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0022783 | Vulvar Lichen Sclerosus | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0023452 | Childhood Acute Lymphoblastic Leukemia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0023453 | L2 Acute Lymphoblastic Leukemia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0023897 | Liver Diseases, Parasitic | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0023903 | Liver neoplasms | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0024121 | Lung Neoplasms | 5 | CTD_human |
| ENSG00000141510 | TP53 | C0024623 | Malignant neoplasm of stomach | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
| ENSG00000141510 | TP53 | C0025202 | melanoma | 4 | CTD_human |
| ENSG00000141510 | TP53 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0027022 | Myeloproliferative disease | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0027708 | Nephroblastoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0029463 | Osteosarcoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0030246 | Pustulosis of Palms and Soles | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0030849 | Penile Neoplasms | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0032578 | Polyploidy | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0033578 | Prostatic Neoplasms | 8 | CTD_human |
| ENSG00000141510 | TP53 | C0033860 | Psoriasis | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0036341 | Schizophrenia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0036920 | Sezary Syndrome | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0037286 | Skin Neoplasms | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0038279 | Sterility, Postpartum | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0038433 | Streptozotocin Diabetes | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0040100 | Thymoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0042065 | Genitourinary Neoplasms | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0042076 | Urologic Neoplasms | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0085136 | Central Nervous System Neoplasms | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0085390 | Li-Fraumeni Syndrome | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0086404 | Experimental Hepatoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0086501 | Keratoma | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0149925 | Small cell carcinoma of lung | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0153452 | Malignant neoplasm of gallbladder | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0153601 | Malignant neoplasm of penis | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205641 | Adenocarcinoma, Basal Cell | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0205642 | Adenocarcinoma, Oxyphilic | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0205643 | Carcinoma, Cribriform | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0205644 | Carcinoma, Granular Cell | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0205645 | Adenocarcinoma, Tubular | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0205646 | Adenoma, Basal Cell | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205647 | Follicular adenoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205648 | Adenoma, Microcystic | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205649 | Adenoma, Monomorphic | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205650 | Papillary adenoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205651 | Adenoma, Trabecular | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205696 | Anaplastic carcinoma | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0205697 | Carcinoma, Spindle-Cell | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0205698 | Undifferentiated carcinoma | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0205699 | Carcinomatosis | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0205770 | Choroid Plexus Papilloma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205944 | Sarcoma, Epithelioid | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205945 | Sarcoma, Spindle Cell | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0205969 | Thymic Carcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0206681 | Adenocarcinoma, Clear Cell | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0206686 | Adrenocortical carcinoma | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0235874 | Disease Exacerbation | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0242379 | Malignant neoplasm of lung | 5 | CTD_human |
| ENSG00000141510 | TP53 | C0259783 | mixed gliomas | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0262584 | Carcinoma, Small Cell | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0263628 | Tumoral calcinosis | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0263859 | Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0274861 | Arsenic Poisoning, Inorganic | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0274862 | Nervous System, Organic Arsenic Poisoning | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 4 | CTD_human |
| ENSG00000141510 | TP53 | C0311375 | Arsenic Poisoning | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0341869 | Subfertility, Female | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0345904 | Malignant neoplasm of liver | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0345905 | Intrahepatic Cholangiocarcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0376358 | Malignant neoplasm of prostate | 8 | CTD_human |
| ENSG00000141510 | TP53 | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0428791 | Aortic valve calcification | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0521174 | Microcalcification | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0546837 | Malignant neoplasm of esophagus | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0549473 | Thyroid carcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0555198 | Malignant Glioma | 3 | CTD_human |
| ENSG00000141510 | TP53 | C0577631 | Carotid Atherosclerosis | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0600178 | External Carotid Artery Diseases | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0678222 | Breast Carcinoma | 6 | CTD_human |
| ENSG00000141510 | TP53 | C0750887 | Adrenal Cancer | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0750986 | Internal Carotid Artery Diseases | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0750987 | Arterial Diseases, Common Carotid | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0751569 | Genitourinary Cancer | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0751571 | Cancer of Urinary Tract | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0751620 | Central Nervous System Neoplasms, Primary | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0751851 | Arsenic Encephalopathy | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0751852 | Arsenic Induced Polyneuropathy | 2 | CTD_human |
| ENSG00000141510 | TP53 | C0848676 | Subfertility, Male | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0876994 | Cardiotoxicity | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0917730 | Female sterility | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0917731 | Male sterility | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0917798 | Cerebral Ischemia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1168401 | Squamous cell carcinoma of the head and neck | 2 | CTD_human |
| ENSG00000141510 | TP53 | C1176475 | Ductal Carcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1257931 | Mammary Neoplasms, Human | 6 | CTD_human |
| ENSG00000141510 | TP53 | C1261473 | Sarcoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1266042 | Chromophobe Renal Cell Carcinoma | 4 | CTD_human |
| ENSG00000141510 | TP53 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 4 | CTD_human |
| ENSG00000141510 | TP53 | C1266044 | Collecting Duct Carcinoma of the Kidney | 4 | CTD_human |
| ENSG00000141510 | TP53 | C1306837 | Papillary Renal Cell Carcinoma | 4 | CTD_human |
| ENSG00000141510 | TP53 | C1368275 | Pigmented Basal Cell Carcinoma | 3 | CTD_human |
| ENSG00000141510 | TP53 | C1458155 | Mammary Neoplasms | 6 | CTD_human |
| ENSG00000141510 | TP53 | C1527303 | Chronic Airflow Obstruction | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | CTD_human |
| ENSG00000141510 | TP53 | C1859972 | ADRENOCORTICAL CARCINOMA, HEREDITARY | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1860789 | Leukemia, Megakaryoblastic, of Down Syndrome | 1 | CTD_human |
| ENSG00000141510 | TP53 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2239176 | Liver carcinoma | 6 | CTD_human |
| ENSG00000141510 | TP53 | C2350037 | Clinically Isolated Syndrome, CNS Demyelinating | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2609414 | Acute kidney injury | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2713368 | Hematopoetic Myelodysplasia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2930471 | Bilateral Wilms Tumor | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2930974 | Acute erythroleukemia | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2930975 | Acute erythroleukemia - M6a subtype | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2930976 | Acute myeloid leukemia FAB-M6 | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2930977 | Acute erythroleukemia - M6b subtype | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2931713 | Chromosome 17 deletion | 1 | CTD_human |
| ENSG00000141510 | TP53 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |
| ENSG00000141510 | TP53 | C3683846 | Chromosome 17p Deletion Syndrome | 1 | CTD_human |
| ENSG00000141510 | TP53 | C3805278 | Extrahepatic Cholangiocarcinoma | 1 | CTD_human |
| ENSG00000141510 | TP53 | C4551472 | Hypertrophic obstructive cardiomyopathy | 1 | CTD_human |
| ENSG00000141510 | TP53 | C4704874 | Mammary Carcinoma, Human | 6 | CTD_human |
| ENSG00000141510 | TP53 | C4721610 | Carcinoma, Ovarian Epithelial | 1 | CTD_human |
| ENSG00000141510 | TP53 | C4721806 | Carcinoma, Basal Cell | 3 | CTD_human |
