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Gene: ENSG00000128602 |
Summary for SMO |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000128602 | Gene symbol | SMO |
| Gene name | smoothened, frizzled class receptor | |
| HGNC | 11119 | |
| Entrez ID | 6608 | |
| Gene type | protein_coding | |
| Synonyms | SMO|FZD11 | |
| UniProtAcc | Q99835 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SMO |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMO | 6.33e+02 | 1.11e+00 | 2.58e-01 | 4.30e+00 | 1.73e-05 | 5.07e-05 | LUAD |
| SMO | 1.37e+03 | -1.33e+00 | 4.91e-01 | -2.71e+00 | 6.69e-03 | 1.76e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SMO |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SMO |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg21913630 | chr7:129188758 | CGI:chr7:129188393-129189525 | promoter | 1.24e-01 | 2.11e-02 | 2.85e+00 | 4.43e-03 | 6.76e-03 | 1.03e-01 |
| LUAD | cg18420512 | chr7:129189141 | CGI:chr7:129188393-129189525 | UTR,promoter,exon,gene body | 1.47e-01 | 1.80e-02 | 2.37e+00 | 1.76e-02 | 2.13e-02 | 1.29e-01 |
| LUAD | cg10586510 | chr7:129189524 | CGI:chr7:129188393-129189525 | promoter,gene body | 2.55e-01 | 1.52e-01 | 2.87e+00 | 4.04e-03 | 6.28e-03 | 1.03e-01 |
| THCA | cg20025238 | chr7:129189948 | CGI:chr7:129188393-129189525 | promoter,gene body | 5.58e-01 | 4.33e-01 | 3.64e+00 | 2.68e-04 | 1.20e-03 | 1.25e-01 |
| COAD | cg00405843 | chr7:129188734 | CGI:chr7:129188393-129189525 | promoter | 1.91e-01 | 1.37e-02 | 2.96e+00 | 3.05e-03 | 5.54e-03 | 1.78e-01 |
| CHOL | cg01475577 | chr7:129189774 | CGI:chr7:129188393-129189525 | promoter,gene body | 2.69e-01 | 1.60e-01 | 2.06e+00 | 3.90e-02 | 4.26e-02 | 1.09e-01 |
| CHOL | cg20025238 | chr7:129189948 | CGI:chr7:129188393-129189525 | promoter,gene body | 5.14e-01 | 3.32e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 1.81e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg04478795 | chr7:129188279 | CGI:chr7:129188393-129189525 | promoter | 3.04e-01 | 1.34e-01 | 1.05e+01 | 8.68e-26 | 7.96e-25 | 1.70e-01 |
| BRCA | cg01475577 | chr7:129189774 | CGI:chr7:129188393-129189525 | promoter,gene body | 3.42e-01 | 2.09e-01 | 8.92e+00 | 4.56e-19 | 2.28e-18 | 1.33e-01 |
| BRCA | cg20025238 | chr7:129189948 | CGI:chr7:129188393-129189525 | promoter,gene body | 5.84e-01 | 4.08e-01 | 1.08e+01 | 3.66e-27 | 3.85e-26 | 1.76e-01 |
| LUAD | cg13567541 | chr7:129188462 | CGI:chr7:129188393-129189525 | promoter | 1.69e-01 | 4.10e-02 | 2.64e+00 | 8.25e-03 | 1.37e-02 | 1.28e-01 |
Top |
Exon skipping events with PSI in TCGA for SMO |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SMO |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SMO |
| TFs related to SMO. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | PLAGL2 | SMO | 4.07e+00 | 9.83e-01 | 3.19e+00 | 6.86e-03 | Male-biased |
| SMO related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SMO |
| RBPs related to ES in SMO. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | SNRNP70 | exon_skip_471141 | 9.84e+00 | 1.82e-03 | 1.03e+01 | 9.97e-01 | Female-biased |
| SMO related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2692449 | chr7:129972246:T:C | - | -0.173982802657556 | 0.0161681831076742 | STAD | Female-baised eQTL |
| rs728600 | chr7:126638754:A:G | - | 0.055043816004807 | 0.0386606347058353 | LGG | Female-baised eQTL |
