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Gene: ENSG00000134240 |
Summary for HMGCS2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000134240 | Gene symbol | HMGCS2 |
| Gene name | 3-hydroxy-3-methylglutaryl-CoA synthase 2 | |
| HGNC | 5008 | |
| Entrez ID | 3158 | |
| Gene type | protein_coding | |
| Synonyms | HMGCS2| | |
| UniProtAcc | P54868 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for HMGCS2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HMGCS2 | 3.41e+03 | -4.58e+00 | 8.99e-01 | -5.09e+00 | 3.50e-07 | 2.74e-05 | BRCA |
| HMGCS2 | 2.59e+03 | -1.43e+00 | 2.16e-01 | -6.62e+00 | 3.70e-11 | 3.03e-09 | KIRC |
| HMGCS2 | 1.69e+02 | 2.41e+00 | 2.61e-01 | 9.23e+00 | 2.76e-20 | 1.70e-17 | LUAD |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HMGCS2 | 1.55e+03 | -4.06e+00 | 7.92e-01 | -5.13e+00 | 2.87e-07 | 1.11e-06 | KIRP |
| HMGCS2 | 4.37e+04 | -5.14e+00 | 1.03e+00 | -4.98e+00 | 6.22e-07 | 4.66e-06 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HMGCS2 | 1.50e+02 | -1.41e+00 | 5.35e-01 | -2.64e+00 | 8.30e-03 | 1.38e-02 | LUAD |
| HMGCS2 | 7.28e+01 | -2.67e+00 | 8.34e-01 | -3.20e+00 | 1.35e-03 | 2.99e-03 | LUSC |
| HMGCS2 | 3.77e+03 | -1.01e+00 | 3.02e-01 | -3.36e+00 | 7.84e-04 | 1.13e-03 | BRCA |
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Sex-biased somatic mutation for HMGCS2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for HMGCS2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13976683 | chr1:119768919 | CGI:chr1:119712221-119712649 | promoter | 6.03e-01 | 4.62e-01 | 2.36e+00 | 1.82e-02 | 3.38e-02 | 1.41e-01 |
| BRCA | cg10212621 | chr1:119769026 | CGI:chr1:119712221-119712649 | promoter | 3.45e-01 | 1.97e-01 | 3.41e+00 | 6.57e-04 | 7.24e-03 | 1.48e-01 |
| BRCA | cg18199617 | chr1:119769030 | CGI:chr1:119712221-119712649 | promoter | 4.58e-01 | 2.80e-01 | 3.56e+00 | 3.76e-04 | 4.92e-03 | 1.78e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg24482350 | chr1:119767398 | CGI:chr1:119712221-119712649 | promoter,gene body | 5.35e-01 | 7.54e-01 | -2.95e+00 | 3.15e-03 | 5.63e-03 | -2.18e-01 |
| BLCA | cg27540878 | chr1:119770107 | CGI:chr1:119712221-119712649 | promoter | 4.66e-01 | 7.16e-01 | -3.03e+00 | 2.41e-03 | 4.55e-03 | -2.49e-01 |
| LIHC | cg24482350 | chr1:119767398 | CGI:chr1:119712221-119712649 | promoter,gene body | 3.21e-01 | 4.32e-01 | -5.08e+00 | 3.79e-07 | 1.62e-06 | -1.11e-01 |
| LIHC | cg13976683 | chr1:119768919 | CGI:chr1:119712221-119712649 | promoter | 3.23e-01 | 4.27e-01 | -4.74e+00 | 2.13e-06 | 7.12e-06 | -1.04e-01 |
| LIHC | cg18199617 | chr1:119769030 | CGI:chr1:119712221-119712649 | promoter | 3.06e-01 | 4.28e-01 | -5.02e+00 | 5.27e-07 | 2.15e-06 | -1.23e-01 |
| KIRP | cg24482350 | chr1:119767398 | CGI:chr1:119712221-119712649 | promoter,gene body | 8.77e-01 | 7.61e-01 | 5.32e+00 | 1.06e-07 | 8.80e-07 | 1.15e-01 |
| KIRP | cg13976683 | chr1:119768919 | CGI:chr1:119712221-119712649 | promoter | 5.55e-01 | 4.02e-01 | 3.70e+00 | 2.17e-04 | 5.00e-04 | 1.53e-01 |
| ESCA | cg22718139 | chr1:119768816 | CGI:chr1:119712221-119712649 | promoter,exon,CDS,gene body | 8.09e-01 | 5.41e-01 | 2.00e+00 | 4.60e-02 | 4.84e-02 | 2.68e-01 |
