|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000135414 |
Summary for GDF11 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000135414 | Gene symbol | GDF11 |
| Gene name | growth differentiation factor 11 | |
| HGNC | 4216 | |
| Entrez ID | 10220 | |
| Gene type | protein_coding | |
| Synonyms | GDF11|BMP-11|BMP11 | |
| UniProtAcc | O95390 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for GDF11 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for GDF11 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for GDF11 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg11151544 | chr12:55741897 | CGI:chr12:55743017-55744000 | promoter | 7.05e-01 | 8.11e-01 | -3.54e+00 | 4.00e-04 | 7.03e-04 | -1.06e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for GDF11 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for GDF11 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for GDF11 |
| TFs related to GDF11. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | ZNF235 | GDF11 | 4.21e+00 | 9.88e-01 | 2.76e+00 | 1.05e-03 | Male-biased |
| DLBC | ZNF287 | GDF11 | 4.21e+00 | 9.87e-01 | 2.82e+00 | 1.29e-03 | Male-biased |
| READ | PLAGL2 | GDF11 | 3.14e+00 | 4.32e-03 | 4.18e+00 | 9.83e-01 | Female-biased |
| GDF11 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for GDF11 |
| RBPs related to ES in GDF11. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GDF11 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7964350 | chr12:55211231:C:T | - | 0.0803836108089717 | 0.0192778268429434 | LUAD | Female-baised eQTL |
| rs2071356 | chr12:47972767:G:A | - | 0.0607428677489365 | 0.0193129672218313 | LUAD | Female-baised eQTL |
| rs4919750 | chr12:52793366:C:T | - | -0.071579895143273 | 0.0225563262928 | LUAD | Female-baised eQTL |
| rs10876347 | chr12:52795256:G:A | - | -0.0718999569281983 | 0.0286313737498507 | LUAD | Female-baised eQTL |
| rs4432093 | chr12:52792338:G:A | - | -0.0682319799148196 | 0.0315173242827703 | LUAD | Female-baised eQTL |
| rs58265689 | chr12:63697728:C:T | - | 0.0528545137687311 | 0.0351747231532962 | LUAD | Female-baised eQTL |
| rs4763113 | chr12:63692588:G:A | - | 0.052830883684773 | 0.0359011123850437 | LUAD | Female-baised eQTL |
| rs4763115 | chr12:63695562:G:A | - | 0.052830883684773 | 0.0359011123850437 | LUAD | Female-baised eQTL |
| rs61934536 | chr12:63696460:G:A | - | 0.052830883684773 | 0.0359011123850437 | LUAD | Female-baised eQTL |
| rs61934539 | chr12:63698802:A:G | - | 0.052830883684773 | 0.0359011123850437 | LUAD | Female-baised eQTL |
| rs61934540 | chr12:63699159:G:C | - | 0.0525646862881157 | 0.0385105156778163 | LUAD | Female-baised eQTL |
| rs740025 | chr12:47948315:T:A | - | 0.0569361634887072 | 0.0397254615992133 | LUAD | Female-baised eQTL |
| rs61935235 | chr12:63686419:T:C | - | 0.0506896723057126 | 0.0413563462367545 | LUAD | Female-baised eQTL |
| rs61935236 | chr12:63686998:A:G | - | 0.0506896723057126 | 0.0413563462367545 | LUAD | Female-baised eQTL |
| rs147075873 | chr12:63687389:C:T | - | 0.0506896723057126 | 0.0413563462367545 | LUAD | Female-baised eQTL |
| rs35393468 | chr12:63687910:C:T | - | 0.0506896723057126 | 0.0413563462367545 | LUAD | Female-baised eQTL |
| rs61935241 | chr12:63688028:C:G | - | 0.0506896723057126 | 0.0413563462367545 | LUAD | Female-baised eQTL |
| rs36054759 | chr12:63688229:A:G | - | 0.0506896723057126 | 0.0413563462367545 | LUAD | Female-baised eQTL |
| rs4417373 | chr12:47963973:C:A | - | 0.0550966905731061 | 0.0417329851302481 | LUAD | Female-baised eQTL |
| rs2898045 | chr12:47948579:C:T | - | 0.0564390520665524 | 0.0427676933710685 | LUAD | Female-baised eQTL |
| rs9888327 | chr12:52800590:T:C | - | -0.0667737579206334 | 0.0429713204178983 | LUAD | Female-baised eQTL |
| rs143607900 | chr12:63682312:T:C | - | 0.0503573540443863 | 0.043020381715661 | LUAD | Female-baised eQTL |
| rs1971379 | chr12:63684436:G:A | - | 0.0503447648016268 | 0.0431735807131593 | LUAD | Female-baised eQTL |
| rs3928243 | chr12:63684648:A:G | - | 0.0503447648016268 | 0.0431735807131593 | LUAD | Female-baised eQTL |
| rs61935227 | chr12:63684768:G:A | - | 0.0503447648016268 | 0.0431735807131593 | LUAD | Female-baised eQTL |
| rs61935228 | chr12:63684777:C:T | - | 0.0503447648016268 | 0.0431735807131593 | LUAD | Female-baised eQTL |
| rs61935229 | chr12:63684832:G:A | - | 0.0503447648016268 | 0.0431735807131593 | LUAD | Female-baised eQTL |
