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Gene: ENSG00000128298 |
Summary for BAIAP2L2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000128298 | Gene symbol | BAIAP2L2 |
| Gene name | BAR/IMD domain containing adaptor protein 2 like 2 | |
| HGNC | 26203 | |
| Entrez ID | 80115 | |
| Gene type | protein_coding | |
| Synonyms | BAIAP2L2|FLJ22582|pinkbar | |
| UniProtAcc | Q6UXY1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for BAIAP2L2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| BAIAP2L2 | 3.50e+02 | 3.15e+00 | 5.75e-01 | 5.49e+00 | 4.08e-08 | 4.53e-07 | BLCA |
| BAIAP2L2 | 1.66e+03 | 4.08e+00 | 4.63e-01 | 8.81e+00 | 1.29e-18 | 1.09e-16 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| BAIAP2L2 | 1.79e+03 | 1.62e+00 | 3.05e-01 | 5.32e+00 | 1.02e-07 | 4.33e-07 | KIRC |
| BAIAP2L2 | 1.35e+02 | 1.26e+00 | 1.55e-01 | 8.11e+00 | 5.21e-16 | 1.49e-15 | BRCA |
Top |
Sex-biased somatic mutation for BAIAP2L2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for BAIAP2L2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg11461302 | chr22:38111444 | CGI:chr22:38120728-38121023 | promoter | 8.25e-01 | 6.97e-01 | 1.26e+01 | 3.62e-36 | 5.99e-35 | 1.28e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg09247692 | chr22:38110774 | CGI:chr22:38120728-38121023 | promoter | 3.80e-01 | 2.48e-01 | 5.39e+00 | 7.17e-08 | 3.76e-07 | 1.32e-01 |
| KIRC | cg11744966 | chr22:38110764 | CGI:chr22:38120728-38121023 | promoter | 5.30e-01 | 4.15e-01 | 4.88e+00 | 1.05e-06 | 3.81e-06 | 1.16e-01 |
| LUAD | cg21007971 | chr22:38112125 | CGI:chr22:38120728-38121023 | promoter | 7.91e-01 | 8.94e-01 | -4.32e+00 | 1.59e-05 | 6.13e-05 | -1.03e-01 |
| HNSC | cg27505627 | chr22:38110582 | CGI:chr22:38120728-38121023 | UTR,promoter,exon,gene body | 7.49e-01 | 9.16e-01 | -3.33e+00 | 8.65e-04 | 1.60e-03 | -1.67e-01 |
| LUSC | cg27505627 | chr22:38110582 | CGI:chr22:38120728-38121023 | UTR,promoter,exon,gene body | 8.44e-01 | 9.70e-01 | -2.67e+00 | 7.68e-03 | 1.13e-02 | -1.26e-01 |
| LUSC | cg09247692 | chr22:38110774 | CGI:chr22:38120728-38121023 | promoter | 4.94e-01 | 6.11e-01 | -2.48e+00 | 1.32e-02 | 1.72e-02 | -1.17e-01 |
| LUSC | cg20207973 | chr22:38110705 | CGI:chr22:38120728-38121023 | promoter | 4.36e-01 | 6.24e-01 | -3.89e+00 | 1.02e-04 | 7.03e-04 | -1.87e-01 |
| LUSC | cg08196512 | chr22:38110730 | CGI:chr22:38120728-38121023 | promoter | 7.41e-01 | 8.77e-01 | -1.99e+00 | 4.63e-02 | 4.69e-02 | -1.36e-01 |
| LUSC | cg11744966 | chr22:38110764 | CGI:chr22:38120728-38121023 | promoter | 6.09e-01 | 7.76e-01 | -3.26e+00 | 1.10e-03 | 2.76e-03 | -1.67e-01 |
| COAD | cg27505627 | chr22:38110582 | CGI:chr22:38120728-38121023 | UTR,promoter,exon,gene body | 3.73e-01 | 4.78e-01 | -2.98e+00 | 2.93e-03 | 5.37e-03 | -1.04e-01 |
| KIRP | cg15944459 | chr22:38111850 | CGI:chr22:38120728-38121023 | promoter | 4.20e-01 | 5.48e-01 | -3.78e+00 | 1.60e-04 | 3.85e-04 | -1.29e-01 |
| CHOL | cg27505627 | chr22:38110582 | CGI:chr22:38120728-38121023 | UTR,promoter,exon,gene body | 4.19e-01 | 9.70e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -5.51e-01 |
| CHOL | cg09247692 | chr22:38110774 | CGI:chr22:38120728-38121023 | promoter | 3.37e-01 | 5.38e-01 | -2.43e+00 | 1.50e-02 | 2.65e-02 | -2.01e-01 |
| CHOL | cg15944459 | chr22:38111850 | CGI:chr22:38120728-38121023 | promoter | 5.30e-01 | 7.97e-01 | -2.95e+00 | 3.19e-03 | 1.32e-02 | -2.67e-01 |
| CHOL | cg17838773 | chr22:38110616 | CGI:chr22:38120728-38121023 | UTR,promoter,exon,gene body | 3.93e-01 | 5.51e-01 | -2.21e+00 | 2.70e-02 | 3.50e-02 | -1.58e-01 |
| CHOL | cg20207973 | chr22:38110705 | CGI:chr22:38120728-38121023 | promoter | 3.03e-01 | 4.71e-01 | -1.99e+00 | 4.65e-02 | 4.65e-02 | -1.68e-01 |
| CHOL | cg08196512 | chr22:38110730 | CGI:chr22:38120728-38121023 | promoter | 3.40e-01 | 6.02e-01 | -2.58e+00 | 9.87e-03 | 2.15e-02 | -2.62e-01 |
| CHOL | cg11744966 | chr22:38110764 | CGI:chr22:38120728-38121023 | promoter | 4.73e-01 | 6.44e-01 | -2.06e+00 | 3.90e-02 | 4.26e-02 | -1.71e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg17838773 | chr22:38110616 | CGI:chr22:38120728-38121023 | UTR,promoter,exon,gene body | 4.18e-01 | 6.07e-01 | -4.60e+00 | 4.26e-06 | 3.69e-05 | -1.89e-01 |
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Exon skipping events with PSI in TCGA for BAIAP2L2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for BAIAP2L2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | BAIAP2L2-001 | chr22_38092306_- | 1.96e-01 | 2.60e-01 | -2.17e+00 | 2.99e-02 | 4.96e-02 | -6.37e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for BAIAP2L2 |
| TFs related to BAIAP2L2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BAIAP2L2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for BAIAP2L2 |
| RBPs related to ES in BAIAP2L2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | BRUNOL6 | exon_skip_369348 | 8.90e+00 | 9.86e-01 | 8.57e+00 | 9.50e-03 | Male-biased |
| BAIAP2L2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs5766534 | chr22:45205730:G:A | - | 0.146761650575646 | 0.00634442720235835 | SARC | Female-baised eQTL |
| rs5994945 | chr22:34485844:G:A | - | 0.335169763773112 | 0.0047513487639408 | KIRP | Female-baised eQTL |
| rs117989688 | chr22:34468648:A:G | - | 0.237117054253163 | 0.00671238339316963 | KIRP | Female-baised eQTL |
| rs141925539 | chr22:34468818:C:A | - | 0.237117054253163 | 0.00671238339316963 | KIRP | Female-baised eQTL |
| rs11912483 | chr22:34469832:G:T | - | 0.237117054253163 | 0.00671238339316963 | KIRP | Female-baised eQTL |
| rs17834639 | chr22:46747452:G:C | - | 0.401949226369159 | 0.0214835836533339 | KIRP | Female-baised eQTL |
| rs56880398 | chr22:45495235:C:T | - | 0.361641768563502 | 0.0375938858024894 | KIRP | Female-baised eQTL |
| rs64547 | chr22:37196464:T:G | - | 0.0698067522290858 | 0.0400235627295305 | LGG | Female-baised eQTL |
| rs229544 | chr22:37197040:G:A | - | 0.0698067522290858 | 0.0400235627295305 | LGG | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6000361 | chr22:36647171:T:C | - | 0.102450191474365 | 0.00653955469036638 | KIRC | Male-baised eQTL |
| rs6000362 | chr22:36647336:C:T | - | 0.102450191474365 | 0.00653955469036638 | KIRC | Male-baised eQTL |
| rs6000363 | chr22:36647441:C:T | - | 0.102450191474365 | 0.00653955469036638 | KIRC | Male-baised eQTL |
| rs6000364 | chr22:36647620:A:G | - | 0.102450191474365 | 0.00653955469036638 | KIRC | Male-baised eQTL |
| rs73884123 | chr22:36647898:C:T | - | 0.102450191474365 | 0.00653955469036638 | KIRC | Male-baised eQTL |
| rs9622436 | chr22:36636116:A:G | - | 0.0979844192376725 | 0.0065670911653219 | KIRC | Male-baised eQTL |
| rs5995320 | chr22:36644152:C:T | - | 0.0991616978243102 | 0.00697562302867281 | KIRC | Male-baised eQTL |
| rs11912444 | chr22:44623299:A:G | - | 0.11903666509748 | 0.00838706960163249 | KIRC | Male-baised eQTL |
| rs12160682 | chr22:34831085:T:A | - | 0.0959486093979905 | 0.0126063577882295 | KIRC | Male-baised eQTL |
| rs9622443 | chr22:36650551:A:T | - | 0.0994293485578344 | 0.0181350099123496 | KIRC | Male-baised eQTL |
| rs1009155 | chr22:46535941:G:A | - | -0.0993762821108963 | 0.0189677025856846 | KIRC | Male-baised eQTL |
| rs9622439 | chr22:36646922:G:A | - | 0.0949162508950267 | 0.0224424808495705 | KIRC | Male-baised eQTL |
| rs17347451 | chr22:40973104:G:C | - | -0.0481042899943251 | 0.0316429648548615 | KIRC | Male-baised eQTL |
| rs2899219 | chr22:34331767:C:A | - | 0.0919594003360543 | 0.044120801392204 | KIRC | Male-baised eQTL |
| rs6006406 | chr22:30230156:G:T | - | 0.0709357229591939 | 0.04478441320235 | KIRC | Male-baised eQTL |
| rs136698 | chr22:44942012:T:G | - | -0.0824869051215966 | 0.0469222812809016 | KIRC | Male-baised eQTL |
| rs5759269 | chr22:43301525:C:T | - | 0.0425955607964992 | 0.0271138449744287 | BLCA | Male-baised eQTL |
| rs5759261 | chr22:43290610:C:T | - | 0.0400315962501811 | 0.0322808750868885 | BLCA | Male-baised eQTL |
| rs5751472 | chr22:43291299:C:A | - | 0.0400315962501811 | 0.0322808750868885 | BLCA | Male-baised eQTL |
| rs5751473 | chr22:43291300:C:G | - | 0.0400315962501811 | 0.0322808750868885 | BLCA | Male-baised eQTL |
| rs17003621 | chr22:43289531:G:C | - | 0.0391992012645311 | 0.0380190615273412 | BLCA | Male-baised eQTL |
| rs12484768 | chr22:47326479:G:C | - | 0.0459990003259368 | 0.0402278353091983 | BLCA | Male-baised eQTL |
| rs11089673 | chr22:34464001:G:C | - | 0.0714128676594974 | 0.0110021609573332 | COAD | Male-baised eQTL |
| rs5998151 | chr22:31863869:G:A | - | 0.0966791139921309 | 0.0211232602372314 | COAD | Male-baised eQTL |
| rs715484 | chr22:34463369:A:T | - | 0.0683502021279874 | 0.0224031761243722 | COAD | Male-baised eQTL |
| rs11703818 | chr22:31864829:C:T | - | 0.0910304785253836 | 0.0340031514834362 | COAD | Male-baised eQTL |
| rs5994446 | chr22:31893933:A:G | - | 0.0754586802206282 | 0.0377677370546275 | COAD | Male-baised eQTL |
| rs28542543 | chr22:31873713:A:G | - | 0.0890262174182779 | 0.0396373367544111 | COAD | Male-baised eQTL |
| rs3213524 | chr22:31879803:G:A | - | 0.0890262174182779 | 0.0396373367544111 | COAD | Male-baised eQTL |
| rs5998170 | chr22:31906744:C:T | - | 0.09110285424119 | 0.0408432504890036 | COAD | Male-baised eQTL |
| rs2051592 | chr22:47331830:A:G | - | 0.0922910297181585 | 0.0418008753545259 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000128298 |
| CpG Site: cg08196512 | |
| Position to Gene: promoter | |
| Male Effect: -0.483044199062803 | |
| Female Effect: - | |
 | Gene ID: ENSG00000128298 |
| CpG Site: cg27505627 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.234589698823912 | |
| Female Effect: - | |
 | Gene ID: ENSG00000128298 |
| CpG Site: cg21007971 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.457909222113954 | |
 | Gene ID: ENSG00000128298 |
| CpG Site: cg15944459 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.324390514304948 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg08196512 | chr22:38110730 | promoter | -0.483044199062803 | 1.35210296147225e-12 | -0.49184809289649234 | 5.500152783025692e-15 | LUAD |
| cg27505627 | chr22:38110582 | gene,exon,promoter,UTR | -0.234589698823912 | 3.06495898769647e-05 | -0.3482727432471271 | 9.309657723051346e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg21007971 | chr22:38112125 | promoter | -0.457909222113954 | 1.54033176378086e-11 | -0.6584653326820866 | 7.17288203868791e-15 | BLCA |
| cg15944459 | chr22:38111850 | promoter | -0.324390514304948 | 8.09863621873874e-11 | -0.6613031636321021 | 5.00908594931655e-15 | BLCA |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of BAIAP2L2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
