|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000135916 |
Summary for ITM2C |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000135916 | Gene symbol | ITM2C |
| Gene name | integral membrane protein 2C | |
| HGNC | 6175 | |
| Entrez ID | 81618 | |
| Gene type | protein_coding | |
| Synonyms | ITM2C|BRI3|E25|hRPC.1050_D_4|ITM3|BRICD2C | |
| UniProtAcc | Q9NQX7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ITM2C |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ITM2C | 3.73e+03 | -1.22e+00 | 3.43e-01 | -3.55e+00 | 3.86e-04 | 5.69e-03 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ITM2C | 2.42e+04 | -1.85e+00 | 3.87e-01 | -4.79e+00 | 1.71e-06 | 1.39e-05 | READ |
Top |
Sex-biased somatic mutation for ITM2C |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ITM2C |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg16819369 | chr2:230865019 | CGI:chr2:230864858-230866106 | UTR,promoter,exon,gene body | 1.34e-01 | 2.65e-01 | -2.25e+00 | 2.46e-02 | 3.78e-02 | -1.31e-01 |
| KICH | cg22177286 | chr2:230864252 | CGI:chr2:230864858-230866106 | promoter | 4.86e-01 | 6.30e-01 | -2.04e+00 | 4.18e-02 | 4.72e-02 | -1.44e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg20333027 | chr2:230864262 | CGI:chr2:230864858-230866106 | promoter | 5.11e-01 | 3.92e-01 | 3.41e+00 | 6.48e-04 | 2.29e-03 | 1.19e-01 |
| LIHC | cg04198215 | chr2:230865710 | CGI:chr2:230864858-230866106 | UTR,promoter,exon,gene body | 4.42e-01 | 3.35e-01 | 3.78e+00 | 1.57e-04 | 3.07e-04 | 1.07e-01 |
| CHOL | cg20333027 | chr2:230864262 | CGI:chr2:230864858-230866106 | promoter | 5.70e-01 | 4.64e-01 | 2.58e+00 | 9.87e-03 | 2.15e-02 | 1.06e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg20333027 | chr2:230864262 | CGI:chr2:230864858-230866106 | promoter | 5.46e-01 | 4.37e-01 | 8.40e+00 | 4.33e-17 | 1.85e-16 | 1.09e-01 |
| BRCA | cg04198215 | chr2:230865710 | CGI:chr2:230864858-230866106 | UTR,promoter,exon,gene body | 2.75e-01 | 1.24e-01 | 8.56e+00 | 1.11e-17 | 4.97e-17 | 1.50e-01 |
| BRCA | cg04293526 | chr2:230866073 | CGI:chr2:230864858-230866106 | promoter,gene body | 2.67e-01 | 1.59e-01 | 6.96e+00 | 3.34e-12 | 9.85e-12 | 1.08e-01 |
| LUAD | cg22177286 | chr2:230864252 | CGI:chr2:230864858-230866106 | promoter | 6.01e-01 | 4.92e-01 | 2.62e+00 | 8.75e-03 | 1.43e-02 | 1.09e-01 |
| LUAD | cg20333027 | chr2:230864262 | CGI:chr2:230864858-230866106 | promoter | 5.20e-01 | 3.98e-01 | 3.32e+00 | 8.85e-04 | 2.95e-03 | 1.22e-01 |
| HNSC | cg22177286 | chr2:230864252 | CGI:chr2:230864858-230866106 | promoter | 6.16e-01 | 5.15e-01 | 2.14e+00 | 3.25e-02 | 3.74e-02 | 1.01e-01 |
| HNSC | cg20333027 | chr2:230864262 | CGI:chr2:230864858-230866106 | promoter | 5.24e-01 | 4.23e-01 | 2.53e+00 | 1.13e-02 | 1.99e-02 | 1.00e-01 |
| KIRP | cg22177286 | chr2:230864252 | CGI:chr2:230864858-230866106 | promoter | 7.01e-01 | 5.59e-01 | 2.33e+00 | 2.00e-02 | 2.67e-02 | 1.42e-01 |
| KIRP | cg20333027 | chr2:230864262 | CGI:chr2:230864858-230866106 | promoter | 5.51e-01 | 3.97e-01 | 3.21e+00 | 1.31e-03 | 4.57e-03 | 1.54e-01 |
Top |
Exon skipping events with PSI in TCGA for ITM2C |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ITM2C |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for ITM2C |
| TFs related to ITM2C. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ITM2C related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ITM2C |
| RBPs related to ES in ITM2C. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | BRUNOL6 | exon_skip_334598 | 8.81e+00 | 9.89e-01 | 8.41e+00 | 6.27e-03 | Male-biased |
| KIRP | BRUNOL6 | exon_skip_334598 | 8.74e+00 | 9.83e-01 | 8.42e+00 | 1.10e-02 | Male-biased |
| ITM2C related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10194615 | chr2:231558391:T:C | - | -0.226712544266297 | 0.021221290478659 | KIRP | Female-baised eQTL |
