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Gene: ENSG00000135677 |
Summary for GNS |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000135677 | Gene symbol | GNS |
| Gene name | glucosamine (N-acetyl)-6-sulfatase | |
| HGNC | 4422 | |
| Entrez ID | 2799 | |
| Gene type | protein_coding | |
| Synonyms | GNS| | |
| UniProtAcc | P15586 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for GNS |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for GNS |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for GNS |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRP | cg00626466 | chr12:64760202 | CGI:chr12:64759089-64759709 | promoter | 4.02e-01 | 2.86e-01 | 3.19e+00 | 1.44e-03 | 6.20e-03 | 1.16e-01 |
| CHOL | cg00626466 | chr12:64760202 | CGI:chr12:64759089-64759709 | promoter | 5.45e-01 | 3.66e-01 | 2.23e+00 | 2.58e-02 | 3.76e-02 | 1.79e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg00626466 | chr12:64760202 | CGI:chr12:64759089-64759709 | promoter | 5.70e-01 | 7.83e-01 | -3.79e+00 | 1.53e-04 | 3.71e-04 | -2.13e-01 |
| LUSC | cg00626466 | chr12:64760202 | CGI:chr12:64759089-64759709 | promoter | 4.72e-01 | 6.85e-01 | -2.86e+00 | 4.19e-03 | 7.14e-03 | -2.13e-01 |
| LIHC | cg00626466 | chr12:64760202 | CGI:chr12:64759089-64759709 | promoter | 3.90e-01 | 5.13e-01 | -3.04e+00 | 2.36e-03 | 3.39e-03 | -1.22e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for GNS |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for GNS |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for GNS |
| TFs related to GNS. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GNS related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for GNS |
| RBPs related to ES in GNS. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ESRP2 | exon_skip_94540 | 8.24e+00 | 6.25e-03 | 8.70e+00 | 9.88e-01 | Female-biased |
| THYM | PCBP2 | exon_skip_94533 | 7.81e+00 | 3.40e-03 | 8.23e+00 | 9.89e-01 | Female-biased |
| LIHC | ZC3H10 | exon_skip_94545 | 9.20e+00 | 1.48e-02 | 9.55e+00 | 9.82e-01 | Female-biased |
| CHOL | FMR1 | exon_skip_94548 | 8.46e+00 | 9.91e-01 | 7.87e+00 | 2.54e-03 | Male-biased |
| CHOL | PCBP2 | exon_skip_94533 | 7.98e+00 | 7.07e-03 | 8.43e+00 | 9.86e-01 | Female-biased |
| PCPG | ZC3H10 | exon_skip_94545 | 9.43e+00 | 9.90e-01 | 9.08e+00 | 7.13e-03 | Male-biased |
| BLCA | ZC3H10 | exon_skip_94545 | 8.97e+00 | 3.07e-03 | 9.44e+00 | 9.94e-01 | Female-biased |
| SKCM | PCBP2 | exon_skip_94533 | 8.54e+00 | 9.86e-01 | 8.17e+00 | 8.12e-03 | Male-biased |
| GNS related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs34791601 | chr12:65484845:C:T | - | 0.209469088926689 | 0.0189483276667711 | GBM | Female-baised eQTL |
| rs35533437 | chr12:74593750:A:G | - | 0.0882639262067004 | 0.0153526589197281 | STAD | Female-baised eQTL |
| rs1837471 | chr12:73823041:C:G | - | 0.092679923829605 | 0.0154477866616655 | STAD | Female-baised eQTL |
| rs4882627 | chr12:74494233:T:G | - | 0.0829477018139338 | 0.0226463846090535 | STAD | Female-baised eQTL |
| rs2886509 | chr12:74500024:C:A | - | 0.0829477018139338 | 0.0226463846090535 | STAD | Female-baised eQTL |
| rs138177541 | chr12:74504403:A:C | - | 0.0829477018139338 | 0.0226463846090535 | STAD | Female-baised eQTL |
| rs12315529 | chr12:70881470:G:C | - | 0.104875394568168 | 0.023766115755781 | STAD | Female-baised eQTL |
| rs7958966 | chr12:74511691:T:G | - | 0.0820499977437734 | 0.0309128583189138 | STAD | Female-baised eQTL |
| rs10877617 | chr12:61309129:T:C | - | 0.0901500477151968 | 0.0391274832509382 | STAD | Female-baised eQTL |
| rs7296589 | chr12:68889608:T:C | - | -0.0787972592796145 | 0.0438367984250793 | STAD | Female-baised eQTL |
