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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000138771

Summary for SHROOM3

check button Gene summary

Gene informationEnsembl ID

ENSG00000138771

Gene symbol

SHROOM3

Gene nameshroom family member 3
HGNC

30422

Entrez ID

57619

Gene typeprotein_coding
SynonymsSHROOM3|ShrmL|SHRM|KIAA1481|APXL3
UniProtAcc

Q8TF72


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for SHROOM3

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
SHROOM31.13e+04-1.44e+005.33e-01-2.71e+006.82e-032.81e-02ESCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
SHROOM34.81e+03-1.12e+001.38e-01-8.05e+008.04e-168.69e-15COAD

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Sex-biased somatic mutation for SHROOM3

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for SHROOM3

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg19162496chr4:76435022CGI:chr4:76420857-76421554promoter2.81e-011.77e-012.89e+003.79e-031.82e-021.04e-01
BRCAcg14898892chr4:76435027CGI:chr4:76420857-76421554promoter3.67e-012.12e-012.27e+002.29e-023.69e-021.55e-01
KIRPcg14898892chr4:76435027CGI:chr4:76420857-76421554promoter6.91e-017.98e-01-2.96e+003.09e-031.02e-02-1.07e-01
KICHcg05951609chr4:76435354CGI:chr4:76420857-76421554UTR,promoter,exon,gene body9.47e-021.99e-01-2.52e+001.18e-022.95e-02-1.04e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg05951609chr4:76435354CGI:chr4:76420857-76421554UTR,promoter,exon,gene body3.93e-012.91e-012.22e+002.61e-022.80e-021.03e-01
LUSCcg24086068chr4:76434855CGI:chr4:76420857-76421554promoter3.13e-015.28e-01-2.03e+004.23e-024.36e-02-2.15e-01
BLCAcg20311846chr4:76435097CGI:chr4:76420857-76421554promoter1.45e-012.65e-01-3.60e+003.22e-049.47e-04-1.20e-01
LIHCcg20311846chr4:76435097CGI:chr4:76420857-76421554promoter4.14e-013.13e-012.87e+004.08e-035.51e-031.01e-01
LIHCcg27417997chr4:76435263CGI:chr4:76420857-76421554UTR,promoter,exon,gene body7.38e-016.37e-015.19e+002.09e-079.80e-071.01e-01
LIHCcg05951609chr4:76435354CGI:chr4:76420857-76421554UTR,promoter,exon,gene body6.08e-014.82e-013.87e+001.10e-042.25e-041.26e-01
ESCAcg05951609chr4:76435354CGI:chr4:76420857-76421554UTR,promoter,exon,gene body2.32e-011.14e-012.00e+004.60e-024.84e-021.18e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg24086068chr4:76434855CGI:chr4:76420857-76421554promoter2.65e-015.38e-01-3.46e+005.39e-047.34e-04-2.74e-01
BRCAcg14898892chr4:76435027CGI:chr4:76420857-76421554promoter3.67e-015.65e-01-7.83e+005.07e-151.85e-14-1.98e-01
KIRCcg20311846chr4:76435097CGI:chr4:76420857-76421554promoter2.40e-011.10e-012.81e+005.03e-031.10e-021.31e-01
HNSCcg14898892chr4:76435027CGI:chr4:76420857-76421554promoter4.66e-013.02e-012.44e+001.46e-022.29e-021.64e-01
HNSCcg27417997chr4:76435263CGI:chr4:76420857-76421554UTR,promoter,exon,gene body3.30e-012.00e-012.23e+002.59e-023.23e-021.30e-01
COADcg14898892chr4:76435027CGI:chr4:76420857-76421554promoter7.08e-018.54e-01-2.06e+003.92e-024.20e-02-1.46e-01
BLCAcg19999035chr4:76434664CGI:chr4:76420857-76421554promoter5.80e-017.82e-012.19e+002.84e-023.41e-02-2.02e-01

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Exon skipping events with PSI in TCGA for SHROOM3

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for SHROOM3

∗Please access CAeditome for RNA editing annotation.
check buttonLandscape of RNA editing events across multiple cancer types.
ED heatmap

check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre
ESCASHROOM3-012chr4_76633234_+2.46e-011.49e-012.60e+009.45e-032.02e-029.68e-02

