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Gene: ENSG00000137936 |
Summary for BCAR3 |
Gene summary |
| Gene information | Ensembl ID | ENSG00000137936 | Gene symbol | BCAR3 |
| Gene name | BCAR3 adaptor protein, NSP family member | |
| HGNC | 973 | |
| Entrez ID | 8412 | |
| Gene type | protein_coding | |
| Synonyms | BCAR3|NSP2|SH2D3B|AND-34|MIG7 | |
| UniProtAcc | O75815 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for BCAR3 |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| BCAR3 | 1.37e+03 | -1.05e+00 | 8.37e-02 | -1.25e+01 | 6.06e-36 | 6.59e-35 | KIRC |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| BCAR3 | 7.03e+02 | -1.12e+00 | 2.36e-01 | -4.74e+00 | 2.10e-06 | 1.66e-05 | READ |
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Sex-biased somatic mutation for BCAR3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for BCAR3 |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for BCAR3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Landscape of exon skipping events across multiple cancer types. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for BCAR3 |
| ∗Please access CAeditome for RNA editing annotation. |
Landscape of RNA editing events across multiple cancer types. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | BCAR3-009 | chr1_93844787_- | 5.06e-01 | 2.51e-01 | 2.93e+00 | 3.35e-03 | 4.96e-02 | 2.55e-01 |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for BCAR3 |
TFs related to BCAR3.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | DMRT2 | BCAR3 | 3.14e+00 | 5.99e-03 | 4.20e+00 | 9.85e-01 | Female-biased |
| CHOL | NKX3-1 | BCAR3 | 2.82e+00 | 3.10e-03 | 4.04e+00 | 9.85e-01 | Female-biased |
| CHOL | ZNF580 | BCAR3 | 2.94e+00 | 6.02e-03 | 3.99e+00 | 9.81e-01 | Female-biased |
| PCPG | CDX2 | BCAR3 | 3.95e+00 | 9.81e-01 | 2.81e+00 | 2.03e-03 | Male-biased |
| PCPG | DMRT2 | BCAR3 | 4.54e+00 | 9.90e-01 | 3.47e+00 | 2.99e-03 | Male-biased |
| PCPG | FOXQ1 | BCAR3 | 4.12e+00 | 9.86e-01 | 2.90e+00 | 1.34e-03 | Male-biased |
| PCPG | HOXA9 | BCAR3 | 4.41e+00 | 9.87e-01 | 3.45e+00 | 4.85e-03 | Male-biased |
| PCPG | HOXB7 | BCAR3 | 4.15e+00 | 9.80e-01 | 3.28e+00 | 7.29e-03 | Male-biased |
| PCPG | HOXC10 | BCAR3 | 4.01e+00 | 9.82e-01 | 2.89e+00 | 2.26e-03 | Male-biased |
| PCPG | LMX1B | BCAR3 | 3.96e+00 | 9.82e-01 | 2.76e+00 | 1.47e-03 | Male-biased |
| PCPG | MEIS1 | BCAR3 | 4.34e+00 | 9.80e-01 | 3.54e+00 | 1.04e-02 | Male-biased |
| PCPG | NKX3-1 | BCAR3 | 4.31e+00 | 9.88e-01 | 3.14e+00 | 1.87e-03 | Male-biased |
| PCPG | POU3F1 | BCAR3 | 4.86e+00 | 9.80e-01 | 4.16e+00 | 1.56e-02 | Male-biased |
| PCPG | POU3F2 | BCAR3 | 3.86e+00 | 9.80e-01 | 2.54e+00 | 7.76e-04 | Male-biased |
| PCPG | POU4F1 | BCAR3 | 4.10e+00 | 9.85e-01 | 2.93e+00 | 1.79e-03 | Male-biased |
| PCPG | POU4F2 | BCAR3 | 3.97e+00 | 9.82e-01 | 2.84e+00 | 2.05e-03 | Male-biased |
| PCPG | POU4F3 | BCAR3 | 4.12e+00 | 9.84e-01 | 3.06e+00 | 3.06e-03 | Male-biased |
| PCPG | UNCX | BCAR3 | 4.36e+00 | 9.87e-01 | 3.34e+00 | 3.73e-03 | Male-biased |
| PCPG | ZNF354B | BCAR3 | 4.10e+00 | 9.83e-01 | 3.05e+00 | 3.15e-03 | Male-biased |
| PCPG | ZNF418 | BCAR3 | 4.14e+00 | 9.88e-01 | 2.21e+00 | 3.05e-05 | Male-biased |
| PCPG | ZNF580 | BCAR3 | 4.25e+00 | 9.87e-01 | 3.12e+00 | 2.30e-03 | Male-biased |
| PCPG | ZNF79 | BCAR3 | 4.07e+00 | 9.86e-01 | 2.39e+00 | 1.18e-04 | Male-biased |
| UVM | ZNF418 | BCAR3 | 4.08e+00 | 1.42e-02 | 5.21e+00 | 9.81e-01 | Female-biased |
BCAR3 related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for BCAR3 |
RBPs related to ES in BCAR3.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | RBM5 | exon_skip_28555 | 9.09e+00 | 6.20e-03 | 9.46e+00 | 9.91e-01 | Female-biased |
| CHOL | RBM5 | exon_skip_28555 | 9.37e+00 | 9.80e-01 | 9.02e+00 | 1.62e-02 | Male-biased |
BCAR3 related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10923084 | chr1:88495193:T:G | - | 0.0518491265119135 | 0.024481009510822 | LGG | Female-baised eQTL |
