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Gene: ENSG00000131055 |
Summary for COX4I2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000131055 | Gene symbol | COX4I2 |
| Gene name | cytochrome c oxidase subunit 4I2 | |
| HGNC | 16232 | |
| Entrez ID | 84701 | |
| Gene type | protein_coding | |
| Synonyms | COX4I2|COXIV-2|COX4B|dJ857M17.2|COX4-2 | |
| UniProtAcc | Q96KJ9 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for COX4I2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| COX4I2 | 4.91e+01 | -1.15e+00 | 2.88e-01 | -4.00e+00 | 6.25e-05 | 1.64e-04 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| COX4I2 | 6.55e+01 | 1.11e+00 | 2.87e-01 | 3.87e+00 | 1.11e-04 | 6.38e-04 | HNSC |
| COX4I2 | 1.13e+02 | -1.59e+00 | 4.18e-01 | -3.80e+00 | 1.45e-04 | 1.87e-03 | BLCA |
Top |
Sex-biased somatic mutation for COX4I2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for COX4I2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| MESO | cg12033622 | chr20:31637770 | CGI:chr20:31637769-31638049 | promoter | 3.98e-01 | 5.45e-01 | -2.62e+00 | 8.71e-03 | 2.60e-02 | -1.47e-01 |
| ACC | cg11704513 | chr20:31638048 | CGI:chr20:31637769-31638049 | promoter,gene body | 7.30e-01 | 6.16e-01 | 2.24e+00 | 2.52e-02 | 3.88e-02 | 1.14e-01 |
| KICH | cg11704513 | chr20:31638048 | CGI:chr20:31637769-31638049 | promoter,gene body | 2.94e-01 | 4.03e-01 | -2.16e+00 | 3.11e-02 | 4.33e-02 | -1.09e-01 |
| DLBC | cg11704513 | chr20:31638048 | CGI:chr20:31637769-31638049 | promoter,gene body | 4.24e-01 | 5.54e-01 | -2.32e+00 | 2.05e-02 | 3.55e-02 | -1.30e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg22588850 | chr20:31639072 | CGI:chr20:31637769-31638049 | promoter,exon,CDS,gene body | 7.68e-01 | 8.91e-01 | -6.86e+00 | 7.12e-12 | 1.08e-09 | -1.23e-01 |
| LUAD | cg09027725 | chr20:31638243 | CGI:chr20:31637769-31638049 | promoter,gene body | 6.00e-01 | 7.23e-01 | -3.24e+00 | 1.19e-03 | 2.25e-03 | -1.23e-01 |
| LUSC | cg11595048 | chr20:31637522 | CGI:chr20:31637769-31638049 | promoter | 6.69e-01 | 7.85e-01 | -2.74e+00 | 6.21e-03 | 9.61e-03 | -1.16e-01 |
| LUSC | cg09027725 | chr20:31638243 | CGI:chr20:31637769-31638049 | promoter,gene body | 5.77e-01 | 7.04e-01 | -2.58e+00 | 9.85e-03 | 1.37e-02 | -1.27e-01 |
| COAD | cg11595048 | chr20:31637522 | CGI:chr20:31637769-31638049 | promoter | 6.71e-01 | 7.90e-01 | -3.51e+00 | 4.43e-04 | 1.16e-03 | -1.19e-01 |
| BLCA | cg11595048 | chr20:31637522 | CGI:chr20:31637769-31638049 | promoter | 5.98e-01 | 7.90e-01 | -4.11e+00 | 4.01e-05 | 2.14e-04 | -1.92e-01 |
| BLCA | cg11704513 | chr20:31638048 | CGI:chr20:31637769-31638049 | promoter,gene body | 4.68e-01 | 6.00e-01 | -2.24e+00 | 2.50e-02 | 2.92e-02 | -1.32e-01 |
| LIHC | cg27413508 | chr20:31637714 | CGI:chr20:31637769-31638049 | promoter | 3.77e-01 | 5.00e-01 | -4.63e+00 | 3.63e-06 | 1.13e-05 | -1.23e-01 |
| LIHC | cg11704513 | chr20:31638048 | CGI:chr20:31637769-31638049 | promoter,gene body | 5.16e-01 | 6.62e-01 | -3.26e+00 | 1.10e-03 | 1.72e-03 | -1.46e-01 |
| LIHC | cg09027725 | chr20:31638243 | CGI:chr20:31637769-31638049 | promoter,gene body | 5.22e-01 | 7.37e-01 | -5.09e+00 | 3.58e-07 | 1.54e-06 | -2.15e-01 |
