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Gene: ENSG00000131508 |
Summary for UBE2D2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000131508 | Gene symbol | UBE2D2 |
| Gene name | ubiquitin conjugating enzyme E2 D2 | |
| HGNC | 12475 | |
| Entrez ID | 7322 | |
| Gene type | protein_coding | |
| Synonyms | UBE2D2|UbcH5B|UBC4 | |
| UniProtAcc | P62837 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000131508 | UBE2D2 | DB02418 | (R,R)-2,3-Butanediol | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for UBE2D2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for UBE2D2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for UBE2D2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for UBE2D2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for UBE2D2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | UBE2D2-006 | chr5_139531888_+ | 7.44e-01 | 7.18e-01 | 2.50e+00 | 1.26e-02 | 4.25e-02 | 2.52e-02 |
| KIRC | UBE2D2-006 | chr5_139531929_+ | 3.60e-01 | 3.29e-01 | 2.42e+00 | 1.57e-02 | 4.41e-02 | 3.15e-02 |
| KIRC | UBE2D2-006 | chr5_139532228_+ | 4.13e-01 | 3.74e-01 | 2.43e+00 | 1.53e-02 | 4.41e-02 | 3.84e-02 |
| KIRC | UBE2D2-006 | chr5_139533503_+ | 1.69e-01 | 2.02e-01 | -2.19e+00 | 2.83e-02 | 4.61e-02 | -3.28e-02 |
| KIRC | UBE2D2-006 | chr5_139536308_+ | 1.29e-01 | 1.87e-01 | -2.36e+00 | 1.85e-02 | 4.41e-02 | -5.82e-02 |
| KIRC | UBE2D2-006 | chr5_139538709_+ | 1.38e-01 | 1.73e-01 | -2.10e+00 | 3.58e-02 | 4.85e-02 | -3.51e-02 |
| KIRC | UBE2D2-006 | chr5_139539154_+ | 1.88e-01 | 2.22e-01 | -1.97e+00 | 4.87e-02 | 4.97e-02 | -3.37e-02 |
| KIRC | UBE2D2-006 | chr5_139541796_+ | 2.01e-01 | 1.77e-01 | 2.36e+00 | 1.82e-02 | 4.41e-02 | 2.36e-02 |
| KIRC | UBE2D2-006 | chr5_139546536_+ | 2.25e-01 | 2.02e-01 | 3.47e+00 | 5.30e-04 | 3.61e-02 | 2.28e-02 |
| KIRC | UBE2D2-006 | chr5_139546748_+ | 5.22e-01 | 4.95e-01 | 2.39e+00 | 1.70e-02 | 4.41e-02 | 2.64e-02 |
| KIRC | UBE2D2-006 | chr5_139546757_+ | 1.41e-01 | 2.08e-01 | -2.35e+00 | 1.86e-02 | 4.41e-02 | -6.71e-02 |
| KIRC | UBE2D2-006 | chr5_139546760_+ | 3.98e-01 | 3.61e-01 | 3.08e+00 | 2.04e-03 | 3.65e-02 | 3.63e-02 |
| KIRC | UBE2D2-006 | chr5_139547018_+ | 5.47e-01 | 5.07e-01 | 2.78e+00 | 5.44e-03 | 4.08e-02 | 4.01e-02 |
| KIRC | UBE2D2-006 | chr5_139547035_+ | 6.01e-01 | 5.63e-01 | 3.42e+00 | 6.30e-04 | 3.61e-02 | 3.76e-02 |
| KIRC | UBE2D2-006 | chr5_139547036_+ | 4.57e-01 | 4.28e-01 | 2.60e+00 | 9.38e-03 | 4.20e-02 | 2.89e-02 |
| KIRC | UBE2D2-006 | chr5_139547079_+ | 3.10e-01 | 2.80e-01 | 2.35e+00 | 1.87e-02 | 4.42e-02 | 2.94e-02 |
| KIRC | UBE2D2-006 | chr5_139547476_+ | 2.47e-01 | 2.27e-01 | 2.50e+00 | 1.24e-02 | 4.23e-02 | 1.93e-02 |
| KIRC | UBE2D2-006 | chr5_139547488_+ | 4.11e-01 | 3.79e-01 | 3.27e+00 | 1.06e-03 | 3.61e-02 | 3.18e-02 |
| KIRC | UBE2D2-006 | chr5_139547714_+ | 1.73e-01 | 1.09e-01 | 2.07e+00 | 3.88e-02 | 4.91e-02 | 6.37e-02 |
| KIRC | UBE2D2-006 | chr5_139624406_+ | 1.86e-01 | 2.52e-01 | -2.18e+00 | 2.93e-02 | 4.64e-02 | -6.64e-02 |
| COAD | UBE2D2-006 | chr5_139570210_+ | 2.31e-01 | 4.55e-01 | -2.74e+00 | 6.17e-03 | 1.72e-02 | -2.24e-01 |
| STAD | UBE2D2-006 | chr5_139585852_+ | 2.39e-01 | 1.86e-01 | 2.12e+00 | 3.44e-02 | 4.96e-02 | 5.31e-02 |
| STAD | UBE2D2-006 | chr5_139585857_+ | 2.49e-01 | 1.71e-01 | 2.67e+00 | 7.54e-03 | 4.96e-02 | 7.86e-02 |
| STAD | UBE2D2-006 | chr5_139592151_+ | 3.70e-01 | 1.85e-01 | 2.74e+00 | 6.17e-03 | 4.96e-02 | 1.85e-01 |
| STAD | UBE2D2-006 | chr5_139606287_+ | 2.55e-01 | 1.59e-01 | 2.16e+00 | 3.06e-02 | 4.96e-02 | 9.62e-02 |
| KIRP | UBE2D2-006 | chr5_139548089_+ | 3.70e-01 | 2.41e-01 | 2.67e+00 | 7.53e-03 | 4.01e-02 | 1.29e-01 |
| ESCA | UBE2D2-006 | chr5_139590315_+ | 3.82e-01 | 2.98e-01 | 2.15e+00 | 3.19e-02 | 4.99e-02 | 8.43e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for UBE2D2 |
| TFs related to UBE2D2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | DMRTA1 | UBE2D2 | 4.72e+00 | 9.82e-01 | 3.17e+00 | 6.03e-03 | Male-biased |
| UVM | FOXP3 | UBE2D2 | 4.88e+00 | 9.83e-01 | 3.43e+00 | 7.54e-03 | Male-biased |
| UVM | ONECUT3 | UBE2D2 | 4.76e+00 | 9.82e-01 | 3.27e+00 | 6.83e-03 | Male-biased |
| UVM | SKOR1 | UBE2D2 | 4.87e+00 | 9.84e-01 | 3.37e+00 | 6.77e-03 | Male-biased |
| UVM | ZNF354A | UBE2D2 | 4.65e+00 | 9.81e-01 | 3.14e+00 | 6.49e-03 | Male-biased |
| UVM | ZNF418 | UBE2D2 | 5.15e+00 | 9.93e-01 | 2.68e+00 | 6.89e-04 | Male-biased |
| UVM | ZNF580 | UBE2D2 | 4.89e+00 | 9.87e-01 | 3.15e+00 | 4.08e-03 | Male-biased |
| UBE2D2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for UBE2D2 |
| RBPs related to ES in UBE2D2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | SART3 | exon_skip_438014 | 9.27e+00 | 9.90e-01 | 8.94e+00 | 6.40e-03 | Male-biased |
| LUAD | MSI1 | exon_skip_438020 | 1.66e+01 | 9.89e-01 | 1.62e+01 | 1.11e-02 | Male-biased |
| CHOL | MSI1 | exon_skip_438020 | 1.81e+01 | 1.00e+00 | 1.73e+01 | 4.20e-04 | Male-biased |
| BRCA | MSI1 | exon_skip_438020 | 1.74e+01 | 9.88e-01 | 1.68e+01 | 1.16e-02 | Male-biased |
| ESCA | SART3 | exon_skip_438014 | 8.51e+00 | 1.34e-02 | 8.92e+00 | 9.82e-01 | Female-biased |
| MESO | MSI1 | exon_skip_438020 | 1.68e+01 | 1.77e-04 | 1.76e+01 | 1.00e+00 | Female-biased |
| KICH | SART3 | exon_skip_438014 | 9.04e+00 | 9.95e-01 | 8.44e+00 | 8.36e-04 | Male-biased |
| BLCA | MBNL1 | exon_skip_438008 | 9.85e+00 | 1.79e-02 | 1.02e+01 | 9.80e-01 | Female-biased |
| UBE2D2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2879358 | chr5:142472242:T:C | - | 0.0422760975904789 | 0.0360903811645446 | THCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs30504 | chr5:134101328:G:A | - | -0.0576730149134842 | 0.0434341183835551 | BLCA | Male-baised eQTL |
| rs12109018 | chr5:145112750:C:T | - | 0.0935573360117081 | 0.0239037003222214 | LUAD | Male-baised eQTL |
| rs249604 | chr5:130174433:G:A | - | -0.102827941387335 | 0.0284092078813522 | LUAD | Male-baised eQTL |
| rs17102866 | chr5:145200473:C:T | - | 0.0922096875250032 | 0.0342458064164146 | LUAD | Male-baised eQTL |
| rs10065472 | chr5:130179741:T:G | - | -0.0974299926809862 | 0.0354279869381484 | LUAD | Male-baised eQTL |
| rs186840853 | chr5:145116285:C:G | - | 0.088661481526359 | 0.0387356383601824 | LUAD | Male-baised eQTL |
| rs11949054 | chr5:145110987:C:A | - | 0.0813559552616586 | 0.0398515712272526 | LUAD | Male-baised eQTL |
| rs10491317 | chr5:145112044:A:T | - | 0.0832514181778834 | 0.0400881720773752 | LUAD | Male-baised eQTL |
| rs115201085 | chr5:145112111:T:A | - | 0.0832514181778834 | 0.0400881720773752 | LUAD | Male-baised eQTL |
| rs72806430 | chr5:145112135:A:G | - | 0.0832514181778834 | 0.0400881720773752 | LUAD | Male-baised eQTL |
| rs2107206 | chr5:130172418:A:C | - | -0.100963904449358 | 0.0435582279936173 | LUAD | Male-baised eQTL |
| rs6885583 | chr5:130178442:G:C | - | -0.100963904449358 | 0.0435582279936173 | LUAD | Male-baised eQTL |
| rs11948285 | chr5:145101453:A:G | - | 0.0773393388657656 | 0.0459326332877562 | LUAD | Male-baised eQTL |
| rs17102699 | chr5:145101987:T:C | - | 0.0773393388657656 | 0.0459326332877562 | LUAD | Male-baised eQTL |
| rs72806424 | chr5:145102129:A:C | - | 0.0773393388657656 | 0.0459326332877562 | LUAD | Male-baised eQTL |
| rs72806425 | chr5:145102135:C:T | - | 0.0773393388657656 | 0.0459326332877562 | LUAD | Male-baised eQTL |
| rs55802363 | chr5:145102305:G:A | - | 0.0773393388657656 | 0.0459326332877562 | LUAD | Male-baised eQTL |
| rs17102702 | chr5:145102503:G:A | - | 0.0773393388657656 | 0.0459326332877562 | LUAD | Male-baised eQTL |
| rs41320250 | chr5:145111730:T:C | - | 0.0809686433772927 | 0.0476241736178501 | LUAD | Male-baised eQTL |
| rs56333322 | chr5:145115208:T:C | - | 0.0868470230019784 | 0.0486301366422616 | LUAD | Male-baised eQTL |
| rs72806431 | chr5:145112302:T:C | - | 0.0798198895578952 | 0.0493349977274445 | LUAD | Male-baised eQTL |
| rs72806433 | chr5:145112306:T:C | - | 0.0798198895578952 | 0.0493349977274445 | LUAD | Male-baised eQTL |
| rs72806434 | chr5:145112401:G:A | - | 0.0798198895578952 | 0.0493349977274445 | LUAD | Male-baised eQTL |
| rs17102863 | chr5:145199897:T:C | - | 0.0878556335625689 | 0.0498144157655416 | LUAD | Male-baised eQTL |
| rs11740851 | chr5:148926578:T:G | - | -0.0534471561612984 | 0.0479300522810679 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of UBE2D2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