| rs11806923 | chr1:88498131:C:G | - | 0.0514970561616773 | 0.025708721465568 | LGG | Female-baised eQTL |
| rs11806920 | chr1:88498088:C:T | - | 0.0515633638810745 | 0.0258528181121352 | LGG | Female-baised eQTL |
| rs4615892 | chr1:95081667:C:T | - | 0.061215690547973 | 0.0263446146331331 | LGG | Female-baised eQTL |
| rs10923085 | chr1:88496741:T:C | - | 0.0503971230374379 | 0.031794209125251 | LGG | Female-baised eQTL |
| rs72733606 | chr1:102069495:C:T | - | 0.10126761726055 | 0.0329682278950118 | LGG | Female-baised eQTL |
| rs6696199 | chr1:88509695:G:A | - | 0.0496922876194422 | 0.0346372923680305 | LGG | Female-baised eQTL |
| rs306325 | chr1:88494551:G:T | - | 0.0476775161894595 | 0.0487317486003878 | LGG | Female-baised eQTL |
| rs4294437 | chr1:101188540:A:C | - | 0.0980403331646316 | 0.0316397219960823 | KIRC | Female-baised eQTL |
| rs2153849 | chr1:95836262:A:G | - | -0.0807296640906413 | 0.00722659726991519 | COAD | Female-baised eQTL |
| rs1578686 | chr1:95839128:T:G | - | -0.0807296640906413 | 0.00722659726991519 | COAD | Female-baised eQTL |
| rs7515746 | chr1:95840979:A:G | - | -0.0807296640906413 | 0.00722659726991519 | COAD | Female-baised eQTL |
| rs10783025 | chr1:95853822:G:A | - | -0.0804824703014197 | 0.00764603714884252 | COAD | Female-baised eQTL |
| rs9324358 | chr1:95831422:A:G | - | -0.0803477748107246 | 0.00785110396322129 | COAD | Female-baised eQTL |
| rs10783024 | chr1:95853756:C:G | - | -0.0801990181660758 | 0.00814282837825213 | COAD | Female-baised eQTL |
| rs11165497 | chr1:95836772:C:T | - | -0.0792872855866189 | 0.00840324418751012 | COAD | Female-baised eQTL |
| rs1935570 | chr1:95832120:G:C | - | -0.075597629509002 | 0.0149854279118819 | COAD | Female-baised eQTL |
| rs6593686 | chr1:95830870:G:A | - | -0.0752086602100844 | 0.0161102541634316 | COAD | Female-baised eQTL |
| rs6421760 | chr1:95830894:C:T | - | -0.0711151184072915 | 0.0181582014364839 | COAD | Female-baised eQTL |
| rs6677557 | chr1:98967821:C:T | - | 0.0704440534891969 | 0.0266505500721565 | COAD | Female-baised eQTL |
| rs10489923 | chr1:98977202:T:G | - | 0.0713896808463892 | 0.0334750654230273 | COAD | Female-baised eQTL |
| rs1458628 | chr1:96082512:G:A | - | 0.102716456764217 | 0.0374093971140161 | COAD | Female-baised eQTL |
| rs112895877 | chr1:96084044:C:T | - | 0.102716456764217 | 0.0374093971140161 | COAD | Female-baised eQTL |
| rs17422145 | chr1:96098014:C:T | - | 0.102716456764217 | 0.0374093971140161 | COAD | Female-baised eQTL |
| rs12087953 | chr1:98984433:G:T | - | 0.0672787441628999 | 0.0403185169094484 | COAD | Female-baised eQTL |
| rs6577289 | chr1:98988814:T:C | - | 0.0672787441628999 | 0.0403185169094484 | COAD | Female-baised eQTL |
| rs12084089 | chr1:98989931:A:G | - | 0.0672787441628999 | 0.0403185169094484 | COAD | Female-baised eQTL |
| rs12042547 | chr1:98992014:T:C | - | 0.0672787441628999 | 0.0403185169094484 | COAD | Female-baised eQTL |
| rs17119315 | chr1:98969065:A:G | - | 0.0671137384726508 | 0.0415689173960662 | COAD | Female-baised eQTL |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6670828 | chr1:101777237:T:C | - | 0.12980315989423 | 0.00978829777769425 | READ | Male-baised eQTL |
| rs6668436 | chr1:101777348:A:G | - | 0.12980315989423 | 0.00978829777769425 | READ | Male-baised eQTL |
| rs6668441 | chr1:101777361:A:G | - | 0.12980315989423 | 0.00978829777769425 | READ | Male-baised eQTL |
| rs9787216 | chr1:96646641:A:T | - | -0.146012170545407 | 0.0301267586449817 | GBM | Male-baised eQTL |
| rs2132423 | chr1:96636397:A:G | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs2132424 | chr1:96636402:T:C | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs2132426 | chr1:96637094:T:C | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs4950000 | chr1:96637306:C:T | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs4950001 | chr1:96637439:T:C | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs4950003 | chr1:96638261:C:G | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs1325757 | chr1:96641361:T:G | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs1325755 | chr1:96641449:A:G | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs4141995 | chr1:96642346:C:T | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs7531641 | chr1:96643912:A:G | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs1359554 | chr1:96644658:G:A | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs1359553 | chr1:96644666:G:A | - | -0.143951374806552 | 0.0368314096074651 | GBM | Male-baised eQTL |
| rs77029442 | chr1:86854354:A:T | - | 0.0750107496138159 | 0.0258440505474034 | STAD | Male-baised eQTL |
| rs17357686 | chr1:86851159:C:T | - | 0.0731293132607615 | 0.0298156671584624 | STAD | Male-baised eQTL |
| rs74953568 | chr1:86851312:G:A | - | 0.0731293132607615 | 0.0298156671584624 | STAD | Male-baised eQTL |
| rs7525266 | chr1:86854714:G:A | - | 0.0731293132607615 | 0.0298156671584624 | STAD | Male-baised eQTL |
| rs28661447 | chr1:94869171:C:T | - | 0.120806044222738 | 0.0084830666768823 | KIRC | Male-baised eQTL |
| rs17112588 | chr1:94869852:A:T | - | 0.111047545389542 | 0.0138870503450404 | KIRC | Male-baised eQTL |
| rs34705125 | chr1:99744510:G:C | - | 0.0966183183086558 | 0.0311111483706755 | KIRC | Male-baised eQTL |
| rs12750612 | chr1:99744578:G:A | - | 0.0966183183086558 | 0.0311111483706755 | KIRC | Male-baised eQTL |
| rs6661181 | chr1:94887008:A:G | - | 0.105381657060983 | 0.0400950797467281 | KIRC | Male-baised eQTL |
| rs116723647 | chr1:94885012:G:A | - | 0.10371317255184 | 0.0423378128345498 | KIRC | Male-baised eQTL |
| rs114538095 | chr1:94885016:C:A | - | 0.10371317255184 | 0.0423378128345498 | KIRC | Male-baised eQTL |
| rs9432612 | chr1:94899620:C:T | - | 0.104223041116289 | 0.0451395863247438 | KIRC | Male-baised eQTL |
| rs76525019 | chr1:94900876:A:C | - | 0.104223041116289 | 0.0451395863247438 | KIRC | Male-baised eQTL |
| rs116127473 | chr1:94901919:C:T | - | 0.104223041116289 | 0.0451395863247438 | KIRC | Male-baised eQTL |
| rs9324135 | chr1:84781985:G:A | - | 0.0449913643227294 | 0.0307493809771161 | LUAD | Male-baised eQTL |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00116430 | chr1:93722712 | gene | -0.38977369788932 | 9.38497996273202e-06 | -0.3704466394557434 | 6.195792051759034e-08 | KIRP |
| cg24937735 | chr1:93779670 | gene | -0.38977369788932 | 9.38497996273202e-06 | -0.3704466394557434 | 6.195792051759034e-08 | KIRP |
| cg02922879 | chr1:93804571 | gene | -0.14492987412112 | 5.39146534956891e-07 | -0.39469418287956926 | 2.3630662535945256e-09 | STAD |
| cg17274827 | chr1:93609998 | gene | -0.397676398472918 | 1.16626764121159e-07 | -0.37498746954026 | 3.50648661452185e-11 | SKCM |
| cg05941840 | chr1:93608477 | gene | -0.397560667533039 | 1.17823804397526e-07 | -0.37512778065342434 | 3.72098029953545e-11 | SKCM |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg24937735 | chr1:93779670 | gene | -0.193907253164705 | 1.8687536949571e-05 | -0.3335892466529732 | 4.816325883529697e-08 | LUAD |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of BCAR3 |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000137936 | BCAR3 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0013146 | Drug abuse | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0013170 | Drug habituation | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0013222 | Drug Use Disorders | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0038580 | Substance Dependence | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0038586 | Substance Use Disorders | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C0740858 | Substance abuse problem | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C1510472 | Drug Dependence | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
| ENSG00000137936 | BCAR3 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |