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Gene: ENSG00000138166 |
Summary for DUSP5 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000138166 | Gene symbol | DUSP5 |
| Gene name | dual specificity phosphatase 5 | |
| HGNC | 3071 | |
| Entrez ID | 1847 | |
| Gene type | protein_coding | |
| Synonyms | DUSP5|HVH3 | |
| UniProtAcc | Q16690 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for DUSP5 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| DUSP5 | 2.84e+03 | 1.43e+00 | 5.21e-01 | 2.74e+00 | 6.12e-03 | 2.59e-02 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| DUSP5 | 8.33e+02 | -1.25e+00 | 3.92e-01 | -3.18e+00 | 1.45e-03 | 4.79e-03 | READ |
Top |
Sex-biased somatic mutation for DUSP5 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for DUSP5 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03652339 | chr10:110498883 | CGI:chr10:110497405-110498926 | promoter,gene body | 3.09e-01 | 1.88e-01 | 3.30e+00 | 9.61e-04 | 9.21e-03 | 1.21e-01 |
| BRCA | cg09357462 | chr10:110499547 | CGI:chr10:110497405-110498926 | promoter,gene body | 2.90e-01 | 1.74e-01 | 2.92e+00 | 3.45e-03 | 1.76e-02 | 1.16e-01 |
| KIRP | cg09357462 | chr10:110499547 | CGI:chr10:110497405-110498926 | promoter,gene body | 3.83e-01 | 4.91e-01 | -3.54e+00 | 4.03e-04 | 2.43e-03 | -1.08e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg06110816 | chr10:110497067 | CGI:chr10:110497405-110498926 | promoter | 3.01e-01 | 4.13e-01 | -3.98e+00 | 6.75e-05 | 1.45e-04 | -1.12e-01 |
| KIRC | cg09357462 | chr10:110499547 | CGI:chr10:110497405-110498926 | promoter,gene body | 5.38e-01 | 6.81e-01 | -5.40e+00 | 6.74e-08 | 3.57e-07 | -1.43e-01 |
| HNSC | cg03652339 | chr10:110498883 | CGI:chr10:110497405-110498926 | promoter,gene body | 4.00e-01 | 5.01e-01 | -3.32e+00 | 9.03e-04 | 1.66e-03 | -1.01e-01 |
| ESCA | cg06110816 | chr10:110497067 | CGI:chr10:110497405-110498926 | promoter | 2.80e-01 | 4.07e-01 | -2.03e+00 | 4.28e-02 | 4.76e-02 | -1.27e-01 |
| CHOL | cg12323347 | chr10:110496759 | CGI:chr10:110497405-110498926 | promoter | 4.02e-01 | 5.38e-01 | -2.14e+00 | 3.25e-02 | 3.87e-02 | -1.37e-01 |
| CHOL | cg20925954 | chr10:110496882 | CGI:chr10:110497405-110498926 | promoter | 5.06e-01 | 6.83e-01 | -2.43e+00 | 1.50e-02 | 2.65e-02 | -1.76e-01 |
| CHOL | cg15667844 | chr10:110496971 | CGI:chr10:110497405-110498926 | promoter | 3.45e-01 | 5.30e-01 | -2.43e+00 | 1.50e-02 | 2.65e-02 | -1.85e-01 |
| CHOL | cg25524473 | chr10:110498636 | CGI:chr10:110497405-110498926 | promoter,gene body | 1.40e-01 | 4.02e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -2.62e-01 |
| CHOL | cg03652339 | chr10:110498883 | CGI:chr10:110497405-110498926 | promoter,gene body | 3.68e-01 | 6.20e-01 | -3.24e+00 | 1.18e-03 | 1.07e-02 | -2.51e-01 |
| CHOL | cg12406703 | chr10:110498922 | CGI:chr10:110497405-110498926 | promoter,gene body | 2.45e-01 | 4.44e-01 | -2.65e+00 | 7.96e-03 | 1.92e-02 | -1.99e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03652339 | chr10:110498883 | CGI:chr10:110497405-110498926 | promoter,gene body | 3.09e-01 | 4.09e-01 | -8.76e+00 | 1.93e-18 | 9.18e-18 | -1.00e-01 |
| COAD | cg25524473 | chr10:110498636 | CGI:chr10:110497405-110498926 | promoter,gene body | 2.22e-01 | 1.14e-01 | 2.99e+00 | 2.77e-03 | 6.18e-03 | 1.08e-01 |
| LIHC | cg25524473 | chr10:110498636 | CGI:chr10:110497405-110498926 | promoter,gene body | 3.42e-01 | 4.43e-01 | -2.14e+00 | 3.24e-02 | 3.54e-02 | -1.00e-01 |
| LIHC | cg03652339 | chr10:110498883 | CGI:chr10:110497405-110498926 | promoter,gene body | 5.43e-01 | 6.58e-01 | -2.74e+00 | 6.23e-03 | 9.57e-03 | -1.15e-01 |