| KIRP | cg26070540 | chr20:31637863 | CGI:chr20:31637769-31638049 | promoter | 5.02e-01 | 3.87e-01 | 2.43e+00 | 1.53e-02 | 1.83e-02 | 1.15e-01 |
| CHOL | cg17116120 | chr20:31637878 | CGI:chr20:31637769-31638049 | promoter | 6.80e-01 | 4.80e-01 | 1.99e+00 | 4.65e-02 | 4.65e-02 | 2.00e-01 |
| CHOL | cg08918020 | chr20:31637903 | CGI:chr20:31637769-31638049 | UTR,promoter,exon,gene body | 6.58e-01 | 5.27e-01 | 2.29e+00 | 2.23e-02 | 3.24e-02 | 1.31e-01 |
| CHOL | cg12033622 | chr20:31637770 | CGI:chr20:31637769-31638049 | promoter | 8.29e-01 | 6.70e-01 | 2.73e+00 | 6.38e-03 | 1.82e-02 | 1.58e-01 |
| CHOL | cg26070540 | chr20:31637863 | CGI:chr20:31637769-31638049 | promoter | 7.31e-01 | 5.86e-01 | 2.14e+00 | 3.25e-02 | 3.87e-02 | 1.44e-01 |
| CHOL | cg21543589 | chr20:31637882 | CGI:chr20:31637769-31638049 | promoter | 7.19e-01 | 5.34e-01 | 2.06e+00 | 3.90e-02 | 4.26e-02 | 1.84e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg17116120 | chr20:31637878 | CGI:chr20:31637769-31638049 | promoter | 6.00e-01 | 3.97e-01 | 9.43e+00 | 4.07e-21 | 2.42e-20 | 2.03e-01 |
| BRCA | cg08918020 | chr20:31637903 | CGI:chr20:31637769-31638049 | UTR,promoter,exon,gene body | 6.35e-01 | 4.34e-01 | 1.27e+01 | 3.80e-37 | 1.63e-35 | 2.01e-01 |
| BRCA | cg12033622 | chr20:31637770 | CGI:chr20:31637769-31638049 | promoter | 7.84e-01 | 4.19e-01 | 1.19e+01 | 1.05e-32 | 2.18e-31 | 3.64e-01 |
| BRCA | cg26070540 | chr20:31637863 | CGI:chr20:31637769-31638049 | promoter | 6.46e-01 | 4.71e-01 | 9.26e+00 | 2.13e-20 | 1.19e-19 | 1.75e-01 |
| BRCA | cg21543589 | chr20:31637882 | CGI:chr20:31637769-31638049 | promoter | 6.59e-01 | 4.64e-01 | 1.15e+01 | 9.74e-31 | 1.55e-29 | 1.96e-01 |
| BRCA | cg27413508 | chr20:31637714 | CGI:chr20:31637769-31638049 | promoter | 4.76e-01 | 3.41e-01 | 8.48e+00 | 2.30e-17 | 1.01e-16 | 1.35e-01 |
| LUAD | cg17116120 | chr20:31637878 | CGI:chr20:31637769-31638049 | promoter | 6.25e-01 | 4.98e-01 | 2.67e+00 | 7.53e-03 | 1.28e-02 | 1.26e-01 |
| LUAD | cg08918020 | chr20:31637903 | CGI:chr20:31637769-31638049 | UTR,promoter,exon,gene body | 6.01e-01 | 4.78e-01 | 3.59e+00 | 3.31e-04 | 1.60e-03 | 1.23e-01 |
| LUAD | cg21543589 | chr20:31637882 | CGI:chr20:31637769-31638049 | promoter | 6.44e-01 | 5.36e-01 | 2.98e+00 | 2.85e-03 | 6.50e-03 | 1.09e-01 |
| THCA | cg17116120 | chr20:31637878 | CGI:chr20:31637769-31638049 | promoter | 2.93e-01 | 3.93e-01 | -4.12e+00 | 3.78e-05 | 1.38e-04 | -1.01e-01 |
| THCA | cg11704513 | chr20:31638048 | CGI:chr20:31637769-31638049 | promoter,gene body | 4.11e-01 | 5.16e-01 | -3.58e+00 | 3.40e-04 | 8.90e-04 | -1.05e-01 |
| HNSC | cg08918020 | chr20:31637903 | CGI:chr20:31637769-31638049 | UTR,promoter,exon,gene body | 5.36e-01 | 4.21e-01 | 2.47e+00 | 1.37e-02 | 2.21e-02 | 1.16e-01 |
| HNSC | cg12033622 | chr20:31637770 | CGI:chr20:31637769-31638049 | promoter | 6.72e-01 | 4.87e-01 | 2.04e+00 | 4.18e-02 | 4.40e-02 | 1.85e-01 |
| HNSC | cg21543589 | chr20:31637882 | CGI:chr20:31637769-31638049 | promoter | 5.48e-01 | 4.36e-01 | 2.28e+00 | 2.23e-02 | 2.95e-02 | 1.12e-01 |
| BLCA | cg12033622 | chr20:31637770 | CGI:chr20:31637769-31638049 | promoter | 6.37e-01 | 4.90e-01 | 2.14e+00 | 3.25e-02 | 3.74e-02 | 1.46e-01 |