| rs6733018 | chr2:231560565:A:G | - | -0.225234652288862 | 0.0245002432444487 | KIRP | Female-baised eQTL |
| rs12993888 | chr2:231561052:A:G | - | -0.225234652288862 | 0.0245002432444487 | KIRP | Female-baised eQTL |
| rs4973007 | chr2:231562797:T:C | - | -0.225234652288862 | 0.0245002432444487 | KIRP | Female-baised eQTL |
| rs2290275 | chr2:231277016:G:A | - | 0.116594668301076 | 0.0157547464146612 | LUSC | Female-baised eQTL |
| rs6437091 | chr2:233098164:A:G | - | -0.0843737350439862 | 0.0241569729184832 | LUSC | Female-baised eQTL |
| rs7594542 | chr2:233098182:T:C | - | -0.0843737350439862 | 0.0241569729184832 | LUSC | Female-baised eQTL |
| rs80008616 | chr2:231229073:A:G | - | 0.106870302620375 | 0.0264675659396098 | LUSC | Female-baised eQTL |
| rs72984594 | chr2:238561528:G:A | - | 0.144270354499554 | 0.0188358746443504 | STAD | Female-baised eQTL |
| rs56411186 | chr2:238558112:A:C | - | 0.144178465964278 | 0.0195128940082851 | STAD | Female-baised eQTL |
| rs72984524 | chr2:238560051:G:T | - | 0.144178465964278 | 0.0195128940082851 | STAD | Female-baised eQTL |
| rs72984533 | chr2:238561364:T:C | - | 0.14389235906122 | 0.0197941296314941 | STAD | Female-baised eQTL |
| rs72984535 | chr2:238561381:T:C | - | 0.14389235906122 | 0.0197941296314941 | STAD | Female-baised eQTL |
| rs72984525 | chr2:238560677:T:C | - | 0.143452517615671 | 0.0209825922044371 | STAD | Female-baised eQTL |
| rs72984528 | chr2:238560732:T:C | - | 0.143452517615671 | 0.0209825922044371 | STAD | Female-baised eQTL |
| rs72984530 | chr2:238560790:C:T | - | 0.143452517615671 | 0.0209825922044371 | STAD | Female-baised eQTL |
| rs61178898 | chr2:238553169:C:T | - | 0.143245526953768 | 0.0214460593764391 | STAD | Female-baised eQTL |
| rs59039294 | chr2:238562013:G:A | - | 0.140158988341619 | 0.0214713403669351 | STAD | Female-baised eQTL |
| rs72984508 | chr2:238554124:C:G | - | 0.143226785235528 | 0.0216989652080209 | STAD | Female-baised eQTL |
| rs16864264 | chr2:222959819:T:C | - | 0.170376434108241 | 0.023581927274911 | BLCA | Female-baised eQTL |
| rs16863257 | chr2:221982495:G:C | - | 0.136955720353866 | 0.0410578838242345 | BLCA | Female-baised eQTL |
| rs13398149 | chr2:231700171:A:C | - | 0.0430995107213852 | 0.0298280147854716 | LUAD | Female-baised eQTL |
| rs6752648 | chr2:223728434:G:A | - | -0.0908092151909179 | 0.0116328578789966 | COAD | Female-baised eQTL |
| rs611017 | chr2:223732721:C:T | - | -0.0910312799908075 | 0.013992390470048 | COAD | Female-baised eQTL |
| rs6436427 | chr2:223729425:T:G | - | -0.0891621391733941 | 0.0188506771098161 | COAD | Female-baised eQTL |
| rs7607927 | chr2:223730084:C:T | - | -0.0891621391733941 | 0.0188506771098161 | COAD | Female-baised eQTL |
| rs6710382 | chr2:223728417:T:C | - | -0.0887037040264439 | 0.0196865506701684 | COAD | Female-baised eQTL |
| rs6735609 | chr2:223731165:A:G | - | -0.0877881471391383 | 0.0227756156866057 | COAD | Female-baised eQTL |
| rs656797 | chr2:223735570:C:G | - | -0.080698699217181 | 0.0379447187614091 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs67028357 | chr2:236908073:C:A | - | 0.140943651492173 | 0.000174813235261138 | KIRP | Male-baised eQTL |
| rs12467164 | chr2:222656078:T:G | - | 0.129238899079515 | 0.0241305532091252 | KIRP | Male-baised eQTL |
| rs13409615 | chr2:228079566:C:T | - | 0.0570077484680762 | 0.00684188280880222 | LUSC | Male-baised eQTL |
| rs7574308 | chr2:228194836:C:G | - | 0.0809944157751165 | 0.00166639591032095 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000135916 |
| CpG Site: cg14649507 | |
| Position to Gene: gene | |
| Male Effect: -0.231381050234925 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135916 |
