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Gene: ENSG00000133816 |
Summary for MICAL2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000133816 | Gene symbol | MICAL2 |
| Gene name | microtubule associated monooxygenase, calponin and LIM domain containing 2 | |
| HGNC | 24693 | |
| Entrez ID | 9645 | |
| Gene type | protein_coding | |
| Synonyms | MICAL2|KIAA0750|FLJ14966 | |
| UniProtAcc | O94851 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MICAL2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MICAL2 | 3.10e+03 | 1.05e+00 | 1.39e-01 | 7.54e+00 | 4.77e-14 | 1.63e-13 | KIRC |
| MICAL2 | 2.36e+03 | 1.24e+00 | 4.44e-01 | 2.80e+00 | 5.17e-03 | 1.41e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MICAL2 | 5.97e+03 | 1.47e+00 | 8.40e-02 | 1.75e+01 | 1.14e-68 | 1.93e-67 | BRCA |
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Sex-biased somatic mutation for MICAL2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MICAL2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for MICAL2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for MICAL2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MICAL2 |
| TFs related to MICAL2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MICAL2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MICAL2 |
| RBPs related to ES in MICAL2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| COAD | SAMD4A | exon_skip_57011 | 6.26e+00 | 2.54e-03 | 6.73e+00 | 9.82e-01 | Female-biased |
| BRCA | FXR2 | exon_skip_56981 | 9.48e+00 | 9.85e-03 | 1.01e+01 | 9.88e-01 | Female-biased |
| ESCA | SAMD4A | exon_skip_56986 | 6.28e+00 | 3.16e-03 | 6.87e+00 | 9.82e-01 | Female-biased |
| MICAL2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000133816 | AC108134.3,hsa-mir-433,MICAL2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000133816 | AL024507.2,hsa-mir-433,MICAL2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000133816 | GNAS-AS1,hsa-mir-433,MICAL2 | Female-specific ceRNA | TCGA-KICH |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs201746053 | chr11:12335453:T:C | - | 0.210906354790015 | 1.97658038238772e-05 | PCPG | Female-baised eQTL |
| rs75108468 | chr11:5335909:G:C | - | 0.140437290192599 | 0.0380518659814859 | STAD | Female-baised eQTL |
| rs78129990 | chr11:5185567:A:G | - | 0.140622089067445 | 0.00255016861859198 | KIRC | Female-baised eQTL |
| rs76758765 | chr11:5186107:C:T | - | 0.140622089067445 | 0.00255016861859198 | KIRC | Female-baised eQTL |
| rs77383571 | chr11:5186175:G:A | - | 0.140622089067445 | 0.00255016861859198 | KIRC | Female-baised eQTL |
| rs76598510 | chr11:5188561:C:A | - | 0.140353965427018 | 0.00268031557310284 | KIRC | Female-baised eQTL |
| rs2568119 | chr11:19983411:G:A | - | -0.0571629459868124 | 0.0456015754299136 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs745361 | chr11:12924656:G:T | - | 0.0461867398035827 | 0.00852610649268982 | LUSC | Male-baised eQTL |
| rs214933 | chr11:17173037:C:T | - | -0.0371941050549401 | 0.0472488778466716 | BLCA | Male-baised eQTL |
| rs11026371 | chr11:22004226:A:G | - | 0.0781362490697533 | 0.0287375181569271 | LUAD | Male-baised eQTL |
| rs35332117 | chr11:22083041:T:A | - | 0.0779108577730884 | 0.0377133504905052 | LUAD | Male-baised eQTL |
| rs11026399 | chr11:22063801:G:A | - | 0.0770982272340618 | 0.0416721075969632 | LUAD | Male-baised eQTL |
| rs12223314 | chr11:22065284:C:T | - | 0.0770982272340618 | 0.0416721075969632 | LUAD | Male-baised eQTL |
| rs716778 | chr11:22078960:G:A | - | 0.0770043518908452 | 0.0436128606800327 | LUAD | Male-baised eQTL |
| rs11022889 | chr11:13567463:G:A | - | 0.0774259688201587 | 0.019637361775965 | COAD | Male-baised eQTL |
| rs188643 | chr11:13479287:G:T | - | 0.0777875156967508 | 0.0224057504251915 | COAD | Male-baised eQTL |
| rs307254 | chr11:13487269:C:T | - | 0.0777875156967508 | 0.0224057504251915 | COAD | Male-baised eQTL |
| rs7103458 | chr11:5534595:C:G | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs7125746 | chr11:5534775:T:C | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs11037984 | chr11:5535432:C:T | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs11037985 | chr11:5535490:C:T | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs12796126 | chr11:5535826:T:C | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs11038000 | chr11:5536474:A:G | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs11038004 | chr11:5536688:G:T | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs2201868 | chr11:5536981:C:A | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs10838290 | chr11:5538920:T:C | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs10500649 | chr11:5539873:T:C | - | 0.0592110059060558 | 0.0315728707203457 | COAD | Male-baised eQTL |
| rs2879824 | chr11:5537412:T:C | - | 0.0590754832260225 | 0.0333907260345745 | COAD | Male-baised eQTL |
| rs2879825 | chr11:5537413:T:G | - | 0.0590754832260225 | 0.0333907260345745 | COAD | Male-baised eQTL |
| rs11026080 | chr11:3236413:C:A | - | -0.111203404376055 | 0.0342622447152569 | COAD | Male-baised eQTL |
| rs10832048 | chr11:13518700:C:T | - | 0.0731645438971057 | 0.0414070988277579 | COAD | Male-baised eQTL |
| rs10832052 | chr11:13523105:T:G | - | 0.0731645438971057 | 0.0414070988277579 | COAD | Male-baised eQTL |
| rs11022884 | chr11:13562684:C:T | - | 0.0731645438971057 | 0.0414070988277579 | COAD | Male-baised eQTL |
| rs7478830 | chr11:13566737:A:T | - | 0.0731645438971057 | 0.0414070988277579 | COAD | Male-baised eQTL |
| rs11022892 | chr11:13573573:C:T | - | 0.0731645438971057 | 0.0414070988277579 | COAD | Male-baised eQTL |
| rs11037994 | chr11:5535987:A:T | - | 0.0572681077076954 | 0.0439875230964978 | COAD | Male-baised eQTL |
| rs2018276 | chr11:13562586:G:A | - | 0.071008344431823 | 0.0454674429589696 | COAD | Male-baised eQTL |
| rs141026476 | chr11:13574587:G:A | - | 0.071008344431823 | 0.0454674429589696 | COAD | Male-baised eQTL |
| rs10741620 | chr11:13517154:A:G | - | 0.0714767616163943 | 0.0460974629799966 | COAD | Male-baised eQTL |
| rs10838276 | chr11:5534273:C:A | - | 0.0552585258892194 | 0.049691709428039 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000133816 |
| CpG Site: cg09371112 | |
| Position to Gene: gene | |
| Male Effect: -0.404658889575298 | |
| Female Effect: - | |
 | Gene ID: ENSG00000133816 |
| CpG Site: cg12122057 | |
| Position to Gene: gene | |
| Male Effect: -0.263064185968978 | |
| Female Effect: - | |
 | Gene ID: ENSG00000133816 |
| CpG Site: cg24022152 | |
| Position to Gene: gene | |
| Male Effect: -0.254132318009189 | |
| Female Effect: - | |
 | Gene ID: ENSG00000133816 |
| CpG Site: cg23044178 | |
| Position to Gene: gene | |
| Male Effect: -0.163480899437936 | |
| Female Effect: - | |
 | Gene ID: ENSG00000133816 |
| CpG Site: cg09371112 | |
| Position to Gene: gene | |
| Male Effect: -0.295377832332704 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09371112 | chr11:12201023 | gene | -0.404658889575298 | 7.2758625733867e-05 | -0.33015714263976026 | 4.540827536560105e-07 | LUAD |
| cg12122057 | chr11:12111468 | gene | -0.263064185968978 | 2.78354931235095e-19 | -0.5350507641038564 | 5.0111774038733926e-23 | SKCM |
| cg24022152 | chr11:12111649 | gene | -0.254132318009189 | 1.01969441934344e-17 | -0.5147958276333917 | 3.673674201165294e-21 | SKCM |
| cg23044178 | chr11:12114858 | gene | -0.163480899437936 | 5.33056305908586e-14 | -0.46384869104966836 | 5.5250942432960506e-17 | SKCM |
| cg09371112 | chr11:12201023 | gene | -0.295377832332704 | 5.22846454259365e-08 | -0.3296161659249671 | 8.949830224563785e-11 | HNSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs10831817 | chr11:12433095:G:A | Distant downstream | 0.0238655359223761 | 0.00623810305043951 | STAD | Male-baised sQTL |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs7118604 | chr11:12429265:T:A | Distant downstream | -0.0203483002803997 | 0.0106580486833354 | STAD | Male-baised sQTL |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs952251 | chr11:12428690:G:A | Distant downstream | 0.0198414905377326 | 0.0129814921662001 | STAD | Male-baised sQTL |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs952250 | chr11:12428717:C:A | Distant downstream | -0.019717090028011 | 0.0178669614223554 | STAD | Male-baised sQTL |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs10765948 | chr11:12427848:G:A | Distant downstream | -0.0189315092467484 | 0.0206397678050765 | STAD | Male-baised sQTL |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs10741589 | chr11:12426987:A:G | Distant downstream | -0.0191040545158847 | 0.0233851140649759 | STAD | Male-baised sQTL |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs35612658 | chr11:12435105:G:A | Distant downstream | 0.0204994210884838 | 0.0364154576339618 | STAD | Male-baised sQTL |
| exon_skip_57011 | chr11:12255642:12255750 | In-frame | rs10831816 | chr11:12428256:T:C | Distant downstream | 0.0186319151726296 | 0.0420930120611881 | STAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MICAL2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
