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Gene: ENSG00000128283 |
Summary for CDC42EP1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000128283 | Gene symbol | CDC42EP1 |
| Gene name | CDC42 effector protein 1 | |
| HGNC | 17014 | |
| Entrez ID | 11135 | |
| Gene type | protein_coding | |
| Synonyms | CDC42EP1|MSE55|CEP1|Borg5 | |
| UniProtAcc | Q00587 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for CDC42EP1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CDC42EP1 | 1.13e+04 | 1.19e+00 | 3.64e-01 | 3.28e+00 | 1.04e-03 | 3.52e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CDC42EP1 | 4.91e+03 | 1.01e+00 | 3.50e-01 | 2.90e+00 | 3.73e-03 | 1.07e-02 | READ |
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Sex-biased somatic mutation for CDC42EP1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CDC42EP1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg16432009 | chr22:37559929 | CGI:chr22:37560095-37561919 | promoter | 5.93e-01 | 4.85e-01 | 3.12e+00 | 1.82e-03 | 3.91e-03 | 1.07e-01 |
| BLCA | cg20307496 | chr22:37559920 | CGI:chr22:37560095-37561919 | promoter | 4.80e-01 | 5.90e-01 | -2.74e+00 | 6.08e-03 | 9.51e-03 | -1.11e-01 |
| BLCA | cg16432009 | chr22:37559929 | CGI:chr22:37560095-37561919 | promoter | 5.09e-01 | 6.61e-01 | -2.99e+00 | 2.76e-03 | 5.07e-03 | -1.51e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg16432009 | chr22:37559929 | CGI:chr22:37560095-37561919 | promoter | 6.08e-01 | 4.92e-01 | 2.54e+00 | 1.09e-02 | 1.95e-02 | 1.15e-01 |
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Exon skipping events with PSI in TCGA for CDC42EP1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CDC42EP1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CDC42EP1 |
| TFs related to CDC42EP1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CDC42EP1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CDC42EP1 |
| RBPs related to ES in CDC42EP1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CDC42EP1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs5995122 | chr22:35586398:G:C | - | 0.122467404617724 | 0.00799391416471529 | PAAD | Female-baised eQTL |
| rs738370 | chr22:35586625:G:A | - | 0.122467404617724 | 0.00799391416471529 | PAAD | Female-baised eQTL |
| rs9606938 | chr22:32324640:C:T | - | 0.126108750968172 | 0.00595566494166685 | LGG | Female-baised eQTL |
| rs9610680 | chr22:37225911:G:A | - | 0.101618379533546 | 0.0209221939000696 | KIRC | Female-baised eQTL |
| rs9625587 | chr22:28828866:G:T | - | 0.0841565972734125 | 0.0106140644208123 | LUAD | Female-baised eQTL |
| rs739151 | chr22:42345460:C:G | - | -0.0678916921323205 | 0.0145837928475614 | COAD | Female-baised eQTL |
| rs130896 | chr22:34360281:A:G | - | 0.0740661205596766 | 0.04625989310842 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9614956 | chr22:44860276:A:C | - | 0.0947401065927378 | 0.0482423989005094 | STAD | Male-baised eQTL |
| rs5752968 | chr22:29837457:A:G | - | 0.034124601197988 | 0.0414468648649298 | KIRC | Male-baised eQTL |
| rs6002976 | chr22:42911199:C:T | - | 0.0454216570457578 | 0.0427541574496822 | KIRC | Male-baised eQTL |
| rs5996247 | chr22:42917747:T:C | - | 0.0444881862026945 | 0.0435743653838177 | KIRC | Male-baised eQTL |
| rs5759039 | chr22:42924279:T:G | - | 0.0462398554218668 | 0.0460536456272591 | KIRC | Male-baised eQTL |
| rs5759040 | chr22:42925290:G:A | - | 0.0462398554218668 | 0.0460536456272591 | KIRC | Male-baised eQTL |
| rs2267474 | chr22:42925800:T:A | - | 0.0462398554218668 | 0.0460536456272591 | KIRC | Male-baised eQTL |
| rs130657 | chr22:39214642:A:C | - | 0.0326820627559605 | 0.0368554460089452 | BLCA | Male-baised eQTL |
| rs9611266 | chr22:40104848:C:T | - | -0.0853429685218744 | 0.00893677780703752 | COAD | Male-baised eQTL |
| rs714008 | chr22:40010268:C:T | - | -0.0898587884549139 | 0.0296468531818622 | COAD | Male-baised eQTL |
| rs12373990 | chr22:40000024:C:T | - | -0.0898472857620065 | 0.029920095418878 | COAD | Male-baised eQTL |
| rs5753449 | chr22:31068240:A:G | - | 0.0695607439102314 | 0.0374506415376229 | COAD | Male-baised eQTL |
| rs1990125 | chr22:31068419:T:C | - | 0.0695607439102314 | 0.0374506415376229 | COAD | Male-baised eQTL |
| rs2413016 | chr22:31062217:C:T | - | 0.0674109880132809 | 0.0424313671031472 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000128283 |
| CpG Site: cg15035133 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: 0.160586037117932 | |
| Female Effect: - | |
 | Gene ID: ENSG00000128283 |
| CpG Site: cg03419948 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.254460595382181 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15035133 | chr22:37566630 | gene,exon,CDS | 0.160586037117932 | 3.10163642409666e-06 | 0.6172707889787525 | 1.0737520556100766e-09 | LAML |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg03419948 | chr22:37566015 | gene | -0.254460595382181 | 1.02706020009107e-05 | -0.33816807123210524 | 3.066787717581541e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CDC42EP1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
