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Gene: ENSG00000131016 |
Summary for AKAP12 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000131016 | Gene symbol | AKAP12 |
| Gene name | A-kinase anchoring protein 12 | |
| HGNC | 370 | |
| Entrez ID | 9590 | |
| Gene type | protein_coding | |
| Synonyms | AKAP12|AKAP250|SSeCKS | |
| UniProtAcc | Q02952 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for AKAP12 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AKAP12 | 1.21e+03 | -1.37e+00 | 2.79e-01 | -4.91e+00 | 8.91e-07 | 3.34e-06 | HNSC |
| AKAP12 | 3.79e+03 | -2.46e+00 | 5.40e-01 | -4.55e+00 | 5.29e-06 | 9.39e-05 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AKAP12 | 2.39e+03 | -1.74e+00 | 2.38e-01 | -7.30e+00 | 2.93e-13 | 1.86e-12 | LUAD |
| AKAP12 | 3.08e+03 | -2.69e+00 | 1.18e-01 | -2.28e+01 | 3.02e-115 | 1.65e-113 | BRCA |
| AKAP12 | 1.21e+03 | -2.78e+00 | 5.23e-01 | -5.31e+00 | 1.09e-07 | 1.26e-06 | READ |
Top |
Sex-biased somatic mutation for AKAP12 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for AKAP12 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg20068535 | chr6:151239846 | CGI:chr6:151239631-151239858 | promoter | 5.83e-01 | 6.91e-01 | -2.39e+00 | 1.70e-02 | 3.28e-02 | -1.08e-01 |
| BRCA | cg14219620 | chr6:151240033 | CGI:chr6:151240148-151241415 | UTR,promoter,exon,gene body | 3.33e-01 | 4.77e-01 | -2.13e+00 | 3.33e-02 | 4.28e-02 | -1.44e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg11348249 | chr6:151239696 | CGI:chr6:151239631-151239858 | promoter | 6.17e-01 | 4.43e-01 | 3.12e+00 | 1.82e-03 | 3.91e-03 | 1.74e-01 |
| LUSC | cg12061236 | chr6:151239751 | CGI:chr6:151239631-151239858 | promoter | 5.32e-01 | 4.05e-01 | 2.44e+00 | 1.45e-02 | 1.85e-02 | 1.27e-01 |
| ESCA | cg13033898 | chr6:151239920 | CGI:chr6:151239631-151239858 | promoter | 4.34e-01 | 2.69e-01 | 2.02e+00 | 4.39e-02 | 4.78e-02 | 1.65e-01 |
| CHOL | cg22942200 | chr6:151239857 | CGI:chr6:151239631-151239858 | promoter | 5.27e-01 | 3.68e-01 | 2.06e+00 | 3.90e-02 | 4.26e-02 | 1.59e-01 |
| CHOL | cg12061236 | chr6:151239751 | CGI:chr6:151239631-151239858 | promoter | 6.67e-01 | 4.15e-01 | 2.88e+00 | 4.04e-03 | 1.47e-02 | 2.51e-01 |
| CHOL | cg17520539 | chr6:151239792 | CGI:chr6:151239631-151239858 | promoter | 6.11e-01 | 4.36e-01 | 2.65e+00 | 7.96e-03 | 1.92e-02 | 1.74e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg20068535 | chr6:151239846 | CGI:chr6:151239631-151239858 | promoter | 5.83e-01 | 3.87e-01 | 1.06e+01 | 2.57e-26 | 2.48e-25 | 1.96e-01 |
| BRCA | cg22942200 | chr6:151239857 | CGI:chr6:151239631-151239858 | promoter | 5.42e-01 | 3.64e-01 | 9.18e+00 | 4.14e-20 | 2.26e-19 | 1.78e-01 |
| BRCA | cg10270306 | chr6:151239897 | CGI:chr6:151239631-151239858 | promoter | 5.38e-01 | 3.54e-01 | 9.21e+00 | 3.29e-20 | 1.81e-19 | 1.84e-01 |
| BRCA | cg11348249 | chr6:151239696 | CGI:chr6:151239631-151239858 | promoter | 6.99e-01 | 5.48e-01 | 8.59e+00 | 8.36e-18 | 3.78e-17 | 1.50e-01 |
