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Gene: ENSG00000131323 |
Summary for TRAF3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000131323 | Gene symbol | TRAF3 |
| Gene name | TNF receptor associated factor 3 | |
| HGNC | 12033 | |
| Entrez ID | 7187 | |
| Gene type | protein_coding | |
| Synonyms | TRAF3|CAP-1|CD40bp|CRAF1|LAP1|RNF118 | |
| UniProtAcc | Q13114 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for TRAF3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for TRAF3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TRAF3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg09991769 | chr14:102776592 | CGI:chr14:102776904-102778368 | promoter | 7.20e-01 | 8.64e-01 | -3.55e+00 | 3.78e-04 | 7.96e-04 | -1.45e-01 |
| LUSC | cg09991769 | chr14:102776592 | CGI:chr14:102776904-102778368 | promoter | 8.12e-01 | 9.54e-01 | -4.33e+00 | 1.47e-05 | 5.26e-04 | -1.42e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for TRAF3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TRAF3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TRAF3 |
| TFs related to TRAF3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF141 | TRAF3 | 3.92e+00 | 9.83e-01 | 2.89e+00 | 3.54e-03 | Male-biased |
| ACC | ZNF28 | TRAF3 | 3.89e+00 | 9.80e-01 | 2.96e+00 | 5.44e-03 | Male-biased |
| ACC | ZNF454 | TRAF3 | 3.89e+00 | 9.84e-01 | 2.70e+00 | 1.83e-03 | Male-biased |
| ACC | ZNF611 | TRAF3 | 3.95e+00 | 9.81e-01 | 3.05e+00 | 6.15e-03 | Male-biased |
| TRAF3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TRAF3 |
| RBPs related to ES in TRAF3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LGG | CNOT4 | exon_skip_110245 | 8.09e+00 | 8.42e-03 | 8.44e+00 | 9.85e-01 | Female-biased |
| TRAF3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs79556714 | chr14:103836458:C:T | - | 0.0836422955788087 | 0.0361822701265187 | LUAD | Female-baised eQTL |
| rs11623518 | chr14:103748441:A:T | - | 0.077656129510614 | 0.0488449665357384 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17097925 | chr14:98855137:C:A | - | 0.20135349892327 | 1.00791596915903e-05 | SARC | Male-baised eQTL |
| rs17094214 | chr14:96624651:A:G | - | 0.150528293651319 | 9.96295064703746e-05 | SARC | Male-baised eQTL |
| rs927268 | chr14:98534528:C:T | - | 0.10014427151152 | 0.0278985638884425 | SARC | Male-baised eQTL |
| rs10484061 | chr14:98856203:G:A | - | 0.105286519647505 | 0.031390986983012 | SARC | Male-baised eQTL |
| rs78746254 | chr14:95257238:G:T | - | 0.0925316233235017 | 0.0327735734005252 | SARC | Male-baised eQTL |
| rs78847060 | chr14:95257244:G:C | - | 0.0925316233235017 | 0.0327735734005252 | SARC | Male-baised eQTL |
| rs74680578 | chr14:95257278:G:A | - | 0.0925316233235017 | 0.0327735734005252 | SARC | Male-baised eQTL |
| rs998479 | chr14:98733350:C:T | - | 0.0963135843924051 | 0.0450667486865178 | SARC | Male-baised eQTL |
| rs1003595 | chr14:98736756:T:A | - | 0.0958933833922726 | 0.0471338761129428 | SARC | Male-baised eQTL |
| rs10129884 | chr14:97652481:G:A | - | 0.0485872254681726 | 0.0464559010949629 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000131323 |
| CpG Site: cg04846720 | |
| Position to Gene: gene | |
| Male Effect: -0.452898828561574 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg04846720 | chr14:102829303 | gene | -0.452898828561574 | 5.07088302467113e-09 | -0.8694283814732593 | 3.07817788734047e-34 | SARC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_110231 | chr14:102830333:102830472 | 5UTR-5UTR | rs2092971 | chr14:102904753:T:C | Distant downstream | 0.0530162265633468 | 0.0471716463854601 | STAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TRAF3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000131323 | TRAF3 | C0001338 | Herpetic Acute Necrotizing Encephalitis | 1 | CTD_human |
| ENSG00000131323 | TRAF3 | C0019385 | Herpetic meningoencephalitis | 1 | CTD_human |
| ENSG00000131323 | TRAF3 | C0276226 | Herpes encephalitis | 1 | CTD_human |