| rs2106311 | chr7:126589336:G:A | - | 0.0519333655755858 | 0.0437318727162453 | LGG | Female-baised eQTL |
| rs10261636 | chr7:121478507:A:T | - | -0.160733864847134 | 0.00119663895498435 | BLCA | Female-baised eQTL |
| rs1534528 | chr7:121481968:C:G | - | -0.12790188511442 | 0.00946940505238081 | BLCA | Female-baised eQTL |
| rs17810687 | chr7:130997028:C:A | - | 0.135152437788399 | 0.0141750639671931 | BLCA | Female-baised eQTL |
| rs78749406 | chr7:133031572:T:C | - | 0.0951646111180984 | 0.0211112090692105 | LUAD | Female-baised eQTL |
| rs112302911 | chr7:138255505:C:T | - | 0.0913886264803106 | 0.0265254678694086 | LUAD | Female-baised eQTL |
| rs151147487 | chr7:138255526:T:A | - | 0.0913886264803106 | 0.0265254678694086 | LUAD | Female-baised eQTL |
| rs113899449 | chr7:138255905:G:A | - | 0.0913886264803106 | 0.0265254678694086 | LUAD | Female-baised eQTL |
| rs141797397 | chr7:138256091:T:A | - | 0.0913886264803106 | 0.0265254678694086 | LUAD | Female-baised eQTL |
| rs13244086 | chr7:123130031:T:C | - | 0.0511076489371559 | 0.0299436979556302 | LUAD | Female-baised eQTL |
| rs12671490 | chr7:123134931:G:A | - | 0.0511497072567804 | 0.0309057585473547 | LUAD | Female-baised eQTL |
| rs10500090 | chr7:123105814:T:C | - | 0.0518850907360333 | 0.0309224599522213 | LUAD | Female-baised eQTL |
| rs13247367 | chr7:123130462:T:G | - | 0.0510945224682837 | 0.0311479127373656 | LUAD | Female-baised eQTL |
| rs12706492 | chr7:123131485:C:G | - | 0.0509184622769217 | 0.032760712239784 | LUAD | Female-baised eQTL |
| rs12706493 | chr7:123131486:T:A | - | 0.0509184622769217 | 0.032760712239784 | LUAD | Female-baised eQTL |
| rs12706490 | chr7:123130813:G:T | - | 0.0507317128540236 | 0.0340906274182538 | LUAD | Female-baised eQTL |
| rs28455752 | chr7:138256117:T:A | - | 0.0871126637637972 | 0.0390406133117596 | LUAD | Female-baised eQTL |
| rs115979408 | chr7:138255600:T:C | - | 0.0871374752233326 | 0.0391231795658097 | LUAD | Female-baised eQTL |
| rs13243580 | chr7:123129562:T:C | - | 0.0494852820559912 | 0.0423284483731343 | LUAD | Female-baised eQTL |
| rs13229376 | chr7:123129574:G:A | - | 0.0494852820559912 | 0.0423284483731343 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7797352 | chr7:136060579:G:A | - | 0.125841465531971 | 0.0448225384108106 | STAD | Male-baised eQTL |
| rs9986883 | chr7:136061298:A:G | - | 0.125841465531971 | 0.0448225384108106 | STAD | Male-baised eQTL |
| rs10243714 | chr7:136065009:C:T | - | 0.125841465531971 | 0.0448225384108106 | STAD | Male-baised eQTL |
| rs7786448 | chr7:136065617:A:G | - | 0.125841465531971 | 0.0448225384108106 | STAD | Male-baised eQTL |
| rs6467629 | chr7:136062725:C:T | - | 0.125504174128355 | 0.0465051965610211 | STAD | Male-baised eQTL |
| rs274008 | chr7:137962425:T:C | - | 0.0367242777872667 | 0.0310406698519825 | KIRC | Male-baised eQTL |
| rs274012 | chr7:137965298:C:A | - | 0.0344161466736716 | 0.0363218524943496 | KIRC | Male-baised eQTL |
| rs274009 | chr7:137962516:T:C | - | 0.0355004090817839 | 0.0431689369475036 | KIRC | Male-baised eQTL |
| rs274010 | chr7:137962586:T:C | - | 0.0348082671720567 | 0.0434491903233712 | KIRC | Male-baised eQTL |
| rs73157228 | chr7:132256103:C:T | - | 0.0764213715268176 | 0.00829565262889125 | BLCA | Male-baised eQTL |
| rs9692533 | chr7:132770487:T:G | - | 0.0599767928892936 | 0.0154746970918578 | BLCA | Male-baised eQTL |