| rs57206444 | chr12:63685276:T:C | - | 0.0503447648016268 | 0.0431735807131593 | LUAD | Female-baised eQTL |
| rs34456202 | chr12:63690126:T:A | - | 0.0517329476261303 | 0.0433368119776505 | LUAD | Female-baised eQTL |
| rs1873648 | chr12:52796199:A:G | - | -0.0683542783652141 | 0.0447322903768347 | LUAD | Female-baised eQTL |
| rs55816657 | chr12:63685359:C:A | - | 0.0511911210971615 | 0.0468551037406566 | LUAD | Female-baised eQTL |
| rs11503709 | chr12:63679741:T:C | - | 0.0492441816806769 | 0.0468914383894794 | LUAD | Female-baised eQTL |
| rs2429406 | chr12:63689521:T:C | - | 0.0497310504898494 | 0.0473601000416061 | LUAD | Female-baised eQTL |
| rs61935246 | chr12:63690236:C:T | - | 0.0509301935952617 | 0.0481129853348832 | LUAD | Female-baised eQTL |
| rs57454598 | chr12:63686044:G:C | - | 0.0512061710605514 | 0.0483281130297404 | LUAD | Female-baised eQTL |
| rs182094576 | chr12:63686570:C:T | - | 0.0512061710605514 | 0.0483281130297404 | LUAD | Female-baised eQTL |
| rs61935237 | chr12:63687023:C:T | - | 0.0512061710605514 | 0.0483281130297404 | LUAD | Female-baised eQTL |
| rs140680216 | chr12:63687253:T:C | - | 0.0512061710605514 | 0.0483281130297404 | LUAD | Female-baised eQTL |
| rs12815924 | chr12:63683663:C:T | - | 0.050942388484996 | 0.0492038059821953 | LUAD | Female-baised eQTL |
| rs61935224 | chr12:63684020:A:G | - | 0.0510030244561876 | 0.0495540404237644 | LUAD | Female-baised eQTL |
| rs61935225 | chr12:63684038:C:T | - | 0.0510030244561876 | 0.0495540404237644 | LUAD | Female-baised eQTL |
| rs7962061 | chr12:53365647:T:C | - | -0.147327811928804 | 0.00523009950380169 | COAD | Female-baised eQTL |
| rs17098246 | chr12:62732293:G:A | - | 0.169442135683728 | 0.00845747753799695 | COAD | Female-baised eQTL |
| rs58319688 | chr12:62732665:G:A | - | 0.169442135683728 | 0.00845747753799695 | COAD | Female-baised eQTL |
| rs7297013 | chr12:62775933:T:C | - | 0.0921792063407894 | 0.0450017367788044 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs808919 | chr12:56254127:G:C | - | -0.118332259917822 | 0.00670644288743378 | KIRP | Male-baised eQTL |
| rs1274490 | chr12:56255817:A:G | - | -0.116205948150182 | 0.00984702191051581 | KIRP | Male-baised eQTL |
| rs1295772 | chr12:56234594:C:T | - | -0.111845929426397 | 0.0142124372987545 | KIRP | Male-baised eQTL |
| rs2629452 | chr12:56247102:C:T | - | -0.110941859395904 | 0.0180874974841846 | KIRP | Male-baised eQTL |
| rs1274496 | chr12:56231909:C:A | - | -0.11299668769282 | 0.0201998149278676 | KIRP | Male-baised eQTL |
| rs12318251 | chr12:55248287:G:A | - | 0.0918571989117782 | 0.00134612573146249 | BLCA | Male-baised eQTL |
| rs12297028 | chr12:55251189:G:A | - | 0.0918571989117782 | 0.00134612573146249 | BLCA | Male-baised eQTL |
| rs3922689 | chr12:55253966:G:A | - | 0.0918571989117782 | 0.00134612573146249 | BLCA | Male-baised eQTL |
| rs7978249 | chr12:55255319:G:A | - | 0.0918571989117782 | 0.00134612573146249 | BLCA | Male-baised eQTL |
| rs12314598 | chr12:62840199:C:T | - | 0.0943444131990744 | 0.0071223996784776 | BLCA | Male-baised eQTL |
| rs2888287 | chr12:57939942:T:C | - | 0.0715971489869088 | 0.0355671691143385 | BLCA | Male-baised eQTL |
| rs2888286 | chr12:57940086:G:A | - | 0.0715971489869088 | 0.0355671691143385 | BLCA | Male-baised eQTL |
| rs7133275 | chr12:57942320:A:G | - | 0.0712989890470793 | 0.0372313673164333 | BLCA | Male-baised eQTL |
| rs12426555 | chr12:58909072:T:A | - | 0.0689272593937653 | 0.0113182480906852 | LUAD | Male-baised eQTL |
| rs7303924 | chr12:58905078:A:G | - | 0.054519596624873 | 0.0229942244404855 | LUAD | Male-baised eQTL |
| rs1456152 | chr12:58797056:G:A | - | 0.0623768177893326 | 0.0395783985422585 | LUAD | Male-baised eQTL |
| rs11172733 | chr12:58812181:T:C | - | 0.0622368750701648 | 0.0405777683972481 | LUAD | Male-baised eQTL |
| rs11172736 | chr12:58813084:A:G | - | 0.0622368750701648 | 0.0405777683972481 | LUAD | Male-baised eQTL |
| rs17121482 | chr12:58806190:G:A | - | 0.0621192014124 | 0.041564096067689 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000135414 |
| CpG Site: cg09890930 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.439475180191066 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09890930 | chr12:55755612 | gene,exon,UTR | -0.439475180191066 | 1.90765970382831e-06 | -0.33436090715613664 | 4.465829742914701e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of GDF11 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
