|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000134138 |
Summary for MEIS2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000134138 | Gene symbol | MEIS2 |
| Gene name | Meis homeobox 2 | |
| HGNC | 7001 | |
| Entrez ID | 4212 | |
| Gene type | protein_coding | |
| Synonyms | MEIS2|MRG1|HsT18361 | |
| UniProtAcc | O14770 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for MEIS2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MEIS2 | 5.84e+02 | -1.40e+00 | 1.52e-01 | -9.24e+00 | 2.48e-20 | 5.25e-19 | HNSC |
| MEIS2 | 1.71e+03 | 1.39e+00 | 5.33e-01 | 2.62e+00 | 8.92e-03 | 2.26e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MEIS2 | 1.28e+03 | -1.29e+00 | 3.22e-01 | -4.00e+00 | 6.30e-05 | 6.26e-04 | STAD |
| MEIS2 | 8.69e+02 | 1.05e+00 | 2.91e-01 | 3.62e+00 | 2.94e-04 | 8.51e-04 | LIHC |
| MEIS2 | 7.03e+02 | -2.87e+00 | 3.32e-01 | -8.64e+00 | 5.46e-18 | 9.60e-17 | KICH |
Top |
Sex-biased somatic mutation for MEIS2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for MEIS2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg11686722 | chr15:37099520 | CGI:chr15:37100400-37100672 | UTR,promoter,exon,gene body | 1.62e-01 | 3.21e-01 | -2.85e+00 | 4.42e-03 | 1.93e-02 | -1.60e-01 |
| BRCA | cg24504442 | chr15:37099474 | CGI:chr15:37100400-37100672 | UTR,promoter,exon,gene body | 3.29e-01 | 5.35e-01 | -2.31e+00 | 2.12e-02 | 3.58e-02 | -2.05e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg24504442 | chr15:37099474 | CGI:chr15:37100400-37100672 | UTR,promoter,exon,gene body | 1.96e-01 | 3.28e-01 | -4.47e+00 | 7.76e-06 | 2.17e-05 | -1.32e-01 |
| HNSC | cg25381383 | chr15:37102429 | CGI:chr15:37101465-37102045 | promoter | 2.36e-01 | 1.16e-01 | 2.73e+00 | 6.35e-03 | 8.71e-03 | 1.19e-01 |
| HNSC | cg09840968 | chr15:37102639 | CGI:chr15:37101465-37102045 | promoter | 2.53e-01 | 6.36e-02 | 4.01e+00 | 6.03e-05 | 1.69e-04 | 1.89e-01 |
| COAD | cg16409367 | chr15:37102553 | CGI:chr15:37101465-37102045 | promoter | 4.07e-01 | 3.05e-01 | 2.67e+00 | 7.51e-03 | 1.14e-02 | 1.02e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg11686722 | chr15:37099520 | CGI:chr15:37100400-37100672 | UTR,promoter,exon,gene body | 1.62e-01 | 5.35e-02 | 9.56e+00 | 1.19e-21 | 7.42e-21 | 1.08e-01 |
| BRCA | cg00797346 | chr15:37099372 | CGI:chr15:37100400-37100672 | UTR,promoter,exon,gene body | 1.85e-01 | 6.04e-02 | 8.41e+00 | 3.94e-17 | 1.69e-16 | 1.24e-01 |
| BRCA | cg24504442 | chr15:37099474 | CGI:chr15:37100400-37100672 | UTR,promoter,exon,gene body | 3.29e-01 | 1.06e-01 | 9.54e+00 | 1.45e-21 | 8.95e-21 | 2.23e-01 |
| BRCA | cg25381383 | chr15:37102429 | CGI:chr15:37101465-37102045 | promoter | 2.85e-01 | 1.32e-01 | 4.66e+00 | 3.22e-06 | 5.68e-06 | 1.53e-01 |
| BRCA | cg16409367 | chr15:37102553 | CGI:chr15:37101465-37102045 | promoter | 3.29e-01 | 1.68e-01 | 9.86e+00 | 6.05e-23 | 4.24e-22 | 1.61e-01 |
| BRCA | cg09840968 | chr15:37102639 | CGI:chr15:37101465-37102045 | promoter | 3.32e-01 | 1.01e-01 | 9.51e+00 | 1.83e-21 | 1.12e-20 | 2.31e-01 |
| BLCA | cg09840968 | chr15:37102639 | CGI:chr15:37101465-37102045 | promoter | 4.19e-01 | 1.58e-01 | 2.11e+00 | 3.52e-02 | 3.94e-02 | 2.61e-01 |
| LIHC | cg09840968 | chr15:37102639 | CGI:chr15:37101465-37102045 | promoter | 1.05e-01 | 2.11e-01 | -4.59e+00 | 4.39e-06 | 3.77e-05 | -1.06e-01 |
Top |
Exon skipping events with PSI in TCGA for MEIS2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| ESCA | exon_skip_125948 | 4.78e-01 | 6.01e-01 | -2.50e+00 | 1.25e-02 | 2.67e-02 | -1.22e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for MEIS2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for MEIS2 |
| TFs related to MEIS2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SKCM | BARX2 | MEIS2 | 3.35e+00 | 3.84e-03 | 4.63e+00 | 9.85e-01 | Female-biased |
| SKCM | DMRT3 | MEIS2 | 3.46e+00 | 5.64e-03 | 4.62e+00 | 9.83e-01 | Female-biased |
| SKCM | FOXD2 | MEIS2 | 2.94e+00 | 2.67e-03 | 4.33e+00 | 9.81e-01 | Female-biased |
| SKCM | FOXP3 | MEIS2 | 3.35e+00 | 3.49e-03 | 4.66e+00 | 9.86e-01 | Female-biased |
| SKCM | NKX6-1 | MEIS2 | 2.79e+00 | 1.73e-03 | 4.30e+00 | 9.81e-01 | Female-biased |
| SKCM | ONECUT3 | MEIS2 | 3.08e+00 | 3.79e-03 | 4.36e+00 | 9.80e-01 | Female-biased |
| SKCM | SOX2 | MEIS2 | 3.41e+00 | 5.88e-03 | 4.55e+00 | 9.82e-01 | Female-biased |
| SKCM | SOX5 | MEIS2 | 3.69e+00 | 5.94e-03 | 4.84e+00 | 9.86e-01 | Female-biased |
| SKCM | SRY | MEIS2 | 3.42e+00 | 4.80e-03 | 4.63e+00 | 9.84e-01 | Female-biased |
| SKCM | TLX3 | MEIS2 | 4.58e+00 | 1.60e-02 | 5.41e+00 | 9.80e-01 | Female-biased |
| SKCM | ZNF334 | MEIS2 | 2.58e+00 | 3.16e-04 | 4.58e+00 | 9.88e-01 | Female-biased |
| SKCM | ZNF354A | MEIS2 | 3.09e+00 | 3.51e-03 | 4.40e+00 | 9.81e-01 | Female-biased |
| SKCM | ZNF418 | MEIS2 | 2.36e+00 | 9.42e-05 | 4.69e+00 | 9.90e-01 | Female-biased |
| SKCM | ZNF580 | MEIS2 | 3.11e+00 | 2.27e-03 | 4.55e+00 | 9.85e-01 | Female-biased |
| SKCM | ZNF79 | MEIS2 | 2.59e+00 | 7.84e-04 | 4.33e+00 | 9.83e-01 | Female-biased |
| MEIS2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
 |
Top |
Sex-biased RBP-ES network for MEIS2 |
| RBPs related to ES in MEIS2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MEIS2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000134138 | SNHG14,hsa-mir-133b,MEIS2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000134138 | AC048341.1,hsa-mir-133b,MEIS2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000134138 | AC004594.1,hsa-mir-133b,MEIS2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000134138 | MCM3AP-AS1,hsa-mir-133b,MEIS2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000134138 | DPH6-DT,hsa-mir-144,MEIS2 | Female-specific ceRNA | TCGA-STAD |
| ENSG00000134138 | LINC00476,hsa-mir-144,MEIS2 | Female-specific ceRNA | TCGA-STAD |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs73391226 | chr15:39572111:T:C | - | 0.105039424717519 | 0.0208937008693873 | PCPG | Female-baised eQTL |
| rs59948124 | chr15:39533800:T:C | - | 0.0955568846056304 | 0.0334206078189724 | PCPG | Female-baised eQTL |
| rs113045109 | chr15:42259215:T:C | - | 0.16885278433809 | 0.0133699078538998 | KIRC | Female-baised eQTL |
| rs1659215 | chr15:42327310:C:T | - | -0.149663531203556 | 0.0467343485563727 | KIRC | Female-baised eQTL |
| rs1704395 | chr15:41918821:T:C | - | 0.124963136663271 | 0.00627270421530961 | BLCA | Female-baised eQTL |
| rs1648821 | chr15:41919918:C:T | - | 0.124963136663271 | 0.00627270421530961 | BLCA | Female-baised eQTL |
| rs1025226 | chr15:41922027:C:A | - | 0.122593870437176 | 0.00640203371411225 | BLCA | Female-baised eQTL |
| rs12101559 | chr15:42450266:A:G | - | 0.129792439792432 | 0.0103564470646047 | BLCA | Female-baised eQTL |
| rs7181688 | chr15:42455497:C:T | - | 0.129792439792432 | 0.0103564470646047 | BLCA | Female-baised eQTL |
| rs16973261 | chr15:42456825:G:A | - | 0.129792439792432 | 0.0103564470646047 | BLCA | Female-baised eQTL |
| rs785425 | chr15:29886411:G:A | - | 0.117817717242888 | 0.0313578527327954 | BLCA | Female-baised eQTL |
| rs8043317 | chr15:27506640:C:T | - | 0.101017043416603 | 0.031825290974262 | BLCA | Female-baised eQTL |
| rs74005020 | chr15:27506169:G:A | - | 0.102341967821441 | 0.0330988084594226 | BLCA | Female-baised eQTL |
| rs1704397 | chr15:41919794:T:C | - | 0.101675012216773 | 0.0338891193897025 | BLCA | Female-baised eQTL |
| rs1648822 | chr15:41920585:T:C | - | 0.101675012216773 | 0.0338891193897025 | BLCA | Female-baised eQTL |
| rs76024922 | chr15:41921117:G:C | - | 0.101675012216773 | 0.0338891193897025 | BLCA | Female-baised eQTL |
| rs1712427 | chr15:42040705:T:C | - | 0.119102515204951 | 0.0481112771475485 | BLCA | Female-baised eQTL |
| rs117735333 | chr15:27955489:G:A | - | 0.0966686255931585 | 0.0107389662138028 | LUAD | Female-baised eQTL |
| rs45495598 | chr15:27957495:C:T | - | 0.0966686255931585 | 0.0107389662138028 | LUAD | Female-baised eQTL |
| rs139403059 | chr15:27995845:C:T | - | 0.0920590904725992 | 0.0148391642146294 | LUAD | Female-baised eQTL |
| rs117003001 | chr15:27996675:T:G | - | 0.0920590904725992 | 0.0148391642146294 | LUAD | Female-baised eQTL |
| rs16958757 | chr15:46858443:G:T | - | 0.10215836045536 | 0.0267958170047658 | LUAD | Female-baised eQTL |
| rs7165923 | chr15:27963288:T:C | - | 0.0605319537045195 | 0.0281667177386606 | LUAD | Female-baised eQTL |
| rs4778135 | chr15:27982117:T:C | - | 0.0631473199542312 | 0.0289593758735847 | LUAD | Female-baised eQTL |
| rs4778214 | chr15:27960418:A:G | - | 0.0595300034916436 | 0.04343309085415 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3892720 | chr15:39305092:C:T | - | 0.0984722306017367 | 0.0152503703023911 | PAAD | Male-baised eQTL |
| rs12442333 | chr15:31019385:C:A | - | 0.102065917772631 | 0.000233131904113258 | LIHC | Male-baised eQTL |
| rs2339035 | chr15:30773727:G:A | - | 0.102405347874569 | 0.000346050325512642 | LIHC | Male-baised eQTL |
| rs16956366 | chr15:30909365:C:T | - | 0.0909128438307865 | 0.00146701829271337 | LIHC | Male-baised eQTL |
| rs76312270 | chr15:31003392:G:T | - | 0.0922993002018667 | 0.00158725918055825 | LIHC | Male-baised eQTL |
| rs12441456 | chr15:31012082:A:G | - | 0.0922993002018667 | 0.00158725918055825 | LIHC | Male-baised eQTL |
| rs78802665 | chr15:31012578:G:A | - | 0.0922993002018667 | 0.00158725918055825 | LIHC | Male-baised eQTL |
| rs16956422 | chr15:30978555:C:A | - | 0.0858888135624751 | 0.0024568537121688 | LIHC | Male-baised eQTL |
| rs36042462 | chr15:31014155:C:T | - | 0.0880247534268703 | 0.00340309088879252 | LIHC | Male-baised eQTL |
| rs77719498 | chr15:30974920:A:T | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs79225637 | chr15:30983022:G:A | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs116909211 | chr15:30987798:G:C | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs3743232 | chr15:30991110:G:A | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs79030302 | chr15:30992114:C:A | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs12437677 | chr15:30993495:G:A | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs12442823 | chr15:30995758:A:G | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs117586493 | chr15:30996584:G:A | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs77445807 | chr15:30996999:A:G | - | 0.0839479607874133 | 0.00480742232160102 | LIHC | Male-baised eQTL |
| rs9672538 | chr15:31379949:A:G | - | 0.0819630941397932 | 0.00549828657771467 | LIHC | Male-baised eQTL |
| rs16956414 | chr15:30967707:T:C | - | 0.0812609339650038 | 0.00610723175259119 | LIHC | Male-baised eQTL |
| rs10519726 | chr15:31029672:G:A | - | 0.0790373699587467 | 0.00619629642607249 | LIHC | Male-baised eQTL |
| rs16956460 | chr15:31025242:A:G | - | 0.0792255462019139 | 0.00699620961256834 | LIHC | Male-baised eQTL |
| rs28487996 | chr15:31024053:T:C | - | 0.0791585403071055 | 0.00727529318942601 | LIHC | Male-baised eQTL |
| rs66501706 | chr15:31336855:G:A | - | 0.0848003195777077 | 0.00754729403713275 | LIHC | Male-baised eQTL |
| rs76472542 | chr15:30940415:A:C | - | 0.0804416942787593 | 0.00858360732799172 | LIHC | Male-baised eQTL |
| rs75814343 | chr15:30940417:T:C | - | 0.0804416942787593 | 0.00858360732799172 | LIHC | Male-baised eQTL |
| rs3784588 | chr15:31002451:C:T | - | 0.081761730512664 | 0.00887388806894277 | LIHC | Male-baised eQTL |
| rs871312 | chr15:30924458:G:A | - | 0.0777856778938923 | 0.0108617592441765 | LIHC | Male-baised eQTL |
| rs118098310 | chr15:30931951:G:A | - | 0.0777856778938923 | 0.0108617592441765 | LIHC | Male-baised eQTL |
| rs73368444 | chr15:31012484:A:T | - | 0.0792619300506215 | 0.0108671705569719 | LIHC | Male-baised eQTL |
| rs77436390 | chr15:31269694:C:T | - | 0.0773854501183129 | 0.0122581739829668 | LIHC | Male-baised eQTL |
| rs150045922 | chr15:30919488:C:T | - | 0.0751932725070446 | 0.0155708539332474 | LIHC | Male-baised eQTL |
| rs77648093 | chr15:30920338:C:T | - | 0.075078694485678 | 0.0157535220894222 | LIHC | Male-baised eQTL |
| rs76554225 | chr15:30920698:C:T | - | 0.075078694485678 | 0.0157535220894222 | LIHC | Male-baised eQTL |
| rs145553982 | chr15:30911963:G:C | - | 0.072943702944999 | 0.0208663536769897 | LIHC | Male-baised eQTL |
| rs12439079 | chr15:30915419:A:G | - | 0.0729327595643294 | 0.0210141666216375 | LIHC | Male-baised eQTL |
| rs16956362 | chr15:30906769:A:G | - | 0.0708665364783948 | 0.0270428057402777 | LIHC | Male-baised eQTL |
| rs76991098 | chr15:31268598:T:A | - | 0.069939688954205 | 0.03127979011886 | LIHC | Male-baised eQTL |
| rs141794488 | chr15:31259616:G:A | - | 0.0696516315018216 | 0.0328979660208695 | LIHC | Male-baised eQTL |
| rs80220087 | chr15:31263614:G:A | - | 0.0696516315018216 | 0.0328979660208695 | LIHC | Male-baised eQTL |
| rs116998504 | chr15:31253739:C:T | - | 0.0694283090467502 | 0.0342089570582195 | LIHC | Male-baised eQTL |
| rs12324838 | chr15:42648592:C:T | - | 0.0671712965203408 | 0.0413146451454147 | LIHC | Male-baised eQTL |
| rs147082669 | chr15:30816061:G:A | - | 0.0655792985540752 | 0.0420734292294825 | LIHC | Male-baised eQTL |
| rs7180905 | chr15:30817179:C:T | - | 0.0655792985540752 | 0.0420734292294825 | LIHC | Male-baised eQTL |
| rs77764895 | chr15:30817682:G:A | - | 0.0655792985540752 | 0.0420734292294825 | LIHC | Male-baised eQTL |
| rs3815122 | chr15:30818055:C:T | - | 0.0655792985540752 | 0.0420734292294825 | LIHC | Male-baised eQTL |
| rs12442141 | chr15:31187083:C:T | - | 0.0647923403385173 | 0.0425039373074983 | LIHC | Male-baised eQTL |
| rs117089113 | chr15:31215896:G:C | - | 0.0633581463727819 | 0.0458266925595503 | LIHC | Male-baised eQTL |
| rs28631253 | chr15:31216968:G:A | - | 0.0633539632336817 | 0.0460533654900562 | LIHC | Male-baised eQTL |
| rs78884938 | chr15:31218682:C:T | - | 0.0633539632336817 | 0.0460533654900562 | LIHC | Male-baised eQTL |
| rs3743235 | chr15:31223653:G:A | - | 0.0633826794443929 | 0.0464683458522757 | LIHC | Male-baised eQTL |
| rs74221455 | chr15:31224750:G:A | - | 0.0633826794443929 | 0.0464683458522757 | LIHC | Male-baised eQTL |
| rs76710398 | chr15:31226496:A:G | - | 0.0633826794443929 | 0.0464683458522757 | LIHC | Male-baised eQTL |
| rs114793100 | chr15:42640157:A:T | - | 0.076252877749416 | 0.0470743757463945 | LIHC | Male-baised eQTL |
| rs12101670 | chr15:31229978:C:T | - | 0.0631119377285816 | 0.0483375972422922 | LIHC | Male-baised eQTL |
| rs12437996 | chr15:31234703:C:G | - | 0.0631119377285816 | 0.0483375972422922 | LIHC | Male-baised eQTL |
| rs76293909 | chr15:31238188:C:T | - | 0.0631119377285816 | 0.0483375972422922 | LIHC | Male-baised eQTL |
| rs79619564 | chr15:31242083:A:G | - | 0.0631119377285816 | 0.0483375972422922 | LIHC | Male-baised eQTL |
| rs1972825 | chr15:31230156:C:T | - | 0.0629354676158199 | 0.0499740463114314 | LIHC | Male-baised eQTL |
| rs2412504 | chr15:40265863:A:G | - | 0.0449455469003655 | 0.00642119174016792 | BLCA | Male-baised eQTL |
| rs3743131 | chr15:40265669:C:T | - | 0.0452531356886619 | 0.00645682752791726 | BLCA | Male-baised eQTL |
| rs3743132 | chr15:40265801:A:G | - | 0.0452531356886619 | 0.00645682752791726 | BLCA | Male-baised eQTL |
| rs3743135 | chr15:40266281:A:G | - | 0.0449070541461579 | 0.00653605976183622 | BLCA | Male-baised eQTL |
| rs1075508 | chr15:40264175:G:A | - | 0.0443492052664354 | 0.0070488946705623 | BLCA | Male-baised eQTL |
| rs936217 | chr15:40264219:G:A | - | 0.0443492052664354 | 0.0070488946705623 | BLCA | Male-baised eQTL |
| rs1075506 | chr15:40264380:G:A | - | 0.0443492052664354 | 0.0070488946705623 | BLCA | Male-baised eQTL |
| rs1075507 | chr15:40264453:G:A | - | 0.0443492052664354 | 0.0070488946705623 | BLCA | Male-baised eQTL |
| rs2277563 | chr15:40264751:A:C | - | 0.0443492052664354 | 0.0070488946705623 | BLCA | Male-baised eQTL |
| rs2277564 | chr15:40264752:G:A | - | 0.0443492052664354 | 0.0070488946705623 | BLCA | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg25221496 | |
| Position to Gene: gene,exon,CDS,UTR | |
| Male Effect: - | |
| Female Effect: -0.394023708718868 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg02366856 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.38940330796455 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg15902390 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.444574918871422 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg26708220 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.444574918871422 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg03396151 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.218740806306712 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg06933370 | |
| Position to Gene: gene | |
| Male Effect: -0.433115987344767 | |
| Female Effect: - | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg02377544 | |
| Position to Gene: gene,exon | |
| Male Effect: -0.433115987344767 | |
| Female Effect: - | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg21177426 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.354945509947911 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg06933370 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.354945509947911 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg02377544 | |
| Position to Gene: gene,exon | |
| Male Effect: - | |
| Female Effect: -0.354945509947911 | |
 | Gene ID: ENSG00000134138 |
| CpG Site: cg06933370 | |
| Position to Gene: gene | |
| Male Effect: -0.170068019367937 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06933370 | chr15:37095322 | gene | -0.433115987344767 | 1.1577375238959e-11 | -0.48765871634916946 | 1.5234018463173853e-14 | STAD |
| cg02377544 | chr15:37096158 | gene,exon | -0.433115987344767 | 1.1577375238959e-11 | -0.48765871634916946 | 1.5234018463173853e-14 | STAD |
| cg06933370 | chr15:37095322 | gene | -0.170068019367937 | 5.03234765525029e-10 | -0.4042013527911782 | 6.65501770585073e-13 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg25221496 | chr15:37093699 | gene,exon,CDS,UTR | -0.394023708718868 | 1.85570230711283e-06 | -0.6300761858411562 | 3.0263486208143825e-09 | PAAD |
| cg02366856 | chr15:36947004 | gene | -0.38940330796455 | 2.81748563503561e-06 | -0.6070656264282053 | 3.0108961395612375e-09 | PAAD |
| cg15902390 | chr15:37095237 | gene | -0.444574918871422 | 4.32087944451143e-24 | -0.6221539120111131 | 1.0241894217918196e-28 | LUAD |
| cg26708220 | chr15:37095376 | gene | -0.444574918871422 | 4.32087944451143e-24 | -0.6221539120111131 | 1.0241894217918196e-28 | LUAD |
| cg03396151 | chr15:37095103 | gene | -0.218740806306712 | 7.02190701710693e-10 | -0.4426939870421366 | 1.157482364293173e-13 | LUAD |
| cg21177426 | chr15:37094385 | gene | -0.354945509947911 | 1.53993211298446e-10 | -0.6275951604791958 | 1.3262804583044552e-14 | LIHC |
| cg06933370 | chr15:37095322 | gene | -0.354945509947911 | 1.53993211298446e-10 | -0.6275951604791958 | 1.3262804583044552e-14 | LIHC |
| cg02377544 | chr15:37096158 | gene,exon | -0.354945509947911 | 1.53993211298446e-10 | -0.6275951604791958 | 1.3262804583044552e-14 | LIHC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_125958 | chr15:37096288:37096430 | Frame-shift | rs12438620 | chr15:37854355:G:A | Distant upstream | -0.0342255589015175 | 0.0223534983917318 | LGG | Female-baised sQTL |
| exon_skip_125958 | chr15:37096288:37096430 | Frame-shift | rs35403798 | chr15:37553563:T:C | Distant upstream | 0.0210972097945614 | 0.0463620978597322 | LGG | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_125958 | chr15:37096288:37096430 | Frame-shift | rs16963938 | chr15:36724895:T:C | Distant downstream | 0.022635787175592 | 0.0358078901383886 | LGG | Male-baised sQTL |
| exon_skip_125958 | chr15:37096288:37096430 | Frame-shift | rs62002344 | chr15:36738156:G:C | Distant downstream | 0.0225353062400974 | 0.0462219142671833 | LGG | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of MEIS2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000134138 | MEIS2 | C1832950 | Cardiac Malformation, Cleft Lip-Palate, Microcephaly and Digital Anomalies | 1 | CTD_human |
