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Gene: ENSG00000129518 |
Summary for EAPP |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000129518 | Gene symbol | EAPP |
| Gene name | E2F associated phosphoprotein | |
| HGNC | 19312 | |
| Entrez ID | 55837 | |
| Gene type | protein_coding | |
| Synonyms | EAPP|BM036|FLJ20578 | |
| UniProtAcc | Q56P03 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for EAPP |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| EAPP | 1.35e+03 | -1.02e+00 | 2.25e-01 | -4.55e+00 | 5.46e-06 | 3.85e-05 | READ |
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Sex-biased somatic mutation for EAPP |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for EAPP |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg19590858 | chr14:34540646 | CGI:chr14:34539320-34539774 | promoter | 6.76e-01 | 8.88e-01 | -5.31e+00 | 1.12e-07 | 1.06e-06 | -2.12e-01 |
| LUSC | cg24276491 | chr14:34540286 | CGI:chr14:34539320-34539774 | promoter | 5.17e-01 | 6.82e-01 | -3.87e+00 | 1.08e-04 | 7.20e-04 | -1.65e-01 |
| LUSC | cg19590858 | chr14:34540646 | CGI:chr14:34539320-34539774 | promoter | 6.61e-01 | 8.52e-01 | -3.50e+00 | 4.66e-04 | 1.59e-03 | -1.91e-01 |
| COAD | cg24276491 | chr14:34540286 | CGI:chr14:34539320-34539774 | promoter | 5.10e-01 | 6.39e-01 | -2.82e+00 | 4.83e-03 | 8.03e-03 | -1.29e-01 |
| ESCA | cg24276491 | chr14:34540286 | CGI:chr14:34539320-34539774 | promoter | 5.25e-01 | 6.36e-01 | -2.22e+00 | 2.62e-02 | 4.25e-02 | -1.11e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for EAPP |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for EAPP |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for EAPP |
| TFs related to EAPP. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PAAD | PRDM6 | EAPP | 2.80e+00 | 1.25e-03 | 4.00e+00 | 9.85e-01 | Female-biased |
| PAAD | ZNF182 | EAPP | 2.98e+00 | 4.38e-03 | 3.94e+00 | 9.81e-01 | Female-biased |
| PAAD | ZNF22 | EAPP | 2.96e+00 | 1.92e-03 | 4.07e+00 | 9.86e-01 | Female-biased |
| PAAD | ZNF235 | EAPP | 3.11e+00 | 7.29e-04 | 4.42e+00 | 9.93e-01 | Female-biased |
| PAAD | ZNF287 | EAPP | 3.04e+00 | 1.43e-03 | 4.21e+00 | 9.89e-01 | Female-biased |
| PAAD | ZNF487 | EAPP | 2.98e+00 | 2.87e-03 | 4.03e+00 | 9.84e-01 | Female-biased |
| SKCM | ZNF418 | EAPP | 4.32e+00 | 1.08e-02 | 5.28e+00 | 9.85e-01 | Female-biased |
| EAPP related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for EAPP |
| RBPs related to ES in EAPP. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | G3BP2 | exon_skip_112541 | 6.81e+00 | 2.61e-03 | 7.23e+00 | 9.85e-01 | Female-biased |
| UVM | LIN28A | exon_skip_112542 | 7.69e+00 | 5.36e-03 | 8.04e+00 | 9.86e-01 | Female-biased |
| THYM | G3BP2 | exon_skip_112541 | 6.91e+00 | 5.23e-03 | 7.28e+00 | 9.83e-01 | Female-biased |
| MESO | hnRNPK | exon_skip_112532 | 8.76e+00 | 9.64e-03 | 9.11e+00 | 9.86e-01 | Female-biased |
| MESO | LIN28A | exon_skip_112542 | 7.87e+00 | 9.74e-03 | 8.22e+00 | 9.82e-01 | Female-biased |
| GBM | hnRNPK | exon_skip_112532 | 8.80e+00 | 1.51e-02 | 9.10e+00 | 9.81e-01 | Female-biased |