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for SHROOM3

check buttonTFs related to SHROOM3.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
BRCAZNF418SHROOM34.42e+009.91e-012.34e+007.57e-04Male-biased
BRCAZNF79SHROOM34.31e+009.83e-012.95e+006.52e-03Male-biased
CHOLLHX2SHROOM33.60e+009.46e-034.54e+009.85e-01Female-biased
CHOLMSX1SHROOM32.96e+006.70e-033.98e+009.80e-01Female-biased
MESOFOXA1SHROOM32.47e+003.04e-034.08e+009.84e-01Female-biased
MESOFOXG1SHROOM32.20e+002.00e-033.92e+009.82e-01Female-biased
MESOFOXR2SHROOM32.01e+001.08e-033.89e+009.82e-01Female-biased
MESOMSX1SHROOM32.89e+006.35e-034.29e+009.84e-01Female-biased
MESONKX6-1SHROOM32.27e+002.19e-033.97e+009.83e-01Female-biased
MESOPOU6F2SHROOM33.22e+001.11e-024.45e+009.81e-01Female-biased
MESOZKSCAN2SHROOM32.68e+005.15e-034.14e+009.83e-01Female-biased
MESOZNF25SHROOM32.06e+001.44e-033.87e+009.81e-01Female-biased
MESOZNF33BSHROOM32.64e+005.02e-034.11e+009.82e-01Female-biased
MESOZNF35SHROOM32.56e+002.97e-034.18e+009.86e-01Female-biased
MESOZNF418SHROOM31.36e+002.69e-054.18e+009.89e-01Female-biased
MESOZNF79SHROOM31.99e+004.04e-044.13e+009.88e-01Female-biased

check buttonSHROOM3 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for SHROOM3

check buttonRBPs related to ES in SHROOM3.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
COADESRP2exon_skip_4245338.22e+007.43e-038.57e+009.86e-01Female-biased
CHOLYBX2exon_skip_4245441.17e+019.95e-011.11e+013.76e-03Male-biased
BRCAYBX2exon_skip_4245441.15e+019.82e-011.10e+011.68e-02Male-biased
KICHYBX2exon_skip_4245441.13e+014.50e-031.17e+019.95e-01Female-biased

