SexAnnoDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structure and Gene expression level

leaf

Sex-biased somatic mutation

leaf

DNA methylation with beta values in gene

leaf

Exon skipping events with PSI in TCGA

leaf

RNA A-to-I editing events in TCGA

leaf

Sex-biased TF-Gene network of gene

leaf

Sex-biased RBP-ES network of gene

leaf

Sex-biased CeRNA regulation of gene

leaf

Sex-biased eQTL regulation of gene

leaf

Sex-biased eQTM regulation of gene

leaf

Sex-biased sQTL regulation of gene

leaf

Sex-biased sQTM regulation of gene

leaf

Related disease information of gene

Gene: ENSG00000136457

Summary for CHAD

check button Gene summary

Gene informationEnsembl ID

ENSG00000136457

Gene symbol

CHAD

Gene namechondroadherin
HGNC

1909

Entrez ID

1101

Gene typeprotein_coding
SynonymsCHAD|SLRR4A
UniProtAcc

O15335


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

Top

Structure and expression level for CHAD

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
CHAD8.20e+011.22e+005.32e-012.29e+002.23e-024.71e-02BLCA
CHAD2.33e+02-3.23e+006.67e-01-4.84e+001.27e-062.93e-05ESCA
CHAD5.69e+02-3.68e+006.77e-01-5.43e+005.54e-085.31e-07CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
CHAD6.37e+01-3.17e+003.19e-01-9.95e+002.41e-236.09e-22COAD
CHAD2.31e+031.50e+002.19e-016.85e+007.25e-121.70e-11BRCA