| CHOL | cg24482350 | chr1:119767398 | CGI:chr1:119712221-119712649 | promoter,gene body | 7.00e-01 | 3.75e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 3.25e-01 |
| CHOL | cg22718139 | chr1:119768816 | CGI:chr1:119712221-119712649 | promoter,exon,CDS,gene body | 9.13e-01 | 4.92e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 4.21e-01 |
| CHOL | cg13976683 | chr1:119768919 | CGI:chr1:119712221-119712649 | promoter | 5.88e-01 | 3.57e-01 | 2.95e+00 | 3.19e-03 | 1.32e-02 | 2.32e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg24482350 | chr1:119767398 | CGI:chr1:119712221-119712649 | promoter,gene body | 6.62e-01 | 7.88e-01 | -6.62e+00 | 3.59e-11 | 9.78e-11 | -1.26e-01 |
| BRCA | cg13976683 | chr1:119768919 | CGI:chr1:119712221-119712649 | promoter | 6.03e-01 | 7.15e-01 | -5.42e+00 | 6.07e-08 | 1.27e-07 | -1.12e-01 |
| HNSC | cg13976683 | chr1:119768919 | CGI:chr1:119712221-119712649 | promoter | 5.90e-01 | 4.51e-01 | 2.34e+00 | 1.92e-02 | 2.69e-02 | 1.39e-01 |
| HNSC | cg10212621 | chr1:119769026 | CGI:chr1:119712221-119712649 | promoter | 3.99e-01 | 2.75e-01 | 2.62e+00 | 8.69e-03 | 1.73e-02 | 1.24e-01 |
| HNSC | cg18199617 | chr1:119769030 | CGI:chr1:119712221-119712649 | promoter | 4.83e-01 | 3.48e-01 | 2.65e+00 | 8.13e-03 | 1.67e-02 | 1.34e-01 |
| COAD | cg24482350 | chr1:119767398 | CGI:chr1:119712221-119712649 | promoter,gene body | 4.89e-01 | 3.51e-01 | 2.47e+00 | 1.33e-02 | 1.94e-02 | 1.38e-01 |
| COAD | cg22718139 | chr1:119768816 | CGI:chr1:119712221-119712649 | promoter,exon,CDS,gene body | 6.14e-01 | 3.97e-01 | 2.28e+00 | 2.26e-02 | 2.84e-02 | 2.17e-01 |
Top |
Exon skipping events with PSI in TCGA for HMGCS2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for HMGCS2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for HMGCS2 |
| TFs related to HMGCS2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LGG | ZNF707 | HMGCS2 | 3.58e+00 | 5.21e-03 | 4.19e+00 | 9.81e-01 | Female-biased |
| MESO | NFATC4 | HMGCS2 | 4.57e+00 | 9.83e-01 | 3.40e+00 | 1.12e-02 | Male-biased |
| MESO | NKX3-1 | HMGCS2 | 3.92e+00 | 9.82e-01 | 2.20e+00 | 1.61e-03 | Male-biased |
| MESO | POU5F1B | HMGCS2 | 3.95e+00 | 9.81e-01 | 2.44e+00 | 3.42e-03 | Male-biased |
| MESO | SOX21 | HMGCS2 | 3.97e+00 | 9.82e-01 | 2.44e+00 | 3.14e-03 | Male-biased |
| MESO | SOX7 | HMGCS2 | 3.87e+00 | 9.81e-01 | 2.08e+00 | 1.27e-03 | Male-biased |
| MESO | ZNF354A | HMGCS2 | 4.03e+00 | 9.83e-01 | 2.51e+00 | 3.35e-03 | Male-biased |
| MESO | ZNF354B | HMGCS2 | 3.95e+00 | 9.82e-01 | 2.37e+00 | 2.65e-03 | Male-biased |
| MESO | ZNF525 | HMGCS2 | 4.53e+00 | 9.88e-01 | 3.13e+00 | 5.33e-03 | Male-biased |
| SARC | ZNF525 | HMGCS2 | 4.39e+00 | 9.81e-01 | 3.84e+00 | 1.07e-02 | Male-biased |
| HMGCS2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for HMGCS2 |
| RBPs related to ES in HMGCS2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| HMGCS2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76497233 | chr1:117173492:C:A | - | 0.233101975219687 | 0.0236843278467566 | BLCA | Female-baised eQTL |
| rs138897127 | chr1:117174577:G:A | - | 0.233101975219687 | 0.0236843278467566 | BLCA | Female-baised eQTL |
| rs143529196 | chr1:117174680:T:C | - | 0.233101975219687 | 0.0236843278467566 | BLCA | Female-baised eQTL |
| rs114400714 | chr1:117175406:T:C | - | 0.233101975219687 | 0.0236843278467566 | BLCA | Female-baised eQTL |
| rs115269712 | chr1:117175433:C:T | - | 0.233101975219687 | 0.0236843278467566 | BLCA | Female-baised eQTL |
| rs74740062 | chr1:117176509:A:G | - | 0.233101975219687 | 0.0236843278467566 | BLCA | Female-baised eQTL |
| rs115178076 | chr1:117176822:A:G | - | 0.232076715408238 | 0.0251085900901272 | BLCA | Female-baised eQTL |
| rs78886318 | chr1:117177697:G:C | - | 0.232076715408238 | 0.0251085900901272 | BLCA | Female-baised eQTL |
| rs77457286 | chr1:117173195:C:A | - | 0.231363865408893 | 0.0261670481313425 | BLCA | Female-baised eQTL |
| rs112458566 | chr1:115546412:T:C | - | 0.253893804162652 | 0.000378360609656855 | COAD | Female-baised eQTL |
| rs17359302 | chr1:113644997:T:G | - | 0.106457268329634 | 0.00382647273031769 | COAD | Female-baised eQTL |
| rs2359173 | chr1:113653873:A:G | - | 0.106941348477586 | 0.00453942594315618 | COAD | Female-baised eQTL |
| rs112741751 | chr1:115544347:G:A | - | 0.230634851299266 | 0.00461030294544348 | COAD | Female-baised eQTL |
| rs61784660 | chr1:110436761:G:A | - | 0.18953011979348 | 0.00465763337003793 | COAD | Female-baised eQTL |
| rs17679096 | chr1:110437892:C:T | - | 0.189553763108146 | 0.00466327439534207 | COAD | Female-baised eQTL |
| rs1885454 | chr1:113676463:T:G | - | 0.104615873255903 | 0.00472477655561002 | COAD | Female-baised eQTL |
| rs12758546 | chr1:113681013:C:T | - | 0.104615873255903 | 0.00472477655561002 | COAD | Female-baised eQTL |
| rs61817579 | chr1:113691811:G:A | - | 0.104615873255903 | 0.00472477655561002 | COAD | Female-baised eQTL |
| rs12746609 | chr1:113692432:A:G | - | 0.104615873255903 | 0.00472477655561002 | COAD | Female-baised eQTL |
| rs1080307 | chr1:113673827:T:G | - | 0.103702262915112 | 0.00511633950059872 | COAD | Female-baised eQTL |
| rs17274550 | chr1:113644604:A:G | - | 0.105549935424084 | 0.00539131925645074 | COAD | Female-baised eQTL |
| rs17274620 | chr1:113674733:A:T | - | 0.103546862357051 | 0.00548894584388097 | COAD | Female-baised eQTL |
| rs2359174 | chr1:113653742:T:G | - | 0.104311641764743 | 0.00568953837474244 | COAD | Female-baised eQTL |
| rs3789595 | chr1:113649025:G:A | - | 0.103783962818467 | 0.00603397777855045 | COAD | Female-baised eQTL |
| rs3748003 | chr1:113672138:T:C | - | 0.101318899310444 | 0.00630143572299145 | COAD | Female-baised eQTL |
| rs10802028 | chr1:115837748:G:C | - | 0.145602043892838 | 0.00639589172842325 | COAD | Female-baised eQTL |
| rs12752932 | chr1:113727537:G:A | - | 0.101874154185524 | 0.00643320440326055 | COAD | Female-baised eQTL |
| rs12734625 | chr1:113718954:C:A | - | 0.101419877104615 | 0.00647297652919275 | COAD | Female-baised eQTL |
| rs6674848 | chr1:113726169:A:C | - | 0.101419877104615 | 0.00647297652919275 | COAD | Female-baised eQTL |
| rs13374352 | chr1:113728116:G:A | - | 0.101419877104615 | 0.00647297652919275 | COAD | Female-baised eQTL |
| rs3747998 | chr1:113643516:G:C | - | 0.105006336011033 | 0.00690499050825626 | COAD | Female-baised eQTL |
| rs61820162 | chr1:113668828:C:T | - | 0.10301550097425 | 0.00698825420101222 | COAD | Female-baised eQTL |
| rs10802046 | chr1:115846541:G:A | - | 0.144489631021693 | 0.00716476967965658 | COAD | Female-baised eQTL |
| rs10923633 | chr1:115848710:A:C | - | 0.144489631021693 | 0.00716476967965658 | COAD | Female-baised eQTL |
| rs12129434 | chr1:115852451:T:G | - | 0.144489631021693 | 0.00716476967965658 | COAD | Female-baised eQTL |
| rs34877889 | chr1:113853747:T:A | - | 0.0982390305425179 | 0.00730124601268328 | COAD | Female-baised eQTL |
| rs12731969 | chr1:113576120:G:T | - | 0.100812705316885 | 0.00796430066739631 | COAD | Female-baised eQTL |
| rs61817586 | chr1:113732812:T:C | - | 0.0984461857271494 | 0.00813262489693429 | COAD | Female-baised eQTL |
| rs17462614 | chr1:113776891:C:T | - | 0.0984461857271494 | 0.00813262489693429 | COAD | Female-baised eQTL |
| rs10127930 | chr1:113786299:T:C | - | 0.0984461857271494 | 0.00813262489693429 | COAD | Female-baised eQTL |
| rs6668829 | chr1:113787831:C:T | - | 0.0984461857271494 | 0.00813262489693429 | COAD | Female-baised eQTL |
| rs34042871 | chr1:113792470:A:G | - | 0.0984461857271494 | 0.00813262489693429 | COAD | Female-baised eQTL |
| rs12729708 | chr1:113853844:G:C | - | 0.0972957541587855 | 0.00835178779531364 | COAD | Female-baised eQTL |
| rs3789609 | chr1:113855177:C:T | - | 0.0972957541587855 | 0.00835178779531364 | COAD | Female-baised eQTL |
| rs12140266 | chr1:112243077:C:T | - | 0.108195762634445 | 0.00846684531874477 | COAD | Female-baised eQTL |
| rs61817617 | chr1:113792861:A:T | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs6703387 | chr1:113798710:T:C | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs34341173 | chr1:113806320:G:A | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs34649199 | chr1:113807867:T:C | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs17509390 | chr1:113810702:T:C | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs3789607 | chr1:113823812:T:C | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs12735104 | chr1:113824721:G:A | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs12730735 | chr1:113838835:T:C | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs7555354 | chr1:113841809:G:A | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs7533605 | chr1:113841852:C:T | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs36115604 | chr1:113841978:G:A | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs71662845 | chr1:113843057:G:A | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs12748727 | chr1:113845283:G:A | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs12760457 | chr1:113847126:C:T | - | 0.0982842383138387 | 0.00850281994739273 | COAD | Female-baised eQTL |
| rs34799402 | chr1:113575952:C:T | - | 0.0985127283747747 | 0.00972102064550239 | COAD | Female-baised eQTL |
| rs7534975 | chr1:112242296:C:T | - | 0.105526637411244 | 0.0102065351534072 | COAD | Female-baised eQTL |
| rs2040040 | chr1:113789023:T:A | - | 0.096973744514461 | 0.0102965218127765 | COAD | Female-baised eQTL |
| rs7549685 | chr1:113864699:G:A | - | 0.0987196154022145 | 0.0107586904660934 | COAD | Female-baised eQTL |
| rs7523715 | chr1:115797639:A:G | - | 0.0849342076807572 | 0.0110848886022062 | COAD | Female-baised eQTL |
| rs17508814 | chr1:113564147:T:C | - | 0.0955270993085478 | 0.0149227193241015 | COAD | Female-baised eQTL |
| rs1857214 | chr1:115856611:C:T | - | 0.135367008094796 | 0.0153068001905308 | COAD | Female-baised eQTL |