check buttonSHROOM3 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10026125chr4:75504304:C:G-0.03303760643352830.0397978963296799LUADFemale-baised eQTL
rs1841933chr4:75477348:G:A-0.0324237148253180.0499083846348408LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs1828825chr4:70274245:C:T-0.07127262735214710.00741688418260859HNSCMale-baised eQTL
rs72663281chr4:76857360:A:G-0.1375292065518730.0124880655388552KIRPMale-baised eQTL
rs62301074chr4:76853992:T:C-0.1369024946990560.0136750225547748KIRPMale-baised eQTL
rs7693122chr4:76863143:T:A-0.08982932615598970.0452349106750361KIRPMale-baised eQTL
rs963857chr4:81003942:C:A--0.0834018932785260.0406123453372616LIHCMale-baised eQTL
rs3846350chr4:82635847:A:G--0.1369752140452280.00144839590988375BLCAMale-baised eQTL
rs6535368chr4:82645737:T:C--0.1364679684911140.0015627959687258BLCAMale-baised eQTL
rs4693467chr4:82626350:T:C--0.1318848259251110.00246107037086982BLCAMale-baised eQTL
rs7673383chr4:82627000:G:A--0.1318848259251110.00246107037086982BLCAMale-baised eQTL
rs4693469chr4:82628611:A:C--0.1317954368364460.00250255356092913BLCAMale-baised eQTL
rs906152chr4:82648414:G:C--0.1312657644724040.00270757135954393BLCAMale-baised eQTL
rs6831105chr4:82656651:C:T--0.1250495140443090.00371152246015789BLCAMale-baised eQTL
rs6819516chr4:82657574:T:C--0.126031217441260.00460863607894976BLCAMale-baised eQTL
rs4693476chr4:82652041:A:G--0.1255270984287540.00491157421257843BLCAMale-baised eQTL
rs1568931chr4:82653154:C:A--0.1255270984287540.00491157421257843BLCAMale-baised eQTL
rs10019352chr4:82653756:G:A--0.1255270984287540.00491157421257843BLCAMale-baised eQTL
rs6822383chr4:82655480:G:A--0.1255270984287540.00491157421257843BLCAMale-baised eQTL
rs6830953chr4:82664509:T:C--0.1239509393356630.00511808167812941BLCAMale-baised eQTL
rs13148104chr4:82693897:T:C--0.1064736805228610.0150158200306265BLCAMale-baised eQTL
rs2202570chr4:82665161:A:G--0.1043641858019990.0283581068011074BLCAMale-baised eQTL
rs4693480chr4:82668505:A:G--0.1043641858019990.0283581068011074BLCAMale-baised eQTL
rs1608942chr4:82671389:A:G--0.1043641858019990.0283581068011074BLCAMale-baised eQTL
rs4693482chr4:82673899:A:G--0.1043641858019990.0283581068011074BLCAMale-baised eQTL
rs76102569chr4:79974477:C:T-0.1665691672253460.00241143648129302LUADMale-baised eQTL
rs138736215chr4:75166090:C:T-0.15223947530580.00829976897825499LUADMale-baised eQTL
rs34469188chr4:75167877:G:A-0.15223947530580.00829976897825499LUADMale-baised eQTL
rs34815715chr4:75179316:T:C-0.15223947530580.00829976897825499LUADMale-baised eQTL
rs62316905chr4:75194368:C:T-0.15223947530580.00829976897825499LUADMale-baised eQTL
rs13126635chr4:75207765:T:G-0.15223947530580.00829976897825499LUADMale-baised eQTL
rs151252257chr4:75217629:T:C-0.15223947530580.00829976897825499LUADMale-baised eQTL
rs13140394chr4:75232263:T:G-0.15223947530580.00829976897825499LUADMale-baised eQTL
rs34531386chr4:75217176:G:A-0.150290886273230.00861824133055783LUADMale-baised eQTL
rs35592442chr4:75296026:C:T-0.1745169017625510.025732760247885LUADMale-baised eQTL
rs7356447chr4:79178950:G:A--0.1014897083487330.0267961563440767LUADMale-baised eQTL
rs787370chr4:67045686:G:T--0.1237250981829880.0352955102978479LUADMale-baised eQTL
rs10018724chr4:81841131:T:A-0.06360250258577340.0107325219241739COADMale-baised eQTL
rs524737chr4:81842917:A:C-0.06341500738820070.0133235567172856COADMale-baised eQTL
rs523017chr4:81843083:A:G-0.06341500738820070.0133235567172856COADMale-baised eQTL
rs522875chr4:81843133:T:C-0.06341500738820070.0133235567172856COADMale-baised eQTL
rs600754chr4:81843290:C:A-0.06341500738820070.0133235567172856COADMale-baised eQTL
rs547188chr4:81844228:A:G-0.06341500738820070.0133235567172856COADMale-baised eQTL
rs572255chr4:81843741:A:G-0.06326586682157980.0137331828487458COADMale-baised eQTL
rs598543chr4:81843772:G:A-0.06326586682157980.0137331828487458COADMale-baised eQTL
rs660505chr4:81845757:C:T-0.06216604901432760.0178164370601347COADMale-baised eQTL
rs658862chr4:81846093:C:T-0.06216604901432760.0178164370601347COADMale-baised eQTL
rs508846chr4:81846110:T:C-0.06216604901432760.0178164370601347COADMale-baised eQTL
rs647540chr4:81846290:G:A-0.06216604901432760.0178164370601347COADMale-baised eQTL
rs545073chr4:81859914:T:C-0.06202983159867880.0183020412051554COADMale-baised eQTL
rs667443chr4:81858739:T:C-0.0597925618987160.0281420354856443COADMale-baised eQTL
rs637408chr4:81860870:T:G-0.05805593947161360.0389048745316531COADMale-baised eQTL
rs660076chr4:81845835:T:A-0.05654153281629120.0458279403370312COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000138771
CpG Site: cg27466235
Position to Gene: gene
Male Effect: -0.241241111646434
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000138771
CpG Site: cg11615509
Position to Gene: gene
Male Effect: -
Female Effect: -0.21482822485527

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg27466235chr4:76703942gene-0.2412411116464348.54109190652643e-05-0.32883558250346935.077361472202228e-07LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg11615509chr4:76607435gene-0.214828224855278.44633598140875e-07-0.35739280778256124.248426059255118e-09LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of SHROOM3

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource