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Gene: ENSG00000135540 |
Summary for NHSL1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000135540 | Gene symbol | NHSL1 |
| Gene name | NHS like 1 | |
| HGNC | 21021 | |
| Entrez ID | 57224 | |
| Gene type | protein_coding | |
| Synonyms | NHSL1|bA43P8.1|KIAA1357 | |
| UniProtAcc | Q5SYE7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for NHSL1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NHSL1 | 1.06e+03 | 1.10e+00 | 2.46e-01 | 4.46e+00 | 8.03e-06 | 4.87e-05 | BLCA |
| NHSL1 | 1.76e+03 | -1.50e+00 | 4.09e-01 | -3.66e+00 | 2.53e-04 | 1.01e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NHSL1 | 2.09e+03 | -1.28e+00 | 1.62e-01 | -7.90e+00 | 2.73e-15 | 2.75e-14 | COAD |
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Sex-biased somatic mutation for NHSL1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for NHSL1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg03271093 | chr6:138691481 | CGI:chr6:138692238-138693744 | promoter,gene body | 7.95e-01 | 6.36e-01 | 2.61e+00 | 9.04e-03 | 2.00e-02 | 1.59e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg03271093 | chr6:138691481 | CGI:chr6:138692238-138693744 | promoter,gene body | 4.85e-01 | 7.70e-01 | -2.56e+00 | 1.04e-02 | 1.43e-02 | -2.85e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg07185983 | chr6:138691723 | CGI:chr6:138692238-138693744 | promoter,gene body | 1.83e-01 | 2.83e-01 | -2.90e+00 | 3.67e-03 | 9.53e-03 | -1.00e-01 |
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Exon skipping events with PSI in TCGA for NHSL1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for NHSL1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | NHSL1-003 | chr6_138629479_- | 2.48e-01 | 3.45e-01 | -1.98e+00 | 4.74e-02 | 4.96e-02 | -9.76e-02 |
| STAD | NHSL1-003 | chr6_138659187_- | 3.80e-01 | 4.92e-01 | -2.61e+00 | 9.13e-03 | 4.96e-02 | -1.12e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for NHSL1 |
| TFs related to NHSL1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF879 | NHSL1 | 3.93e+00 | 9.81e-01 | 1.47e+00 | 2.08e-04 | Male-biased |
| NHSL1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for NHSL1 |
| RBPs related to ES in NHSL1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| NHSL1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9492436 | chr6:130012889:C:T | - | 0.186780918047234 | 0.0431488384629532 | LIHC | Female-baised eQTL |
| rs12660510 | chr6:129345169:G:A | - | 0.147377152514621 | 0.0354669388710649 | KIRC | Female-baised eQTL |
| rs17057158 | chr6:129349403:C:T | - | 0.142958025907558 | 0.0374741883566118 | KIRC | Female-baised eQTL |
| rs9492176 | chr6:128983891:A:G | - | 0.0765707300671431 | 0.0101905741212321 | LUAD | Female-baised eQTL |
| rs79934959 | chr6:128981942:C:A | - | 0.0761331378018814 | 0.0117767067191157 | LUAD | Female-baised eQTL |
| rs11155401 | chr6:145079491:T:C | - | 0.0514814441617354 | 0.0322078305133738 | LUAD | Female-baised eQTL |
| rs77868189 | chr6:132044140:G:A | - | 0.102776717018921 | 0.0024475118565121 | COAD | Female-baised eQTL |
| rs7770448 | chr6:130130675:G:A | - | 0.135285150122351 | 0.00542957969344867 | COAD | Female-baised eQTL |
| rs59998617 | chr6:130131150:A:G | - | 0.135285150122351 | 0.00542957969344867 | COAD | Female-baised eQTL |