| rs1217422 | chr1:113882846:T:G | - | -0.0938184000933346 | 0.0159216932572031 | COAD | Female-baised eQTL |
| rs1230715 | chr1:113885464:A:C | - | -0.0932047703978111 | 0.0171454931531425 | COAD | Female-baised eQTL |
| rs56257513 | chr1:113564422:T:G | - | 0.0934368454965952 | 0.0175028896506862 | COAD | Female-baised eQTL |
| rs17508163 | chr1:113535317:A:G | - | 0.0943426209108993 | 0.0185280311829565 | COAD | Female-baised eQTL |
| rs17274634 | chr1:113674905:T:C | - | 0.0943701388868161 | 0.0194224620607624 | COAD | Female-baised eQTL |
| rs1217394 | chr1:113891037:G:A | - | -0.0914661335698123 | 0.0202438249227936 | COAD | Female-baised eQTL |
| rs1539438 | chr1:113887734:C:T | - | -0.0917780997840177 | 0.0205115854090407 | COAD | Female-baised eQTL |
| rs2488456 | chr1:113888843:T:G | - | -0.0917780997840177 | 0.0205115854090407 | COAD | Female-baised eQTL |
| rs2797206 | chr1:115845461:C:A | - | -0.125537247942653 | 0.0209289233466752 | COAD | Female-baised eQTL |
| rs10802053 | chr1:115851873:G:C | - | 0.122937560767877 | 0.0219675320911053 | COAD | Female-baised eQTL |
| rs10923616 | chr1:115844437:G:A | - | 0.12248690269964 | 0.0233046089052968 | COAD | Female-baised eQTL |
| rs2018365 | chr1:113891849:G:A | - | 0.0902940533120685 | 0.0233193415447766 | COAD | Female-baised eQTL |
| rs4581284 | chr1:113555877:G:A | - | 0.0943713639477821 | 0.0240257818092751 | COAD | Female-baised eQTL |
| rs55855422 | chr1:113550293:G:A | - | 0.0942221650319884 | 0.0241175139154653 | COAD | Female-baised eQTL |
| rs12730675 | chr1:113551422:A:G | - | 0.0942221650319884 | 0.0241175139154653 | COAD | Female-baised eQTL |
| rs7533391 | chr1:113841637:C:T | - | 0.0888075258910784 | 0.025067561119612 | COAD | Female-baised eQTL |
| rs10399824 | chr1:115829215:A:G | - | 0.128457314432393 | 0.0265726034290456 | COAD | Female-baised eQTL |
| rs34258372 | chr1:113553128:A:G | - | 0.0920273833885132 | 0.0282164081800264 | COAD | Female-baised eQTL |
| rs35912050 | chr1:119754632:A:C | gene | 0.0791300993692591 | 0.0330504679646114 | COAD | Female-baised eQTL |
| rs34301696 | chr1:115505696:G:A | - | 0.104933917164401 | 0.0402225990522749 | COAD | Female-baised eQTL |
| rs1217384 | chr1:113877138:G:C | - | -0.0859110035121531 | 0.041494081622687 | COAD | Female-baised eQTL |
| rs12563433 | chr1:119766352:T:C | gene | 0.082645020885313 | 0.0479032373087648 | COAD | Female-baised eQTL |
| rs34857922 | chr1:113878138:C:T | - | 0.0871222767355077 | 0.0481028431570496 | COAD | Female-baised eQTL |
| rs3017162 | chr1:115543488:G:A | - | 0.143036959761294 | 0.048396818636849 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6658884 | chr1:115660190:C:T | - | 0.0323876009368339 | 0.0188963525325028 | BLCA | Male-baised eQTL |
| rs6659181 | chr1:115660395:C:T | - | 0.0323748763495951 | 0.019170311966257 | BLCA | Male-baised eQTL |
| rs7519517 | chr1:111130715:T:A | - | 0.031962988640134 | 0.0210438023407515 | BLCA | Male-baised eQTL |
| rs7519518 | chr1:111130716:T:A | - | 0.031962988640134 | 0.0210438023407515 | BLCA | Male-baised eQTL |
| rs7550484 | chr1:111130733:C:T | - | 0.031962988640134 | 0.0210438023407515 | BLCA | Male-baised eQTL |
