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Gene: ENSG00000130988 |
Summary for RGN |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000130988 | Gene symbol | RGN |
| Gene name | regucalcin | |
| HGNC | 9989 | |
| Entrez ID | 9104 | |
| Gene type | protein_coding | |
| Synonyms | RGN|SMP30|RC | |
| UniProtAcc | Q15493 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000130988 | RGN | DB11093 | Calcium citrate | SmallMoleculeDrug |
| ENSG00000130988 | RGN | DB11348 | Calcium Phosphate | SmallMoleculeDrug |
| ENSG00000130988 | RGN | DB14481 | Calcium phosphate dihydrate | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RGN |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RGN | 3.00e+02 | -1.07e+00 | 2.65e-01 | -4.03e+00 | 5.53e-05 | 1.49e-04 | LUAD |
| RGN | 3.39e+02 | -1.20e+00 | 4.07e-01 | -2.95e+00 | 3.13e-03 | 7.67e-03 | STAD |
| RGN | 1.28e+03 | -1.29e+00 | 2.39e-01 | -5.38e+00 | 7.61e-08 | 3.25e-07 | KIRP |
| RGN | 5.04e+03 | -4.46e+00 | 5.50e-01 | -8.10e+00 | 5.35e-16 | 2.67e-14 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RGN | 7.62e+03 | -1.29e+00 | 2.92e-01 | -4.41e+00 | 1.04e-05 | 4.16e-05 | LIHC |
Top |
Sex-biased somatic mutation for RGN |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for RGN |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 4.48e-01 | 5.66e-01 | -2.05e+00 | 4.02e-02 | 4.61e-02 | -1.18e-01 |
| BRCA | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.44e-01 | 7.53e-01 | -3.64e+00 | 2.76e-04 | 3.90e-03 | -1.09e-01 |
| BRCA | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.43e-01 | 7.63e-01 | -3.03e+00 | 2.45e-03 | 1.50e-02 | -1.20e-01 |
| BRCA | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 6.15e-01 | 7.42e-01 | -2.79e+00 | 5.33e-03 | 2.09e-02 | -1.27e-01 |
| BRCA | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 6.59e-01 | 8.44e-01 | -3.87e+00 | 1.08e-04 | 1.79e-03 | -1.85e-01 |
| BRCA | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 6.69e-01 | 8.21e-01 | -3.41e+00 | 6.39e-04 | 7.12e-03 | -1.52e-01 |
| KIRC | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 2.52e-01 | 1.39e-01 | 8.01e+00 | 1.14e-15 | 1.25e-14 | 1.13e-01 |
| LUAD | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.78e-01 | 7.89e-01 | -1.44e+01 | 4.82e-47 | 1.21e-45 | -1.12e-01 |
| LGG | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 7.06e-01 | 8.30e-01 | -1.59e+01 | 6.02e-57 | 7.29e-56 | -1.24e-01 |
| LGG | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 7.21e-01 | 8.66e-01 | -1.73e+01 | 3.36e-67 | 4.95e-66 | -1.45e-01 |
| LGG | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 6.57e-01 | 8.32e-01 | -1.27e+01 | 7.34e-37 | 6.47e-36 | -1.75e-01 |
| HNSC | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 7.00e-01 | 8.18e-01 | -1.07e+01 | 5.94e-27 | 1.13e-25 | -1.18e-01 |
| LUSC | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.57e-01 | 7.82e-01 | -1.05e+01 | 8.52e-26 | 1.01e-24 | -1.25e-01 |
| SKCM | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 6.31e-01 | 7.61e-01 | -9.44e+00 | 3.69e-21 | 2.92e-20 | -1.30e-01 |
| SKCM | cg06472116 | chrX:47078254 | CGI:chrX:47078232-47078570 | promoter | 7.61e-01 | 9.07e-01 | -1.34e+01 | 6.12e-41 | 7.60e-40 | -1.46e-01 |
| SKCM | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.47e-01 | 7.75e-01 | -1.25e+01 | 4.10e-36 | 4.54e-35 | -1.28e-01 |