Top |
Exon skipping events with PSI in TCGA for COX4I2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for COX4I2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for COX4I2 |
| TFs related to COX4I2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | PRDM6 | COX4I2 | 4.96e+00 | 9.85e-01 | 4.18e+00 | 1.17e-02 | Male-biased |
| READ | ZNF22 | COX4I2 | 5.09e+00 | 9.88e-01 | 4.25e+00 | 9.04e-03 | Male-biased |
| READ | ZNF98 | COX4I2 | 4.71e+00 | 9.80e-01 | 3.97e+00 | 1.40e-02 | Male-biased |
| COX4I2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for COX4I2 |
| RBPs related to ES in COX4I2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| COX4I2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6106778 | chr20:24071089:T:A | - | 0.112829626090724 | 0.00396179105141773 | LUAD | Female-baised eQTL |
| rs6049370 | chr20:24066199:A:G | - | 0.106495855797053 | 0.00513657147937418 | LUAD | Female-baised eQTL |
| rs6102193 | chr20:40870685:G:T | - | 0.0996409462237737 | 0.0188204191584409 | LUAD | Female-baised eQTL |
| rs6036631 | chr20:24065786:A:G | - | 0.0890446818856058 | 0.0253664617443464 | LUAD | Female-baised eQTL |
| rs6036630 | chr20:24065596:C:T | - | 0.0864794903566096 | 0.0313346978125279 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6025492 | chr20:38412952:C:T | - | 0.0812252976844892 | 0.000293371817202605 | KIRP | Male-baised eQTL |
| rs295175 | chr20:39724229:T:C | - | 0.0793764060233532 | 0.000353741833416247 | KIRP | Male-baised eQTL |
| rs6036393 | chr20:23365313:G:A | - | 0.0769928435239367 | 0.000693793696617317 | KIRP | Male-baised eQTL |
| rs6099524 | chr20:38409465:C:T | - | 0.0754112563048763 | 0.000917062084148948 | KIRP | Male-baised eQTL |
| rs6036723 | chr20:24297328:C:T | - | 0.0675756592454322 | 0.00258231185207348 | KIRP | Male-baised eQTL |
| rs17091441 | chr20:33956370:T:C | - | 0.0691890338262185 | 0.00289081559495252 | KIRP | Male-baised eQTL |
| rs60210935 | chr20:33958550:A:T | - | 0.0691890338262185 | 0.00289081559495252 | KIRP | Male-baised eQTL |
| rs2153986 | chr20:23341691:G:A | - | 0.0667717328704375 | 0.00412565923321765 | KIRP | Male-baised eQTL |
| rs9753690 | chr20:33952995:C:T | - | 0.066935233760526 | 0.00428851098156489 | KIRP | Male-baised eQTL |
| rs6049295 | chr20:23999069:G:A | - | 0.0644976491309796 | 0.00522922311592613 | KIRP | Male-baised eQTL |
| rs148531621 | chr20:35120794:C:T | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs7266787 | chr20:35121054:C:T | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs113822426 | chr20:35123368:G:A | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs112216983 | chr20:35123522:G:A | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs112662371 | chr20:35123540:C:T | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs73279923 | chr20:35123621:A:G | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs17092309 | chr20:35123858:T:C | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs73279926 | chr20:35124109:A:T | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs73279928 | chr20:35124267:A:T | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs7263165 | chr20:35127763:A:G | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs7264663 | chr20:35127789:T:C | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs11907524 | chr20:35131010:T:C | - | 0.0618732537244541 | 0.00778376742650558 | KIRP | Male-baised eQTL |