| BRCA | cg12061236 | chr6:151239751 | CGI:chr6:151239631-151239858 | promoter | 6.13e-01 | 4.95e-01 | 6.60e+00 | 4.13e-11 | 1.12e-10 | 1.18e-01 |
| BRCA | cg17520539 | chr6:151239792 | CGI:chr6:151239631-151239858 | promoter | 5.84e-01 | 4.28e-01 | 1.02e+01 | 1.33e-24 | 1.09e-23 | 1.55e-01 |
| BRCA | cg13033898 | chr6:151239920 | CGI:chr6:151239631-151239858 | promoter | 4.83e-01 | 2.75e-01 | 8.20e+00 | 2.39e-16 | 9.65e-16 | 2.07e-01 |
| BRCA | cg14219620 | chr6:151240033 | CGI:chr6:151240148-151241415 | UTR,promoter,exon,gene body | 3.33e-01 | 1.85e-01 | 7.72e+00 | 1.18e-14 | 4.19e-14 | 1.48e-01 |
| BRCA | cg09070799 | chr6:151240101 | CGI:chr6:151240148-151241415 | promoter,gene body | 3.57e-01 | 1.91e-01 | 6.04e+00 | 1.51e-09 | 3.61e-09 | 1.66e-01 |
| BRCA | cg01555431 | chr6:151240891 | CGI:chr6:151240148-151241415 | promoter,gene body | 1.80e-01 | 5.66e-02 | 8.05e+00 | 8.24e-16 | 3.20e-15 | 1.23e-01 |
| HNSC | cg01555431 | chr6:151240891 | CGI:chr6:151240148-151241415 | promoter,gene body | 1.60e-01 | 5.64e-02 | 2.26e+00 | 2.37e-02 | 3.06e-02 | 1.04e-01 |
| LIHC | cg22942200 | chr6:151239857 | CGI:chr6:151239631-151239858 | promoter | 5.26e-01 | 2.84e-01 | 4.57e+00 | 4.80e-06 | 4.02e-05 | 2.42e-01 |
| LIHC | cg10270306 | chr6:151239897 | CGI:chr6:151239631-151239858 | promoter | 5.13e-01 | 3.00e-01 | 4.12e+00 | 3.87e-05 | 1.88e-04 | 2.13e-01 |
| LIHC | cg11348249 | chr6:151239696 | CGI:chr6:151239631-151239858 | promoter | 6.32e-01 | 4.60e-01 | 3.85e+00 | 1.17e-04 | 4.34e-04 | 1.72e-01 |
| LIHC | cg12061236 | chr6:151239751 | CGI:chr6:151239631-151239858 | promoter | 5.39e-01 | 3.50e-01 | 3.27e+00 | 1.08e-03 | 2.40e-03 | 1.89e-01 |
| LIHC | cg17520539 | chr6:151239792 | CGI:chr6:151239631-151239858 | promoter | 5.50e-01 | 3.79e-01 | 4.35e+00 | 1.38e-05 | 8.70e-05 | 1.71e-01 |
| LIHC | cg13033898 | chr6:151239920 | CGI:chr6:151239631-151239858 | promoter | 4.81e-01 | 2.55e-01 | 3.95e+00 | 7.95e-05 | 3.23e-04 | 2.26e-01 |
Top |
Exon skipping events with PSI in TCGA for AKAP12 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for AKAP12 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for AKAP12 |
| TFs related to AKAP12. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| AKAP12 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for AKAP12 |
| RBPs related to ES in AKAP12. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| AKAP12 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000131016 | AC124312.3,hsa-mir-206,AKAP12 | Male-specific ceRNA | TCGA-HNSC |
| ENSG00000131016 | LINC00924,hsa-mir-206,AKAP12 | Male-specific ceRNA | TCGA-HNSC |
| ENSG00000131016 | LINC01197,hsa-mir-206,AKAP12 | Male-specific ceRNA | TCGA-HNSC |
| ENSG00000131016 | MAGI2-AS3,hsa-mir-577,AKAP12 | Male-specific ceRNA | TCGA-HNSC |
| ENSG00000131016 | AC093010.2,hsa-mir-577,AKAP12 | Male-specific ceRNA | TCGA-HNSC |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs78797168 | chr6:160038159:A:G | - | 0.196046352769635 | 0.0145241504517844 | HNSC | Female-baised eQTL |