| SKCM | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.36e-01 | 7.89e-01 | -1.22e+01 | 3.21e-34 | 3.39e-33 | -1.53e-01 |
| SKCM | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 7.44e-01 | 8.88e-01 | -1.29e+01 | 8.50e-38 | 9.79e-37 | -1.44e-01 |
| SKCM | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 7.69e-01 | 9.22e-01 | -1.43e+01 | 1.30e-46 | 1.78e-45 | -1.52e-01 |
| SKCM | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 7.22e-01 | 8.50e-01 | -1.06e+01 | 3.91e-26 | 3.49e-25 | -1.28e-01 |
| BLCA | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 5.91e-01 | 6.93e-01 | -6.47e+00 | 9.92e-11 | 9.29e-10 | -1.02e-01 |
| STAD | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 4.95e-01 | 3.92e-01 | 5.43e+00 | 5.75e-08 | 3.69e-07 | 1.03e-01 |
| LIHC | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 3.85e-01 | 2.58e-01 | 6.73e+00 | 1.71e-11 | 3.29e-10 | 1.27e-01 |
| KIRP | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 7.01e-01 | 8.10e-01 | -8.84e+00 | 9.37e-19 | 1.60e-17 | -1.09e-01 |
| KIRP | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 7.20e-01 | 8.58e-01 | -9.89e+00 | 4.40e-23 | 8.68e-22 | -1.38e-01 |
| PCPG | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 5.59e-01 | 6.61e-01 | -5.11e+00 | 3.21e-07 | 1.56e-06 | -1.02e-01 |
| PAAD | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 2.87e-01 | 1.71e-01 | 7.25e+00 | 4.29e-13 | 4.20e-12 | 1.16e-01 |
| PAAD | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.74e-01 | 7.78e-01 | -9.59e+00 | 8.69e-22 | 1.41e-20 | -1.04e-01 |
| PAAD | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.63e-01 | 7.71e-01 | -8.58e+00 | 9.28e-18 | 1.19e-16 | -1.08e-01 |
| PAAD | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 6.79e-01 | 5.70e-01 | 6.30e+00 | 3.06e-10 | 2.53e-09 | 1.09e-01 |
| PAAD | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 4.62e-01 | 3.39e-01 | 6.99e+00 | 2.71e-12 | 2.53e-11 | 1.23e-01 |
| PAAD | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 4.92e-01 | 3.02e-01 | 9.04e+00 | 1.59e-19 | 2.27e-18 | 1.90e-01 |
| READ | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.25e-01 | 7.65e-01 | -6.99e+00 | 2.70e-12 | 2.58e-11 | -1.40e-01 |
| READ | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.54e-01 | 7.81e-01 | -5.44e+00 | 5.47e-08 | 3.61e-07 | -1.28e-01 |
| GBM | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.32e-01 | 7.45e-01 | -3.88e+00 | 1.07e-04 | 5.27e-04 | -1.12e-01 |
| GBM | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.55e-01 | 8.30e-01 | -5.43e+00 | 5.62e-08 | 4.41e-07 | -1.75e-01 |
| GBM | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 4.93e-01 | 3.82e-01 | 2.60e+00 | 9.40e-03 | 2.37e-02 | 1.11e-01 |
| ESCA | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.42e-01 | 7.53e-01 | -4.36e+00 | 1.30e-05 | 7.91e-05 | -1.11e-01 |
| LAML | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 8.10e-01 | 9.22e-01 | -5.94e+00 | 2.84e-09 | 1.21e-08 | -1.12e-01 |
| THYM | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 7.24e-01 | 8.47e-01 | -8.54e+00 | 1.31e-17 | 1.06e-16 | -1.24e-01 |
| THYM | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 7.26e-01 | 8.92e-01 | -9.01e+00 | 2.14e-19 | 2.12e-18 | -1.66e-01 |
| THYM | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 7.32e-01 | 8.63e-01 | -6.00e+00 | 2.03e-09 | 8.56e-09 | -1.31e-01 |
| MESO | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.90e-01 | 7.93e-01 | -4.56e+00 | 5.17e-06 | 3.80e-05 | -1.03e-01 |
| MESO | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.78e-01 | 7.92e-01 | -3.14e+00 | 1.72e-03 | 8.03e-03 | -1.14e-01 |
| MESO | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 6.00e-01 | 7.16e-01 | -2.12e+00 | 3.38e-02 | 4.58e-02 | -1.16e-01 |
| UVM | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 6.73e-01 | 7.84e-01 | -3.17e+00 | 1.54e-03 | 4.52e-03 | -1.11e-01 |
| UVM | cg06472116 | chrX:47078254 | CGI:chrX:47078232-47078570 | promoter | 7.83e-01 | 8.96e-01 | -5.43e+00 | 5.75e-08 | 3.20e-07 | -1.13e-01 |
| UVM | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 7.38e-01 | 8.66e-01 | -5.98e+00 | 2.24e-09 | 1.54e-08 | -1.28e-01 |
| UVM | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 7.81e-01 | 8.92e-01 | -5.68e+00 | 1.36e-08 | 8.13e-08 | -1.11e-01 |
| UVM | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 8.12e-01 | 9.37e-01 | -4.79e+00 | 1.70e-06 | 7.66e-06 | -1.25e-01 |
| UVM | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 8.26e-01 | 9.43e-01 | -5.35e+00 | 8.86e-08 | 4.83e-07 | -1.17e-01 |
| ACC | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 3.90e-01 | 1.47e-01 | 6.02e+00 | 1.70e-09 | 1.84e-08 | 2.43e-01 |
| ACC | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 2.07e-01 | 9.46e-02 | 3.63e+00 | 2.78e-04 | 1.73e-03 | 1.12e-01 |
| ACC | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 4.08e-01 | 1.98e-01 | 5.15e+00 | 2.60e-07 | 2.30e-06 | 2.10e-01 |
| ACC | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 5.49e-01 | 3.36e-01 | 5.05e+00 | 4.41e-07 | 3.82e-06 | 2.13e-01 |
| ACC | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 3.62e-01 | 2.32e-01 | 3.59e+00 | 3.25e-04 | 1.99e-03 | 1.30e-01 |
| KICH | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 4.01e-01 | 2.86e-01 | 3.60e+00 | 3.16e-04 | 2.00e-03 | 1.15e-01 |
| KICH | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 3.75e-01 | 2.64e-01 | 2.33e+00 | 1.98e-02 | 3.70e-02 | 1.10e-01 |
| KICH | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 3.39e-01 | 1.89e-01 | 3.66e+00 | 2.57e-04 | 1.66e-03 | 1.50e-01 |
| DLBC | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.09e-01 | 7.20e-01 | -3.58e+00 | 3.44e-04 | 1.39e-03 | -1.11e-01 |
| DLBC | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 5.76e-01 | 6.88e-01 | -2.63e+00 | 8.59e-03 | 2.04e-02 | -1.12e-01 |
| CHOL | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 3.89e-01 | 2.00e-01 | 2.74e+00 | 6.18e-03 | 1.53e-02 | 1.89e-01 |
| CHOL | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.41e-01 | 7.53e-01 | -3.44e+00 | 5.85e-04 | 2.45e-03 | -1.12e-01 |
| CHOL | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 5.32e-01 | 3.59e-01 | 2.83e+00 | 4.61e-03 | 1.23e-02 | 1.74e-01 |
| CHOL | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 5.27e-01 | 3.76e-01 | 2.13e+00 | 3.29e-02 | 4.20e-02 | 1.50e-01 |
| CHOL | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 5.09e-01 | 2.89e-01 | 3.25e+00 | 1.17e-03 | 4.25e-03 | 2.19e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 7.12e-01 | 8.28e-01 | -6.20e+00 | 5.70e-10 | 8.05e-09 | -1.16e-01 |
| KIRC | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 4.54e-01 | 2.72e-01 | 5.76e+00 | 8.25e-09 | 6.22e-08 | 1.82e-01 |
| LUAD | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 7.89e-01 | 6.86e-01 | 5.33e+00 | 1.00e-07 | 1.26e-06 | 1.03e-01 |
| HNSC | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 8.18e-01 | 6.95e-01 | 3.95e+00 | 7.83e-05 | 2.11e-04 | 1.23e-01 |
| LUSC | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 5.30e-01 | 1.98e-01 | 3.11e+00 | 1.88e-03 | 4.00e-03 | 3.32e-01 |
| LUSC | cg06472116 | chrX:47078254 | CGI:chrX:47078232-47078570 | promoter | 7.40e-01 | 5.80e-01 | 2.70e+00 | 6.96e-03 | 1.05e-02 | 1.60e-01 |
| LUSC | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 7.82e-01 | 6.74e-01 | 3.43e+00 | 5.95e-04 | 1.85e-03 | 1.08e-01 |
| LUSC | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 7.82e-01 | 6.77e-01 | 2.28e+00 | 2.26e-02 | 2.63e-02 | 1.05e-01 |
| LUSC | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 6.69e-01 | 4.43e-01 | 2.81e+00 | 4.92e-03 | 8.06e-03 | 2.26e-01 |
| LUSC | cg21049587 | chrX:47078749 | CGI:chrX:47078232-47078570 | promoter,gene body | 7.46e-01 | 5.97e-01 | 2.44e+00 | 1.47e-02 | 1.87e-02 | 1.49e-01 |
| LUSC | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 6.28e-01 | 4.40e-01 | 2.36e+00 | 1.83e-02 | 2.22e-02 | 1.88e-01 |
| COAD | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 5.02e-01 | 2.14e-01 | 2.43e+00 | 1.50e-02 | 1.98e-02 | 2.87e-01 |
| COAD | cg06472116 | chrX:47078254 | CGI:chrX:47078232-47078570 | promoter | 6.89e-01 | 5.74e-01 | 2.27e+00 | 2.29e-02 | 2.75e-02 | 1.15e-01 |
| COAD | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 7.20e-01 | 6.06e-01 | 2.18e+00 | 2.94e-02 | 3.33e-02 | 1.14e-01 |
| BLCA | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 4.95e-01 | 2.19e-01 | 2.79e+00 | 5.30e-03 | 8.53e-03 | 2.77e-01 |
| BLCA | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 6.91e-01 | 8.14e-01 | -3.96e+00 | 7.55e-05 | 3.28e-04 | -1.24e-01 |
| BLCA | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 8.06e-01 | 6.56e-01 | 2.94e+00 | 3.31e-03 | 5.85e-03 | 1.50e-01 |
| BLCA | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 6.35e-01 | 4.44e-01 | 2.39e+00 | 1.67e-02 | 2.12e-02 | 1.92e-01 |
| BLCA | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 6.23e-01 | 4.54e-01 | 2.39e+00 | 1.70e-02 | 2.15e-02 | 1.69e-01 |
| KIRP | cg06472116 | chrX:47078254 | CGI:chrX:47078232-47078570 | promoter | 4.50e-01 | 3.28e-01 | 3.24e+00 | 1.20e-03 | 2.12e-03 | 1.22e-01 |
| KIRP | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 3.12e-01 | 1.99e-01 | 2.83e+00 | 4.61e-03 | 6.66e-03 | 1.14e-01 |
| ESCA | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 3.73e-01 | 1.39e-01 | 2.34e+00 | 1.91e-02 | 4.01e-02 | 2.33e-01 |
| ESCA | cg06472116 | chrX:47078254 | CGI:chrX:47078232-47078570 | promoter | 6.44e-01 | 4.42e-01 | 2.60e+00 | 9.30e-03 | 3.58e-02 | 2.02e-01 |
| ESCA | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 7.03e-01 | 4.24e-01 | 2.81e+00 | 4.96e-03 | 3.43e-02 | 2.79e-01 |
| CHOL | cg22256180 | chrX:47076964 | CGI:chrX:47078232-47078570 | promoter | 7.52e-01 | 6.23e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 1.29e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 4.48e-01 | 2.26e-01 | 9.90e+00 | 4.16e-23 | 2.96e-22 | 2.22e-01 |
| BRCA | cg06472116 | chrX:47078254 | CGI:chrX:47078232-47078570 | promoter | 6.43e-01 | 5.23e-01 | 9.22e+00 | 2.91e-20 | 1.61e-19 | 1.19e-01 |
| BRCA | cg09625066 | chrX:47078172 | CGI:chrX:47078232-47078570 | promoter | 7.80e-01 | 6.67e-01 | 9.10e+00 | 8.84e-20 | 4.69e-19 | 1.14e-01 |
| BRCA | cg07654896 | chrX:47078430 | CGI:chrX:47078232-47078570 | UTR,promoter,exon,gene body | 6.15e-01 | 4.23e-01 | 1.12e+01 | 3.19e-29 | 4.24e-28 | 1.92e-01 |
| BRCA | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 6.69e-01 | 5.43e-01 | 8.48e+00 | 2.28e-17 | 9.96e-17 | 1.26e-01 |
| KIRC | cg03139204 | chrX:47078259 | CGI:chrX:47078232-47078570 | promoter | 2.52e-01 | 1.27e-01 | 2.43e+00 | 1.53e-02 | 2.26e-02 | 1.25e-01 |
| HNSC | cg19639792 | chrX:47077105 | CGI:chrX:47078232-47078570 | promoter | 6.48e-01 | 7.53e-01 | -2.54e+00 | 1.09e-02 | 1.95e-02 | -1.05e-01 |
| LIHC | cg00926894 | chrX:47078830 | CGI:chrX:47078232-47078570 | promoter,gene body | 3.26e-01 | 4.35e-01 | -3.11e+00 | 1.86e-03 | 3.68e-03 | -1.09e-01 |
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Exon skipping events with PSI in TCGA for RGN |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| KIRC | exon_skip_509931 | 6.20e-01 | 5.03e-01 | 2.03e+00 | 4.25e-02 | 4.54e-02 | 1.17e-01 |
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RNA A-to-I editing events in TCGA for RGN |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LIHC | RGN-003 | chrX_47085756_+ | 3.28e-01 | 2.13e-01 | 1.97e+00 | 4.91e-02 | 4.97e-02 | 1.14e-01 |
| LIHC | RGN-003 | chrX_47088669_+ | 2.06e-01 | 1.56e-01 | 1.97e+00 | 4.85e-02 | 4.94e-02 | 4.96e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RGN |
| TFs related to RGN. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | FOXP3 | RGN | 3.57e+00 | 1.01e-02 | 4.50e+00 | 9.84e-01 | Female-biased |
| CHOL | MSX1 | RGN | 3.02e+00 | 6.37e-03 | 4.06e+00 | 9.82e-01 | Female-biased |
| CHOL | SOX10 | RGN | 3.05e+00 | 6.02e-03 | 4.10e+00 | 9.83e-01 | Female-biased |
| CHOL | ZKSCAN2 | RGN | 3.21e+00 | 6.28e-03 | 4.26e+00 | 9.85e-01 | Female-biased |
| CHOL | ZNF79 | RGN | 2.65e+00 | 1.26e-03 | 4.08e+00 | 9.88e-01 | Female-biased |
| DLBC | ZNF22 | RGN | 4.63e+00 | 9.82e-01 | 3.81e+00 | 1.19e-02 | Male-biased |
| DLBC | ZNF225 | RGN | 4.64e+00 | 9.81e-01 | 3.86e+00 | 1.35e-02 | Male-biased |
| DLBC | ZNF235 | RGN | 5.11e+00 | 9.86e-01 | 4.27e+00 | 1.09e-02 | Male-biased |
| DLBC | ZNF487 | RGN | 4.79e+00 | 9.83e-01 | 3.99e+00 | 1.25e-02 | Male-biased |
| DLBC | ZNF879 | RGN | 4.67e+00 | 9.90e-01 | 3.59e+00 | 4.40e-03 | Male-biased |
| UVM | PATZ1 | RGN | 2.86e+00 | 4.15e-03 | 4.58e+00 | 9.83e-01 | Female-biased |
| UVM | ZNF28 | RGN | 2.93e+00 | 4.62e-03 | 4.61e+00 | 9.83e-01 | Female-biased |
| UVM | ZNF454 | RGN | 2.52e+00 | 2.60e-03 | 4.45e+00 | 9.82e-01 | Female-biased |
| UVM | ZNF530 | RGN | 2.81e+00 | 4.55e-03 | 4.48e+00 | 9.80e-01 | Female-biased |
| UVM | ZNF816 | RGN | 3.06e+00 | 4.81e-03 | 4.72e+00 | 9.84e-01 | Female-biased |
| RGN related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RGN |
| RBPs related to ES in RGN. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KIRC | PTBP1 | exon_skip_509935 | 8.72e+00 | 9.83e-01 | 8.42e+00 | 1.21e-02 | Male-biased |
| RGN related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000130988 | AL359915.1,hsa-mir-485,RGN | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000130988 | ZFAND2A-DT,hsa-mir-485,RGN | Male-specific ceRNA | TCGA-LUAD |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000130988 |
| CpG Site: cg06472116 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.446291495149245 | |
 | Gene ID: ENSG00000130988 |
| CpG Site: cg09625066 | |
| Position to Gene: promoter | |
| Male Effect: -0.154534535825582 | |
| Female Effect: - | |
 | Gene ID: ENSG00000130988 |
| CpG Site: cg07654896 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.0979143154124313 | |
| Female Effect: - | |
 | Gene ID: ENSG00000130988 |
| CpG Site: cg06472116 | |
| Position to Gene: promoter | |
| Male Effect: -0.446028208462526 | |
| Female Effect: - | |
 | Gene ID: ENSG00000130988 |
| CpG Site: cg00926894 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.0812182561870627 | |
| Female Effect: - | |
 | Gene ID: ENSG00000130988 |
| CpG Site: cg21049587 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.136751761179452 | |
| Female Effect: - | |
 | Gene ID: ENSG00000130988 |
| CpG Site: cg00926894 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.123167427647277 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09625066 | chrX:47078172 | promoter | -0.154534535825582 | 2.79011858867475e-05 | -0.41936187474217906 | 3.062055499424454e-07 | THCA |
| cg07654896 | chrX:47078430 | gene,exon,promoter,UTR | -0.0979143154124313 | 7.80286064826014e-05 | -0.40773686802068143 | 6.916419228789987e-07 | THCA |
| cg06472116 | chrX:47078254 | promoter | -0.446028208462526 | 5.96059390642232e-09 | -0.4304754577531249 | 1.7858091319952123e-11 | LUAD |
| cg00926894 | chrX:47078830 | gene,promoter | -0.0812182561870627 | 1.64934393390053e-06 | -0.3802482386779582 | 4.4022181653642375e-09 | LUAD |
| cg21049587 | chrX:47078749 | gene,promoter | -0.136751761179452 | 2.07125338844469e-06 | -0.37907679659682714 | 5.808496271840513e-09 | LUAD |
| cg00926894 | chrX:47078830 | gene,promoter | -0.123167427647277 | 4.20392090746932e-06 | -0.3309742218830501 | 8.142508891823772e-09 | LGG |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06472116 | chrX:47078254 | promoter | -0.446291495149245 | 3.23916862912776e-12 | -0.7520289072768819 | 8.993726509185719e-16 | PAAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RGN |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000130988 | RGN | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| ENSG00000130988 | RGN | C0019207 | Hepatoma, Morris | 1 | CTD_human |
| ENSG00000130988 | RGN | C0019208 | Hepatoma, Novikoff | 1 | CTD_human |
| ENSG00000130988 | RGN | C0022658 | Kidney Diseases | 1 | CTD_human |
| ENSG00000130988 | RGN | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| ENSG00000130988 | RGN | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| ENSG00000130988 | RGN | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| ENSG00000130988 | RGN | C0086404 | Experimental Hepatoma | 1 | CTD_human |
| ENSG00000130988 | RGN | C0239946 | Fibrosis, Liver | 1 | CTD_human |
| ENSG00000130988 | RGN | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| ENSG00000130988 | RGN | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| ENSG00000130988 | RGN | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| ENSG00000130988 | RGN | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| ENSG00000130988 | RGN | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