| rs7775285 | chr6:130131455:C:A | - | 0.135285150122351 | 0.00542957969344867 | COAD | Female-baised eQTL |
| rs17058390 | chr6:130132636:C:T | - | 0.135285150122351 | 0.00542957969344867 | COAD | Female-baised eQTL |
| rs3777428 | chr6:130132697:C:T | - | 0.135285150122351 | 0.00542957969344867 | COAD | Female-baised eQTL |
| rs73602370 | chr6:130133222:A:G | - | 0.135285150122351 | 0.00542957969344867 | COAD | Female-baised eQTL |
| rs7763267 | chr6:130134740:C:T | - | 0.135285150122351 | 0.00542957969344867 | COAD | Female-baised eQTL |
| rs73620864 | chr6:130609452:G:A | - | 0.121994436293392 | 0.0063818878762502 | COAD | Female-baised eQTL |
| rs6935438 | chr6:134825563:G:A | - | 0.0873518796276851 | 0.00924964236482662 | COAD | Female-baised eQTL |
| rs9494071 | chr6:134822461:T:G | - | 0.0835329873708512 | 0.0162203813517137 | COAD | Female-baised eQTL |
| rs9494073 | chr6:134822830:C:T | - | 0.0835329873708512 | 0.0162203813517137 | COAD | Female-baised eQTL |
| rs12207504 | chr6:132030726:G:A | - | 0.0822178803496734 | 0.0287538980805578 | COAD | Female-baised eQTL |
| rs9494072 | chr6:134822466:A:G | - | 0.0772308489019093 | 0.0304460843181143 | COAD | Female-baised eQTL |
| rs7740065 | chr6:134822422:C:T | - | 0.0836106716320812 | 0.032053429519522 | COAD | Female-baised eQTL |
| rs9493712 | chr6:133733211:T:C | - | 0.0586450865996434 | 0.0338248448559233 | COAD | Female-baised eQTL |
| rs61611016 | chr6:130523281:T:C | - | 0.0737964414348261 | 0.0345988201505208 | COAD | Female-baised eQTL |
| rs2027035 | chr6:131998611:C:T | - | 0.0815179800346817 | 0.0367228567977867 | COAD | Female-baised eQTL |
| rs12200142 | chr6:131997025:G:C | - | 0.0814494008794048 | 0.0367925642743293 | COAD | Female-baised eQTL |
| rs12182255 | chr6:134668957:C:T | - | 0.0708223282586447 | 0.0412146713943524 | COAD | Female-baised eQTL |
| rs28633558 | chr6:134420248:A:G | - | 0.0777940329006694 | 0.0428854204190849 | COAD | Female-baised eQTL |
| rs6922573 | chr6:140813435:C:A | - | 0.0818238270657346 | 0.0483327333549487 | COAD | Female-baised eQTL |
| rs2064661 | chr6:144012841:T:C | - | -0.0698295448959098 | 0.0483634782893116 | COAD | Female-baised eQTL |
| rs9389023 | chr6:132648161:A:G | - | 0.0698170792897186 | 0.0495721541530707 | COAD | Female-baised eQTL |
| rs9494022 | chr6:134673193:A:G | - | 0.0758937321562159 | 0.0496725591974397 | COAD | Female-baised eQTL |
| rs62430444 | chr6:134674513:A:C | - | 0.0758937321562159 | 0.0496725591974397 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9495470 | chr6:139429738:C:A | - | 0.10074111931751 | 0.0194487956675395 | BLCA | Male-baised eQTL |
| rs12210721 | chr6:132463730:G:C | - | 0.081117370206602 | 7.37510143576706e-05 | LUAD | Male-baised eQTL |
| rs3778572 | chr6:132469194:T:C | - | 0.081117370206602 | 7.37510143576706e-05 | LUAD | Male-baised eQTL |
| rs17061323 | chr6:132476769:G:A | - | 0.0800243486048642 | 8.9777694488371e-05 | LUAD | Male-baised eQTL |
| rs72998845 | chr6:132477477:G:A | - | 0.0800243486048642 | 8.9777694488371e-05 | LUAD | Male-baised eQTL |
| rs12207033 | chr6:132462003:C:T | - | 0.0789018255554539 | 0.00013687052637986 | LUAD | Male-baised eQTL |
| rs3823289 | chr6:132462307:C:T | - | 0.0789018255554539 | 0.00013687052637986 | LUAD | Male-baised eQTL |
| rs3757298 | chr6:132463877:A:C | - | 0.0789018255554539 | 0.00013687052637986 | LUAD | Male-baised eQTL |
