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Gene: ENSG00000141448 |
Summary for GATA6 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000141448 | Gene symbol | GATA6 |
| Gene name | GATA binding protein 6 | |
| HGNC | 4174 | |
| Entrez ID | 2627 | |
| Gene type | protein_coding | |
| Synonyms | GATA6| | |
| UniProtAcc | Q92908 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for GATA6 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| GATA6 | 2.02e+02 | -2.89e+00 | 3.65e-01 | -7.93e+00 | 2.28e-15 | 2.89e-14 | KICH |
Top |
Sex-biased somatic mutation for GATA6 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for GATA6 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg23267759 | chr18:22171374 | CGI:chr18:22164975-22172402 | promoter,exon,CDS,gene body | 3.21e-01 | 3.81e-02 | 3.66e+00 | 2.48e-04 | 1.09e-03 | 2.82e-01 |
| LIHC | cg23267759 | chr18:22171374 | CGI:chr18:22164975-22172402 | promoter,exon,CDS,gene body | 6.24e-01 | 4.00e-01 | 5.13e+00 | 2.88e-07 | 1.29e-06 | 2.24e-01 |
| CHOL | cg23267759 | chr18:22171374 | CGI:chr18:22164975-22172402 | promoter,exon,CDS,gene body | 1.39e-01 | 5.16e-01 | -2.88e+00 | 4.04e-03 | 1.47e-02 | -3.77e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg23267759 | chr18:22171374 | CGI:chr18:22164975-22172402 | promoter,exon,CDS,gene body | 4.81e-01 | 1.54e-01 | 1.01e+01 | 5.39e-24 | 4.16e-23 | 3.27e-01 |
Top |
Exon skipping events with PSI in TCGA for GATA6 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for GATA6 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for GATA6 |
| TFs related to GATA6. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | ZNF33B | GATA6 | 2.97e+00 | 4.73e-03 | 4.47e+00 | 9.88e-01 | Female-biased |
| GATA6 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
 |
Top |
Sex-biased RBP-ES network for GATA6 |
| RBPs related to ES in GATA6. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PAAD | FMR1 | exon_skip_295965 | 8.30e+00 | 5.54e-03 | 8.65e+00 | 9.89e-01 | Female-biased |
| GATA6 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9946894 | chr18:27653331:A:G | - | 0.187207701389104 | 0.0119551223696491 | PCPG | Female-baised eQTL |
| rs6508523 | chr18:27991502:C:T | - | 0.187229318076358 | 0.00853320840743831 | SARC | Female-baised eQTL |
| rs72883720 | chr18:26412656:C:T | - | 0.150135628698604 | 0.00468836657500307 | KIRP | Female-baised eQTL |
| rs12607965 | chr18:32083511:T:C | - | 0.199753008187011 | 0.0107254966602304 | KIRP | Female-baised eQTL |
| rs4800736 | chr18:26414721:A:T | - | 0.141269492462899 | 0.011295197527352 | KIRP | Female-baised eQTL |
| rs58748151 | chr18:24521299:G:C | - | 0.0953272779186808 | 0.0462952753793474 | KIRC | Female-baised eQTL |
| rs17658536 | chr18:31268630:C:T | - | 0.127259872164477 | 0.026734759459216 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2053167 | chr18:30872612:C:A | - | 0.127852959469131 | 0.0180532629348443 | SARC | Male-baised eQTL |
| rs56352067 | chr18:30876598:C:T | - | 0.126271120457059 | 0.0276574100821613 | SARC | Male-baised eQTL |
| rs68134899 | chr18:30883526:T:A | - | 0.12608864662862 | 0.0325327896813953 | SARC | Male-baised eQTL |
| rs9957598 | chr18:30890917:A:G | - | 0.123931733684356 | 0.0400980980011834 | SARC | Male-baised eQTL |
| rs9953253 | chr18:30890968:G:A | - | 0.123931733684356 | 0.0400980980011834 | SARC | Male-baised eQTL |
| rs113442636 | chr18:30891394:T:A | - | 0.123931733684356 | 0.0400980980011834 | SARC | Male-baised eQTL |
| rs10164247 | chr18:30895488:G:C | - | 0.123931733684356 | 0.0400980980011834 | SARC | Male-baised eQTL |
| rs9955310 | chr18:27154269:A:T | - | -0.0434172952596773 | 0.0404113595870938 | LIHC | Male-baised eQTL |
| rs55693855 | chr18:27139500:C:T | - | -0.0434719792619973 | 0.0419164313685957 | LIHC | Male-baised eQTL |
| rs1863631 | chr18:27110082:C:T | - | -0.0428339694512308 | 0.0453903699824523 | LIHC | Male-baised eQTL |
| rs62082887 | chr18:27112013:C:A | - | -0.0428339694512308 | 0.0453903699824523 | LIHC | Male-baised eQTL |
| rs12607664 | chr18:27113257:G:T | - | -0.0428339694512308 | 0.0453903699824523 | LIHC | Male-baised eQTL |
| rs8099553 | chr18:27100598:G:C | - | -0.0427160446201917 | 0.0461018224981578 | LIHC | Male-baised eQTL |
| rs9949089 | chr18:27121219:G:T | - | -0.0425261429787022 | 0.0462462333875493 | LIHC | Male-baised eQTL |
| rs16943290 | chr18:27121858:A:G | - | -0.0425261429787022 | 0.0462462333875493 | LIHC | Male-baised eQTL |
