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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000134215

Summary for VAV3

check button Gene summary

Gene informationEnsembl ID

ENSG00000134215

Gene symbol

VAV3

Gene namevav guanine nucleotide exchange factor 3
HGNC

12659

Entrez ID

10451

Gene typeprotein_coding
SynonymsVAV3|
UniProtAcc

Q9UKW4


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for VAV3

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
VAV36.64e+02-1.32e+001.78e-01-7.44e+009.96e-143.62e-11SARC

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
VAV32.42e+03-1.10e+002.21e-01-4.98e+006.43e-072.46e-06HNSC
VAV31.58e+031.15e+002.52e-014.55e+005.25e-069.90e-06LUSC
VAV32.85e+031.75e+004.47e-013.93e+008.59e-053.90e-04BLCA
VAV31.25e+033.25e+007.04e-014.62e+003.79e-062.39e-05CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
VAV33.11e+021.10e+003.65e-013.01e+002.63e-036.03e-03LIHC
VAV31.08e+041.35e+001.23e-011.10e+014.93e-282.33e-27BRCA

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Sex-biased somatic mutation for VAV3

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for VAV3

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg01422262chr1:107963669CGI:chr1:107964629-107965419promoter,gene body3.62e-011.81e-012.19e+002.85e-023.16e-021.81e-01
LUADcg12619536chr1:107965445CGI:chr1:107964629-107965419promoter1.56e-015.24e-022.83e+004.66e-037.06e-031.04e-01
LUADcg05937496chr1:107965585CGI:chr1:107964629-107965419promoter1.49e-014.70e-024.64e+003.45e-061.79e-051.02e-01
HNSCcg06543087chr1:107965926CGI:chr1:107964629-107965419promoter2.55e-013.63e-023.74e+001.86e-044.36e-042.19e-01
HNSCcg19918758chr1:107965491CGI:chr1:107964629-107965419promoter1.85e-017.63e-022.42e+001.57e-021.88e-021.08e-01
LUSCcg05937496chr1:107965585CGI:chr1:107964629-107965419promoter1.39e-013.88e-024.02e+005.76e-055.76e-041.01e-01
BLCAcg12619536chr1:107965445CGI:chr1:107964629-107965419promoter1.59e-015.50e-022.13e+003.36e-023.67e-021.04e-01
BLCAcg19918758chr1:107965491CGI:chr1:107964629-107965419promoter1.79e-017.36e-022.25e+002.43e-022.85e-021.05e-01
ESCAcg01422262chr1:107963669CGI:chr1:107964629-107965419promoter,gene body5.14e-012.84e-012.56e+001.04e-023.64e-022.29e-01
CHOLcg06543087chr1:107965926CGI:chr1:107964629-107965419promoter2.42e-012.71e-022.43e+001.50e-022.65e-022.15e-01
CHOLcg19753230chr1:107964190CGI:chr1:107964629-107965419promoter,gene body2.04e-014.82e-022.73e+006.38e-031.82e-021.55e-01
CHOLcg17099397chr1:107965563CGI:chr1:107964629-107965419promoter3.97e-011.18e-013.10e+001.96e-031.07e-022.79e-01
CHOLcg05937496chr1:107965585CGI:chr1:107964629-107965419promoter1.77e-016.09e-022.51e+001.22e-022.39e-021.16e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg24662718chr1:107964846CGI:chr1:107964629-107965419promoter,exon,CDS,gene body2.48e-011.01e-012.35e+001.90e-022.49e-021.47e-01
BLCAcg01422262chr1:107963669CGI:chr1:107964629-107965419promoter,gene body3.04e-011.51e-012.29e+002.21e-022.89e-021.53e-01
BLCAcg25602490chr1:107964456CGI:chr1:107964629-107965419promoter,gene body2.18e-018.54e-022.18e+002.92e-023.48e-021.33e-01
LIHCcg25602490chr1:107964456CGI:chr1:107964629-107965419promoter,gene body1.77e-015.66e-022.44e+001.47e-021.88e-021.20e-01
LIHCcg05937496chr1:107965585CGI:chr1:107964629-107965419promoter2.14e-015.76e-022.79e+005.35e-038.47e-031.56e-01

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Exon skipping events with PSI in TCGA for VAV3

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for VAV3

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for VAV3

check buttonTFs related to VAV3.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
DLBCAIREVAV33.99e+009.83e-012.50e+008.74e-04Male-biased
DLBCBARX2VAV34.13e+009.87e-012.55e+006.53e-04Male-biased
DLBCDLX3VAV34.43e+009.88e-013.32e+003.86e-03Male-biased
DLBCDMRTA1VAV34.20e+009.88e-012.50e+004.54e-04Male-biased
DLBCDMRTA2VAV34.21e+009.88e-012.56e+005.30e-04Male-biased
DLBCE2F2VAV34.21e+009.81e-013.28e+007.32e-03Male-biased
DLBCFOXD2VAV33.93e+009.82e-012.21e+004.21e-04Male-biased
DLBCFOXP1VAV34.04e+009.83e-012.83e+002.44e-03Male-biased
DLBCGBX1VAV34.53e+009.86e-013.61e+007.69e-03Male-biased
DLBCGBX2VAV34.60e+009.91e-013.46e+003.47e-03Male-biased
DLBCHMX2VAV34.30e+009.88e-013.11e+002.75e-03Male-biased
DLBCHOXB7VAV33.94e+009.82e-012.50e+001.04e-03Male-biased
DLBCHOXB8VAV34.11e+009.86e-012.75e+001.40e-03Male-biased
DLBCIRF7VAV34.21e+009.84e-013.17e+004.82e-03Male-biased
DLBCLBX2VAV34.68e+009.83e-013.88e+001.22e-02Male-biased
DLBCLHX6VAV34.72e+009.92e-013.53e+002.75e-03Male-biased
DLBCNKX3-1VAV34.15e+009.87e-012.28e+002.68e-04Male-biased
DLBCPBX2VAV33.89e+009.80e-012.51e+001.30e-03Male-biased
DLBCPDX1VAV34.14e+009.86e-012.79e+001.47e-03Male-biased
DLBCPOU3F1VAV34.71e+009.92e-013.53e+002.88e-03Male-biased
DLBCPOU3F3VAV33.99e+009.84e-011.88e+001.32e-04Male-biased
DLBCPOU3F4VAV34.82e+009.93e-013.67e+003.30e-03Male-biased
DLBCSKOR1VAV34.14e+009.87e-012.62e+008.01e-04Male-biased
DLBCSOX14VAV33.97e+009.82e-012.64e+001.57e-03Male-biased
DLBCSOX15VAV34.13e+009.87e-012.61e+008.13e-04Male-biased
DLBCSOX18VAV33.95e+009.82e-012.47e+009.12e-04Male-biased
DLBCSOX2VAV34.04e+009.85e-012.48e+006.92e-04Male-biased
DLBCSOX5VAV34.49e+009.92e-013.09e+001.25e-03Male-biased
DLBCSRYVAV34.07e+009.85e-012.49e+006.55e-04Male-biased
DLBCZBTB32VAV34.98e+009.92e-013.91e+004.46e-03Male-biased
DLBCZFHX3VAV35.07e+009.89e-014.17e+008.48e-03Male-biased
DLBCZNF232VAV34.15e+009.86e-012.85e+001.83e-03Male-biased
DLBCZNF418VAV34.18e+009.88e-011.16e+001.02e-05Male-biased
DLBCZNF433VAV34.22e+009.86e-013.09e+003.38e-03Male-biased
UVMZNF418VAV34.11e+001.20e-025.33e+009.84e-01Female-biased

check buttonVAV3 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for VAV3

check buttonRBPs related to ES in VAV3.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
COADU2AF2exon_skip_288398.91e+001.32e-029.22e+009.83e-01Female-biased
KIRPHNRNPH2exon_skip_288508.45e+009.91e-017.98e+002.44e-03Male-biased
KIRPPTBP1exon_skip_288349.02e+009.85e-018.70e+001.03e-02Male-biased
BRCAHNRNPH2exon_skip_288507.70e+006.22e-038.47e+009.87e-01Female-biased
KICHPTBP1exon_skip_288348.93e+009.81e-018.64e+001.39e-02Male-biased

check buttonVAV3 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000134215LINC02671,hsa-mir-499a,VAV3Tumor sex-biased ceRNATCGA-ACC
ENSG00000134215AC100861.1,hsa-mir-203a,VAV3Male-specific ceRNATCGA-BLCA
ENSG00000134215AC024075.1,hsa-mir-203a,VAV3Male-specific ceRNATCGA-BLCA
ENSG00000134215AC105339.2,hsa-mir-340,VAV3Male-specific ceRNATCGA-BLCA
ENSG00000134215KCNQ1OT1,hsa-mir-655,VAV3Female-specific ceRNATCGA-LIHC
ENSG00000134215LINC02803,hsa-mir-655,VAV3Female-specific ceRNATCGA-LIHC
ENSG00000134215Z95331.1,hsa-mir-655,VAV3Female-specific ceRNATCGA-LIHC
ENSG00000134215LINC00298,hsa-mir-211,VAV3Tumor sex-biased ceRNATCGA-SARC

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs35430228chr1:115449983:G:C-0.1121158354301440.0232577936032349LUSCFemale-baised eQTL
rs34774919chr1:115450253:G:A-0.1121158354301440.0232577936032349LUSCFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs114048919chr1:115587340:C:T-0.1793675039768160.0213707757414256READMale-baised eQTL
rs3010381chr1:115646511:T:G-0.1624194022835220.0368549370983417READMale-baised eQTL
rs12732821chr1:115033554:G:A-0.1092313462347750.00139407136239402LUADMale-baised eQTL
rs641227chr1:110497433:A:G--0.07988350023212930.0232363126403196COADMale-baised eQTL
rs11164580chr1:102695717:G:A-0.07517260168456070.0286554153740293COADMale-baised eQTL
rs10782902chr1:102698495:G:A-0.07388332727662670.0331349677045062COADMale-baised eQTL
rs7527414chr1:102699725:A:G-0.07388332727662670.0331349677045062COADMale-baised eQTL
rs720315chr1:102709493:T:A-0.07388332727662670.0331349677045062COADMale-baised eQTL
rs12740872chr1:102718119:C:T-0.07005026755952250.044523743890797COADMale-baised eQTL
rs561606chr1:110499303:G:A--0.06999308148227810.048662137800964COADMale-baised eQTL
rs2138801chr1:102659496:C:T-0.07014353347972260.0488450499419447COADMale-baised eQTL
rs10443190chr1:102687552:G:A-0.07083216430096950.049535104974109COADMale-baised eQTL
rs1451031chr1:102729105:A:G-0.06886083912328990.049898269978343COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000134215
CpG Site: cg09896211
Position to Gene: gene
Male Effect: -0.141911248092009
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000134215
CpG Site: cg09896211
Position to Gene: gene
Male Effect: -0.139368998501429
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg09896211chr1:107689799gene-0.1419112480920093.39772186262981e-10-0.4667659103111864.958503100095405e-13LUAD
cg09896211chr1:107689799gene-0.1393689985014291.12285851489656e-05-0.31342448734816948.034510861955615e-08BLCA

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_28852chr1:107683487:107683533Frame-shiftrs11184955chr1:106656184:A:CDistant downstream-0.02289684594909570.0345684845133635COADFemale-baised sQTL
exon_skip_28852chr1:107683487:107683533Frame-shiftrs12048938chr1:106652708:G:ADistant downstream-0.02281670556310360.0371895197119824COADFemale-baised sQTL
exon_skip_28852chr1:107683487:107683533Frame-shiftrs4915093chr1:108029484:G:ADistant upstream-0.06835571947947310.0494290260511553KIRPFemale-baised sQTL

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_28852chr1:107683487:107683533Frame-shiftrs6583047chr1:107767670:A:CDistant upstream0.02383006865151850.0140310645294296HNSCMale-baised sQTL
exon_skip_28852chr1:107683487:107683533Frame-shiftrs6703924chr1:107764137:C:GDistant upstream0.02058476958916270.0419424860596766HNSCMale-baised sQTL

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of VAV3

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000134215VAV3C0017661IGA Glomerulonephritis1CTD_human
ENSG00000134215VAV3C0020538Hypertensive disease1CTD_human
ENSG00000134215VAV3C0020578Hyperventilation1CTD_human
ENSG00000134215VAV3C0033578Prostatic Neoplasms1CTD_human
ENSG00000134215VAV3C0039231Tachycardia1CTD_human
ENSG00000134215VAV3C0080203Tachyarrhythmia1CTD_human
ENSG00000134215VAV3C0376358Malignant neoplasm of prostate1CTD_human