| rs6059585 | chr20:33947566:G:C | - | 0.0610961988356932 | 0.0115268208615792 | KIRP | Male-baised eQTL |
| rs11904925 | chr20:33949026:C:T | - | 0.0594448864112658 | 0.0150045189928659 | KIRP | Male-baised eQTL |
| rs7263012 | chr20:35097238:T:C | - | 0.0554178150477177 | 0.0209293028196549 | KIRP | Male-baised eQTL |
| rs9753569 | chr20:33952903:A:G | - | 0.0561405757583269 | 0.0262442436478218 | KIRP | Male-baised eQTL |
| rs73296667 | chr20:22458318:C:T | - | 0.0529796506376209 | 0.0350948227752828 | KIRP | Male-baised eQTL |
| rs7261823 | chr20:35130826:C:T | - | 0.0524280924790369 | 0.0351261254253128 | KIRP | Male-baised eQTL |
| rs6048773 | chr20:23389081:C:T | - | 0.0533185872459192 | 0.0351872445480673 | KIRP | Male-baised eQTL |
| rs295177 | chr20:39726135:C:T | - | 0.0512111488843869 | 0.0380873611372674 | KIRP | Male-baised eQTL |
| rs6048726 | chr20:23332395:G:A | - | 0.0497950603310624 | 0.0479216532257687 | KIRP | Male-baised eQTL |
| rs71349739 | chr20:33897991:G:A | - | 0.0356316047469115 | 0.0336162271266526 | LGG | Male-baised eQTL |
| rs2050206 | chr20:33898718:C:T | - | 0.0342375495853836 | 0.0463453131256262 | LGG | Male-baised eQTL |
| rs6057742 | chr20:33172380:A:G | - | 0.0801587550472231 | 0.000772476866122038 | KIRC | Male-baised eQTL |
| rs6120141 | chr20:33180849:T:C | - | 0.0822996594727593 | 0.00160064847299565 | KIRC | Male-baised eQTL |
| rs1321426 | chr20:33178398:T:G | - | 0.0744284306830321 | 0.00200927144789867 | KIRC | Male-baised eQTL |
| rs17124271 | chr20:33165801:T:C | - | 0.0731480637584473 | 0.00242591920741445 | KIRC | Male-baised eQTL |
| rs6120132 | chr20:33170177:T:C | - | 0.0731480637584473 | 0.00242591920741445 | KIRC | Male-baised eQTL |
| rs6120127 | chr20:33161919:A:C | - | 0.0709818647544192 | 0.0037112073115568 | KIRC | Male-baised eQTL |
| rs1415814 | chr20:22497376:T:C | - | 0.0640572101309529 | 0.0063796114807953 | KIRC | Male-baised eQTL |
| rs7274637 | chr20:25762485:G:A | - | 0.0508689670989333 | 0.0187753765380036 | KIRC | Male-baised eQTL |
| rs61425731 | chr20:22491906:T:C | - | 0.082045689925068 | 0.0228450664531313 | KIRC | Male-baised eQTL |
| rs6048129 | chr20:22495599:G:A | - | 0.0759562794929423 | 0.0264453051490284 | KIRC | Male-baised eQTL |
| rs73900501 | chr20:22494242:A:T | - | 0.0766598232282623 | 0.0274682495573968 | KIRC | Male-baised eQTL |
| rs6048124 | chr20:22493492:T:A | - | 0.076634732724116 | 0.0275188647850831 | KIRC | Male-baised eQTL |
| rs199764 | chr20:22389273:G:A | - | 0.0589910475363454 | 0.035368847294754 | KIRC | Male-baised eQTL |
| rs199840 | chr20:22380294:T:G | - | 0.0534619177669282 | 0.0367745258822222 | KIRC | Male-baised eQTL |
| rs6048130 | chr20:22496674:T:C | - | 0.0747454081125564 | 0.0420786522724429 | KIRC | Male-baised eQTL |
| rs6037169 | chr20:25631417:A:C | - | 0.0384052772837146 | 0.0472892126469461 | KIRC | Male-baised eQTL |