| rs76839760 | chr6:158446909:C:G | - | 0.140959273916456 | 0.0333809192025686 | HNSC | Female-baised eQTL |
| rs59182060 | chr6:158448628:C:A | - | 0.140959273916456 | 0.0333809192025686 | HNSC | Female-baised eQTL |
| rs6920842 | chr6:158449515:G:C | - | 0.140959273916456 | 0.0333809192025686 | HNSC | Female-baised eQTL |
| rs62429684 | chr6:144876451:A:G | - | 0.317748974392274 | 0.0401970071097873 | KIRP | Female-baised eQTL |
| rs12195987 | chr6:145724912:A:G | - | 0.206522866051132 | 6.39026821612952e-08 | LIHC | Female-baised eQTL |
| rs12193627 | chr6:145736153:C:T | - | 0.206507996301036 | 6.52576390197769e-08 | LIHC | Female-baised eQTL |
| rs34312543 | chr6:145547295:T:G | - | 0.186966638330285 | 1.33370656543021e-06 | LIHC | Female-baised eQTL |
| rs6899772 | chr6:145571639:G:A | - | 0.186747265283064 | 1.33653431075938e-06 | LIHC | Female-baised eQTL |
| rs13196875 | chr6:145605064:G:A | - | 0.186747265283064 | 1.33653431075938e-06 | LIHC | Female-baised eQTL |
| rs12195117 | chr6:145683624:A:T | - | 0.186747265283064 | 1.33653431075938e-06 | LIHC | Female-baised eQTL |
| rs149717262 | chr6:145664729:C:T | - | 0.186635129470351 | 1.40546928125808e-06 | LIHC | Female-baised eQTL |
| rs55863840 | chr6:148539772:C:A | - | 0.178561152793622 | 1.14131423779304e-05 | LIHC | Female-baised eQTL |
| rs55670014 | chr6:148539849:G:A | - | 0.178561152793622 | 1.14131423779304e-05 | LIHC | Female-baised eQTL |
| rs9485004 | chr6:145568614:C:T | - | 0.170670450523619 | 1.4012498138363e-05 | LIHC | Female-baised eQTL |
| rs12203609 | chr6:145556496:C:T | - | 0.170590455768983 | 1.45632060887341e-05 | LIHC | Female-baised eQTL |
| rs10457055 | chr6:145537321:C:T | - | 0.170464275334275 | 1.55701454636017e-05 | LIHC | Female-baised eQTL |
| rs952407 | chr6:145604826:A:G | - | 0.170074167926535 | 1.67979342810075e-05 | LIHC | Female-baised eQTL |
| rs13200495 | chr6:145635657:G:C | - | 0.170074167926535 | 1.67979342810075e-05 | LIHC | Female-baised eQTL |
| rs73579446 | chr6:145650203:G:C | - | 0.170074167926535 | 1.67979342810075e-05 | LIHC | Female-baised eQTL |
| rs71566412 | chr6:145464497:G:C | - | 0.168240816007538 | 2.46630676872456e-05 | LIHC | Female-baised eQTL |
| rs12199971 | chr6:145474307:C:T | - | 0.168240816007538 | 2.46630676872456e-05 | LIHC | Female-baised eQTL |
| rs79433730 | chr6:145765608:C:T | - | 0.168070570844212 | 2.58489259011217e-05 | LIHC | Female-baised eQTL |
| rs12208721 | chr6:145766964:A:G | - | 0.167993501658016 | 2.65597119794677e-05 | LIHC | Female-baised eQTL |
| rs13210966 | chr6:145778885:C:T | - | 0.167993501658016 | 2.65597119794677e-05 | LIHC | Female-baised eQTL |
| rs12200607 | chr6:145801001:T:G | - | 0.167957872707893 | 2.68141189434512e-05 | LIHC | Female-baised eQTL |
| rs35807318 | chr6:145807444:A:G | - | 0.155519426629686 | 0.000110482112858315 | LIHC | Female-baised eQTL |
