|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000137975 |
Summary for CLCA2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000137975 | Gene symbol | CLCA2 |
| Gene name | chloride channel accessory 2 | |
| HGNC | 2016 | |
| Entrez ID | 9635 | |
| Gene type | protein_coding | |
| Synonyms | CLCA2|CLCRG2 | |
| UniProtAcc | Q9UQC9 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CLCA2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CLCA2 | 1.72e+03 | -6.05e+00 | 8.65e-01 | -7.00e+00 | 2.57e-12 | 2.70e-09 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CLCA2 | 5.91e+03 | 3.05e+00 | 8.77e-01 | 3.47e+00 | 5.16e-04 | 1.86e-03 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CLCA2 | 8.14e+01 | 3.90e+00 | 9.90e-01 | 3.94e+00 | 8.15e-05 | 7.61e-04 | STAD |
| CLCA2 | 2.49e+01 | 3.70e+00 | 9.63e-01 | 3.84e+00 | 1.22e-04 | 9.44e-04 | KIRP |
Top |
Sex-biased somatic mutation for CLCA2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for CLCA2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg01769468 | chr1:86422902 | CGI:chr1:86395883-86396400 | promoter | 8.34e-01 | 7.12e-01 | 2.39e+00 | 1.67e-02 | 3.26e-02 | 1.22e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg06785712 | chr1:86422941 | CGI:chr1:86395883-86396400 | promoter | 8.17e-01 | 9.42e-01 | -3.65e+00 | 2.67e-04 | 1.14e-03 | -1.25e-01 |
| LUSC | cg01769468 | chr1:86422902 | CGI:chr1:86395883-86396400 | promoter | 6.89e-01 | 8.65e-01 | -3.42e+00 | 6.27e-04 | 1.91e-03 | -1.76e-01 |
| BLCA | cg01769468 | chr1:86422902 | CGI:chr1:86395883-86396400 | promoter | 7.72e-01 | 8.86e-01 | -2.49e+00 | 1.26e-02 | 1.70e-02 | -1.15e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for CLCA2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for CLCA2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for CLCA2 |
| TFs related to CLCA2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | ALX1 | CLCA2 | 5.25e+00 | 9.90e-01 | 4.21e+00 | 7.73e-03 | Male-biased |
| CHOL | ELF3 | CLCA2 | 4.40e+00 | 9.90e-01 | 3.20e+00 | 4.02e-03 | Male-biased |
| CHOL | HMX1 | CLCA2 | 5.05e+00 | 9.87e-01 | 4.09e+00 | 1.09e-02 | Male-biased |
| CHOL | HOXA9 | CLCA2 | 5.22e+00 | 9.82e-01 | 4.36e+00 | 1.57e-02 | Male-biased |
| CHOL | MECOM | CLCA2 | 4.89e+00 | 9.82e-01 | 4.01e+00 | 1.47e-02 | Male-biased |
| CHOL | NKX3-1 | CLCA2 | 4.83e+00 | 9.90e-01 | 3.76e+00 | 6.93e-03 | Male-biased |
| CHOL | NKX6-1 | CLCA2 | 4.15e+00 | 9.88e-01 | 2.87e+00 | 2.87e-03 | Male-biased |
| CHOL | PHOX2B | CLCA2 | 5.16e+00 | 9.89e-01 | 4.17e+00 | 9.37e-03 | Male-biased |
| CHOL | PRDM1 | CLCA2 | 4.20e+00 | 9.82e-01 | 3.21e+00 | 9.25e-03 | Male-biased |
| CHOL | PRRX1 | CLCA2 | 5.40e+00 | 9.90e-01 | 4.39e+00 | 8.70e-03 | Male-biased |
| CHOL | SOX7 | CLCA2 | 4.59e+00 | 9.86e-01 | 3.61e+00 | 9.75e-03 | Male-biased |
| CHOL | ZFP82 | CLCA2 | 4.33e+00 | 9.87e-01 | 3.26e+00 | 6.65e-03 | Male-biased |
| CHOL | ZNF175 | CLCA2 | 4.30e+00 | 9.89e-01 | 3.10e+00 | 3.97e-03 | Male-biased |
| CHOL | ZNF354B | CLCA2 | 4.82e+00 | 9.84e-01 | 3.91e+00 | 1.30e-02 | Male-biased |
| CHOL | ZNF79 | CLCA2 | 3.92e+00 | 9.85e-01 | 2.59e+00 | 2.18e-03 | Male-biased |
| MESO | ALX1 | CLCA2 | 4.86e+00 | 9.84e-01 | 3.72e+00 | 1.25e-02 | Male-biased |
| MESO | MEIS1 | CLCA2 | 5.03e+00 | 9.80e-01 | 3.98e+00 | 1.69e-02 | Male-biased |
| MESO | NKX3-1 | CLCA2 | 4.67e+00 | 9.86e-01 | 3.41e+00 | 8.52e-03 | Male-biased |
| MESO | NKX6-1 | CLCA2 | 4.08e+00 | 9.84e-01 | 2.54e+00 | 3.15e-03 | Male-biased |
| MESO | PHOX2B | CLCA2 | 4.78e+00 | 9.83e-01 | 3.65e+00 | 1.29e-02 | Male-biased |
| MESO | PRDM1 | CLCA2 | 4.17e+00 | 9.82e-01 | 2.86e+00 | 6.82e-03 | Male-biased |
| PCPG | ALX1 | CLCA2 | 3.50e+00 | 7.97e-03 | 4.35e+00 | 9.84e-01 | Female-biased |
| PCPG | HMX1 | CLCA2 | 3.48e+00 | 9.22e-03 | 4.30e+00 | 9.82e-01 | Female-biased |
| PCPG | PRRX1 | CLCA2 | 3.77e+00 | 9.36e-03 | 4.59e+00 | 9.85e-01 | Female-biased |
| PCPG | ZNF16 | CLCA2 | 3.98e+00 | 9.80e-01 | 2.95e+00 | 3.45e-03 | Male-biased |
| PCPG | ZNF300 | CLCA2 | 3.85e+00 | 9.80e-01 | 2.33e+00 | 2.75e-04 | Male-biased |
| PCPG | ZNF415 | CLCA2 | 3.93e+00 | 9.82e-01 | 2.66e+00 | 1.08e-03 | Male-biased |
| PCPG | ZNF573 | CLCA2 | 4.21e+00 | 9.83e-01 | 3.30e+00 | 6.10e-03 | Male-biased |
| PCPG | ZNF816 | CLCA2 | 3.93e+00 | 9.82e-01 | 2.52e+00 | 5.08e-04 | Male-biased |
| CLCA2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for CLCA2 |
| RBPs related to ES in CLCA2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CLCA2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000137975 | AL513534.2,hsa-mir-410,CLCA2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000137975 | AC021851.1,hsa-mir-410,CLCA2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000137975 | CAVIN2-AS1,hsa-mir-410,CLCA2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000137975 | TNFRSF10A-AS1,hsa-mir-410,CLCA2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000137975 | HAS2-AS1,hsa-mir-410,CLCA2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000137975 | AL031985.3,hsa-mir-410,CLCA2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000137975 | SNHG29,hsa-mir-410,CLCA2 | Female-specific ceRNA | TCGA-KICH |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12119972 | chr1:79847745:T:C | - | 0.0850998315503589 | 0.0322282485473877 | STAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of CLCA2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000137975 | CLCA2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| ENSG00000137975 | CLCA2 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