Top

Sex-biased somatic mutation for CHAD

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

Top

DNA methylation with beta values for CHAD

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg15506894chr17:50468444CGI:chr17:50468209-50469539promoter,exon,CDS,gene body5.15e-013.89e-011.99e+004.69e-024.88e-021.26e-01
SARCcg25792518chr17:50468589CGI:chr17:50468209-50469539promoter,exon,CDS,gene body5.11e-013.77e-013.15e+001.64e-035.10e-031.34e-01
MESOcg22627841chr17:50468897CGI:chr17:50468209-50469539UTR,promoter,exon,gene body2.28e-013.65e-01-2.13e+003.29e-024.55e-02-1.37e-01
MESOcg15880760chr17:50468929CGI:chr17:50468209-50469539UTR,promoter,exon,gene body2.29e-013.41e-01-2.08e+003.78e-024.71e-02-1.12e-01
MESOcg19046826chr17:50468936CGI:chr17:50468209-50469539UTR,promoter,exon,gene body2.04e-013.26e-01-2.04e+004.11e-024.79e-02-1.22e-01
MESOcg05180443chr17:50469193CGI:chr17:50468209-50469539promoter1.47e-012.53e-01-2.18e+002.93e-024.40e-02-1.06e-01
MESOcg06958829chr17:50468757CGI:chr17:50468209-50469539promoter,exon,CDS,gene body3.60e-014.76e-01-2.30e+002.12e-023.95e-02-1.16e-01
MESOcg17890928chr17:50468832CGI:chr17:50468209-50469539UTR,promoter,exon,gene body2.09e-013.21e-01-2.38e+001.71e-023.65e-02-1.12e-01
ACCcg22627841chr17:50468897CGI:chr17:50468209-50469539UTR,promoter,exon,gene body4.09e-015.54e-01-2.25e+002.45e-023.84e-02-1.45e-01
CHOLcg25792518chr17:50468589CGI:chr17:50468209-50469539promoter,exon,CDS,gene body8.40e-017.21e-012.10e+003.56e-024.34e-021.19e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
THCAcg09576319chr17:50467363CGI:chr17:50468209-50469539promoter,gene body7.73e-016.57e-013.62e+002.95e-041.29e-031.16e-01
COADcg25792518chr17:50468589CGI:chr17:50468209-50469539promoter,exon,CDS,gene body8.51e-017.48e-013.18e+001.47e-033.07e-031.03e-01
COADcg19961043chr17:50469070CGI:chr17:50468209-50469539promoter6.28e-015.20e-013.69e+002.21e-046.61e-041.08e-01
COADcg05180443chr17:50469193CGI:chr17:50468209-50469539promoter5.75e-014.42e-013.64e+002.73e-047.84e-041.33e-01
COADcg06958829chr17:50468757CGI:chr17:50468209-50469539promoter,exon,CDS,gene body7.35e-016.29e-013.64e+002.73e-047.84e-041.06e-01
COADcg06818777chr17:50469259CGI:chr17:50468209-50469539promoter5.79e-014.66e-013.74e+001.87e-045.77e-041.13e-01
BLCAcg15506894chr17:50468444CGI:chr17:50468209-50469539promoter,exon,CDS,gene body8.70e-017.28e-013.91e+009.24e-053.78e-041.41e-01
ESCAcg25792518chr17:50468589CGI:chr17:50468209-50469539promoter,exon,CDS,gene body6.84e-014.52e-012.52e+001.17e-023.69e-022.32e-01
ESCAcg15880760chr17:50468929CGI:chr17:50468209-50469539UTR,promoter,exon,gene body4.65e-013.53e-012.05e+004.09e-024.70e-021.12e-01
ESCAcg19046826chr17:50468936CGI:chr17:50468209-50469539UTR,promoter,exon,gene body4.63e-013.43e-012.14e+003.20e-024.44e-021.20e-01
ESCAcg10421979chr17:50468960CGI:chr17:50468209-50469539UTR,promoter,exon,gene body4.66e-013.25e-012.16e+003.05e-024.39e-021.41e-01
ESCAcg19961043chr17:50469070CGI:chr17:50468209-50469539promoter4.12e-012.02e-012.48e+001.31e-023.74e-022.10e-01
ESCAcg13764778chr17:50469142CGI:chr17:50468209-50469539promoter5.00e-012.70e-012.14e+003.20e-024.44e-022.29e-01
ESCAcg05180443chr17:50469193CGI:chr17:50468209-50469539promoter4.30e-011.65e-012.87e+004.12e-033.39e-022.65e-01
ESCAcg17890928chr17:50468832CGI:chr17:50468209-50469539UTR,promoter,exon,gene body4.80e-012.92e-012.28e+002.24e-024.12e-021.88e-01
ESCAcg06818777chr17:50469259CGI:chr17:50468209-50469539promoter4.71e-012.85e-012.97e+002.99e-033.38e-021.86e-01
CHOLcg25792518chr17:50468589CGI:chr17:50468209-50469539promoter,exon,CDS,gene body7.21e-013.81e-012.88e+004.04e-031.47e-023.40e-01
CHOLcg15506894chr17:50468444CGI:chr17:50468209-50469539promoter,exon,CDS,gene body8.70e-016.93e-012.73e+006.38e-031.82e-021.77e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg22627841chr17:50468897CGI:chr17:50468209-50469539UTR,promoter,exon,gene body2.12e-016.96e-023.38e+007.17e-049.59e-041.42e-01
BRCAcg15880760chr17:50468929CGI:chr17:50468209-50469539UTR,promoter,exon,gene body2.26e-011.04e-014.65e+003.40e-065.98e-061.21e-01
BRCAcg19046826chr17:50468936CGI:chr17:50468209-50469539UTR,promoter,exon,gene body1.96e-016.44e-023.77e+001.66e-042.41e-041.32e-01
BRCAcg10421979chr17:50468960CGI:chr17:50468209-50469539UTR,promoter,exon,gene body1.87e-015.87e-022.59e+009.61e-031.09e-021.28e-01
BRCAcg19961043chr17:50469070CGI:chr17:50468209-50469539promoter1.68e-013.45e-023.22e+001.28e-031.65e-031.34e-01
BRCAcg13764778chr17:50469142CGI:chr17:50468209-50469539promoter2.32e-011.02e-012.30e+002.15e-022.30e-021.31e-01
BRCAcg05180443chr17:50469193CGI:chr17:50468209-50469539promoter2.14e-016.71e-022.98e+002.86e-033.52e-031.47e-01
BRCAcg09576319chr17:50467363CGI:chr17:50468209-50469539promoter,gene body8.02e-019.07e-01-7.63e+002.37e-148.21e-14-1.05e-01
BRCAcg15506894chr17:50468444CGI:chr17:50468209-50469539promoter,exon,CDS,gene body5.15e-016.32e-01-6.04e+001.55e-093.70e-09-1.17e-01
BRCAcg06958829chr17:50468757CGI:chr17:50468209-50469539promoter,exon,CDS,gene body3.00e-011.86e-012.76e+005.72e-036.71e-031.13e-01
BRCAcg17890928chr17:50468832CGI:chr17:50468209-50469539UTR,promoter,exon,gene body2.15e-019.13e-024.51e+006.43e-061.10e-051.24e-01
LIHCcg15880760chr17:50468929CGI:chr17:50468209-50469539UTR,promoter,exon,gene body6.07e-015.02e-014.85e+001.24e-061.54e-051.05e-01
LIHCcg19046826chr17:50468936CGI:chr17:50468209-50469539UTR,promoter,exon,gene body6.18e-015.06e-014.75e+002.05e-062.19e-051.12e-01
LIHCcg10421979chr17:50468960CGI:chr17:50468209-50469539UTR,promoter,exon,gene body6.23e-015.12e-014.55e+005.25e-064.30e-051.11e-01
LIHCcg06818777chr17:50469259CGI:chr17:50468209-50469539promoter6.04e-014.99e-014.00e+006.44e-052.76e-041.05e-01

Top

Exon skipping events with PSI in TCGA for CHAD

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

Top

RNA A-to-I editing events in TCGA for CHAD

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

Top

Sex-biased TF-Gene network for CHAD

check buttonTFs related to CHAD.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
UVMZNF235CHAD4.44e+009.83e-011.53e+001.88e-04Male-biased
UVMZNF287CHAD4.46e+009.83e-011.74e+003.27e-04Male-biased
UVMZNF879CHAD4.41e+009.82e-011.31e+001.07e-04Male-biased

check buttonCHAD related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

Top

Sex-biased RBP-ES network for CHAD

check buttonRBPs related to ES in CHAD.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonCHAD related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

Top

Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

Top

Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs12602493chr17:41061195:T:C-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs76044633chr17:41061453:A:G-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs76228597chr17:41062054:T:C-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs74421445chr17:41062061:A:G-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs77525318chr17:41062120:C:T-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs75476906chr17:41062365:T:A-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs113631986chr17:41062447:A:G-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs75363163chr17:41062553:G:A-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs111513610chr17:41062776:G:T-0.04067977422190330.00954295653503451LUADFemale-baised eQTL
rs113397060chr17:41059833:C:T-0.03986405252088760.0114369927243728LUADFemale-baised eQTL
rs2004600chr17:57742429:G:A-0.03637392330663810.0133389792997069LUADFemale-baised eQTL
rs12453194chr17:41053203:C:T-0.0391208309018580.0133720596117702LUADFemale-baised eQTL
rs2958950chr17:54853060:A:G-0.03414656514712350.0255885242034597LUADFemale-baised eQTL
rs2958946chr17:54858322:A:G-0.03319471621415150.0311580143230572LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs72628303chr17:42481967:G:A-0.1167280410640680.0427615579566847SARCMale-baised eQTL
rs75848506chr17:58189912:G:A-0.1445416524605270.0462713616914402LIHCMale-baised eQTL
rs1317254chr17:43577832:T:C-0.05016067568802510.0378407886159187LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

Top

Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000136457
CpG Site: cg06958829
Position to Gene: gene,exon,CDS,promoter
Male Effect: -
Female Effect: -0.10021724326041
eQTM boxplot analysisGene ID: ENSG00000136457
CpG Site: cg25792518
Position to Gene: gene,exon,CDS,promoter
Male Effect: -
Female Effect: -0.0944703831545115
eQTM boxplot analysisGene ID: ENSG00000136457
CpG Site: cg06958829
Position to Gene: gene,exon,CDS,promoter
Male Effect: -
Female Effect: -0.0729614357846166
eQTM boxplot analysisGene ID: ENSG00000136457
CpG Site: cg15506894
Position to Gene: gene,exon,CDS,promoter
Male Effect: -
Female Effect: -0.228253176484858

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg06958829chr17:50468757gene,exon,CDS,promoter-0.100217243260416.90436072943305e-10-0.424583477143023971.3926534198116438e-12LUAD
cg25792518chr17:50468589gene,exon,CDS,promoter-0.09447038315451153.7875709237743e-10-0.51560043428297131.5165040065628074e-13SKCM
cg06958829chr17:50468757gene,exon,CDS,promoter-0.07296143578461661.42493893050272e-07-0.455240206479424041.5280233432494978e-10SKCM
cg15506894chr17:50468444gene,exon,CDS,promoter-0.2282531764848584.0409903505943e-05-0.38747064731000158.39153066717708e-08SKCM

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

Top

Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

Top

Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

Top

Related disease information of CHAD

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource