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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000132561

Summary for MATN2

check button Gene summary

Gene informationEnsembl ID

ENSG00000132561

Gene symbol

MATN2

Gene namematrilin 2
HGNC

6908

Entrez ID

4147

Gene typeprotein_coding
SynonymsMATN2|
UniProtAcc

O00339


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for MATN2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
MATN22.02e+03-1.71e+004.25e-01-4.03e+005.54e-051.30e-03BRCA

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
MATN21.99e+03-1.18e+002.20e-01-5.34e+009.21e-083.88e-07KIRP
MATN21.15e+03-1.81e+004.37e-01-4.14e+003.52e-051.74e-04CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
MATN22.83e+03-1.25e+004.39e-01-2.84e+004.54e-031.85e-02STAD
MATN22.94e+03-2.53e+001.40e-01-1.81e+011.60e-733.16e-72BRCA
MATN21.77e+03-1.96e+005.23e-01-3.74e+001.82e-048.01e-04READ

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Sex-biased somatic mutation for MATN2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for MATN2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg10039928chr8:97868632CGI:chr8:97868809-97869615promoter4.31e-015.33e-01-4.36e+001.29e-053.40e-05-1.02e-01
KIRCcg09093931chr8:97868698CGI:chr8:97868809-97869615promoter2.22e-013.43e-01-5.19e+002.09e-079.38e-07-1.21e-01
LUSCcg10039928chr8:97868632CGI:chr8:97868809-97869615promoter3.68e-014.79e-01-3.27e+001.06e-032.70e-03-1.11e-01
LUSCcg09093931chr8:97868698CGI:chr8:97868809-97869615promoter2.25e-013.47e-01-3.61e+003.03e-041.23e-03-1.22e-01
BLCAcg16129200chr8:97867665CGI:chr8:97868809-97869615promoter3.83e-016.20e-01-3.43e+006.14e-041.56e-03-2.37e-01
BLCAcg09093931chr8:97868698CGI:chr8:97868809-97869615promoter1.99e-013.22e-01-3.82e+001.33e-044.92e-04-1.22e-01
LIHCcg16129200chr8:97867665CGI:chr8:97868809-97869615promoter4.22e-015.50e-01-3.91e+009.39e-051.95e-04-1.28e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg09093931chr8:97868698CGI:chr8:97868809-97869615promoter2.54e-013.56e-01-3.13e+001.74e-034.64e-03-1.02e-01

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Exon skipping events with PSI in TCGA for MATN2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for MATN2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for MATN2

check buttonTFs related to MATN2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
MESOZNF418MATN22.45e+008.66e-044.40e+009.91e-01Female-biased
MESOZNF79MATN22.83e+007.15e-034.19e+009.81e-01Female-biased
SKCMFOXD3MATN22.75e+001.47e-034.32e+009.81e-01Female-biased
SKCMFOXO1MATN23.51e+006.85e-034.60e+009.81e-01Female-biased
SKCMFOXP3MATN23.45e+003.98e-034.72e+009.86e-01Female-biased
SKCMFOXR2MATN22.37e+004.03e-044.30e+009.82e-01Female-biased
SKCMLHX2MATN23.72e+007.36e-034.80e+009.84e-01Female-biased
SKCMLHX6MATN24.06e+001.17e-024.99e+009.81e-01Female-biased
SKCMLHX9MATN23.56e+006.11e-034.69e+009.83e-01Female-biased
SKCMNFIL3MATN24.10e+001.10e-025.05e+009.83e-01Female-biased
SKCMNKX3-2MATN23.27e+003.88e-034.55e+009.84e-01Female-biased
SKCMONECUT3MATN23.17e+003.94e-034.44e+009.82e-01Female-biased
SKCMPDX1MATN23.52e+005.59e-034.69e+009.84e-01Female-biased
SKCMPOU4F1MATN22.99e+002.44e-034.41e+009.82e-01Female-biased
SKCMPOU4F3MATN23.18e+003.29e-034.51e+009.83e-01Female-biased
SKCMSOX15MATN23.35e+004.87e-034.55e+009.83e-01Female-biased
SKCMSOX2MATN23.45e+004.64e-034.67e+009.85e-01Female-biased
SKCMSOX5MATN23.84e+005.21e-035.03e+009.88e-01Female-biased
SKCMSRYMATN23.39e+003.86e-034.67e+009.85e-01Female-biased
SKCMZNF580MATN23.14e+001.79e-034.65e+009.87e-01Female-biased
SKCMZNF79MATN22.21e+002.61e-044.26e+009.81e-01Female-biased

check buttonMATN2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for MATN2

check buttonRBPs related to ES in MATN2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
CHOLSRSF7exon_skip_4851361.06e+019.89e-011.02e+011.00e-02Male-biased
ESCAANKHD1exon_skip_4851211.60e+011.52e-031.67e+019.98e-01Female-biased
PCPGKHDRBS2exon_skip_4851267.84e+009.82e-017.50e+008.41e-03Male-biased
KICHRBM5exon_skip_4851289.29e+009.87e-018.97e+001.01e-02Male-biased

check buttonMATN2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000132561DHRS4-AS1,hsa-mir-202,MATN2Male-specific ceRNATCGA-KIRP

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs3134257chr8:103423309:C:A-0.1299779833716520.0407009193928473STADFemale-baised eQTL
rs10097386chr8:92633008:C:T-0.06232150977290510.0299658161379524LGGFemale-baised eQTL
rs1449239chr8:92634427:T:C-0.06246617751799480.0307857744306804LGGFemale-baised eQTL
rs12675482chr8:92631642:C:T-0.06242192948497040.0311353524120036LGGFemale-baised eQTL
rs10956851chr8:92627004:C:T-0.06272775273951510.0349617289820529LGGFemale-baised eQTL
rs12335130chr8:95148461:C:G-0.07247744265015930.0161575796247492KIRCFemale-baised eQTL
rs60036223chr8:95136284:A:G-0.07149952431336240.019911401102089KIRCFemale-baised eQTL
rs2053893chr8:89147842:C:A--0.105986717522760.0230403886820911KIRCFemale-baised eQTL
rs10087996chr8:96963357:A:T-0.1246312310394370.0241786311540023KIRCFemale-baised eQTL
rs62518677chr8:92570730:T:G-0.1351011411397890.0283312653815514KIRCFemale-baised eQTL
rs11987777chr8:97019990:T:C-0.1209878174541660.0286383383624446KIRCFemale-baised eQTL
rs905556chr8:106343451:A:G-0.0723494424495470.0308575614520357KIRCFemale-baised eQTL
rs28820108chr8:97021654:A:C-0.1237094302650830.0343761111530222KIRCFemale-baised eQTL
rs28749318chr8:97020141:T:A-0.1186843396317560.0460566048866606KIRCFemale-baised eQTL
rs3890744chr8:97030697:C:T-0.2025431435033340.0195083522896324BLCAFemale-baised eQTL
rs6994621chr8:97047175:T:C-0.1874247924182790.037912540422293BLCAFemale-baised eQTL
rs73695756chr8:97050608:T:C-0.1871637355403260.0383246171614107BLCAFemale-baised eQTL
rs10089867chr8:97063656:A:G-0.1871637355403260.0383246171614107BLCAFemale-baised eQTL
rs11990753chr8:97069471:A:C-0.1871637355403260.0383246171614107BLCAFemale-baised eQTL
rs7010155chr8:106544992:A:G-0.08077030091767830.00783555923408082LUADFemale-baised eQTL
rs76611715chr8:105908646:G:A-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs60859367chr8:105915240:T:G-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs59483767chr8:105915690:C:T-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs78355739chr8:105916079:A:C-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs76058931chr8:105917218:C:A-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs1603360chr8:105918434:C:A-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs75275129chr8:105919079:A:G-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs75559883chr8:105923241:C:A-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs76297930chr8:105924687:T:C-0.06729953037033410.0110886205559547LUADFemale-baised eQTL
rs76173617chr8:106575145:T:C-0.07392502963694370.0452207038885084LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs73268397chr8:95342102:C:T-0.2996584459300820.0227336695439999READMale-baised eQTL
rs11985598chr8:95894765:C:T-0.03709648194602290.0130718008894705KIRCMale-baised eQTL