| CpG Site: cg18994033 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.436639647851147 | |
 | Gene ID: ENSG00000135916 |
| CpG Site: cg20307347 | |
| Position to Gene: gene | |
| Male Effect: -0.26688688585352 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg14649507 | chr2:230870322 | gene | -0.231381050234925 | 6.15569235066646e-05 | -0.3340801863060813 | 1.25438554335757e-06 | KIRP |
| cg20307347 | chr2:230869848 | gene | -0.26688688585352 | 2.77862128907588e-11 | -0.4381522093075779 | 2.2473865660240495e-14 | LUSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg18994033 | chr2:230868701 | gene,enhancer | -0.436639647851147 | 3.03085206175468e-10 | -0.43365796687599967 | 4.0791138171185366e-13 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs12463918 | chr2:230381148:C:T | Distant upstream | -0.0304067486349487 | 0.00113604408520483 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs2396782 | chr2:230861510:A:T | Distant upstream | 0.0229319971756384 | 0.00134779134913599 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs11900191 | chr2:230372445:G:C | Distant upstream | -0.029843692766999 | 0.00153374717465784 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs35412999 | chr2:230372657:G:A | Distant upstream | -0.029843692766999 | 0.00153374717465784 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs2396781 | chr2:230861508:G:A | Distant upstream | 0.0224269875399048 | 0.00197693583321839 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs11900156 | chr2:230372491:C:T | Distant upstream | -0.0290408222467673 | 0.00269562486963301 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs58646765 | chr2:230375937:C:T | Distant upstream | -0.0291487880933318 | 0.00301213244972263 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs59543717 | chr2:230377516:G:A | Distant upstream | -0.0291487880933318 | 0.00301213244972263 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs2396747 | chr2:230374231:G:A | Distant upstream | -0.0291985315136594 | 0.0030294400953802 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs12470112 | chr2:230374493:A:C | Distant upstream | -0.0291985315136594 | 0.0030294400953802 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs2894720 | chr2:230861441:G:C | Distant upstream | 0.0214713260383125 | 0.00309022014275148 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs4355094 | chr2:230861303:A:G | Distant upstream | 0.0217604740510387 | 0.00345179122882653 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs1974983 | chr2:230384765:C:T | Distant upstream | -0.0289950017371277 | 0.00376045624930988 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs74204431 | chr2:230374701:G:C | Distant upstream | -0.0288026282013912 | 0.0040728762128395 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs10933335 | chr2:230384171:G:A | Distant upstream | -0.0285304885373167 | 0.00477989410046852 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs3754939 | chr2:230385700:T:C | Distant upstream | -0.0288210162122265 | 0.00488539775623249 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs11886779 | chr2:230388129:C:G | Distant upstream | -0.0284539765209213 | 0.00571942986687923 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs28497362 | chr2:230383546:C:T | Distant upstream | -0.0247065213405689 | 0.0175251067014131 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs13383946 | chr2:230381210:C:T | Distant upstream | 0.0222893591213034 | 0.0175566772577346 | BLCA | Male-baised sQTL |
| exon_skip_334598 | chr2:230873416:230873557 | In-frame | rs12694848 | chr2:230372598:A:G | Distant upstream | 0.0191450606395939 | 0.0338176040459768 | BLCA | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ITM2C |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