| rs17225931 | chr12:69980871:C:T | - | 0.0682667765329435 | 0.0451050074202931 | STAD | Female-baised eQTL |
| rs11178016 | chr12:69982381:C:T | - | 0.0682667765329435 | 0.0451050074202931 | STAD | Female-baised eQTL |
| rs17226003 | chr12:70029989:T:C | - | 0.0760308497316552 | 0.0490578313617081 | STAD | Female-baised eQTL |
| rs10784733 | chr12:68891314:T:G | - | -0.07054941956058 | 0.0329332260591145 | LGG | Female-baised eQTL |
| rs2013072 | chr12:68890488:C:T | - | -0.0702933629664773 | 0.0342930875145778 | LGG | Female-baised eQTL |
| rs7134186 | chr12:68891641:A:G | - | -0.0702933629664773 | 0.0342930875145778 | LGG | Female-baised eQTL |
| rs2647948 | chr12:68886933:T:C | - | -0.0700744648660515 | 0.0368224276163302 | LGG | Female-baised eQTL |
| rs2701085 | chr12:68885956:A:G | - | -0.0698863727773374 | 0.0376509389439552 | LGG | Female-baised eQTL |
| rs1147085 | chr12:64881988:A:G | - | 0.048700565214666 | 0.0387024639707371 | LGG | Female-baised eQTL |
| rs2647949 | chr12:68886371:G:A | - | -0.0696311016435303 | 0.0387292895211112 | LGG | Female-baised eQTL |
| rs686283 | chr12:68394118:T:C | - | 0.0735729307652622 | 0.0403755822277897 | LGG | Female-baised eQTL |
| rs80197700 | chr12:65130895:A:T | - | 0.182158463134494 | 0.0190181375139564 | BLCA | Female-baised eQTL |
| rs74550524 | chr12:65539580:C:T | - | 0.155789926383059 | 0.03312073553003 | BLCA | Female-baised eQTL |
| rs79281410 | chr12:65536509:C:T | - | 0.155334415123158 | 0.0346697182731668 | BLCA | Female-baised eQTL |
| rs17786070 | chr12:74583005:A:G | - | 0.072386052220621 | 0.00013598288608943 | LUAD | Female-baised eQTL |
| rs78149366 | chr12:74652690:G:A | - | 0.0691088176047502 | 0.000262800906150925 | LUAD | Female-baised eQTL |
| rs78565220 | chr12:74645490:G:T | - | 0.0643348239324895 | 0.000685357607886675 | LUAD | Female-baised eQTL |
| rs113895426 | chr12:74645877:G:A | - | 0.0621882338165702 | 0.00123629647831174 | LUAD | Female-baised eQTL |
| rs17788160 | chr12:74657341:A:G | - | 0.0606373943367118 | 0.00182257791163505 | LUAD | Female-baised eQTL |
| rs17183685 | chr12:74647310:T:C | - | 0.0603066178096748 | 0.00202104118822387 | LUAD | Female-baised eQTL |
| rs78244809 | chr12:74602397:A:G | - | 0.0583544706773997 | 0.00277413251514368 | LUAD | Female-baised eQTL |
| rs17787309 | chr12:74602422:G:A | - | 0.0583544706773997 | 0.00277413251514368 | LUAD | Female-baised eQTL |
| rs7967033 | chr12:74603641:A:C | - | 0.0583544706773997 | 0.00277413251514368 | LUAD | Female-baised eQTL |
| rs79814648 | chr12:74604558:A:G | - | 0.0583544706773997 | 0.00277413251514368 | LUAD | Female-baised eQTL |
| rs17787103 | chr12:74601695:C:T | - | 0.0579892541422661 | 0.002842692620676 | LUAD | Female-baised eQTL |
| rs73138722 | chr12:67416443:G:A | - | 0.0780322672709923 | 0.00284456643718714 | LUAD | Female-baised eQTL |
| rs73138723 | chr12:67417176:C:T | - | 0.0780322672709923 | 0.00284456643718714 | LUAD | Female-baised eQTL |
| rs55877587 | chr12:67419276:G:T | - | 0.0789354091520858 | 0.0028985909464712 | LUAD | Female-baised eQTL |
| rs17113906 | chr12:74597040:C:T | - | 0.0578937841663041 | 0.00325091869444207 | LUAD | Female-baised eQTL |
| rs1353156 | chr12:74601762:C:G | - | -0.0600575622919156 | 0.00337081529098232 | LUAD | Female-baised eQTL |
| rs1353157 | chr12:74601753:A:G | - | -0.0596234270849123 | 0.00411518756579023 | LUAD | Female-baised eQTL |
| rs489582 | chr12:69518982:A:G | - | 0.0422976634272269 | 0.00421539625724938 | LUAD | Female-baised eQTL |
| rs55917370 | chr12:67419642:C:G | - | 0.0760115542161825 | 0.00442366865368284 | LUAD | Female-baised eQTL |
| rs56367833 | chr12:67420596:G:C | - | 0.0760115542161825 | 0.00442366865368284 | LUAD | Female-baised eQTL |