rs16894144chr8:95945990:T:G-0.03792604611059580.0136988042673541KIRCMale-baised eQTL
rs10091342chr8:95895457:C:T-0.03687634719360870.0141179624635796KIRCMale-baised eQTL
rs10094696chr8:95895863:C:T-0.03687634719360870.0141179624635796KIRCMale-baised eQTL
rs10094475chr8:95895771:A:T-0.0367995331984820.0146292694358257KIRCMale-baised eQTL
rs28499400chr8:95922664:T:C-0.0376859837289530.0150542914818175KIRCMale-baised eQTL
rs2013433chr8:95924073:C:T-0.0376859837289530.0150542914818175KIRCMale-baised eQTL
rs75309424chr8:95596411:T:C-0.05510240992495230.0156693008712397KIRCMale-baised eQTL
rs7357516chr8:95941795:G:A-0.03662798038147870.0194721188117014KIRCMale-baised eQTL
rs10113520chr8:95936276:C:T-0.03585515441942020.0200283767955313KIRCMale-baised eQTL
rs57360858chr8:95891284:G:A-0.03789425848613520.021253948938832KIRCMale-baised eQTL
rs2305832chr8:102254577:C:A-0.05393291862251750.0243230398378748KIRCMale-baised eQTL
rs7845444chr8:95914366:C:G-0.03664596205202290.02528166801227KIRCMale-baised eQTL
rs7462810chr8:94707805:C:G-0.03163679002028930.027694196922788KIRCMale-baised eQTL
rs67763699chr8:103345161:C:T-0.04165849759145130.0282827264736282KIRCMale-baised eQTL
rs1975282chr8:95897429:C:A-0.03610709903032930.0314401006098011KIRCMale-baised eQTL
rs34342692chr8:95897996:G:A-0.03610709903032930.0314401006098011KIRCMale-baised eQTL
rs16904279chr8:90289949:A:G-0.02711086207895330.0391619121768916KIRCMale-baised eQTL
rs10504958chr8:95947591:T:C--0.02685902592086770.0394923202779483KIRCMale-baised eQTL
rs9643257chr8:90246171:T:C-0.02840551373402830.0415441160287542KIRCMale-baised eQTL
rs2879344chr8:90264815:G:A-0.02906879629605220.0418803038977729KIRCMale-baised eQTL
rs56295922chr8:90245823:A:T-0.02817743110492580.0448607155817348KIRCMale-baised eQTL
rs9643256chr8:90244696:C:T-0.02789922511340710.0486565150226553KIRCMale-baised eQTL
rs10086980chr8:90245444:A:G-0.02789922511340710.0486565150226553KIRCMale-baised eQTL
rs2514329chr8:98241781:G:C--0.06274270341324620.000171356254688886BLCAMale-baised eQTL
rs2443566chr8:98241411:C:T--0.05993803133268420.000863955425864525BLCAMale-baised eQTL
rs2514328chr8:98239887:G:A--0.05996127522590840.000864218777896183BLCAMale-baised eQTL
rs2443567chr8:98241649:G:A--0.05920329478177060.00103510756273925BLCAMale-baised eQTL
rs2443568chr8:98241817:C:T--0.05920329478177060.00103510756273925BLCAMale-baised eQTL
rs4454248chr8:98242315:G:T--0.05936440229977320.00111397662031443BLCAMale-baised eQTL
rs2443569chr8:98242093:G:C--0.05865623071672630.00131406255724033BLCAMale-baised eQTL
rs3102495chr8:95657319:A:C--0.06599021494777630.00237903455239948BLCAMale-baised eQTL
rs1449789chr8:99751449:T:G--0.08883125771460430.0133491135205954LUADMale-baised eQTL
rs75309424chr8:95596411:T:C-0.06929967301090110.0449916035809241LUADMale-baised eQTL
rs2607066chr8:94229250:A:G-0.1525743950914570.0447354953198334COADMale-baised eQTL
rs2607067chr8:94229627:C:T-0.1525743950914570.0447354953198334COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000132561
CpG Site: cg16016960
Position to Gene: gene,enhancer
Male Effect: -
Female Effect: -0.328242766481957

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg16016960chr8:97870998gene,enhancer-0.3282427664819572.70571738013533e-07-0.38165092159555182.885779411608396e-10LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of MATN2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource