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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000131668

Summary for BARX1

check button Gene summary

Gene informationEnsembl ID

ENSG00000131668

Gene symbol

BARX1

Gene nameBARX homeobox 1
HGNC

955

Entrez ID

56033

Gene typeprotein_coding
SynonymsBARX1|
UniProtAcc

Q9HBU1


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for BARX1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BARX17.17e+01-4.63e+007.56e-01-6.12e+009.46e-102.71e-07BRCA
BARX12.96e+02-1.41e+003.89e-01-3.63e+002.83e-043.61e-03SARC
BARX19.11e+011.20e+003.28e-013.66e+002.57e-043.65e-02PAAD

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BARX14.63e+021.30e+003.80e-013.50e+005.40e-041.30e-03HNSC
BARX14.56e+02-2.76e+008.53e-01-3.23e+001.23e-037.37e-03ESCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BARX16.77e+011.77e+002.42e-017.31e+002.70e-136.79e-13BRCA

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Sex-biased somatic mutation for BARX1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for BARX1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg14127859chr9:93954646CGI:chr9:93951044-93955904promoter,gene body4.47e-016.00e-01-2.37e+001.77e-023.34e-02-1.53e-01
BRCAcg00418027chr9:93954716CGI:chr9:93951044-93955904promoter,gene body2.80e-014.01e-01-2.01e+004.43e-024.78e-02-1.20e-01
BRCAcg05385163chr9:93955067CGI:chr9:93951044-93955904promoter,exon,CDS,gene body2.64e-014.26e-01-2.39e+001.71e-023.29e-02-1.62e-01
GBMcg13773631chr9:93953561CGI:chr9:93951044-93955904promoter,gene body2.22e-013.43e-01-2.53e+001.15e-022.66e-02-1.20e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg14127859chr9:93954646CGI:chr9:93951044-93955904promoter,gene body3.75e-012.56e-013.91e+009.33e-051.92e-041.19e-01
THCAcg17354303chr9:93954383CGI:chr9:93951044-93955904promoter,gene body5.37e-014.30e-013.18e+001.46e-034.11e-031.07e-01
LUSCcg14127859chr9:93954646CGI:chr9:93951044-93955904promoter,gene body4.33e-012.00e-013.71e+002.10e-049.96e-042.33e-01
LUSCcg00927495chr9:93953405CGI:chr9:93951044-93955904UTR,promoter,exon,gene body3.85e-011.07e-013.80e+001.47e-048.29e-042.78e-01
LUSCcg13773631chr9:93953561CGI:chr9:93951044-93955904promoter,gene body4.27e-011.83e-013.44e+005.75e-041.81e-032.44e-01
LUSCcg06071058chr9:93953809CGI:chr9:93951044-93955904promoter,gene body5.37e-012.61e-014.07e+004.61e-055.49e-042.76e-01
LUSCcg13808083chr9:93954245CGI:chr9:93951044-93955904promoter,gene body5.57e-013.20e-013.92e+008.72e-056.61e-042.37e-01
LUSCcg17354303chr9:93954383CGI:chr9:93951044-93955904promoter,gene body5.82e-013.79e-014.04e+005.31e-055.65e-042.03e-01
LUSCcg00418027chr9:93954716CGI:chr9:93951044-93955904promoter,gene body3.03e-011.39e-013.63e+002.82e-041.18e-031.63e-01
LUSCcg06288684chr9:93956361CGI:chr9:93951044-93955904promoter7.51e-016.00e-013.81e+001.39e-048.07e-041.51e-01
BLCAcg00418027chr9:93954716CGI:chr9:93951044-93955904promoter,gene body4.02e-011.77e-013.00e+002.66e-034.92e-032.25e-01
BLCAcg05385163chr9:93955067CGI:chr9:93951044-93955904promoter,exon,CDS,gene body3.11e-011.29e-012.31e+002.10e-022.54e-021.82e-01
CHOLcg14127859chr9:93954646CGI:chr9:93951044-93955904promoter,gene body4.41e-011.87e-012.51e+001.22e-022.39e-022.54e-01
CHOLcg06071058chr9:93953809CGI:chr9:93951044-93955904promoter,gene body4.93e-012.45e-012.80e+005.09e-031.63e-022.47e-01
CHOLcg17354303chr9:93954383CGI:chr9:93951044-93955904promoter,gene body5.87e-013.66e-013.54e+004.02e-048.32e-032.20e-01
CHOLcg00418027chr9:93954716CGI:chr9:93951044-93955904promoter,gene body2.52e-011.50e-011.99e+004.65e-024.65e-021.02e-01
CHOLcg06288684chr9:93956361CGI:chr9:93951044-93955904promoter7.47e-016.19e-012.36e+001.83e-022.92e-021.28e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg14127859chr9:93954646CGI:chr9:93951044-93955904promoter,gene body4.47e-012.49e-019.68e+003.72e-222.43e-211.98e-01
BRCAcg00927495chr9:93953405CGI:chr9:93951044-93955904UTR,promoter,exon,gene body3.26e-012.13e-015.86e+004.56e-091.05e-081.13e-01
BRCAcg06071058chr9:93953809CGI:chr9:93951044-93955904promoter,gene body6.14e-014.41e-018.45e+003.00e-171.30e-161.73e-01
BRCAcg13808083chr9:93954245CGI:chr9:93951044-93955904promoter,gene body6.40e-015.33e-016.48e+009.09e-112.40e-101.08e-01
BRCAcg17354303chr9:93954383CGI:chr9:93951044-93955904promoter,gene body6.37e-014.92e-011.11e+018.73e-291.10e-271.45e-01
BRCAcg00418027chr9:93954716CGI:chr9:93951044-93955904promoter,gene body2.80e-011.72e-014.64e+003.50e-066.15e-061.08e-01
BRCAcg05385163chr9:93955067CGI:chr9:93951044-93955904promoter,exon,CDS,gene body2.64e-011.09e-018.75e+002.09e-189.93e-181.56e-01
LIHCcg14127859chr9:93954646CGI:chr9:93951044-93955904promoter,gene body3.83e-011.84e-013.53e+004.13e-041.14e-031.99e-01
LIHCcg06071058chr9:93953809CGI:chr9:93951044-93955904promoter,gene body4.49e-012.21e-014.02e+005.79e-052.54e-042.28e-01
LIHCcg13808083chr9:93954245CGI:chr9:93951044-93955904promoter,gene body4.25e-012.40e-013.12e+001.82e-033.62e-031.85e-01
LIHCcg05385163chr9:93955067CGI:chr9:93951044-93955904promoter,exon,CDS,gene body2.69e-011.11e-012.99e+002.83e-035.11e-031.58e-01

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Exon skipping events with PSI in TCGA for BARX1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for BARX1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for BARX1

check buttonTFs related to BARX1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
SARCZNF100BARX13.78e+001.12e-024.40e+009.81e-01Female-biased

check buttonBARX1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.
related_gene

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Sex-biased RBP-ES network for BARX1

check buttonRBPs related to ES in BARX1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonBARX1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2417367chr9:102494715:A:T-0.1526257461131730.000849980489220805BLCAFemale-baised eQTL
rs62577380chr9:101615469:G:T-0.08920356269084960.00101381725940692LUADFemale-baised eQTL
rs7851338chr9:101614130:A:G-0.08653182587067460.00153803826213194LUADFemale-baised eQTL
rs35441547chr9:101614662:C:T-0.08653182587067460.00153803826213194LUADFemale-baised eQTL
rs62577396chr9:101617718:G:T-0.09451390664970530.00272285269694363LUADFemale-baised eQTL
rs111863667chr9:101615449:T:C-0.07862810109521180.00321829971809993LUADFemale-baised eQTL
rs62577381chr9:101615639:A:G-0.07862810109521180.00321829971809993LUADFemale-baised eQTL
rs76457315chr9:101616843:A:T-0.09003030227810960.00491748935961378LUADFemale-baised eQTL
rs10121465chr9:101615213:C:A-0.07302784041962680.00632722089101331LUADFemale-baised eQTL
rs62577382chr9:101615844:G:T-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs62577383chr9:101616028:C:T-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs58984022chr9:101616244:G:A-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs60523933chr9:101616265:C:T-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs58492917chr9:101616485:G:A-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs59550329chr9:101616615:C:G-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs62577392chr9:101617320:G:C-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs62577393chr9:101617577:A:T-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs62577394chr9:101617628:A:T-0.08723129376501710.00657034033796393LUADFemale-baised eQTL
rs11998854chr9:101619388:G:T-0.08713079970856370.00670786664882055LUADFemale-baised eQTL
rs62577398chr9:101617784:T:C-0.08058360887496580.00937616346809709LUADFemale-baised eQTL
rs62577402chr9:101619914:G:A-0.08389741457359530.00966860938277378LUADFemale-baised eQTL
rs73659569chr9:101619938:C:T-0.08389741457359530.00966860938277378LUADFemale-baised eQTL
rs73659570chr9:101619951:G:C-0.08389741457359530.00966860938277378LUADFemale-baised eQTL
rs55889755chr9:101620173:G:T-0.08389741457359530.00966860938277378LUADFemale-baised eQTL
rs62577404chr9:101621268:G:A-0.08389741457359530.00966860938277378LUADFemale-baised eQTL
rs7047606chr9:87440415:G:A-0.07404692632588380.0120894958890618LUADFemale-baised eQTL
rs10985825chr9:98310561:C:T-0.05177339520254970.0139806485667245LUADFemale-baised eQTL
rs10117679chr9:101616197:C:T-0.07509686264520710.0177149470498015LUADFemale-baised eQTL
rs28710967chr9:101617180:A:C-0.07509686264520710.0177149470498015LUADFemale-baised eQTL
rs58955229chr9:101617236:A:G-0.07509686264520710.0177149470498015LUADFemale-baised eQTL
rs10120369chr9:101619432:C:T-0.0749994412912820.0180457655343205LUADFemale-baised eQTL
rs41343045chr9:101617518:T:C-0.07629982585860680.0189963755200395LUADFemale-baised eQTL
rs10124297chr9:101619905:T:A-0.072544588300150.0235119082287915LUADFemale-baised eQTL
rs10120524chr9:101620029:C:T-0.072544588300150.0235119082287915LUADFemale-baised eQTL
rs10123684chr9:101620151:A:T-0.072544588300150.0235119082287915LUADFemale-baised eQTL
rs10121191chr9:101620232:C:T-0.072544588300150.0235119082287915LUADFemale-baised eQTL
rs356664chr9:95302247:T:C--0.0384724189829330.0313461660696325LUADFemale-baised eQTL
rs80044157chr9:96315320:C:T-0.07566310743135750.0317906947972854LUADFemale-baised eQTL
rs473825chr9:95306492:C:A--0.03806526872233130.0335809554676475LUADFemale-baised eQTL
rs7022252chr9:87459127:G:T-0.06884839244045490.047627257008016LUADFemale-baised eQTL
rs10120552chr9:96318180:C:T-0.08027249932958680.049755527778183LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs12353276chr9:91139758:G:A-0.03765325215674880.0445950147409302LUSCMale-baised eQTL
rs4743900chr9:93194985:T:C--0.03445600137074160.049992906583108LUSCMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000131668
CpG Site: cg17354303
Position to Gene: gene,promoter
Male Effect: -0.372696083215133
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000131668
CpG Site: cg17354303
Position to Gene: gene,promoter
Male Effect: -0.149410305842176
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000131668
CpG Site: cg17354303
Position to Gene: gene,promoter
Male Effect: -0.448582954151725
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg17354303chr9:93954383gene,promoter-0.3726960832151338.98668874528104e-05-0.327875860989068465.838956436648365e-07LUAD
cg17354303chr9:93954383gene,promoter-0.1494103058421765.29352518741342e-06-0.333836751639986441.3091825420657853e-08LUSC
cg17354303chr9:93954383gene,promoter-0.4485829541517255.32102617883975e-19-0.51686900525958593.112601469539514e-22BLCA

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of BARX1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000131668BARX1C0279628Adenocarcinoma Of Esophagus1CTD_human