| rs7977113 | chr12:74588053:C:T | - | 0.0562227696600542 | 0.0048214426581082 | LUAD | Female-baised eQTL |
| rs17786699 | chr12:74595978:T:C | - | 0.0562227696600542 | 0.0048214426581082 | LUAD | Female-baised eQTL |
| rs515945 | chr12:69547719:G:C | - | -0.0400516192303949 | 0.00592855024087845 | LUAD | Female-baised eQTL |
| rs73138706 | chr12:67402936:T:C | - | 0.0686956792071283 | 0.00631712194813526 | LUAD | Female-baised eQTL |
| rs7978564 | chr12:67408706:A:G | - | 0.0686956792071283 | 0.00631712194813526 | LUAD | Female-baised eQTL |
| rs73138712 | chr12:67409766:T:C | - | 0.0685542955556991 | 0.00653402389459143 | LUAD | Female-baised eQTL |
| rs73138713 | chr12:67409800:G:A | - | 0.0685542955556991 | 0.00653402389459143 | LUAD | Female-baised eQTL |
| rs56204723 | chr12:67413472:C:T | - | 0.0684784110876899 | 0.00666122683108813 | LUAD | Female-baised eQTL |
| rs73138794 | chr12:67424331:G:A | - | 0.0725739637137049 | 0.00749490744654152 | LUAD | Female-baised eQTL |
| rs693909 | chr12:69513146:A:G | - | -0.0396868077969971 | 0.0078848817502581 | LUAD | Female-baised eQTL |
| rs17113796 | chr12:74579623:C:T | - | 0.053734481187889 | 0.00803453857591277 | LUAD | Female-baised eQTL |
| rs17113803 | chr12:74580636:C:T | - | 0.053734481187889 | 0.00803453857591277 | LUAD | Female-baised eQTL |
| rs1493837 | chr12:74580937:C:G | - | 0.053734481187889 | 0.00803453857591277 | LUAD | Female-baised eQTL |
| rs55860467 | chr12:67406931:C:A | - | 0.0706601824340454 | 0.0092576070830759 | LUAD | Female-baised eQTL |
| rs146076006 | chr12:67407513:C:T | - | 0.0706601824340454 | 0.0092576070830759 | LUAD | Female-baised eQTL |
| rs56698804 | chr12:67412214:C:T | - | 0.0704525088891225 | 0.00968091230730706 | LUAD | Female-baised eQTL |
| rs73138717 | chr12:67413343:T:C | - | 0.0704525088891225 | 0.00968091230730706 | LUAD | Female-baised eQTL |
| rs471721 | chr12:69513116:T:C | - | -0.0386775784574372 | 0.0100956596740891 | LUAD | Female-baised eQTL |
| rs74725127 | chr12:74563643:C:T | - | 0.0525368186395034 | 0.0102947610841874 | LUAD | Female-baised eQTL |
| rs2219609 | chr12:74566892:G:C | - | 0.0525368186395034 | 0.0102947610841874 | LUAD | Female-baised eQTL |
| rs78606675 | chr12:74572851:T:C | - | 0.0525368186395034 | 0.0102947610841874 | LUAD | Female-baised eQTL |
| rs56327009 | chr12:74575929:T:C | - | 0.0525368186395034 | 0.0102947610841874 | LUAD | Female-baised eQTL |
| rs73136781 | chr12:67390348:C:T | - | 0.0602035497952438 | 0.0199194021002312 | LUAD | Female-baised eQTL |
| rs1144960 | chr12:68915558:T:G | - | -0.0382942089990209 | 0.021402436965733 | LUAD | Female-baised eQTL |
| rs539339 | chr12:69529057:C:T | - | -0.0370889287503947 | 0.0215419685095985 | LUAD | Female-baised eQTL |
| rs2120743 | chr12:68916514:C:T | - | -0.0391795892886441 | 0.0220281920140944 | LUAD | Female-baised eQTL |
| rs496673 | chr12:69512740:G:C | - | -0.0351937336138287 | 0.0223251906352315 | LUAD | Female-baised eQTL |
| rs528856 | chr12:69514369:C:T | - | -0.0348658697472267 | 0.0224159794621075 | LUAD | Female-baised eQTL |
| rs2674899 | chr12:61365726:G:A | - | -0.0403116288238814 | 0.023544379142689 | LUAD | Female-baised eQTL |
| rs1144961 | chr12:68915597:A:G | - | -0.0388767593331108 | 0.0236985545633022 | LUAD | Female-baised eQTL |
| rs536065 | chr12:69535647:G:A | - | -0.0368072976671842 | 0.0240100017611548 | LUAD | Female-baised eQTL |
| rs710773 | chr12:69593714:G:A | - | -0.0345536594663457 | 0.0252074096473244 | LUAD | Female-baised eQTL |
| rs716226 | chr12:66695550:G:A | - | 0.0414204635739174 | 0.0266008657420136 | LUAD | Female-baised eQTL |
| rs76890377 | chr12:69972098:G:A | - | 0.0437610885053938 | 0.0271984650032529 | LUAD | Female-baised eQTL |
| rs77477390 | chr12:69972464:C:T | - | 0.0437610885053938 | 0.0271984650032529 | LUAD | Female-baised eQTL |
| rs12369300 | chr12:56864432:G:A | - | 0.0805947016033075 | 0.0272604676347976 | LUAD | Female-baised eQTL |
| rs77508063 | chr12:69972691:T:C | - | 0.0433668512362922 | 0.0289312965261313 | LUAD | Female-baised eQTL |
| rs78532166 | chr12:69973672:C:T | - | 0.0433668512362922 | 0.0289312965261313 | LUAD | Female-baised eQTL |
| rs74834001 | chr12:69974580:A:T | - | 0.0433668512362922 | 0.0289312965261313 | LUAD | Female-baised eQTL |
| rs1144959 | chr12:68913551:T:C | - | -0.0376681877779815 | 0.0298959986112212 | LUAD | Female-baised eQTL |
| rs2642558 | chr12:68920699:C:T | - | -0.0378879801251836 | 0.0300692663606285 | LUAD | Female-baised eQTL |
| rs524286 | chr12:69545155:T:A | - | -0.0359575686230405 | 0.0305928431298627 | LUAD | Female-baised eQTL |
| rs10879803 | chr12:74530299:A:T | - | 0.0442979242441288 | 0.0316459528428918 | LUAD | Female-baised eQTL |
| rs11176720 | chr12:67395970:T:C | - | 0.0582115355609189 | 0.032021084637134 | LUAD | Female-baised eQTL |
| rs80222951 | chr12:69972060:G:A | - | 0.042915498311321 | 0.0323056715003719 | LUAD | Female-baised eQTL |
| rs521001 | chr12:69563910:C:G | - | -0.0347615688036413 | 0.0338053853036317 | LUAD | Female-baised eQTL |
| rs2647951 | chr12:68921636:C:T | - | -0.0371186387331979 | 0.0340939952378149 | LUAD | Female-baised eQTL |
| rs55743626 | chr12:66705058:T:C | - | 0.0397345954826623 | 0.0344926216144274 | LUAD | Female-baised eQTL |
| rs7959395 | chr12:66708558:G:C | - | 0.0397345954826623 | 0.0344926216144274 | LUAD | Female-baised eQTL |
| rs77584433 | chr12:67381713:C:G | - | 0.0705374895574237 | 0.0379842899720058 | LUAD | Female-baised eQTL |
| rs117488979 | chr12:69971785:C:T | - | 0.0420608142019657 | 0.0385827564459453 | LUAD | Female-baised eQTL |
| rs149687626 | chr12:69971790:C:T | - | 0.0420608142019657 | 0.0385827564459453 | LUAD | Female-baised eQTL |
| rs551565 | chr12:69558730:G:A | - | -0.0348197983068003 | 0.0416442291889377 | LUAD | Female-baised eQTL |
| rs2133315 | chr12:68923046:A:G | - | -0.0359787727248582 | 0.0420039484614758 | LUAD | Female-baised eQTL |
| rs74374772 | chr12:69971218:T:C | - | 0.0415025969364465 | 0.0436419052112713 | LUAD | Female-baised eQTL |
| rs117264246 | chr12:69971493:A:G | - | 0.0415025969364465 | 0.0436419052112713 | LUAD | Female-baised eQTL |
| rs112214896 | chr12:69971508:C:A | - | 0.0415025969364465 | 0.0436419052112713 | LUAD | Female-baised eQTL |
| rs2647952 | chr12:68925483:G:A | - | -0.0355303256290133 | 0.0467129480004737 | LUAD | Female-baised eQTL |
| rs2870932 | chr12:67234729:C:T | - | 0.072349678286714 | 0.0468896178209402 | LUAD | Female-baised eQTL |
| rs112245764 | chr12:69971795:C:T | - | 0.040922354914316 | 0.0499890940753901 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11172574 | chr12:58374369:T:C | - | 0.203654259571206 | 2.89210767033807e-07 | GBM | Male-baised eQTL |
| rs11172567 | chr12:58369956:C:G | - | 0.185802936505748 | 3.82267219224092e-06 | GBM | Male-baised eQTL |
| rs79512872 | chr12:57536527:G:A | - | 0.193961802612137 | 3.93327535970167e-06 | GBM | Male-baised eQTL |
| rs77241748 | chr12:57553572:G:A | - | 0.193961802612137 | 3.93327535970167e-06 | GBM | Male-baised eQTL |
| rs143931609 | chr12:57573938:C:T | - | 0.193961802612137 | 3.93327535970167e-06 | GBM | Male-baised eQTL |
| rs2355007 | chr12:58413212:G:T | - | 0.168373670609271 | 4.94772591531415e-05 | GBM | Male-baised eQTL |
| rs11172610 | chr12:58435447:A:G | - | 0.132414039679428 | 0.00208316492624157 | GBM | Male-baised eQTL |
| rs12302398 | chr12:62941202:A:C | - | 0.109973510495291 | 0.0158589767293646 | GBM | Male-baised eQTL |
| rs12302449 | chr12:62941267:A:C | - | 0.109973510495291 | 0.0158589767293646 | GBM | Male-baised eQTL |
| rs2950573 | chr12:56192368:A:T | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs2930788 | chr12:56192465:T:C | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs2695784 | chr12:56192660:T:C | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs2463365 | chr12:56193792:C:T | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs2695783 | chr12:56194669:G:A | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs2629451 | chr12:56196766:C:T | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs7489249 | chr12:56199247:G:A | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs10876878 | chr12:56200157:C:A | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs7956599 | chr12:56200715:A:G | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs7956926 | chr12:56200734:G:A | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs11171777 | chr12:56201227:G:A | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs773657 | chr12:56203195:T:C | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs773655 | chr12:56203799:G:A | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs773654 | chr12:56204260:C:T | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs703823 | chr12:56207453:A:G | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs773661 | chr12:56209112:G:A | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs773659 | chr12:56209981:C:T | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs773658 | chr12:56210050:G:C | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs1274503 | chr12:56210912:C:T | - | -0.279676382877297 | 1.2469026238436e-10 | SARC | Male-baised eQTL |
| rs1274502 | chr12:56211436:A:C | - | -0.279688244174225 | 1.25771625655325e-10 | SARC | Male-baised eQTL |
| rs11175166 | chr12:63765717:T:C | - | 0.292955331859305 | 1.16215650871337e-09 | SARC | Male-baised eQTL |
| rs7138528 | chr12:71286429:G:A | - | 0.190736925295945 | 0.000173192717333478 | SARC | Male-baised eQTL |
| rs12299212 | chr12:65555604:T:C | - | 0.16025369260998 | 0.000405140235489583 | SARC | Male-baised eQTL |
| rs905724 | chr12:60373300:A:G | - | 0.16109911541072 | 0.000996010661671559 | SARC | Male-baised eQTL |
| rs4631931 | chr12:65572195:G:A | - | 0.138672873452011 | 0.00133641069263948 | SARC | Male-baised eQTL |
| rs11176960 | chr12:67947265:A:G | - | 0.138146215370646 | 0.00556787069989439 | SARC | Male-baised eQTL |
| rs71452360 | chr12:67808702:T:G | - | 0.112963427184772 | 0.00725730944840653 | SARC | Male-baised eQTL |
| rs12810001 | chr12:67808322:G:A | - | 0.114401301923556 | 0.00830838438784738 | SARC | Male-baised eQTL |
| rs34371932 | chr12:67810023:C:T | - | 0.114401301923556 | 0.00830838438784738 | SARC | Male-baised eQTL |
| rs113491408 | chr12:55520927:T:C | - | 0.136763682601202 | 0.00880576102817424 | SARC | Male-baised eQTL |
| rs971126 | chr12:67810874:T:C | - | 0.10555110760155 | 0.0167456455883518 | SARC | Male-baised eQTL |
| rs12427268 | chr12:67811369:C:T | - | 0.10555110760155 | 0.0167456455883518 | SARC | Male-baised eQTL |
| rs12426394 | chr12:67814060:G:C | - | 0.105459486207415 | 0.0172246017144685 | SARC | Male-baised eQTL |
| rs56024126 | chr12:67818759:T:C | - | 0.105459486207415 | 0.0172246017144685 | SARC | Male-baised eQTL |
| rs12814379 | chr12:67821450:G:A | - | 0.105459486207415 | 0.0172246017144685 | SARC | Male-baised eQTL |
| rs12814422 | chr12:67821507:G:A | - | 0.105459486207415 | 0.0172246017144685 | SARC | Male-baised eQTL |
| rs899660 | chr12:68350131:G:C | - | 0.117272911502241 | 0.0196496929363346 | SARC | Male-baised eQTL |
| rs4419419 | chr12:55519661:G:A | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs369626258 | chr12:55521122:G:T | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs11171539 | chr12:55521834:T:G | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs10783755 | chr12:55522599:T:A | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs4513498 | chr12:55522853:A:C | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs10876807 | chr12:55524287:A:G | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs10876808 | chr12:55526489:T:C | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs6581065 | chr12:55531641:C:G | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs7305830 | chr12:55533243:T:G | - | 0.121881739725665 | 0.021028474979529 | SARC | Male-baised eQTL |
| rs7955895 | chr12:71743544:T:C | - | 0.131386855654861 | 0.0243681277739168 | SARC | Male-baised eQTL |
| rs12423705 | chr12:71743588:A:T | - | 0.131386855654861 | 0.0243681277739168 | SARC | Male-baised eQTL |
| rs56324239 | chr12:71287563:C:T | - | 0.120530489849439 | 0.0311924716029731 | SARC | Male-baised eQTL |
| rs971125 | chr12:67810853:T:C | - | 0.093312916493824 | 0.0386464916134276 | SARC | Male-baised eQTL |
| rs79533141 | chr12:70928495:G:T | - | 0.0783223999679505 | 0.0443886075735185 | SARC | Male-baised eQTL |
| rs12296976 | chr12:70947573:T:C | - | 0.0738513260723445 | 0.044969531066811 | SARC | Male-baised eQTL |
| rs7976176 | chr12:70949668:C:T | - | 0.0738513260723445 | 0.044969531066811 | SARC | Male-baised eQTL |
| rs11178503 | chr12:70951408:T:C | - | 0.0738513260723445 | 0.044969531066811 | SARC | Male-baised eQTL |
| rs11178504 | chr12:70951481:T:C | - | 0.0738513260723445 | 0.044969531066811 | SARC | Male-baised eQTL |
| rs10219453 | chr12:70951693:C:T | - | 0.0738513260723445 | 0.044969531066811 | SARC | Male-baised eQTL |
| rs10219638 | chr12:70951866:A:G | - | 0.0738513260723445 | 0.044969531066811 | SARC | Male-baised eQTL |
| rs10783753 | chr12:55503570:G:C | - | 0.112278670641041 | 0.0452600891994755 | SARC | Male-baised eQTL |
| rs7308897 | chr12:70964356:A:C | - | 0.0709087049270307 | 0.0468818316126333 | SARC | Male-baised eQTL |
| rs11178499 | chr12:70948490:G:A | - | 0.0703891667401552 | 0.0477199284953275 | SARC | Male-baised eQTL |
| rs17104820 | chr12:68110541:C:T | - | 0.108115621827042 | 0.003353771977786 | STAD | Male-baised eQTL |
| rs74934012 | chr12:68111176:A:T | - | 0.108115621827042 | 0.003353771977786 | STAD | Male-baised eQTL |
| rs11177057 | chr12:68111596:T:G | - | 0.108002435386509 | 0.00345535271904959 | STAD | Male-baised eQTL |
| rs74549417 | chr12:68110300:C:T | - | 0.10465641294197 | 0.00458543720446355 | STAD | Male-baised eQTL |
| rs2160440 | chr12:68108474:T:C | - | 0.0935040480118118 | 0.0150277478719911 | STAD | Male-baised eQTL |
| rs17826057 | chr12:66239384:G:A | - | 0.0848133115229019 | 0.0179583899977694 | STAD | Male-baised eQTL |
| rs7303207 | chr12:68109851:G:C | - | 0.0911324825098499 | 0.0220343793782128 | STAD | Male-baised eQTL |
| rs73326522 | chr12:68477761:T:C | - | 0.0660685107562037 | 0.0233258128474763 | BLCA | Male-baised eQTL |
| rs73326509 | chr12:68473401:T:A | - | 0.0622871187417482 | 0.0359159744981651 | BLCA | Male-baised eQTL |
| rs10437971 | chr12:67233032:A:T | - | 0.0650883324999522 | 0.00764181837731645 | LUAD | Male-baised eQTL |
| rs463965 | chr12:64922152:T:C | - | 0.0473129959142174 | 0.0175192561137286 | LUAD | Male-baised eQTL |
| rs17247841 | chr12:66962451:G:A | - | 0.0583614831939269 | 0.029883541013336 | LUAD | Male-baised eQTL |
| rs117284313 | chr12:66486563:G:A | - | 0.0408528283859792 | 0.0400879522091754 | LUAD | Male-baised eQTL |
| rs4913513 | chr12:66487708:A:G | - | 0.0408528283859792 | 0.0400879522091754 | LUAD | Male-baised eQTL |
| rs56409231 | chr12:67894063:T:C | - | 0.0527191521404698 | 0.0425383408206942 | LUAD | Male-baised eQTL |
| rs11832276 | chr12:66970271:G:C | - | 0.0551057664457514 | 0.0497640453808865 | LUAD | Male-baised eQTL |
| rs61933735 | chr12:72881077:C:T | - | 0.0748996732478618 | 0.0186021211642207 | COAD | Male-baised eQTL |
| rs7486778 | chr12:72881746:G:A | - | 0.0748996732478618 | 0.0186021211642207 | COAD | Male-baised eQTL |
| rs6582119 | chr12:72869805:C:T | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs7296954 | chr12:72873358:G:A | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs12425754 | chr12:72873768:G:A | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs61933732 | chr12:72874211:G:A | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs12426425 | chr12:72875228:G:A | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs7488963 | chr12:72877903:A:G | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs74105673 | chr12:72878059:T:A | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs12422363 | chr12:72878587:G:A | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs7485192 | chr12:72879044:G:C | - | 0.0749409623101705 | 0.018627185832262 | COAD | Male-baised eQTL |
| rs7310330 | chr12:72876909:C:T | - | 0.0745113414150399 | 0.0199977020953389 | COAD | Male-baised eQTL |
| rs61933731 | chr12:72874126:C:T | - | 0.0742839639376295 | 0.0206708010665478 | COAD | Male-baised eQTL |
| rs146827204 | chr12:72857152:G:T | - | 0.0736323421336315 | 0.022004330688136 | COAD | Male-baised eQTL |
| rs55839537 | chr12:72859729:C:T | - | 0.0736323421336315 | 0.022004330688136 | COAD | Male-baised eQTL |
| rs56024096 | chr12:72859885:T:A | - | 0.0736323421336315 | 0.022004330688136 | COAD | Male-baised eQTL |
| rs6582122 | chr12:72877765:C:T | - | 0.0738593591998985 | 0.0221657394495292 | COAD | Male-baised eQTL |
| rs74315582 | chr12:74324129:A:G | - | 0.113448001715002 | 0.022819751488198 | COAD | Male-baised eQTL |
| rs77072279 | chr12:74327169:A:G | - | 0.113448001715002 | 0.022819751488198 | COAD | Male-baised eQTL |
| rs7961566 | chr12:72845186:A:G | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933677 | chr12:72846238:A:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933678 | chr12:72846827:A:G | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs73153380 | chr12:72846892:C:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933679 | chr12:72847297:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933680 | chr12:72847350:T:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs56076335 | chr12:72847697:C:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933682 | chr12:72848365:G:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs56386184 | chr12:72848697:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs58832887 | chr12:72850491:T:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs12425198 | chr12:72850990:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs78082064 | chr12:72852110:A:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs146215185 | chr12:72852635:A:G | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933685 | chr12:72853442:A:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs7976607 | chr12:72854294:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs150846779 | chr12:72854943:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs149929013 | chr12:72855013:G:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs140227391 | chr12:72855510:G:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs144014880 | chr12:72855908:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs57122704 | chr12:72855984:C:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933690 | chr12:72856238:G:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933691 | chr12:72856421:T:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs138127755 | chr12:72857253:G:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs73155309 | chr12:72857447:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs73155310 | chr12:72858334:G:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933693 | chr12:72858529:G:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933723 | chr12:72861742:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs73155329 | chr12:72861770:A:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs73155333 | chr12:72861794:C:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933724 | chr12:72863053:A:G | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933725 | chr12:72863205:G:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933726 | chr12:72863352:A:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs7315305 | chr12:72865239:A:G | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs12425041 | chr12:72866020:G:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs7309343 | chr12:72866964:T:C | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs73155342 | chr12:72867233:C:A | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs61933727 | chr12:72867543:C:T | - | 0.070473066890118 | 0.0294050656002054 | COAD | Male-baised eQTL |
| rs75540463 | chr12:72857412:C:T | - | 0.0695447388594828 | 0.0320259622006188 | COAD | Male-baised eQTL |
| rs7974313 | chr12:72848802:A:G | - | 0.0687583158699663 | 0.0343136059036758 | COAD | Male-baised eQTL |
| rs114464587 | chr12:72857039:A:G | - | 0.0687583158699663 | 0.0343136059036758 | COAD | Male-baised eQTL |
| rs12296264 | chr12:72883477:G:A | - | 0.0682962085860582 | 0.0358643297788792 | COAD | Male-baised eQTL |
| rs7307223 | chr12:72870774:C:A | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs10879515 | chr12:72875352:C:G | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs7485055 | chr12:72875396:T:G | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs11179434 | chr12:72876501:T:A | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs7313786 | chr12:72877031:G:A | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs7487121 | chr12:72877969:T:C | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs12296623 | chr12:72878329:C:T | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs7962238 | chr12:72880412:G:A | - | 0.0674137816228533 | 0.0396051778061155 | COAD | Male-baised eQTL |
| rs12296613 | chr12:72878201:G:C | - | 0.0672100572576301 | 0.0412333308261309 | COAD | Male-baised eQTL |
| rs7976562 | chr12:72854095:G:A | - | 0.0667001471601845 | 0.0447080028136356 | COAD | Male-baised eQTL |
| rs11179928 | chr12:74124048:T:C | - | 0.0993046527982771 | 0.0461607504602214 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000135677 |
| CpG Site: cg27476482 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.469782897162214 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg27476482 | chr12:64756673 | gene,exon,CDS | -0.469782897162214 | 4.21831795269133e-53 | -0.8325782572315652 | 2.3180946564588542e-58 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of GNS |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000135677 | GNS | C0026706 | Mucopolysaccharidosis III | 1 | CTD_human |
| ENSG00000135677 | GNS | C0086647 | Mucopolysaccharidosis Type IIIA | 1 | CTD_human |
| ENSG00000135677 | GNS | C0086648 | MPS III B | 1 | CTD_human |
| ENSG00000135677 | GNS | C0086649 | MPS III C | 1 | CTD_human |
| ENSG00000135677 | GNS | C0086650 | MPS III D | 1 | CTD_human |