| rs56273250 | chr1:111133140:G:A | - | 0.0299141862556734 | 0.0370294076879822 | BLCA | Male-baised eQTL |
| rs1335645 | chr1:111141654:A:G | - | 0.0300633092492682 | 0.037265524776778 | BLCA | Male-baised eQTL |
| rs61805898 | chr1:111142097:A:G | - | 0.0300633092492682 | 0.037265524776778 | BLCA | Male-baised eQTL |
| rs7552535 | chr1:111151636:T:A | - | 0.0296543876254331 | 0.0406810399468659 | BLCA | Male-baised eQTL |
| rs1043096 | chr1:111139685:G:C | - | 0.0295462704174045 | 0.0419483617682694 | BLCA | Male-baised eQTL |
| rs61804635 | chr1:111137114:G:A | - | 0.0291030023458231 | 0.0423495945331783 | BLCA | Male-baised eQTL |
| rs17559092 | chr1:115654373:A:G | - | 0.0626631637326815 | 0.0190946817910854 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000134240 |
| CpG Site: cg24482350 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.490666595781683 | |
| Female Effect: - | |
 | Gene ID: ENSG00000134240 |
| CpG Site: cg22718139 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: -0.490666595781683 | |
| Female Effect: - | |
 | Gene ID: ENSG00000134240 |
| CpG Site: cg13976683 | |
| Position to Gene: promoter | |
| Male Effect: -0.490666595781683 | |
| Female Effect: - | |
 | Gene ID: ENSG00000134240 |
| CpG Site: cg27540878 | |
| Position to Gene: promoter | |
| Male Effect: -0.490666595781683 | |
| Female Effect: - | |
 | Gene ID: ENSG00000134240 |
| CpG Site: cg18199617 | |
| Position to Gene: promoter | |
| Male Effect: -0.242940732633222 | |
| Female Effect: - | |
 | Gene ID: ENSG00000134240 |
| CpG Site: cg10212621 | |
| Position to Gene: promoter | |
| Male Effect: -0.0644842965186145 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg24482350 | chr1:119767398 | gene,promoter | -0.490666595781683 | 9.86937486891177e-15 | -0.5560197561630618 | 1.0480000876770899e-17 | KIRP |
| cg22718139 | chr1:119768816 | gene,exon,CDS,promoter | -0.490666595781683 | 9.86937486891177e-15 | -0.5560197561630618 | 1.0480000876770899e-17 | KIRP |
| cg13976683 | chr1:119768919 | promoter | -0.490666595781683 | 9.86937486891177e-15 | -0.5560197561630618 | 1.0480000876770899e-17 | KIRP |
| cg27540878 | chr1:119770107 | promoter | -0.490666595781683 | 9.86937486891177e-15 | -0.5560197561630618 | 1.0480000876770899e-17 | KIRP |
| cg18199617 | chr1:119769030 | promoter | -0.242940732633222 | 3.11287771949564e-06 | -0.38646484143005144 | 1.4563697540608076e-08 | KIRP |
| cg10212621 | chr1:119769026 | promoter | -0.0644842965186145 | 8.05351976075706e-09 | -0.4501780837533681 | 1.5852907692894319e-12 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of HMGCS2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000134240 | HMGCS2 | C0007102 | Malignant tumor of colon | 2 | CTD_human |
| ENSG00000134240 | HMGCS2 | C0009375 | Colonic Neoplasms | 2 | CTD_human |
| ENSG00000134240 | HMGCS2 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| ENSG00000134240 | HMGCS2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| ENSG00000134240 | HMGCS2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| ENSG00000134240 | HMGCS2 | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human |
| ENSG00000134240 | HMGCS2 | C2751532 | 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency | 1 | CTD_human |
