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Gene: ENSG00000136158 |
Summary for SPRY2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000136158 | Gene symbol | SPRY2 |
| Gene name | sprouty RTK signaling antagonist 2 | |
| HGNC | 11270 | |
| Entrez ID | 10253 | |
| Gene type | protein_coding | |
| Synonyms | SPRY2|hSPRY2 | |
| UniProtAcc | O43597 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SPRY2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SPRY2 | 7.27e+02 | -1.25e+00 | 3.19e-01 | -3.92e+00 | 9.03e-05 | 1.91e-03 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SPRY2 | 9.76e+02 | -1.06e+00 | 2.03e-01 | -5.23e+00 | 1.69e-07 | 7.11e-07 | HNSC |
| SPRY2 | 7.95e+02 | -1.42e+00 | 3.91e-01 | -3.65e+00 | 2.65e-04 | 1.05e-03 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SPRY2 | 1.03e+03 | -2.44e+00 | 1.05e-01 | -2.32e+01 | 2.47e-119 | 1.48e-117 | BRCA |
Top |
Sex-biased somatic mutation for SPRY2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SPRY2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg08421519 | chr13:80339313 | CGI:chr13:80339022-80339326 | UTR,promoter,exon,gene body | 3.12e-01 | 1.75e-01 | 5.01e+00 | 5.55e-07 | 1.06e-06 | 1.36e-01 |
Top |
Exon skipping events with PSI in TCGA for SPRY2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SPRY2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SPRY2 |
| TFs related to SPRY2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | PRDM6 | SPRY2 | 4.28e+00 | 9.85e-01 | 3.27e+00 | 5.40e-03 | Male-biased |
| DLBC | ZNF287 | SPRY2 | 4.51e+00 | 9.89e-01 | 3.41e+00 | 4.05e-03 | Male-biased |
| DLBC | ZNF487 | SPRY2 | 4.44e+00 | 9.88e-01 | 3.39e+00 | 4.73e-03 | Male-biased |
| SPRY2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SPRY2 |
| RBPs related to ES in SPRY2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SPRY2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000136158 | AC073254.1,hsa-mir-340,SPRY2 | Male-specific ceRNA | TCGA-BLCA |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs112096205 | chr13:70340878:G:A | - | 0.254618731804803 | 0.0017295648592478 | HNSC | Female-baised eQTL |
| rs77857797 | chr13:70342616:G:T | - | 0.254618731804803 | 0.0017295648592478 | HNSC | Female-baised eQTL |
| rs66629785 | chr13:70344888:C:A | - | 0.168048951269785 | 0.0348140475852662 | HNSC | Female-baised eQTL |
| rs66740192 | chr13:70351116:G:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs17086822 | chr13:70351688:G:A | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs59988209 | chr13:70351858:C:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs17086842 | chr13:70352108:T:C | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs55797989 | chr13:70352563:G:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs59966760 | chr13:70352598:A:C | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs58593035 | chr13:70352739:C:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs73206585 | chr13:70354861:A:C | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs57467508 | chr13:70357873:T:A | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs73509285 | chr13:70359171:A:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs73206588 | chr13:70359653:G:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs17086891 | chr13:70359802:C:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs67988251 | chr13:70361859:T:C | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs67516771 | chr13:70361940:A:G | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs66887781 | chr13:70362238:G:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs55978302 | chr13:70362508:C:A | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs17086923 | chr13:70363618:C:T | - | 0.161168632527656 | 0.0437582186046992 | HNSC | Female-baised eQTL |
| rs7989310 | chr13:87509884:C:G | - | 0.194019404683657 | 0.0170494749358947 | KIRP | Female-baised eQTL |
| rs6562676 | chr13:71581650:A:G | - | 0.184573480151671 | 0.00127329821823472 | KIRC | Female-baised eQTL |
| rs9652245 | chr13:76741237:A:G | - | 0.308234410990459 | 1.50054292979457e-05 | BLCA | Female-baised eQTL |
| rs9593124 | chr13:75739388:G:A | - | 0.117016257407602 | 0.0429670325174028 | BLCA | Female-baised eQTL |
| rs17706535 | chr13:75760973:A:G | - | 0.116796236531742 | 0.0435304786673084 | BLCA | Female-baised eQTL |
| rs73226589 | chr13:79077813:T:C | - | 0.0720473527930664 | 0.00325082923110925 | LUAD | Female-baised eQTL |
| rs73226563 | chr13:79033307:C:T | - | 0.0752409101227626 | 0.00369715452469385 | LUAD | Female-baised eQTL |
| rs73226575 | chr13:79043103:C:T | - | 0.0716556170547374 | 0.00471572983455474 | LUAD | Female-baised eQTL |
| rs2329105 | chr13:79032561:G:A | - | -0.0713305502950046 | 0.00662271884406562 | LUAD | Female-baised eQTL |
| rs1372180 | chr13:79023775:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1372181 | chr13:79023851:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs2165465 | chr13:79024120:G:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs9601159 | chr13:79024410:G:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs9593366 | chr13:79024439:T:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1441257 | chr13:79024527:G:A | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1975415 | chr13:79025416:G:A | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1975416 | chr13:79025417:T:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs7991135 | chr13:79025679:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs7991177 | chr13:79025780:A:G | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs2119542 | chr13:79026441:A:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs2119543 | chr13:79026502:A:G | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs2165466 | chr13:79026615:G:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1811440 | chr13:79026951:A:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs920533 | chr13:79027157:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs2044011 | chr13:79027385:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1036745 | chr13:79027566:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1036746 | chr13:79027786:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs984909 | chr13:79028138:G:A | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1319622 | chr13:79028287:G:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1822152 | chr13:79028364:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1822153 | chr13:79028616:G:A | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs1372182 | chr13:79028961:C:T | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs9530849 | chr13:79029506:T:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs9530850 | chr13:79029510:T:C | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs9544970 | chr13:79029747:A:G | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs4379956 | chr13:79032736:G:A | - | -0.0708592379660492 | 0.00728060620923503 | LUAD | Female-baised eQTL |
| rs17070838 | chr13:79109998:G:A | - | 0.0652911215625351 | 0.00766519048224206 | LUAD | Female-baised eQTL |
| rs73228414 | chr13:79113358:A:G | - | 0.0652911215625351 | 0.00766519048224206 | LUAD | Female-baised eQTL |
| rs146165645 | chr13:79114599:T:C | - | 0.0652911215625351 | 0.00766519048224206 | LUAD | Female-baised eQTL |
| rs73228415 | chr13:79115465:T:C | - | 0.0652911215625351 | 0.00766519048224206 | LUAD | Female-baised eQTL |
| rs7324350 | chr13:79108202:C:T | - | 0.0651044286627143 | 0.00801839755890105 | LUAD | Female-baised eQTL |
| rs17070828 | chr13:79108429:C:A | - | 0.0651044286627143 | 0.00801839755890105 | LUAD | Female-baised eQTL |
| rs17070831 | chr13:79108748:G:T | - | 0.0651044286627143 | 0.00801839755890105 | LUAD | Female-baised eQTL |
| rs79896538 | chr13:85907192:C:T | - | 0.0414495873133136 | 0.00982595021998351 | LUAD | Female-baised eQTL |
| rs11839750 | chr13:85908419:A:G | - | 0.0414495873133136 | 0.00982595021998351 | LUAD | Female-baised eQTL |
| rs12100363 | chr13:85909317:G:T | - | 0.0414495873133136 | 0.00982595021998351 | LUAD | Female-baised eQTL |
| rs17080277 | chr13:85910364:C:A | - | 0.0414495873133136 | 0.00982595021998351 | LUAD | Female-baised eQTL |
| rs17611014 | chr13:85910586:A:G | - | 0.0414495873133136 | 0.00982595021998351 | LUAD | Female-baised eQTL |
| rs74654635 | chr13:85911747:T:C | - | 0.0414495873133136 | 0.00982595021998351 | LUAD | Female-baised eQTL |
| rs11842905 | chr13:85921800:A:T | - | 0.0436329987202483 | 0.0106636028323545 | LUAD | Female-baised eQTL |
| rs138658073 | chr13:85917099:G:A | - | 0.0410442492004121 | 0.0111870574322609 | LUAD | Female-baised eQTL |
| rs2026126 | chr13:85918899:C:T | - | 0.0410442492004121 | 0.0111870574322609 | LUAD | Female-baised eQTL |
| rs374001646 | chr13:75709481:A:T | - | 0.0598626773389021 | 0.0117862004923836 | LUAD | Female-baised eQTL |
| rs17066901 | chr13:76905191:C:T | - | 0.0565326825494271 | 0.0129813960409377 | LUAD | Female-baised eQTL |
| rs56985807 | chr13:76905821:C:A | - | 0.0565326825494271 | 0.0129813960409377 | LUAD | Female-baised eQTL |
| rs66558433 | chr13:78137637:G:A | - | 0.0458674878350857 | 0.0133105938496328 | LUAD | Female-baised eQTL |
| rs75360564 | chr13:90322876:T:C | - | 0.0536347969868193 | 0.0160846678427396 | LUAD | Female-baised eQTL |
| rs75165634 | chr13:90324431:C:A | - | 0.0535505768191973 | 0.0164444547776566 | LUAD | Female-baised eQTL |
| rs17526310 | chr13:85908986:G:A | - | 0.0417069700028497 | 0.0169084036813702 | LUAD | Female-baised eQTL |
| rs113560002 | chr13:85913926:A:G | - | 0.0417069700028497 | 0.0169084036813702 | LUAD | Female-baised eQTL |
| rs138648952 | chr13:79107484:G:A | - | 0.0598573462449458 | 0.0172283595425047 | LUAD | Female-baised eQTL |
| rs11843840 | chr13:85911387:G:T | - | 0.0412856368847185 | 0.0189995553017476 | LUAD | Female-baised eQTL |
| rs78370388 | chr13:85930766:T:C | - | 0.0410772943159098 | 0.0191112043062182 | LUAD | Female-baised eQTL |
| rs140160727 | chr13:85932836:G:A | - | 0.0410808577921118 | 0.0224758995752613 | LUAD | Female-baised eQTL |
| rs9522593 | chr13:89612870:T:G | - | 0.0427612456611213 | 0.0230150268408869 | LUAD | Female-baised eQTL |
| rs79697990 | chr13:90319669:C:G | - | 0.0501359811394859 | 0.0249155655897777 | LUAD | Female-baised eQTL |
| rs79305834 | chr13:90315276:C:G | - | 0.0500867859093927 | 0.0253120102989887 | LUAD | Female-baised eQTL |
| rs12873196 | chr13:78137538:T:G | - | 0.0413543976612173 | 0.0297787777191727 | LUAD | Female-baised eQTL |
| rs12877533 | chr13:78138671:G:A | - | 0.0413543976612173 | 0.0297787777191727 | LUAD | Female-baised eQTL |
| rs9522597 | chr13:89636126:T:C | - | 0.043752961179207 | 0.0329836499057438 | LUAD | Female-baised eQTL |
| rs68153755 | chr13:79071135:G:T | - | 0.0542700784487625 | 0.0382408507579 | LUAD | Female-baised eQTL |
| rs58566379 | chr13:76857150:C:G | - | 0.0486523753515103 | 0.0383391778712755 | LUAD | Female-baised eQTL |
| rs61966437 | chr13:79142953:G:A | - | 0.0540842533470179 | 0.0388235687380785 | LUAD | Female-baised eQTL |
| rs61966438 | chr13:79143820:C:T | - | 0.0540842533470179 | 0.0388235687380785 | LUAD | Female-baised eQTL |
| rs168556 | chr13:85837720:C:T | - | 0.0335053302064195 | 0.0419503945066617 | LUAD | Female-baised eQTL |
| rs73544577 | chr13:76859928:G:A | - | 0.0468248516547424 | 0.0460951014054144 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9318778 | chr13:81504783:A:T | - | 0.169510700070757 | 0.0429068510537986 | READ | Male-baised eQTL |
| rs17385387 | chr13:76943184:C:A | - | 0.0937762265332475 | 0.0109556014536406 | LIHC | Male-baised eQTL |
| rs7321339 | chr13:76788623:G:A | - | 0.0631910541190498 | 0.0238365205471431 | LIHC | Male-baised eQTL |
| rs6562966 | chr13:76785160:C:A | - | 0.0597424294170775 | 0.04847146091365 | LIHC | Male-baised eQTL |
| rs34993149 | chr13:79678016:G:A | - | 0.0634518920716867 | 0.00561795393246832 | BLCA | Male-baised eQTL |
| rs8001082 | chr13:79660392:C:G | - | 0.0582392304530656 | 0.00829986739565382 | BLCA | Male-baised eQTL |
| rs6563128 | chr13:79660992:T:C | - | 0.0582392304530656 | 0.00829986739565382 | BLCA | Male-baised eQTL |
| rs7335083 | chr13:79661692:T:C | - | 0.0582392304530656 | 0.00829986739565382 | BLCA | Male-baised eQTL |
| rs2329127 | chr13:79671495:C:T | - | 0.0582392304530656 | 0.00829986739565382 | BLCA | Male-baised eQTL |
| rs12872859 | chr13:79675695:C:T | - | 0.0582392304530656 | 0.00829986739565382 | BLCA | Male-baised eQTL |
| rs4506784 | chr13:79677292:A:G | - | 0.0582392304530656 | 0.00829986739565382 | BLCA | Male-baised eQTL |
| rs7999478 | chr13:79657101:C:T | - | 0.0597002108070666 | 0.00850601256206043 | BLCA | Male-baised eQTL |
| rs58360508 | chr13:79660098:A:G | - | 0.0597002108070666 | 0.00850601256206043 | BLCA | Male-baised eQTL |
| rs17071740 | chr13:79666799:T:C | - | 0.0597002108070666 | 0.00850601256206043 | BLCA | Male-baised eQTL |
| rs79337165 | chr13:79667735:C:T | - | 0.0597002108070666 | 0.00850601256206043 | BLCA | Male-baised eQTL |
| rs12583361 | chr13:79676376:C:T | - | 0.0597002108070666 | 0.00850601256206043 | BLCA | Male-baised eQTL |
| rs2208937 | chr13:79667560:T:A | - | 0.0595490529974145 | 0.00885422134677436 | BLCA | Male-baised eQTL |
| rs6563130 | chr13:79678046:A:C | - | 0.0575172019964205 | 0.0121283725047895 | BLCA | Male-baised eQTL |
| rs4335681 | chr13:79677111:T:C | - | 0.0545724259782455 | 0.0134435245221589 | BLCA | Male-baised eQTL |
| rs7324718 | chr13:79644411:T:C | - | 0.0535694521243962 | 0.0171061061346092 | BLCA | Male-baised eQTL |
| rs7329850 | chr13:79645379:C:T | - | 0.0535694521243962 | 0.0171061061346092 | BLCA | Male-baised eQTL |
| rs60407730 | chr13:79648272:T:C | - | 0.0535694521243962 | 0.0171061061346092 | BLCA | Male-baised eQTL |
| rs34629137 | chr13:79654525:T:C | - | 0.0535694521243962 | 0.0171061061346092 | BLCA | Male-baised eQTL |
| rs12874186 | chr13:79647032:T:C | - | 0.054678803926718 | 0.0180126455057852 | BLCA | Male-baised eQTL |
| rs34757198 | chr13:79654719:T:C | - | 0.054678803926718 | 0.0180126455057852 | BLCA | Male-baised eQTL |
| rs12583029 | chr13:79655045:T:A | - | 0.054678803926718 | 0.0180126455057852 | BLCA | Male-baised eQTL |
| rs9564777 | chr13:71084622:C:A | - | 0.0305478321832855 | 0.0243366110459208 | BLCA | Male-baised eQTL |
| rs2181996 | chr13:71073807:A:G | - | 0.0303852917908776 | 0.0253796500935415 | BLCA | Male-baised eQTL |
| rs9572644 | chr13:71075376:G:A | - | 0.0303852917908776 | 0.0253796500935415 | BLCA | Male-baised eQTL |
| rs1011860 | chr13:71078182:A:G | - | 0.0303852917908776 | 0.0253796500935415 | BLCA | Male-baised eQTL |
| rs9592768 | chr13:71079080:G:A | - | 0.0303852917908776 | 0.0253796500935415 | BLCA | Male-baised eQTL |
| rs9599775 | chr13:71081463:A:G | - | 0.0303852917908776 | 0.0253796500935415 | BLCA | Male-baised eQTL |
| rs9572646 | chr13:71082752:C:T | - | 0.0303852917908776 | 0.0253796500935415 | BLCA | Male-baised eQTL |
| rs6563123 | chr13:79614197:T:G | - | 0.0501057181391122 | 0.0289370192328389 | BLCA | Male-baised eQTL |
| rs9572648 | chr13:71091140:G:A | - | 0.0295817052719778 | 0.0328563502692538 | BLCA | Male-baised eQTL |
| rs9564779 | chr13:71092621:C:G | - | 0.0295817052719778 | 0.0328563502692538 | BLCA | Male-baised eQTL |
| rs9572621 | chr13:71038635:G:A | - | 0.0296078828605913 | 0.0373029379744273 | BLCA | Male-baised eQTL |
| rs9572647 | chr13:71082898:G:A | - | 0.0286379083925259 | 0.038513800133547 | BLCA | Male-baised eQTL |
| rs2202566 | chr13:71055844:G:T | - | 0.0294419960743059 | 0.0410231757117282 | BLCA | Male-baised eQTL |
| rs9572635 | chr13:71054153:C:T | - | 0.0293221446281376 | 0.0423548924475208 | BLCA | Male-baised eQTL |
| rs9572627 | chr13:71039829:G:T | - | 0.0291068375198709 | 0.043908862838286 | BLCA | Male-baised eQTL |
| rs9572630 | chr13:71052179:T:C | - | 0.0290736335226649 | 0.045622281766778 | BLCA | Male-baised eQTL |
| rs9572631 | chr13:71052463:A:G | - | 0.0290736335226649 | 0.045622281766778 | BLCA | Male-baised eQTL |
| rs9317979 | chr13:71042061:A:G | - | 0.0289816367264895 | 0.0467545120494632 | BLCA | Male-baised eQTL |
| rs12431206 | chr13:71045706:A:G | - | 0.0289274466632364 | 0.0480769106136443 | BLCA | Male-baised eQTL |
| rs9572656 | chr13:71108537:C:T | - | 0.0288691866960471 | 0.0483626073295611 | BLCA | Male-baised eQTL |
| rs9572657 | chr13:71111074:C:T | - | 0.0288691866960471 | 0.0483626073295611 | BLCA | Male-baised eQTL |
| rs7330310 | chr13:71063513:C:T | - | 0.0286639692917062 | 0.0487518463421705 | BLCA | Male-baised eQTL |
| rs9592766 | chr13:71062329:A:T | - | 0.0289317657845422 | 0.0487722312937837 | BLCA | Male-baised eQTL |
| rs9572623 | chr13:71038830:G:C | - | 0.0288002077642869 | 0.0493428149987865 | BLCA | Male-baised eQTL |
| rs9572624 | chr13:71038976:G:A | - | 0.0288002077642869 | 0.0493428149987865 | BLCA | Male-baised eQTL |
| rs9572632 | chr13:71053059:A:C | - | 0.0288798705413547 | 0.0493517693212471 | BLCA | Male-baised eQTL |
| rs7317800 | chr13:70924460:G:C | - | -0.0710212859482087 | 0.0314336584244532 | LUAD | Male-baised eQTL |
| rs9547281 | chr13:85592069:T:A | - | 0.0752035029000116 | 0.00334260653099414 | COAD | Male-baised eQTL |
| rs34971145 | chr13:85595347:A:T | - | 0.0761920347875066 | 0.00408405314137831 | COAD | Male-baised eQTL |
| rs34227361 | chr13:85603653:T:A | - | 0.0747210016141278 | 0.005764560446477 | COAD | Male-baised eQTL |
| rs36002467 | chr13:85604297:C:T | - | 0.0741236946174305 | 0.0063515451884724 | COAD | Male-baised eQTL |
| rs34500402 | chr13:85607459:G:T | - | 0.0727393814432854 | 0.00873467436324989 | COAD | Male-baised eQTL |
| rs12876735 | chr13:85619073:T:C | - | 0.0701266020527132 | 0.0170312899466902 | COAD | Male-baised eQTL |
| rs9547275 | chr13:85588914:G:A | - | 0.0669109362637114 | 0.0252877793369575 | COAD | Male-baised eQTL |
| rs9547277 | chr13:85589253:C:T | - | 0.0669109362637114 | 0.0252877793369575 | COAD | Male-baised eQTL |
| rs34103441 | chr13:85589323:G:A | - | 0.0669109362637114 | 0.0252877793369575 | COAD | Male-baised eQTL |
| rs9547278 | chr13:85589333:G:A | - | 0.0669109362637114 | 0.0252877793369575 | COAD | Male-baised eQTL |
| rs9547280 | chr13:85589662:G:A | - | 0.0669109362637114 | 0.0252877793369575 | COAD | Male-baised eQTL |
| rs35417943 | chr13:85585901:C:T | - | 0.0676812077382999 | 0.0254994109838364 | COAD | Male-baised eQTL |
| rs9547279 | chr13:85589633:A:T | - | 0.0658668934914387 | 0.0293712777812395 | COAD | Male-baised eQTL |
| rs9318796 | chr13:81726735:T:C | - | 0.0533224666798514 | 0.0399539116781642 | COAD | Male-baised eQTL |
| rs10162188 | chr13:85326833:A:G | - | 0.0484029603811864 | 0.0490015314665375 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000136158 |
| CpG Site: cg00185066 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.373262084117189 | |
 | Gene ID: ENSG00000136158 |
| CpG Site: cg00185066 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.450729873996433 | |
 | Gene ID: ENSG00000136158 |
| CpG Site: cg18607411 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: - | |
| Female Effect: -0.240815580913569 | |
 | Gene ID: ENSG00000136158 |
| CpG Site: cg15374435 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.287512513447877 | |
| Female Effect: - | |
 | Gene ID: ENSG00000136158 |
| CpG Site: cg18607411 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.379333333673825 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15374435 | chr13:80337557 | gene,exon,CDS | -0.287512513447877 | 2.36858592686944e-12 | -0.4529920585664446 | 2.2692039444791557e-15 | LUSC |
| cg18607411 | chr13:80337673 | gene,exon,CDS | -0.379333333673825 | 5.92636843516365e-05 | -0.30241161265119204 | 3.0286091021279254e-07 | LUSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00185066 | chr13:80336628 | gene,exon,UTR | -0.373262084117189 | 5.28001615702523e-12 | -0.7759130361892683 | 7.505473448960595e-16 | KIRP |
| cg00185066 | chr13:80336628 | gene,exon,UTR | -0.450729873996433 | 1.79423187511965e-36 | -0.7364259663111075 | 6.19894531903194e-42 | LUAD |
| cg18607411 | chr13:80337673 | gene,exon,CDS | -0.240815580913569 | 1.04494189270176e-16 | -0.5467825633469402 | 2.7785499289000316e-21 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SPRY2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000136158 | SPRY2 | C0008924 | Cleft upper lip | 1 | CTD_human |
| ENSG00000136158 | SPRY2 | C0008925 | Cleft Palate | 1 | CTD_human |
| ENSG00000136158 | SPRY2 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| ENSG00000136158 | SPRY2 | C0024115 | Lung diseases | 1 | CTD_human |
| ENSG00000136158 | SPRY2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| ENSG00000136158 | SPRY2 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| ENSG00000136158 | SPRY2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| ENSG00000136158 | SPRY2 | C1837218 | Cleft palate, isolated | 1 | CTD_human |