| rs12195647 | chr6:132463363:A:G | - | 0.0799921206976439 | 0.000140152529789482 | LUAD | Male-baised eQTL |
| rs2795309 | chr6:142249495:T:A | - | -0.0648344952860856 | 0.014516725211826 | LUAD | Male-baised eQTL |
| rs6926799 | chr6:145378883:A:G | - | -0.0897971704043585 | 0.00690542974012184 | COAD | Male-baised eQTL |
| rs67889564 | chr6:148020337:A:G | - | 0.0762261655243868 | 0.0122686718231507 | COAD | Male-baised eQTL |
| rs9321186 | chr6:129806654:A:T | - | 0.095376102894326 | 0.0328928762800484 | COAD | Male-baised eQTL |
| rs2328521 | chr6:143821521:A:G | - | 0.120470154236736 | 0.0400864387344552 | COAD | Male-baised eQTL |
| rs6939860 | chr6:141590872:T:C | - | 0.0662378659066731 | 0.0475605400571885 | COAD | Male-baised eQTL |
| rs149349742 | chr6:129810700:T:G | - | 0.0739489032135076 | 0.0478078116563526 | COAD | Male-baised eQTL |
| rs200106793 | chr6:141566598:G:C | - | 0.0636000216113361 | 0.0496121592763873 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg27243405 | |
| Position to Gene: gene | |
| Male Effect: -0.45029820051138 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg24324628 | |
| Position to Gene: gene | |
| Male Effect: -0.45029820051138 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg15962969 | |
| Position to Gene: gene | |
| Male Effect: -0.45029820051138 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg17353337 | |
| Position to Gene: gene | |
| Male Effect: -0.45029820051138 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg26287741 | |
| Position to Gene: gene | |
| Male Effect: -0.45029820051138 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg03735592 | |
| Position to Gene: gene | |
| Male Effect: -0.219831892448027 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg24601480 | |
| Position to Gene: gene | |
| Male Effect: -0.160156676958061 | |
| Female Effect: - | |
 | Gene ID: ENSG00000135540 |
| CpG Site: cg25781936 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: - | |
| Female Effect: -0.459355528367796 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg27243405 | chr6:138538439 | gene | -0.45029820051138 | 2.80177827684324e-20 | -0.6235554838703465 | 2.008834099657398e-25 | LUAD |
| cg24324628 | chr6:138545745 | gene | -0.45029820051138 | 2.80177827684324e-20 | -0.6235554838703465 | 2.008834099657398e-25 | LUAD |
| cg15962969 | chr6:138545750 | gene | -0.45029820051138 | 2.80177827684324e-20 | -0.6235554838703465 | 2.008834099657398e-25 | LUAD |
| cg17353337 | chr6:138545761 | gene | -0.45029820051138 | 2.80177827684324e-20 | -0.6235554838703465 | 2.008834099657398e-25 | LUAD |
| cg26287741 | chr6:138545988 | gene | -0.45029820051138 | 2.80177827684324e-20 | -0.6235554838703465 | 2.008834099657398e-25 | LUAD |
| cg03735592 | chr6:138500217 | gene | -0.219831892448027 | 6.22871319070709e-08 | -0.42788432403173043 | 2.4275850120627856e-11 | LUAD |
| cg24601480 | chr6:138493579 | gene | -0.160156676958061 | 2.608545336082e-06 | -0.3901792705786325 | 1.7326544054994104e-09 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg25781936 | chr6:138429750 | gene,exon,CDS | -0.459355528367796 | 3.88745007185392e-12 | -0.6623689616182572 | 5.863520632362773e-15 | BLCA |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of NHSL1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
