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Gene: ENSG00000129473 |
Summary for BCL2L2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000129473 | Gene symbol | BCL2L2 |
| Gene name | BCL2 like 2 | |
| HGNC | 995 | |
| Entrez ID | 599 | |
| Gene type | protein_coding | |
| Synonyms | BCL2L2|KIAA0271|BCL-W|PPP1R51 | |
| UniProtAcc | Q92843 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000129473 | BCL2L2 | DB12340 | Navitoclax | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for BCL2L2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| BCL2L2 | 2.35e+03 | -1.00e+00 | 1.25e-01 | -8.05e+00 | 8.09e-16 | 3.50e-14 | STAD |
| BCL2L2 | 1.97e+03 | -1.02e+00 | 1.42e-01 | -7.18e+00 | 6.90e-13 | 6.10e-12 | KIRP |
| BCL2L2 | 1.35e+03 | -1.02e+00 | 1.05e-01 | -9.69e+00 | 3.30e-22 | 8.96e-21 | COAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| BCL2L2 | 6.29e+03 | 1.23e+00 | 1.37e-01 | 8.96e+00 | 3.38e-19 | 6.94e-18 | KICH |
| BCL2L2 | 1.44e+03 | -1.19e+00 | 2.22e-01 | -5.36e+00 | 8.18e-08 | 9.70e-07 | READ |
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Sex-biased somatic mutation for BCL2L2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for BCL2L2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg08239753 | chr14:23300481 | CGI:chr14:23301303-23302693 | promoter,gene body | 1.49e-01 | 2.70e-01 | -2.97e+00 | 2.96e-03 | 5.54e-03 | -1.22e-01 |
| CHOL | cg08239753 | chr14:23300481 | CGI:chr14:23301303-23302693 | promoter,gene body | 3.75e-01 | 7.20e-01 | -2.36e+00 | 1.83e-02 | 2.92e-02 | -3.45e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for BCL2L2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for BCL2L2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for BCL2L2 |
| TFs related to BCL2L2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BCL2L2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for BCL2L2 |
| RBPs related to ES in BCL2L2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BCL2L2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000129473 | AC025171.1,hsa-mir-149,BCL2L2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000129473 | AC253536.3,hsa-mir-149,BCL2L2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000129473 | LINC00963,hsa-mir-149,BCL2L2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000129473 | AL158825.2,hsa-mir-372,BCL2L2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000129473 | AC025171.1,hsa-mir-760,BCL2L2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000129473 | LINC00963,hsa-mir-760,BCL2L2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000129473 | AC016705.2,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AC010273.3,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | CHRM3-AS1,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AC106793.1,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AP000688.2,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AC095032.1,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AC090241.2,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | HAGLR,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AP002761.4,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AP003119.3,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | DHRS4-AS1,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | ZNF674-AS1,hsa-mir-211,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AP000688.2,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | LINC01798,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AL445309.1,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | MIR100HG,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | TEX41,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AL162377.1,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | TBX2-AS1,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000129473 | AC005358.1,hsa-mir-122,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | AC226101.1,hsa-mir-122,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | AC105383.1,hsa-mir-122,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | LINC01018,hsa-mir-122,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | AC018413.1,hsa-mir-373,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | AL731537.1,hsa-mir-373,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | AGAP11,hsa-mir-373,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | AC073349.1,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | AC012558.1,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | SMC2-AS1,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
| ENSG00000129473 | SLC25A21-AS1,hsa-mir-497,BCL2L2 | Male-specific ceRNA | TCGA-STAD |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs8014233 | chr14:20838604:A:G | - | -0.0761480043136509 | 0.00229584824075442 | LUAD | Female-baised eQTL |
| rs1713421 | chr14:20474292:T:G | - | 0.0321930942414387 | 0.0197992805443219 | LUAD | Female-baised eQTL |
| rs12883276 | chr14:31378705:A:G | - | -0.0838261364501292 | 0.042940883511314 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7153691 | chr14:22270222:G:T | - | 0.0686411482702429 | 0.0346580404359726 | KIRC | Male-baised eQTL |
| rs2281680 | chr14:23563861:C:T | - | 0.0732861426017944 | 0.00753119167501953 | BLCA | Male-baised eQTL |
| rs17438210 | chr14:30791480:A:G | - | 0.0500549098251283 | 0.0372120309044479 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000129473 |
| CpG Site: cg23620184 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.223346321292236 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23620184 | chr14:23303407 | gene,enhancer | -0.223346321292236 | 1.75975619365623e-11 | -0.45542600033377273 | 1.8395000728420838e-14 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of BCL2L2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