| EAPP related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2754079 | chr14:25416934:G:A | - | -0.116263911181202 | 0.0282453760282772 | PAAD | Female-baised eQTL |
| rs7141213 | chr14:25409430:C:T | - | -0.116069857986717 | 0.0289062257307703 | PAAD | Female-baised eQTL |
| rs7140186 | chr14:34125301:C:T | - | 0.0920151430960609 | 0.0232581587512226 | SARC | Female-baised eQTL |
| rs1952625 | chr14:34232119:C:A | - | -0.0594358185899356 | 0.00684131124150017 | LUAD | Female-baised eQTL |
| rs6571639 | chr14:34235419:T:C | - | -0.0769799500694108 | 0.0127237647523373 | LUAD | Female-baised eQTL |
| rs150960452 | chr14:32856222:A:G | - | 0.0469801993365682 | 0.0381174932256982 | COAD | Female-baised eQTL |
| rs1959583 | chr14:43655651:T:C | - | 0.0440626594384625 | 0.0468424612666748 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1953439 | chr14:33003217:G:T | - | 0.0618739207039672 | 0.00643034333282189 | HNSC | Male-baised eQTL |
| rs2415415 | chr14:37848050:T:G | - | -0.0590457933539059 | 0.0308549946529727 | HNSC | Male-baised eQTL |
| rs12882430 | chr14:37842650:A:G | - | -0.057695070611916 | 0.0313782045436684 | HNSC | Male-baised eQTL |
| rs4901319 | chr14:37849242:T:C | - | -0.0588710649517694 | 0.0323288855071518 | HNSC | Male-baised eQTL |
| rs1952792 | chr14:37855635:G:C | - | -0.0557499047137031 | 0.0414608941887147 | HNSC | Male-baised eQTL |
| rs1952800 | chr14:37850306:T:G | - | -0.0562747003370312 | 0.0417149194069432 | HNSC | Male-baised eQTL |
| rs2183529 | chr14:37828305:T:C | - | -0.0561460099578817 | 0.0431799724847731 | HNSC | Male-baised eQTL |
| rs1952781 | chr14:37839803:C:G | - | -0.0561460099578817 | 0.0431799724847731 | HNSC | Male-baised eQTL |
| rs1952780 | chr14:37839942:A:G | - | -0.0561460099578817 | 0.0431799724847731 | HNSC | Male-baised eQTL |
| rs10438230 | chr14:27541584:A:T | - | 0.0907529489583057 | 0.00791040169667785 | COAD | Male-baised eQTL |
| rs11844978 | chr14:27542957:A:G | - | 0.0889594583453774 | 0.00805958118576971 | COAD | Male-baised eQTL |
| rs61396435 | chr14:27548646:A:G | - | 0.0892864313920551 | 0.00827923887471726 | COAD | Male-baised eQTL |
| rs2211667 | chr14:27544025:A:G | - | 0.087311030989074 | 0.0111699535030028 | COAD | Male-baised eQTL |
| rs78248703 | chr14:27712000:A:G | - | 0.130596002398613 | 0.0115218329460551 | COAD | Male-baised eQTL |
| rs78801279 | chr14:27716086:C:T | - | 0.130596002398613 | 0.0115218329460551 | COAD | Male-baised eQTL |
| rs117072214 | chr14:27716242:G:A | - | 0.130596002398613 | 0.0115218329460551 | COAD | Male-baised eQTL |
| rs79378827 | chr14:27716549:G:T | - | 0.130596002398613 | 0.0115218329460551 | COAD | Male-baised eQTL |
| rs1959977 | chr14:27719969:T:C | - | 0.129384029100115 | 0.0153744631781229 | COAD | Male-baised eQTL |
| rs17113050 | chr14:27695802:C:T | - | 0.126276448939838 | 0.0201058621022042 | COAD | Male-baised eQTL |
| rs74243058 | chr14:27697203:T:C | - | 0.126276448939838 | 0.0201058621022042 | COAD | Male-baised eQTL |
| rs17113059 | chr14:27700019:A:C | - | 0.126201606739452 | 0.0202890926413676 | COAD | Male-baised eQTL |
| rs56767111 | chr14:27702718:T:A | - | 0.126201606739452 | 0.0202890926413676 | COAD | Male-baised eQTL |
| rs34670324 | chr14:27704604:G:A | - | 0.126201606739452 | 0.0202890926413676 | COAD | Male-baised eQTL |
| rs76898531 | chr14:27709909:A:G | - | 0.126201606739452 | 0.0202890926413676 | COAD | Male-baised eQTL |
| rs2281563 | chr14:31026140:C:T | - | 0.107192977431787 | 0.0216729065435538 | COAD | Male-baised eQTL |
| rs17113026 | chr14:27688898:A:G | - | 0.124911636247987 | 0.0224924503960896 | COAD | Male-baised eQTL |
| rs1954530 | chr14:27690530:G:A | - | 0.124911636247987 | 0.0224924503960896 | COAD | Male-baised eQTL |
| rs17113035 | chr14:27693275:G:T | - | 0.124911636247987 | 0.0224924503960896 | COAD | Male-baised eQTL |
| rs10483356 | chr14:30931476:G:A | - | 0.107375535954122 | 0.0230852221071758 | COAD | Male-baised eQTL |
| rs17113087 | chr14:27726739:G:A | - | 0.114191133212967 | 0.0234965980986223 | COAD | Male-baised eQTL |
| rs79756425 | chr14:27732536:T:A | - | 0.114191133212967 | 0.0234965980986223 | COAD | Male-baised eQTL |
| rs79500334 | chr14:27738081:G:A | - | 0.114191133212967 | 0.0234965980986223 | COAD | Male-baised eQTL |
| rs79966497 | chr14:27740310:G:A | - | 0.114191133212967 | 0.0234965980986223 | COAD | Male-baised eQTL |
| rs17097531 | chr14:30919517:A:G | - | 0.104137615119808 | 0.0235985057472655 | COAD | Male-baised eQTL |
| rs75992006 | chr14:27721497:A:G | - | 0.122549149561765 | 0.0238921487500169 | COAD | Male-baised eQTL |
| rs79428949 | chr14:30924055:A:G | - | 0.104713689078704 | 0.0247108360477882 | COAD | Male-baised eQTL |
| rs8008526 | chr14:31031331:T:A | - | 0.104651485068387 | 0.0277338242515182 | COAD | Male-baised eQTL |
| rs3784158 | chr14:31033430:C:T | - | 0.104481632817621 | 0.0286201404232616 | COAD | Male-baised eQTL |
| rs2064823 | chr14:31034687:G:A | - | 0.100527395224649 | 0.0377334324672507 | COAD | Male-baised eQTL |
| rs10483359 | chr14:30897128:G:C | - | 0.102960465023383 | 0.0418618693449861 | COAD | Male-baised eQTL |
| rs72670320 | chr14:31037953:A:T | - | 0.0942930401601915 | 0.0431660950773501 | COAD | Male-baised eQTL |
| rs55835243 | chr14:43808647:C:A | - | 0.0749053621984016 | 0.0445503539440814 | COAD | Male-baised eQTL |
| rs28421579 | chr14:43819532:T:C | - | 0.0766408930740508 | 0.048157478250201 | COAD | Male-baised eQTL |
| rs17113090 | chr14:27730260:G:A | - | 0.0998832600659533 | 0.0488855743421458 | COAD | Male-baised eQTL |
| rs17113118 | chr14:27754378:A:T | - | 0.0978957600770414 | 0.0497459383328688 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000129518 |
| CpG Site: cg24276491 | |
| Position to Gene: promoter | |
| Male Effect: -0.449044819497377 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg24276491 | chr14:34540286 | promoter | -0.449044819497377 | 1.09455921102523e-22 | -0.6361296737469785 | 1.0823035266152465e-26 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of EAPP |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