| rs55927884 | chr7:132318459:T:C | - | 0.0622518581501503 | 0.0426363004534441 | BLCA | Male-baised eQTL |
| rs73155281 | chr7:132204255:G:A | - | 0.0695670217973323 | 0.0464747028536451 | BLCA | Male-baised eQTL |
| rs113152540 | chr7:132252502:G:C | - | 0.0789454671674545 | 0.00401936404913124 | LUAD | Male-baised eQTL |
| rs12706390 | chr7:122230608:G:A | - | 0.0596440487150935 | 0.00415862104434424 | LUAD | Male-baised eQTL |
| rs284381 | chr7:122261769:G:A | - | 0.0599466677025977 | 0.00494464007361858 | LUAD | Male-baised eQTL |
| rs12706399 | chr7:122264105:T:A | - | 0.0599466677025977 | 0.00494464007361858 | LUAD | Male-baised eQTL |
| rs1344405 | chr7:122220389:G:A | - | 0.0572100067095354 | 0.00547139991499757 | LUAD | Male-baised eQTL |
| rs284363 | chr7:122222408:T:C | - | 0.0572100067095354 | 0.00547139991499757 | LUAD | Male-baised eQTL |
| rs284362 | chr7:122223058:C:T | - | 0.0572100067095354 | 0.00547139991499757 | LUAD | Male-baised eQTL |
| rs284360 | chr7:122223791:A:C | - | 0.0572100067095354 | 0.00547139991499757 | LUAD | Male-baised eQTL |
| rs284357 | chr7:122224646:G:A | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs284356 | chr7:122224861:G:T | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs284355 | chr7:122225950:T:A | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs284354 | chr7:122226358:A:G | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs284353 | chr7:122226894:A:T | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs11979786 | chr7:122227232:C:T | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs673757 | chr7:122227815:A:G | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs569663 | chr7:122229234:C:T | - | 0.0575316314151227 | 0.00557059663959262 | LUAD | Male-baised eQTL |
| rs148236078 | chr7:121723875:T:C | - | 0.0761444653741858 | 0.00575315343923026 | LUAD | Male-baised eQTL |
| rs570683 | chr7:122229368:T:C | - | 0.0573729769520181 | 0.0057994386355606 | LUAD | Male-baised eQTL |
| rs628339 | chr7:122229676:A:G | - | 0.0573729769520181 | 0.0057994386355606 | LUAD | Male-baised eQTL |
| rs627845 | chr7:122229825:G:A | - | 0.0573729769520181 | 0.0057994386355606 | LUAD | Male-baised eQTL |
| rs2651770 | chr7:122231793:C:T | - | 0.0573729769520181 | 0.0057994386355606 | LUAD | Male-baised eQTL |
| rs13307049 | chr7:122232086:C:T | - | 0.0573729769520181 | 0.0057994386355606 | LUAD | Male-baised eQTL |
| rs13307189 | chr7:122232162:G:T | - | 0.0573729769520181 | 0.0057994386355606 | LUAD | Male-baised eQTL |
| rs13224781 | chr7:122232616:G:A | - | 0.0573729769520181 | 0.0057994386355606 | LUAD | Male-baised eQTL |
| rs61008540 | chr7:121725359:G:A | - | 0.0758050029738618 | 0.00627223467253326 | LUAD | Male-baised eQTL |
| rs80021466 | chr7:121729095:C:T | - | 0.0761170838403987 | 0.00761196466789034 | LUAD | Male-baised eQTL |
| rs284394 | chr7:122245395:G:A | - | 0.0578159998859638 | 0.00814454943614766 | LUAD | Male-baised eQTL |
| rs284393 | chr7:122245990:C:T | - | 0.0578159998859638 | 0.00814454943614766 | LUAD | Male-baised eQTL |
| rs1697517 | chr7:122248182:T:C | - | 0.0578159998859638 | 0.00814454943614766 | LUAD | Male-baised eQTL |
| rs1663006 | chr7:122248218:T:C | - | 0.0578159998859638 | 0.00814454943614766 | LUAD | Male-baised eQTL |
| rs284361 | chr7:122223517:C:T | - | 0.0564629728975479 | 0.00842517101875103 | LUAD | Male-baised eQTL |
| rs1392983 | chr7:122221497:T:C | - | 0.0600110445017873 | 0.00916165814144844 | LUAD | Male-baised eQTL |
| rs12333435 | chr7:121849609:C:T | - | 0.0671997642889263 | 0.0099266259610386 | LUAD | Male-baised eQTL |
| rs57075189 | chr7:121855566:T:C | - | 0.0671997642889263 | 0.0099266259610386 | LUAD | Male-baised eQTL |
| rs10239025 | chr7:121856989:C:T | - | 0.0671997642889263 | 0.0099266259610386 | LUAD | Male-baised eQTL |
| rs675076 | chr7:122234138:A:G | - | 0.0561724340082344 | 0.0113859433326879 | LUAD | Male-baised eQTL |
| rs675027 | chr7:122234165:T:A | - | 0.0561724340082344 | 0.0113859433326879 | LUAD | Male-baised eQTL |
| rs505005 | chr7:122234775:C:T | - | 0.0561724340082344 | 0.0113859433326879 | LUAD | Male-baised eQTL |
| rs1663008 | chr7:122235377:A:G | - | 0.0561724340082344 | 0.0113859433326879 | LUAD | Male-baised eQTL |
| rs76442334 | chr7:121672098:T:G | - | 0.0761763046389415 | 0.0134053863201657 | LUAD | Male-baised eQTL |
| rs78347513 | chr7:121666027:T:C | - | 0.0761353823857717 | 0.0135668292383146 | LUAD | Male-baised eQTL |
| rs78044133 | chr7:121670334:C:T | - | 0.0761353823857717 | 0.0135668292383146 | LUAD | Male-baised eQTL |
| rs11977364 | chr7:121671522:A:G | - | 0.0761353823857717 | 0.0135668292383146 | LUAD | Male-baised eQTL |
| rs112407042 | chr7:121672321:T:C | - | 0.0761353823857717 | 0.0135668292383146 | LUAD | Male-baised eQTL |
| rs79532183 | chr7:121672877:A:G | - | 0.0761353823857717 | 0.0135668292383146 | LUAD | Male-baised eQTL |
| rs4568566 | chr7:135342063:G:T | - | -0.0532829006068788 | 0.0172829135642379 | LUAD | Male-baised eQTL |
| rs80146612 | chr7:121659250:T:C | - | 0.0728319215600712 | 0.0201176704565029 | LUAD | Male-baised eQTL |
| rs79394035 | chr7:121661482:A:G | - | 0.0728319215600712 | 0.0201176704565029 | LUAD | Male-baised eQTL |
| rs111726325 | chr7:121647894:T:C | - | 0.0725215059825184 | 0.021427454606761 | LUAD | Male-baised eQTL |
| rs79354048 | chr7:121651129:A:G | - | 0.0725215059825184 | 0.021427454606761 | LUAD | Male-baised eQTL |
| rs113423760 | chr7:121652130:G:A | - | 0.0725215059825184 | 0.021427454606761 | LUAD | Male-baised eQTL |
| rs112355842 | chr7:121652211:A:G | - | 0.0725215059825184 | 0.021427454606761 | LUAD | Male-baised eQTL |
| rs111985463 | chr7:121656646:T:C | - | 0.0725215059825184 | 0.021427454606761 | LUAD | Male-baised eQTL |
| rs11973890 | chr7:132346187:C:T | - | 0.0601779798089075 | 0.025852365966403 | LUAD | Male-baised eQTL |
| rs11978355 | chr7:132349087:A:G | - | 0.0601779798089075 | 0.025852365966403 | LUAD | Male-baised eQTL |
| rs11971704 | chr7:132349270:G:A | - | 0.0601779798089075 | 0.025852365966403 | LUAD | Male-baised eQTL |
| rs73723800 | chr7:132349481:G:T | - | 0.0601779798089075 | 0.025852365966403 | LUAD | Male-baised eQTL |
| rs77032207 | chr7:132350680:A:C | - | 0.0601779798089075 | 0.025852365966403 | LUAD | Male-baised eQTL |
| rs17166373 | chr7:132342226:T:C | - | 0.0600688883136849 | 0.0265145734183556 | LUAD | Male-baised eQTL |
| rs73156148 | chr7:135244866:A:T | - | 0.053361697006823 | 0.0286442468650772 | LUAD | Male-baised eQTL |
| rs62479514 | chr7:134856752:C:A | - | 0.0589388596308336 | 0.0307009945559455 | LUAD | Male-baised eQTL |
| rs3800570 | chr7:138726587:C:G | - | 0.0534915342913576 | 0.0328467680479799 | LUAD | Male-baised eQTL |
| rs73152915 | chr7:133755632:T:G | - | 0.0642065276378948 | 0.0342264562335257 | LUAD | Male-baised eQTL |
| rs7797067 | chr7:133756655:T:C | - | 0.0642065276378948 | 0.0342264562335257 | LUAD | Male-baised eQTL |
| rs73434896 | chr7:132352990:A:T | - | 0.0566162951855599 | 0.0345574188000632 | LUAD | Male-baised eQTL |
| rs73152917 | chr7:133760104:C:T | - | 0.0641017649555465 | 0.0349857488093227 | LUAD | Male-baised eQTL |
| rs1895024 | chr7:133769580:C:A | - | 0.0639311550777078 | 0.0360922923885174 | LUAD | Male-baised eQTL |
| rs16874343 | chr7:133773067:C:T | - | 0.0639311550777078 | 0.0360922923885174 | LUAD | Male-baised eQTL |
| rs73723792 | chr7:132341181:G:T | - | 0.0575556445865561 | 0.0389460183255379 | LUAD | Male-baised eQTL |
| rs6467563 | chr7:134859051:G:A | - | 0.053625814965018 | 0.0392633447829343 | LUAD | Male-baised eQTL |
| rs11972442 | chr7:122259649:T:C | - | 0.0512334845998486 | 0.0409032790987707 | LUAD | Male-baised eQTL |
| rs11980740 | chr7:121683482:C:T | - | 0.0544474961224174 | 0.0411447243214487 | LUAD | Male-baised eQTL |
| rs10246101 | chr7:133751732:C:T | - | -0.0607814652893305 | 0.048515846566746 | LUAD | Male-baised eQTL |
| rs74575105 | chr7:131157560:G:A | - | 0.132627458066493 | 0.000985636989180357 | COAD | Male-baised eQTL |
| rs12112661 | chr7:131149815:C:T | - | 0.129089869780256 | 0.00116748689232904 | COAD | Male-baised eQTL |
| rs7778040 | chr7:131154771:C:T | - | 0.128856432768739 | 0.0014022167038966 | COAD | Male-baised eQTL |
| rs7805465 | chr7:129608797:A:G | - | -0.0995325637389042 | 0.0030835370625982 | COAD | Male-baised eQTL |
| rs3800616 | chr7:137643629:G:A | - | 0.144045170574393 | 0.0186301838003391 | COAD | Male-baised eQTL |
| rs1968219 | chr7:131771019:T:G | - | 0.084620317328635 | 0.0337022562351772 | COAD | Male-baised eQTL |
| rs12535113 | chr7:131780486:G:A | - | 0.0842825599096091 | 0.0403535257345961 | COAD | Male-baised eQTL |
| rs12535127 | chr7:131780524:G:A | - | 0.0842825599096091 | 0.0403535257345961 | COAD | Male-baised eQTL |
| rs1477227 | chr7:131770632:T:G | - | 0.0814192222365305 | 0.0456436354719765 | COAD | Male-baised eQTL |
| rs1477228 | chr7:131770804:C:T | - | 0.0813370007862833 | 0.0462356650221244 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000128602 |
| CpG Site: cg20025238 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.474048141879893 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20025238 | chr7:129189948 | gene,promoter | -0.474048141879893 | 3.23983904107994e-36 | -0.7390300453524898 | 8.834281331782433e-40 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SMO |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000128602 | SMO | C0002448 | Ameloblastoma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0006118 | Brain Neoplasms | 1 | CTD_human |
| ENSG00000128602 | SMO | C0007114 | Malignant neoplasm of skin | 1 | CTD_human |
| ENSG00000128602 | SMO | C0021361 | Female infertility | 1 | CTD_human |
| ENSG00000128602 | SMO | C0022360 | Jaw Abnormalities | 1 | CTD_human |
| ENSG00000128602 | SMO | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| ENSG00000128602 | SMO | C0024954 | Maxillary Neoplasms | 1 | CTD_human |
| ENSG00000128602 | SMO | C0025286 | Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0029410 | Osteoarthritis of hip | 1 | CTD_human |
| ENSG00000128602 | SMO | C0037286 | Skin Neoplasms | 1 | CTD_human |
| ENSG00000128602 | SMO | C0038279 | Sterility, Postpartum | 1 | CTD_human |
| ENSG00000128602 | SMO | C0153633 | Malignant neoplasm of brain | 1 | CTD_human |
| ENSG00000128602 | SMO | C0205834 | Meningiomas, Multiple | 1 | CTD_human |
| ENSG00000128602 | SMO | C0206663 | Neuroectodermal Tumor, Primitive | 1 | CTD_human |
| ENSG00000128602 | SMO | C0238198 | Gastrointestinal Stromal Tumors | 1 | CTD_human |
| ENSG00000128602 | SMO | C0259785 | Malignant Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0281784 | Benign Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334584 | Spongioblastoma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334596 | Medulloepithelioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334605 | Meningothelial meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334606 | Fibrous Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334607 | Psammomatous Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334608 | Angiomatous Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334609 | Hemangioblastic Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334610 | Hemangiopericytic Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0334611 | Transitional Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0341869 | Subfertility, Female | 1 | CTD_human |
| ENSG00000128602 | SMO | C0347515 | Spinal Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0349604 | Intracranial Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0431121 | Clear Cell Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0457190 | Xanthomatous Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human |
| ENSG00000128602 | SMO | C0700367 | Ependymoblastoma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0750974 | Brain Tumor, Primary | 1 | CTD_human |
| ENSG00000128602 | SMO | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human |
| ENSG00000128602 | SMO | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human |
| ENSG00000128602 | SMO | C0751303 | Cerebral Convexity Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0751304 | Parasagittal Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C0751675 | Cerebral Primitive Neuroectodermal Tumor | 1 | CTD_human |
| ENSG00000128602 | SMO | C0795915 | Winter Shortland Temple syndrome | 1 | CTD_human |
| ENSG00000128602 | SMO | C0917730 | Female sterility | 1 | CTD_human |
| ENSG00000128602 | SMO | C1334261 | Intraorbital Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C1334271 | Intraventricular Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C1335107 | Olfactory Groove Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C1368275 | Pigmented Basal Cell Carcinoma | 2 | CTD_human |
| ENSG00000128602 | SMO | C1384406 | Secretory meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C1384408 | Microcystic meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C1527197 | Angioblastic Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C1527390 | Neoplasms, Intracranial | 1 | CTD_human |
| ENSG00000128602 | SMO | C1565950 | Posterior Fossa Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C1565951 | Sphenoid Wing Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C3163622 | Papillary Meningioma | 1 | CTD_human |
| ENSG00000128602 | SMO | C3179349 | Gastrointestinal Stromal Sarcoma | 1 | CTD_human |
| ENSG00000128602 | SMO | C4721806 | Carcinoma, Basal Cell | 2 | CTD_human |
