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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000138308

Summary for PLA2G12B

check button Gene summary

Gene informationEnsembl ID

ENSG00000138308

Gene symbol

PLA2G12B

Gene namephospholipase A2 group XIIB
HGNC

18555

Entrez ID

84647

Gene typeprotein_coding
SynonymsPLA2G12B|
UniProtAcc

Q9BX93


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for PLA2G12B

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
PLA2G12B1.41e+02-2.61e+006.50e-01-4.01e+005.97e-052.30e-04STAD
PLA2G12B1.14e+02-2.19e+006.00e-01-3.65e+002.62e-046.16e-04KIRP
PLA2G12B7.48e+02-4.72e+009.62e-01-4.91e+009.24e-076.68e-06CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
PLA2G12B1.59e+02-1.33e+005.55e-01-2.41e+001.61e-022.69e-02COAD

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Sex-biased somatic mutation for PLA2G12B

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for PLA2G12B

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg02044879chr10:72955177CGI:chr10:73096100-73097227promoter8.74e-017.67e-012.22e+002.66e-023.90e-021.07e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg07580789chr10:72953702CGI:chr10:73096100-73097227promoter,gene body6.36e-017.39e-01-2.68e+007.31e-039.04e-03-1.03e-01
HNSCcg07580789chr10:72953702CGI:chr10:73096100-73097227promoter,gene body6.47e-017.70e-01-3.05e+002.32e-033.71e-03-1.23e-01
HNSCcg10410852chr10:72954550CGI:chr10:73096100-73097227promoter,exon,CDS,gene body7.25e-018.41e-01-3.04e+002.36e-033.76e-03-1.17e-01
HNSCcg21820890chr10:72954617CGI:chr10:73096100-73097227promoter,exon,CDS,gene body7.48e-018.54e-01-3.04e+002.38e-033.78e-03-1.06e-01
LUSCcg10842126chr10:72954987CGI:chr10:73096100-73097227promoter7.88e-015.78e-013.82e+001.36e-048.00e-042.11e-01
LUSCcg02044879chr10:72955177CGI:chr10:73096100-73097227promoter7.96e-016.30e-013.26e+001.10e-032.76e-031.67e-01
COADcg07580789chr10:72953702CGI:chr10:73096100-73097227promoter,gene body6.56e-018.56e-01-2.23e+002.60e-023.03e-02-2.00e-01
COADcg10410852chr10:72954550CGI:chr10:73096100-73097227promoter,exon,CDS,gene body6.21e-018.53e-01-2.23e+002.60e-023.03e-02-2.32e-01
COADcg21820890chr10:72954617CGI:chr10:73096100-73097227promoter,exon,CDS,gene body6.41e-018.74e-01-2.64e+008.37e-031.25e-02-2.33e-01
BLCAcg02044879chr10:72955177CGI:chr10:73096100-73097227promoter6.28e-017.91e-01-2.03e+004.25e-024.41e-02-1.64e-01
LIHCcg07580789chr10:72953702CGI:chr10:73096100-73097227promoter,gene body3.63e-015.05e-01-4.78e+001.74e-065.98e-06-1.42e-01
LIHCcg10410852chr10:72954550CGI:chr10:73096100-73097227promoter,exon,CDS,gene body3.61e-014.71e-01-4.21e+002.54e-056.17e-05-1.10e-01
LIHCcg21820890chr10:72954617CGI:chr10:73096100-73097227promoter,exon,CDS,gene body4.11e-015.20e-01-5.00e+005.81e-072.33e-06-1.09e-01
LIHCcg02044879chr10:72955177CGI:chr10:73096100-73097227promoter3.36e-014.50e-01-4.19e+002.76e-056.64e-05-1.15e-01
CHOLcg07580789chr10:72953702CGI:chr10:73096100-73097227promoter,gene body7.56e-014.07e-013.10e+001.96e-031.07e-023.50e-01
CHOLcg10410852chr10:72954550CGI:chr10:73096100-73097227promoter,exon,CDS,gene body7.79e-014.39e-013.02e+002.51e-031.19e-023.40e-01
CHOLcg21820890chr10:72954617CGI:chr10:73096100-73097227promoter,exon,CDS,gene body8.10e-014.93e-013.10e+001.96e-031.07e-023.18e-01
CHOLcg10842126chr10:72954987CGI:chr10:73096100-73097227promoter7.42e-014.47e-013.02e+002.51e-031.19e-022.95e-01
CHOLcg02044879chr10:72955177CGI:chr10:73096100-73097227promoter7.71e-014.06e-013.10e+001.96e-031.07e-023.65e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg02044879chr10:72955177CGI:chr10:73096100-73097227promoter5.11e-016.14e-01-2.16e+003.05e-023.50e-02-1.03e-01
KIRPcg10410852chr10:72954550CGI:chr10:73096100-73097227promoter,exon,CDS,gene body8.09e-016.71e-012.60e+009.43e-031.62e-021.38e-01
KIRPcg21820890chr10:72954617CGI:chr10:73096100-73097227promoter,exon,CDS,gene body8.12e-017.06e-012.28e+002.26e-022.91e-021.06e-01

