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Gene: ENSG00000133315 |
Summary for MACROD1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000133315 | Gene symbol | MACROD1 |
| Gene name | mono-ADP ribosylhydrolase 1 | |
| HGNC | 29598 | |
| Entrez ID | 28992 | |
| Gene type | protein_coding | |
| Synonyms | MACROD1|LRP16 | |
| UniProtAcc | Q9BQ69 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MACROD1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MACROD1 | 1.27e+03 | 1.07e+00 | 2.92e-01 | 3.65e+00 | 2.59e-04 | 4.28e-03 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MACROD1 | 1.18e+03 | -1.01e+00 | 2.42e-01 | -4.17e+00 | 3.02e-05 | 1.09e-04 | LIHC |
| MACROD1 | 4.36e+03 | 1.28e+00 | 3.20e-01 | 4.00e+00 | 6.20e-05 | 1.72e-04 | KICH |
| MACROD1 | 1.82e+03 | 1.65e+00 | 3.66e-01 | 4.52e+00 | 6.21e-06 | 4.31e-05 | READ |
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Sex-biased somatic mutation for MACROD1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MACROD1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg26993251 | chr11:64166542 | CGI:chr11:64165518-64166598 | promoter | 2.84e-02 | 1.66e-01 | -4.48e+00 | 7.48e-06 | 5.26e-04 | -1.37e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for MACROD1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| READ | exon_skip_73723 | 6.28e-01 | 8.36e-01 | -3.62e+00 | 3.00e-04 | 4.67e-03 | -2.08e-01 |
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RNA A-to-I editing events in TCGA for MACROD1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MACROD1 |
| TFs related to MACROD1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MACROD1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MACROD1 |
| RBPs related to ES in MACROD1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | FXR2 | exon_skip_73733 | 7.90e+00 | 9.82e-01 | 7.46e+00 | 8.72e-03 | Male-biased |
| MESO | PABPC5 | exon_skip_73760 | 7.13e+00 | 4.75e-03 | 7.55e+00 | 9.85e-01 | Female-biased |
| KIRC | FXR2 | exon_skip_73733 | 7.86e+00 | 9.83e-01 | 7.54e+00 | 7.76e-03 | Male-biased |
| KIRC | SRSF9 | exon_skip_73761 | 7.92e+00 | 9.04e-03 | 8.24e+00 | 9.84e-01 | Female-biased |
| KICH | SRSF9 | exon_skip_73761 | 7.89e+00 | 4.37e-03 | 8.29e+00 | 9.88e-01 | Female-biased |
| MACROD1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs149380209 | chr11:71728407:A:G | - | 0.0727077810635091 | 0.0402157950355096 | LGG | Female-baised eQTL |
| rs144660296 | chr11:71728410:C:T | - | 0.0727077810635091 | 0.0402157950355096 | LGG | Female-baised eQTL |
| rs10501356 | chr11:56758356:A:T | - | 0.193892722484197 | 0.0470349921693215 | BLCA | Female-baised eQTL |
| rs1943635 | chr11:56772993:T:C | - | 0.193892722484197 | 0.0470349921693215 | BLCA | Female-baised eQTL |
| rs111772208 | chr11:56793324:A:G | - | 0.187818608875644 | 0.048409959859092 | BLCA | Female-baised eQTL |
| rs199810661 | chr11:56793704:T:G | - | 0.187818608875644 | 0.048409959859092 | BLCA | Female-baised eQTL |
| rs73478456 | chr11:56798695:T:C | - | 0.187818608875644 | 0.048409959859092 | BLCA | Female-baised eQTL |
| rs7232 | chr11:60173126:T:A | - | 0.0828328253869244 | 0.016378623613927 | COAD | Female-baised eQTL |
| rs11230228 | chr11:60275500:A:G | - | -0.0737960497341653 | 0.0499858987930702 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7121355 | chr11:59571911:C:T | - | 0.293874236814287 | 0.0362950383633227 | READ | Male-baised eQTL |
| rs4938994 | chr11:61051921:A:C | - | 0.0649993630231786 | 0.000646545964764878 | LGG | Male-baised eQTL |
| rs4939493 | chr11:61052224:G:C | - | 0.0640356759243748 | 0.000756755978005347 | LGG | Male-baised eQTL |
| rs11263629 | chr11:69884948:C:T | - | 0.0523430664553113 | 0.00205079849996146 | LGG | Male-baised eQTL |
| rs2250866 | chr11:72093467:G:A | - | 0.0688673499608299 | 0.00280235548293619 | LGG | Male-baised eQTL |
| rs7124792 | chr11:69885178:G:A | - | 0.0502182913777813 | 0.0036032909329318 | LGG | Male-baised eQTL |
| rs2237995 | chr11:60981784:G:A | - | 0.0627373874199255 | 0.00466490914671795 | LGG | Male-baised eQTL |
| rs59258857 | chr11:61018251:T:C | - | 0.050721422939782 | 0.0246123985656297 | LGG | Male-baised eQTL |
| rs11230692 | chr11:61422903:T:C | - | -0.0531606569298374 | 0.0293077034902704 | LGG | Male-baised eQTL |
| rs61899223 | chr11:61008631:T:C | - | 0.0565890018900368 | 0.0301609854204752 | LGG | Male-baised eQTL |
| rs79848107 | chr11:61008835:G:C | - | 0.0565890018900368 | 0.0301609854204752 | LGG | Male-baised eQTL |
| rs748902 | chr11:61474469:T:G | - | -0.0523307145901495 | 0.0336597421572019 | LGG | Male-baised eQTL |
| rs2957860 | chr11:61478471:G:A | - | -0.0523307145901495 | 0.0336597421572019 | LGG | Male-baised eQTL |
| rs2957859 | chr11:61483598:G:T | - | -0.0525273662755883 | 0.0342576673444364 | LGG | Male-baised eQTL |
| rs112167183 | chr11:61464815:C:T | - | 0.0511356857035354 | 0.0373379716600493 | LGG | Male-baised eQTL |
| rs11233076 | chr11:71312044:G:A | - | 0.0496596374503857 | 0.0492732664916993 | LGG | Male-baised eQTL |
| rs4246960 | chr11:70764299:T:A | - | -0.0706062835580187 | 0.0257764329541924 | KIRC | Male-baised eQTL |
| rs4980552 | chr11:70770071:C:T | - | -0.0633685898828886 | 0.0386484877956506 | KIRC | Male-baised eQTL |
| rs4980645 | chr11:70770387:C:T | - | -0.0605837936666717 | 0.0447357781072808 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000133315 |
| CpG Site: cg23459863 | |
| Position to Gene: gene | |
| Male Effect: -0.389326739499978 | |
| Female Effect: - | |
 | Gene ID: ENSG00000133315 |
| CpG Site: cg14085017 | |
| Position to Gene: gene | |
| Male Effect: 0.0593071510992011 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23459863 | chr11:64015795 | gene | -0.389326739499978 | 1.99353525161718e-05 | -0.46276924281824916 | 1.164788909119874e-07 | SARC |
| cg14085017 | chr11:64007754 | gene | 0.0593071510992011 | 3.34847992575982e-05 | 0.3106941843905868 | 1.8775015794052144e-07 | LUSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_73723 | chr11:63998837:63998872 | 5CDS-5UTR | rs61929667 | chr11:63458427:G:C | Distant downstream | -0.0488978709229595 | 0.0294734768243837 | SARC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MACROD1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