Top |
Exon skipping events with PSI in TCGA for DUSP5 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for DUSP5 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for DUSP5 |
| TFs related to DUSP5. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SKCM | FOXL1 | DUSP5 | 3.08e+00 | 3.11e-03 | 4.42e+00 | 9.82e-01 | Female-biased |
| SKCM | ZNF25 | DUSP5 | 3.31e+00 | 3.13e-03 | 4.65e+00 | 9.86e-01 | Female-biased |
| DUSP5 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for DUSP5 |
| RBPs related to ES in DUSP5. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DUSP5 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs74157656 | chr10:119325215:T:A | - | 0.196127752406798 | 0.0301753067037003 | READ | Female-baised eQTL |
| rs61868061 | chr10:120099370:A:G | - | 0.335935173511749 | 0.00444956737632729 | KIRP | Female-baised eQTL |
| rs1467785 | chr10:120100302:T:C | - | 0.335935173511749 | 0.00444956737632729 | KIRP | Female-baised eQTL |
| rs284865 | chr10:102840994:A:C | - | -0.138331686325861 | 0.0445181622235508 | LUSC | Female-baised eQTL |
| rs10736220 | chr10:112394703:A:G | - | -0.136417382488763 | 0.0268225436971239 | STAD | Female-baised eQTL |
| rs11192344 | chr10:105164215:C:T | - | 0.100137861899548 | 0.00826543869354656 | LUAD | Female-baised eQTL |
| rs7913241 | chr10:105166763:T:A | - | 0.100137861899548 | 0.00826543869354656 | LUAD | Female-baised eQTL |
| rs7896544 | chr10:105166767:A:G | - | 0.100137861899548 | 0.00826543869354656 | LUAD | Female-baised eQTL |
| rs9664351 | chr10:105172888:A:C | - | 0.100137861899548 | 0.00826543869354656 | LUAD | Female-baised eQTL |
| rs12358021 | chr10:105173069:A:G | - | 0.100137861899548 | 0.00826543869354656 | LUAD | Female-baised eQTL |
| rs11192352 | chr10:105173831:G:A | - | 0.100137861899548 | 0.00826543869354656 | LUAD | Female-baised eQTL |
| rs11192353 | chr10:105173890:G:T | - | 0.100137861899548 | 0.00826543869354656 | LUAD | Female-baised eQTL |
| rs2120929 | chr10:112640536:G:A | - | -0.0594042156683717 | 0.0454562894246949 | LUAD | Female-baised eQTL |
| rs67762893 | chr10:110274832:A:G | - | 0.0542794877532049 | 0.0393034360640213 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs57792860 | chr10:119351901:A:G | - | 0.239103748985296 | 0.00608881637241374 | PCPG | Male-baised eQTL |
| rs2420617 | chr10:119346895:G:A | - | 0.237267685536843 | 0.0194868261360304 | PCPG | Male-baised eQTL |
| rs142464843 | chr10:119560359:G:C | - | 0.0854867179961845 | 0.000526337975387466 | KIRP | Male-baised eQTL |
| rs111706703 | chr10:119562927:G:A | - | 0.0854867179961845 | 0.000526337975387466 | KIRP | Male-baised eQTL |
| rs7919156 | chr10:119566059:G:A | - | 0.0854867179961845 | 0.000526337975387466 | KIRP | Male-baised eQTL |
| rs2460940 | chr10:105916487:C:A | - | 0.0469590828482131 | 0.0374856982378973 | LGG | Male-baised eQTL |
| rs2644518 | chr10:105916852:T:G | - | 0.0469590828482131 | 0.0374856982378973 | LGG | Male-baised eQTL |
| rs2644519 | chr10:105917428:C:A | - | 0.0469590828482131 | 0.0374856982378973 | LGG | Male-baised eQTL |
| rs111429069 | chr10:105915799:G:A | - | 0.046923641564025 | 0.0380459911148059 | LGG | Male-baised eQTL |
| rs112199015 | chr10:105915820:C:G | - | 0.046923641564025 | 0.0380459911148059 | LGG | Male-baised eQTL |
| rs149825040 | chr10:105915973:A:C | - | 0.046923641564025 | 0.0380459911148059 | LGG | Male-baised eQTL |
| rs9419999 | chr10:105916076:T:C | - | 0.046923641564025 | 0.0380459911148059 | LGG | Male-baised eQTL |
| rs10509809 | chr10:105979074:C:T | - | 0.0451554530104927 | 0.0490315491243141 | LGG | Male-baised eQTL |
| rs11511482 | chr10:118659873:G:T | - | 0.0538616181709673 | 0.0265817003244594 | KIRC | Male-baised eQTL |
| rs11198535 | chr10:118638131:G:A | - | 0.045911128501475 | 0.0379623160435773 | KIRC | Male-baised eQTL |
| rs79528448 | chr10:118641553:A:G | - | 0.044552631371053 | 0.0474086924666437 | KIRC | Male-baised eQTL |
| rs112259391 | chr10:118641995:T:A | - | 0.044552631371053 | 0.0474086924666437 | KIRC | Male-baised eQTL |
| rs17717312 | chr10:114498146:G:A | - | 0.123200331352044 | 0.00579307412689662 | LUAD | Male-baised eQTL |
| rs11812110 | chr10:114479869:T:A | - | 0.122134328145719 | 0.00653236591023403 | LUAD | Male-baised eQTL |
| rs77043423 | chr10:114488480:C:T | - | 0.124607766633777 | 0.00819288975470071 | LUAD | Male-baised eQTL |
| rs75242228 | chr10:114492648:T:C | - | 0.124435994498912 | 0.00840503203852732 | LUAD | Male-baised eQTL |
| rs79260982 | chr10:114515079:G:A | - | 0.102731175340065 | 0.0340716822824419 | LUAD | Male-baised eQTL |
| rs75727228 | chr10:108813000:G:A | - | 0.115153557792605 | 4.41656335546718e-05 | COAD | Male-baised eQTL |
| rs148075307 | chr10:108857635:A:G | - | 0.101889238013598 | 0.000331678989832558 | COAD | Male-baised eQTL |
| rs140404502 | chr10:108796342:T:C | - | 0.0883994296922191 | 0.00145199128440701 | COAD | Male-baised eQTL |
| rs17125208 | chr10:108840659:C:T | - | 0.083363957359277 | 0.00234253309288225 | COAD | Male-baised eQTL |
| rs202036545 | chr10:108933246:T:C | - | 0.0899939610887476 | 0.0028422363196735 | COAD | Male-baised eQTL |
| rs56255130 | chr10:108877886:C:A | - | 0.0922527677186471 | 0.00298093319627806 | COAD | Male-baised eQTL |
| rs138293729 | chr10:108994877:C:G | - | 0.0839781359638344 | 0.0035458952175022 | COAD | Male-baised eQTL |
| rs144482718 | chr10:108995819:T:G | - | 0.0839781359638344 | 0.0035458952175022 | COAD | Male-baised eQTL |
| rs77890706 | chr10:108991645:T:A | - | 0.0837144789928796 | 0.00371052123408796 | COAD | Male-baised eQTL |
| rs115454513 | chr10:108891793:G:C | - | 0.081625088674536 | 0.00726193607835512 | COAD | Male-baised eQTL |
| rs74153123 | chr10:108894458:C:T | - | 0.0680360270116904 | 0.0327596894184297 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000138166 |
| CpG Site: cg06110816 | |
| Position to Gene: promoter | |
| Male Effect: -0.087007658693776 | |
| Female Effect: - | |
 | Gene ID: ENSG00000138166 |
| CpG Site: cg02927679 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.116185485629745 | |
| Female Effect: - | |
 | Gene ID: ENSG00000138166 |
| CpG Site: cg20925954 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.0557907695902866 | |
 | Gene ID: ENSG00000138166 |
| CpG Site: cg12323347 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.052933069599466 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06110816 | chr10:110497067 | promoter | -0.087007658693776 | 1.81201506629898e-05 | -0.35909418889557043 | 3.4402515004540905e-08 | LUAD |
| cg02927679 | chr10:110500751 | gene,enhancer | -0.116185485629745 | 7.52398947242487e-05 | -0.33520982625957535 | 2.94836671748114e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20925954 | chr10:110496882 | promoter | -0.0557907695902866 | 2.7291744223052e-06 | -0.34372923974194525 | 4.9491658810492926e-08 | LGG |
| cg12323347 | chr10:110496759 | promoter | -0.052933069599466 | 5.45467402599852e-06 | -0.33733699055150324 | 9.028502442510147e-08 | LGG |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of DUSP5 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000138166 | DUSP5 | C0020538 | Hypertensive disease | 1 | CTD_human |
