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Gene: ENSG00000132359 |
Summary for RAP1GAP2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000132359 | Gene symbol | RAP1GAP2 |
| Gene name | RAP1 GTPase activating protein 2 | |
| HGNC | 29176 | |
| Entrez ID | 23108 | |
| Gene type | protein_coding | |
| Synonyms | RAP1GAP2|KIAA1039 | |
| UniProtAcc | Q684P5 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for RAP1GAP2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAP1GAP2 | 4.35e+03 | -1.45e+00 | 3.37e-01 | -4.29e+00 | 1.76e-05 | 2.43e-04 | ESCA |
| RAP1GAP2 | 9.34e+02 | 2.65e+00 | 4.83e-01 | 5.50e+00 | 3.88e-08 | 3.86e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for RAP1GAP2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RAP1GAP2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg00740691 | chr17:2776770 | CGI:chr17:2776453-2777218 | promoter | 6.67e-02 | 1.99e-01 | -2.23e+00 | 2.58e-02 | 3.86e-02 | -1.32e-01 |
| BRCA | cg26853607 | chr17:2776481 | CGI:chr17:2776453-2777218 | promoter | 1.45e-01 | 2.81e-01 | -2.40e+00 | 1.65e-02 | 3.25e-02 | -1.36e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg18771327 | chr17:2777458 | CGI:chr17:2776453-2777218 | promoter,gene body | 7.92e-01 | 6.63e-01 | 4.58e+00 | 4.60e-06 | 3.33e-05 | 1.28e-01 |
| LIHC | cg18771327 | chr17:2777458 | CGI:chr17:2776453-2777218 | promoter,gene body | 6.18e-01 | 7.67e-01 | -3.39e+00 | 6.92e-04 | 1.14e-03 | -1.50e-01 |
| CHOL | cg00740691 | chr17:2776770 | CGI:chr17:2776453-2777218 | promoter | 1.76e-01 | 1.77e-02 | 2.88e+00 | 4.04e-03 | 1.47e-02 | 1.58e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg26853607 | chr17:2776481 | CGI:chr17:2776453-2777218 | promoter | 1.55e-01 | 5.16e-02 | 2.50e+00 | 1.25e-02 | 1.85e-02 | 1.04e-01 |
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Exon skipping events with PSI in TCGA for RAP1GAP2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RAP1GAP2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LAML | RAP1GAP2-004 | chr17_3022029_+ | 3.18e-01 | 3.93e-01 | -2.07e+00 | 3.84e-02 | 4.95e-02 | -7.51e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RAP1GAP2 |
| TFs related to RAP1GAP2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | ZNF879 | RAP1GAP2 | 2.46e+00 | 4.45e-04 | 3.91e+00 | 9.81e-01 | Female-biased |
| RAP1GAP2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RAP1GAP2 |
| RBPs related to ES in RAP1GAP2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KICH | HNRNPH2 | exon_skip_147873 | 7.79e+00 | 8.50e-04 | 8.37e+00 | 9.92e-01 | Female-biased |
| RAP1GAP2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000132359 | Z95331.1,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | Z92544.1,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | AC116351.1,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | AC068790.9,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | LHFPL3-AS2,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | AC007066.2,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | TMEM147-AS1,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | AP001062.1,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | MCM3AP-AS1,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000132359 | AC232271.1,hsa-mir-485,RAP1GAP2 | Female-specific ceRNA | TCGA-LIHC |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs35856134 | chr17:11618293:G:A | - | 0.0893025003904259 | 0.0029963656590787 | LUAD | Female-baised eQTL |
| rs34410297 | chr17:11615870:G:A | - | 0.0881454254593423 | 0.00375347807033317 | LUAD | Female-baised eQTL |
| rs12936449 | chr17:11616077:C:T | - | 0.0881454254593423 | 0.00375347807033317 | LUAD | Female-baised eQTL |
| rs8072361 | chr17:11616649:T:C | - | 0.0881454254593423 | 0.00375347807033317 | LUAD | Female-baised eQTL |
| rs35341320 | chr17:11617846:T:C | - | 0.087676385213767 | 0.00408369628842124 | LUAD | Female-baised eQTL |
| rs7220312 | chr17:3383881:T:C | - | -0.0510157385577277 | 0.0257450104134164 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000132359 |
| CpG Site: cg02909097 | |
| Position to Gene: gene | |
| Male Effect: -0.442229960817736 | |
| Female Effect: - | |
 | Gene ID: ENSG00000132359 |
| CpG Site: cg12167688 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.323182098427284 | |
 | Gene ID: ENSG00000132359 |
| CpG Site: cg22555517 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.144882732215582 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg02909097 | chr17:2939912 | gene | -0.442229960817736 | 5.27671393586399e-10 | -0.6593504729102835 | 1.5587441638844206e-13 | PAAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg12167688 | chr17:2867931 | gene | -0.323182098427284 | 9.09424147206173e-14 | -0.7946763450874761 | 1.3860439511036935e-18 | PAAD |
| cg22555517 | chr17:2883701 | gene | -0.144882732215582 | 4.46072698017031e-08 | -0.3983556805804138 | 3.964552849521427e-11 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RAP1GAP2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