| rs6115232 | chr20:25633139:G:T | - | 0.0384052772837146 | 0.0472892126469461 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000131055 |
| CpG Site: cg11704513 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.0627925306568301 | |
| Female Effect: - | |
 | Gene ID: ENSG00000131055 |
| CpG Site: cg11704513 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.239786562676141 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg11704513 | chr20:31638048 | gene,promoter | -0.0627925306568301 | 5.42853004959203e-05 | -0.3535589994254981 | 2.624886550118026e-07 | KIRP |
| cg11704513 | chr20:31638048 | gene,promoter | -0.239786562676141 | 7.24635783984765e-05 | -0.35306204338842023 | 1.3737915884794395e-07 | KIRC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs6089100 | chr20:31854195:A:T | Distant downstream | -0.0416433765972792 | 0.00820677605291994 | KIRC | Female-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs6087785 | chr20:31854179:G:C | Distant downstream | -0.0414502327998158 | 0.00842772920398257 | KIRC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs73105930 | chr20:31327265:A:G | Distant upstream | 0.0345351310878941 | 0.0220289053444864 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs148435164 | chr20:31342316:G:A | Distant upstream | 0.0345351310878941 | 0.0220289053444864 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs8122544 | chr20:31346428:C:T | Distant upstream | 0.0345351310878941 | 0.0220289053444864 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs6087445 | chr20:31402449:A:G | Distant upstream | -0.0248690334051743 | 0.0303322669111393 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs73104095 | chr20:31312074:A:T | Distant upstream | 0.0334100389758719 | 0.0311034632643213 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs7273790 | chr20:31312478:C:A | Distant upstream | 0.0330461692532884 | 0.0365245943350867 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs138618662 | chr20:31360232:A:G | Distant upstream | 0.0332738532642041 | 0.0371935913469734 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs73105954 | chr20:31355903:C:T | Distant upstream | 0.032629052931145 | 0.0463676925240011 | KIRC | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs6120374 | chr20:31469501:G:C | Distant upstream | -0.0472339318595002 | 0.024868466705429 | THCA | Male-baised sQTL |
| exon_skip_349923 | chr20:31643403:31643535 | In-frame | rs1543438 | chr20:31473250:A:G | Distant upstream | -0.0457557932200374 | 0.0380009174074235 | THCA | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_349923 |
| CpG Site: cg12033622 | |
| Position to EX: Distant upstream | |
| Male Effect: 0.219492476753281 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_349923 | chr20:31643403:31643535 | cg12033622 | chr20:31637770 | Distant upstream | 0.219492476753281 | 1.03089479166686e-08 | 0.3502652245894111 | 7.779129343947358e-07 | In-frame | LUAD |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of COX4I2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000131055 | COX4I2 | C2675184 | Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, and Calvarial Hyperostosis | 1 | CTD_human |