| rs9960062 | chr18:27124732:C:A | - | -0.0425261429787022 | 0.0462462333875493 | LIHC | Male-baised eQTL |
| rs9952639 | chr18:27129640:G:C | - | -0.0425261429787022 | 0.0462462333875493 | LIHC | Male-baised eQTL |
| rs2114471 | chr18:27130309:A:G | - | -0.0425261429787022 | 0.0462462333875493 | LIHC | Male-baised eQTL |
| rs7233634 | chr18:27137739:T:C | - | -0.0425168095333875 | 0.0464712745876407 | LIHC | Male-baised eQTL |
| rs9789137 | chr18:27147708:A:G | - | -0.0422327110469426 | 0.0483631475878293 | LIHC | Male-baised eQTL |
| rs8098840 | chr18:24306910:G:A | - | 0.0533214126194523 | 0.00835230628370227 | STAD | Male-baised eQTL |
| rs56183663 | chr18:24308062:A:G | - | 0.0526413564699158 | 0.0104867557062301 | STAD | Male-baised eQTL |
| rs12954279 | chr18:24309946:C:G | - | 0.0526413564699158 | 0.0104867557062301 | STAD | Male-baised eQTL |
| rs12966893 | chr18:24314387:A:G | - | 0.0521019214105903 | 0.0119466543875724 | STAD | Male-baised eQTL |
| rs9989557 | chr18:24305557:T:C | - | 0.0518994738908276 | 0.0121136964499055 | STAD | Male-baised eQTL |
| rs35185267 | chr18:21978559:G:A | - | 0.062359784939216 | 0.0238721865159397 | STAD | Male-baised eQTL |
| rs1545780 | chr18:21998843:A:C | - | 0.0611823739473791 | 0.0347529921500481 | STAD | Male-baised eQTL |
| rs12709785 | chr18:24315013:C:T | - | 0.0454117913690942 | 0.0398199073222336 | STAD | Male-baised eQTL |
| rs8085061 | chr18:30473649:C:T | - | 0.147730933641759 | 0.020407155595286 | LUAD | Male-baised eQTL |
| rs75372154 | chr18:30469362:A:T | - | 0.147189378677059 | 0.021511018361279 | LUAD | Male-baised eQTL |
| rs77820850 | chr18:30482761:C:A | - | 0.139860682082637 | 0.0349406478813547 | LUAD | Male-baised eQTL |
| rs80174089 | chr18:30485762:G:A | - | 0.139860682082637 | 0.0349406478813547 | LUAD | Male-baised eQTL |
| rs12957653 | chr18:27773967:T:C | - | -0.0687404342909604 | 0.0447251583569904 | LUAD | Male-baised eQTL |
| rs7240410 | chr18:27773890:G:C | - | -0.0676698954111403 | 0.045110172088072 | LUAD | Male-baised eQTL |
| rs2714372 | chr18:27775896:T:C | - | 0.0709672158780219 | 0.0453797557017155 | LUAD | Male-baised eQTL |
| rs2714371 | chr18:27775686:C:T | - | 0.0706331034572424 | 0.0463020956412701 | LUAD | Male-baised eQTL |
| rs1648587 | chr18:13514019:A:C | - | -0.0717883216774857 | 0.0137131223660905 | COAD | Male-baised eQTL |
| rs1401461 | chr18:27438643:G:T | - | 0.0662527587731735 | 0.0350889638552697 | COAD | Male-baised eQTL |
| rs12959715 | chr18:27438373:T:C | - | 0.0643731776355558 | 0.0445677588248803 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000141448 |
| CpG Site: cg15424989 | |
| Position to Gene: gene | |
| Male Effect: -0.38471482360537 | |
| Female Effect: - | |
 | Gene ID: ENSG00000141448 |
| CpG Site: cg19177125 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.179758728019611 | |
| Female Effect: - | |
 | Gene ID: ENSG00000141448 |
| CpG Site: cg14439622 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.196315082999231 | |
| Female Effect: - | |
 | Gene ID: ENSG00000141448 |
| CpG Site: cg20921890 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.1852891572517 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15424989 | chr18:22177507 | gene | -0.38471482360537 | 1.96007871941878e-15 | -0.5449660342010137 | 1.1961137082162095e-18 | LUAD |
| cg19177125 | chr18:22172453 | gene,enhancer | -0.179758728019611 | 5.2209810078694e-07 | -0.368831604211894 | 1.4279200507561187e-09 | LIHC |
| cg14439622 | chr18:22172331 | gene,enhancer | -0.196315082999231 | 2.54473501783054e-06 | -0.3528914540769271 | 7.831213386608005e-09 | LIHC |
| cg20921890 | chr18:22173247 | gene,enhancer | -0.1852891572517 | 1.87833141462862e-05 | -0.32824462998611387 | 1.2945906583338899e-07 | LIHC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of GATA6 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000141448 | GATA6 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C0039685 | Tetralogy of Fallot | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C1389016 | ATRIOVENTRICULAR CANAL DEFECT | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C1389018 | Atrioventricular Septal Defect | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C1857586 | CONOTRUNCAL HEART MALFORMATIONS (disorder) | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C3280943 | ATRIAL SEPTAL DEFECT 9 | 1 | CTD_human |
| ENSG00000141448 | GATA6 | C4012454 | HEART DEFECTS, CONGENITAL, AND OTHER CONGENITAL ANOMALIES | 1 | CTD_human |