| rs12214705 | chr6:145797739:G:C | - | 0.155441227902138 | 0.000113889622076033 | LIHC | Female-baised eQTL |
| rs9346804 | chr6:159979996:G:A | - | 0.120918841608473 | 0.00101697634195856 | LIHC | Female-baised eQTL |
| rs12198683 | chr6:145830044:T:A | - | 0.122959907577005 | 0.00239635700905126 | LIHC | Female-baised eQTL |
| rs12212636 | chr6:145856679:G:A | - | 0.122959907577005 | 0.00239635700905126 | LIHC | Female-baised eQTL |
| rs34466436 | chr6:145866556:T:C | - | 0.122959907577005 | 0.00239635700905126 | LIHC | Female-baised eQTL |
| rs34211445 | chr6:145867766:T:G | - | 0.122959907577005 | 0.00239635700905126 | LIHC | Female-baised eQTL |
| rs2080118 | chr6:148546621:T:C | - | 0.129352817257588 | 0.00266950533353342 | LIHC | Female-baised eQTL |
| rs35667536 | chr6:145819105:C:T | - | 0.121560761399906 | 0.00312977563632648 | LIHC | Female-baised eQTL |
| rs10455860 | chr6:159980254:C:T | - | 0.110578132201117 | 0.00348305707271077 | LIHC | Female-baised eQTL |
| rs11232 | chr6:145884865:G:A | - | 0.110662746295114 | 0.0086241901191402 | LIHC | Female-baised eQTL |
| rs10447450 | chr6:145904483:G:A | - | 0.110662746295114 | 0.0086241901191402 | LIHC | Female-baised eQTL |
| rs3923580 | chr6:145909196:T:C | - | 0.110662746295114 | 0.0086241901191402 | LIHC | Female-baised eQTL |
| rs714680 | chr6:146023249:T:C | - | 0.114287687585362 | 0.00989773983373621 | LIHC | Female-baised eQTL |
| rs3811105 | chr6:146028615:A:G | - | 0.114287687585362 | 0.00989773983373621 | LIHC | Female-baised eQTL |
| rs12196298 | chr6:146033289:G:A | - | 0.114287687585362 | 0.00989773983373621 | LIHC | Female-baised eQTL |
| rs10457790 | chr6:146038729:A:G | - | 0.114287687585362 | 0.00989773983373621 | LIHC | Female-baised eQTL |
| rs12205195 | chr6:146043164:G:A | - | 0.114287687585362 | 0.00989773983373621 | LIHC | Female-baised eQTL |
| rs12200649 | chr6:146110918:G:C | - | 0.113871091748061 | 0.0105834607319694 | LIHC | Female-baised eQTL |
| rs12216492 | chr6:146055482:T:C | - | 0.113638890458173 | 0.0107470795029502 | LIHC | Female-baised eQTL |
| rs12203355 | chr6:146063339:T:C | - | 0.113638890458173 | 0.0107470795029502 | LIHC | Female-baised eQTL |
| rs35765437 | chr6:146083954:A:C | - | 0.113591928218715 | 0.0109625763148407 | LIHC | Female-baised eQTL |
| rs12192366 | chr6:146088854:A:G | - | 0.113591928218715 | 0.0109625763148407 | LIHC | Female-baised eQTL |
| rs17225973 | chr6:145920105:A:G | - | 0.104509070511994 | 0.0164515290470298 | LIHC | Female-baised eQTL |
| rs12214668 | chr6:145922876:G:A | - | 0.104509070511994 | 0.0164515290470298 | LIHC | Female-baised eQTL |
| rs13209322 | chr6:145938645:G:A | - | 0.104509070511994 | 0.0164515290470298 | LIHC | Female-baised eQTL |
| rs12189548 | chr6:145953920:G:A | - | 0.104509070511994 | 0.0164515290470298 | LIHC | Female-baised eQTL |
| rs10457789 | chr6:145958227:C:T | - | 0.104426726235608 | 0.0168229019708591 | LIHC | Female-baised eQTL |
| rs149846050 | chr6:145996489:C:G | - | 0.100356955373547 | 0.0235757151732402 | LIHC | Female-baised eQTL |
| rs1304095 | chr6:145999392:A:G | - | 0.100356955373547 | 0.0235757151732402 | LIHC | Female-baised eQTL |
| rs117342111 | chr6:145999462:G:A | - | 0.100356955373547 | 0.0235757151732402 | LIHC | Female-baised eQTL |
| rs2294788 | chr6:148541007:G:C | - | 0.106954222593372 | 0.0293805775315037 | LIHC | Female-baised eQTL |
| rs9347503 | chr6:157700536:G:A | - | 0.179357732865651 | 0.000419001943918152 | STAD | Female-baised eQTL |
| rs61616914 | chr6:157700609:T:C | - | 0.179357732865651 | 0.000419001943918152 | STAD | Female-baised eQTL |
| rs57100697 | chr6:146965033:A:C | - | 0.193781339039358 | 0.00117974186226591 | STAD | Female-baised eQTL |
| rs61069976 | chr6:157700846:T:G | - | 0.16675274571125 | 0.001245798421133 | STAD | Female-baised eQTL |
| rs58466370 | chr6:157700858:C:G | - | 0.16675274571125 | 0.001245798421133 | STAD | Female-baised eQTL |
| rs115084734 | chr6:157701149:A:G | - | 0.16675274571125 | 0.001245798421133 | STAD | Female-baised eQTL |
| rs186571745 | chr6:157701225:A:G | - | 0.16675274571125 | 0.001245798421133 | STAD | Female-baised eQTL |
| rs12216135 | chr6:144101959:T:C | - | 0.208210310010881 | 0.00600321798143092 | STAD | Female-baised eQTL |
| rs56127624 | chr6:147011108:G:A | - | 0.13343141462838 | 0.0151519357938555 | STAD | Female-baised eQTL |
| rs146756560 | chr6:146986216:A:G | - | 0.130430980895334 | 0.0217032593070597 | STAD | Female-baised eQTL |
| rs17237548 | chr6:147001906:A:G | - | 0.130157973589394 | 0.0225495085832316 | STAD | Female-baised eQTL |
| rs66459623 | chr6:147002725:C:T | - | 0.124618938338026 | 0.0330573848976977 | STAD | Female-baised eQTL |
| rs73011819 | chr6:147004318:T:A | - | 0.124618938338026 | 0.0330573848976977 | STAD | Female-baised eQTL |
| rs67538823 | chr6:147006615:A:G | - | 0.124618938338026 | 0.0330573848976977 | STAD | Female-baised eQTL |
| rs2295202 | chr6:143773811:T:C | - | 0.191439810647348 | 0.00161528475284443 | LGG | Female-baised eQTL |
| rs1018463 | chr6:143772215:C:T | - | 0.175238037368037 | 0.00376347684772564 | LGG | Female-baised eQTL |
| rs2073215 | chr6:143760631:C:A | - | 0.165329694799762 | 0.00886045366978546 | LGG | Female-baised eQTL |
| rs11155325 | chr6:143763344:G:A | - | 0.15517622407477 | 0.00946905448176409 | LGG | Female-baised eQTL |
| rs6907533 | chr6:143761916:A:G | - | 0.153453606158032 | 0.0114736896883066 | LGG | Female-baised eQTL |
| rs7770737 | chr6:143762629:T:C | - | 0.152946198867227 | 0.0135138420339043 | LGG | Female-baised eQTL |
| rs6907636 | chr6:143761733:G:A | - | 0.154724794719264 | 0.0137784009833442 | LGG | Female-baised eQTL |
| rs7754387 | chr6:143768470:G:A | - | 0.146933433210379 | 0.0143990850853061 | LGG | Female-baised eQTL |
| rs722754 | chr6:143762316:A:C | - | 0.145291831385347 | 0.0227316742925461 | LGG | Female-baised eQTL |
| rs2144223 | chr6:143769864:C:A | - | 0.147161748964014 | 0.0280915866427892 | LGG | Female-baised eQTL |
| rs28453924 | chr6:145141903:A:T | - | 0.119024975665849 | 0.0158036764086257 | BLCA | Female-baised eQTL |
| rs9403664 | chr6:145136078:A:G | - | 0.118732833494007 | 0.016172474031645 | BLCA | Female-baised eQTL |
| rs9386101 | chr6:145136082:T:A | - | 0.118732833494007 | 0.016172474031645 | BLCA | Female-baised eQTL |
| rs17074848 | chr6:145144351:G:A | - | 0.111424455656364 | 0.028760091373549 | BLCA | Female-baised eQTL |
| rs2603450 | chr6:156398980:C:T | - | -0.0450311602248652 | 0.00900322439253263 | LUAD | Female-baised eQTL |
| rs2603451 | chr6:156399851:G:A | - | -0.0419631291128165 | 0.0175253714832122 | LUAD | Female-baised eQTL |
| rs73002240 | chr6:150577286:A:G | - | 0.0452528594858412 | 0.0428929287213594 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7774404 | chr6:150396706:T:C | - | 0.155069691866877 | 0.0351627940163294 | PAAD | Male-baised eQTL |
| rs6900514 | chr6:148806462:T:C | - | -0.0621905184386946 | 0.0380776348250218 | LIHC | Male-baised eQTL |
| rs17801051 | chr6:144665358:A:G | - | 0.0692319509752248 | 0.0492956351803079 | KIRC | Male-baised eQTL |
| rs4392731 | chr6:144665947:G:T | - | 0.0692319509752248 | 0.0492956351803079 | KIRC | Male-baised eQTL |
| rs73599510 | chr6:144666956:C:T | - | 0.0692319509752248 | 0.0492956351803079 | KIRC | Male-baised eQTL |
| rs4708799 | chr6:158628146:T:C | - | -0.0432752125941832 | 0.0207720982477278 | LUAD | Male-baised eQTL |
| rs4709221 | chr6:158585972:A:G | - | -0.0409776164856716 | 0.0263077466331256 | LUAD | Male-baised eQTL |
| rs17073273 | chr6:143967413:A:C | - | 0.0348178035332923 | 0.0231142597088077 | COAD | Male-baised eQTL |
| rs9397612 | chr6:153315911:T:C | - | -0.03068479901813 | 0.0243363596623665 | COAD | Male-baised eQTL |
| rs10872705 | chr6:154295285:G:A | - | -0.0304217670244021 | 0.0249177031664487 | COAD | Male-baised eQTL |
| rs78797168 | chr6:160038159:A:G | - | 0.0590549717245463 | 0.042238773494729 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000131016 |
| CpG Site: cg13500720 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.474440480545806 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13500720 | chr6:151357962 | gene,exon,UTR | -0.474440480545806 | 4.13790556636072e-23 | -0.604425733304655 | 2.169141561015453e-26 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of AKAP12 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000131016 | AKAP12 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| ENSG00000131016 | AKAP12 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| ENSG00000131016 | AKAP12 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| ENSG00000131016 | AKAP12 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| ENSG00000131016 | AKAP12 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