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Exon skipping events with PSI in TCGA for PLA2G12B

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for PLA2G12B

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for PLA2G12B

check buttonTFs related to PLA2G12B.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCZNF454PLA2G12B4.87e+009.82e-014.17e+001.53e-02Male-biased
ACCZNF530PLA2G12B4.68e+009.81e-013.97e+001.45e-02Male-biased
ACCZNF611PLA2G12B4.79e+009.91e-013.84e+005.32e-03Male-biased
ACCZNF765PLA2G12B4.72e+009.83e-013.99e+001.37e-02Male-biased
ACCZNF792PLA2G12B4.73e+009.81e-014.02e+001.49e-02Male-biased
SARCZNF235PLA2G12B4.90e+009.85e-014.36e+001.16e-02Male-biased

check buttonPLA2G12B related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for PLA2G12B

check buttonRBPs related to ES in PLA2G12B.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonPLA2G12B related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs55818842chr10:66670727:A:C-0.2813094824009370.000172000457060976KIRPFemale-baised eQTL
rs10998731chr10:69342977:G:A-0.3540453421601740.00173033820916995KIRPFemale-baised eQTL
rs10998724chr10:69338620:T:G-0.3535916799511640.00181894036297395KIRPFemale-baised eQTL
rs61863042chr10:82275321:G:A-0.2154244972382020.00259774170001085KIRPFemale-baised eQTL
rs12783362chr10:78780746:G:A-0.304439373561920.00448356221923676KIRPFemale-baised eQTL
rs737109chr10:78783319:G:A-0.3039208719560120.00471217655227485KIRPFemale-baised eQTL
rs10998733chr10:69347582:C:T-0.3596887996519740.00620029476533796KIRPFemale-baised eQTL
rs61863039chr10:82269275:A:G-0.194298967568350.0112945193604478KIRPFemale-baised eQTL
rs77509458chr10:78786308:A:T-0.2689181089417250.0206103338627429KIRPFemale-baised eQTL
rs7075537chr10:78785625:A:G-0.2684053035511150.021698274237342KIRPFemale-baised eQTL
rs142519593chr10:66429682:G:C-0.1464209692865520.0241823585723888KIRPFemale-baised eQTL
rs77521063chr10:66433794:T:C-0.1464209692865520.0241823585723888KIRPFemale-baised eQTL
rs4746591chr10:66450955:G:A-0.1464209692865520.0241823585723888KIRPFemale-baised eQTL
rs12268022chr10:77364655:C:T-0.1497401678698220.0241823585723888KIRPFemale-baised eQTL
rs61867239chr10:66461898:C:T-0.1381758191216970.0346068900904854KIRPFemale-baised eQTL
rs7917556chr10:66463287:C:T-0.1381758191216970.0346068900904854KIRPFemale-baised eQTL
rs12359000chr10:71189978:G:A-0.1488234772211660.0378795000146483KIRPFemale-baised eQTL
rs7080430chr10:71188820:C:T-0.1455874098914190.0463532270645751KIRPFemale-baised eQTL
rs7069026chr10:71189207:A:C-0.1455874098914190.0463532270645751KIRPFemale-baised eQTL
rs6480500chr10:71195066:A:G-0.1455874098914190.0463532270645751KIRPFemale-baised eQTL
rs7074151chr10:71197469:G:C-0.1455874098914190.0463532270645751KIRPFemale-baised eQTL
rs7078728chr10:71198452:C:G-0.1455874098914190.0463532270645751KIRPFemale-baised eQTL
rs35177325chr10:66420352:A:G-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs61867354chr10:66421700:G:A-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs68118260chr10:66422014:T:A-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs12783614chr10:66426268:G:C-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs146363874chr10:66429503:A:G-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs34247065chr10:66431325:G:C-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs56239371chr10:66436173:G:A-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs34129307chr10:66438205:C:T-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs12781320chr10:66438553:C:G-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs4492695chr10:66441785:A:G-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs150532465chr10:66443433:C:T-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs140200294chr10:66443939:G:A-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs144439858chr10:66446633:G:A-0.1348806542005570.0483108723011703KIRPFemale-baised eQTL
rs10998725chr10:69339439:G:A-0.265287964706910.04860662032191KIRPFemale-baised eQTL
rs10998726chr10:69339466:G:T-0.265287964706910.04860662032191KIRPFemale-baised eQTL
rs11188500chr10:81125785:T:C-0.1121556849893590.0224867350282201STADFemale-baised eQTL
rs61853685chr10:81473721:C:T-0.0804212545767010.0432928520266243LUADFemale-baised eQTL
rs10824612chr10:78462986:G:C-0.07068636919471470.0145952552243566COADFemale-baised eQTL
rs11002568chr10:78463819:T:G-0.06785392249580150.0184795174105742COADFemale-baised eQTL
rs3858129chr10:64736382:G:A--0.0685966542623180.0376997714892903COADFemale-baised eQTL
rs4746471chr10:64749024:C:T--0.07201817706211980.0412743084047434COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs9663999chr10:81250996:C:T-0.0740303802835870.0284352529827568LIHCMale-baised eQTL
rs7914081chr10:79170247:C:G--0.07339634654771480.0242801615178965KIRCMale-baised eQTL
rs17600642chr10:70703238:C:A-0.05604092233875560.0102729178600692LUADMale-baised eQTL
rs297044chr10:69553193:A:T--0.05643689779729010.0492310731372276LUADMale-baised eQTL
rs10822744chr10:66192988:G:T--0.06980960433123250.0050642988773251COADMale-baised eQTL
rs7908442chr10:66188438:T:C--0.06964371753234920.0052508417099459COADMale-baised eQTL
rs1462815chr10:66186018:A:G--0.06956784418578230.00533136329765341COADMale-baised eQTL
rs4746554chr10:66200705:C:T--0.0699617374118480.00533284492349916COADMale-baised eQTL
rs1995666chr10:80891645:T:C--0.06577830406971890.0136658957497466COADMale-baised eQTL
rs7904398chr10:66194435:C:T--0.0607973096391910.0274668415278321COADMale-baised eQTL
rs1248640chr10:77860298:G:T--0.05695831026259330.0448024041890092COADMale-baised eQTL
rs1248651chr10:77875856:C:T--0.05671687903264410.0464366121711804COADMale-baised eQTL
rs1248677chr10:77847334:G:A--0.05667957233363390.0470531670261092COADMale-baised eQTL
rs1248672chr10:77844821:C:T--0.05669462490846970.0474600135131233COADMale-baised eQTL
rs1248663chr10:77830968:C:G--0.05626059219285560.0477304738963821COADMale-baised eQTL
rs75014788chr10:81830526:A:C-0.07609608914742240.0499039347241492COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000138308
CpG Site: cg10842126
Position to Gene: promoter
Male Effect: -0.236198527314891
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg10842126chr10:72954987promoter-0.2361985273148911.51794818286228e-09-0.451813945009020831.287381922068013e-12LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of PLA2G12B

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource