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Gene: ENSG00000127948 |
Summary for POR |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000127948 | Gene symbol | POR |
| Gene name | cytochrome p450 oxidoreductase | |
| HGNC | 9208 | |
| Entrez ID | 5447 | |
| Gene type | protein_coding | |
| Synonyms | POR|CYPOR|FLJ26468 | |
| UniProtAcc | P16435 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000127948 | POR | DB03147 | Flavin adenine dinucleotide | SmallMoleculeDrug |
| ENSG00000127948 | POR | DB03247 | Flavin mononucleotide | SmallMoleculeDrug |
| ENSG00000127948 | POR | DB03461 | Nicotinamide adenine dinucleotide phosphate | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for POR |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| POR | 1.35e+04 | -2.47e+00 | 3.78e-01 | -6.51e+00 | 7.30e-11 | 1.30e-09 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| POR | 6.00e+03 | 1.05e+00 | 3.08e-01 | 3.41e+00 | 6.45e-04 | 2.38e-03 | READ |
Top |
Sex-biased somatic mutation for POR |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for POR |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for POR |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for POR |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for POR |
| TFs related to POR. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| POR related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for POR |
| RBPs related to ES in POR. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | PABPC3 | exon_skip_467371 | 1.06e+01 | 9.94e-01 | 1.02e+01 | 5.00e-03 | Male-biased |
| THYM | RBM4 | exon_skip_467382 | 8.22e+00 | 1.10e-02 | 8.53e+00 | 9.83e-01 | Female-biased |
| COAD | PABPC3 | exon_skip_467371 | 9.98e+00 | 5.49e-03 | 1.04e+01 | 9.93e-01 | Female-biased |
| LUAD | PABPC3 | exon_skip_467371 | 1.01e+01 | 1.07e-02 | 1.04e+01 | 9.88e-01 | Female-biased |
| ESCA | ZC3H10 | exon_skip_467376 | 6.65e+00 | 9.83e-01 | 5.73e+00 | 5.35e-04 | Male-biased |
| THCA | PABPC3 | exon_skip_467371 | 1.04e+01 | 9.92e-01 | 1.01e+01 | 6.75e-03 | Male-biased |
| MESO | PABPC3 | exon_skip_467371 | 1.00e+01 | 3.57e-03 | 1.04e+01 | 9.95e-01 | Female-biased |
| MESO | RBM4 | exon_skip_467382 | 8.32e+00 | 8.49e-03 | 8.69e+00 | 9.86e-01 | Female-biased |
| PAAD | FXR2 | exon_skip_467382 | 7.46e+00 | 9.82e-01 | 7.13e+00 | 7.07e-03 | Male-biased |
| KIRC | PABPC3 | exon_skip_467371 | 1.00e+01 | 1.13e-02 | 1.03e+01 | 9.87e-01 | Female-biased |
| BLCA | PABPC3 | exon_skip_467371 | 9.87e+00 | 1.35e-03 | 1.04e+01 | 9.97e-01 | Female-biased |
| SKCM | PABPC3 | exon_skip_467371 | 9.88e+00 | 2.38e-03 | 1.04e+01 | 9.96e-01 | Female-biased |
| SKCM | RBM4 | exon_skip_467382 | 8.33e+00 | 3.49e-03 | 8.80e+00 | 9.91e-01 | Female-biased |
| POR related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11765524 | chr7:68939285:G:A | - | 0.158995037981183 | 0.048246457512413 | HNSC | Female-baised eQTL |
| rs73145314 | chr7:69121979:C:T | - | 0.109627715558316 | 0.0010625928470444 | KIRC | Female-baised eQTL |
| rs13438765 | chr7:72475943:T:C | - | 0.0818791828568419 | 0.0102045299269456 | KIRC | Female-baised eQTL |
| rs7780745 | chr7:72469376:C:T | - | 0.0662766324335786 | 0.020621046205322 | KIRC | Female-baised eQTL |
| rs10251859 | chr7:70398117:G:A | - | 0.0769511032143712 | 0.0222653376786268 | KIRC | Female-baised eQTL |
| rs6965900 | chr7:70398486:T:C | - | 0.0769511032143712 | 0.0222653376786268 | KIRC | Female-baised eQTL |
| rs10277043 | chr7:72467318:G:C | - | 0.0658152888051229 | 0.0229052957912859 | KIRC | Female-baised eQTL |
| rs6460733 | chr7:72481143:G:C | - | 0.0668105014763844 | 0.023516584761562 | KIRC | Female-baised eQTL |
| rs10274795 | chr7:72469006:T:G | - | 0.0631463621246314 | 0.0256916026034836 | KIRC | Female-baised eQTL |
| rs6951037 | chr7:72483411:T:A | - | 0.0656818877423492 | 0.0266654577569775 | KIRC | Female-baised eQTL |
| rs17141545 | chr7:70390187:A:G | - | 0.0692430201263649 | 0.027152114409287 | KIRC | Female-baised eQTL |
| rs41384947 | chr7:70427643:A:G | - | 0.0778897157136552 | 0.027580110581769 | KIRC | Female-baised eQTL |
| rs7786019 | chr7:70427892:C:A | - | 0.0778897157136552 | 0.027580110581769 | KIRC | Female-baised eQTL |
| rs10235543 | chr7:70459357:G:A | - | 0.0773838130827182 | 0.0299249378738063 | KIRC | Female-baised eQTL |
| rs10230510 | chr7:70461430:A:T | - | 0.0773838130827182 | 0.0299249378738063 | KIRC | Female-baised eQTL |
| rs7783204 | chr7:70462778:G:A | - | 0.0773838130827182 | 0.0299249378738063 | KIRC | Female-baised eQTL |
| rs7797735 | chr7:72468158:T:G | - | 0.0651579371299923 | 0.0301907269094119 | KIRC | Female-baised eQTL |
| rs12111684 | chr7:70438781:C:T | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs12113216 | chr7:70440880:G:A | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs13437849 | chr7:70442513:T:C | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs10253217 | chr7:70447453:A:G | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs6460546 | chr7:70448188:T:C | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs6460547 | chr7:70448404:A:C | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs7789284 | chr7:70448776:T:G | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs57762223 | chr7:70457255:G:A | - | 0.0773276636856608 | 0.0305060231987829 | KIRC | Female-baised eQTL |
| rs7807692 | chr7:72470126:T:C | - | 0.0638247728979081 | 0.0306319278804894 | KIRC | Female-baised eQTL |
| rs7804006 | chr7:72470224:A:G | - | 0.0638247728979081 | 0.0306319278804894 | KIRC | Female-baised eQTL |
| rs1833656 | chr7:72470383:A:G | - | 0.0638247728979081 | 0.0306319278804894 | KIRC | Female-baised eQTL |
| rs7810695 | chr7:72467810:C:T | - | 0.0650389695817707 | 0.0306946938078996 | KIRC | Female-baised eQTL |
| rs7790927 | chr7:72471968:T:A | - | 0.0637239079114864 | 0.0315139230572976 | KIRC | Female-baised eQTL |
| rs7799726 | chr7:72462385:A:G | - | 0.0641614965140656 | 0.0365121626531613 | KIRC | Female-baised eQTL |
| rs10246443 | chr7:72462863:A:G | - | 0.0641614965140656 | 0.0365121626531613 | KIRC | Female-baised eQTL |
| rs10231864 | chr7:72463434:C:T | - | 0.0641614965140656 | 0.0365121626531613 | KIRC | Female-baised eQTL |
| rs28529376 | chr7:72465955:G:A | - | 0.0641614965140656 | 0.0365121626531613 | KIRC | Female-baised eQTL |
| rs7784014 | chr7:72475148:C:T | - | 0.0615550869232064 | 0.0399793936865694 | KIRC | Female-baised eQTL |
| rs10229487 | chr7:72475435:G:T | - | 0.0615550869232064 | 0.0399793936865694 | KIRC | Female-baised eQTL |
| rs17141576 | chr7:70413549:G:T | - | 0.0742077595177642 | 0.0429611256296647 | KIRC | Female-baised eQTL |
| rs145680786 | chr7:72462186:T:G | - | 0.0744072007319958 | 0.0431901366517805 | KIRC | Female-baised eQTL |
| rs10954738 | chr7:76022550:T:A | - | 0.058100393357949 | 0.0465623503080277 | KIRC | Female-baised eQTL |
| rs10954739 | chr7:76022574:C:A | - | 0.058100393357949 | 0.0465623503080277 | KIRC | Female-baised eQTL |
| rs6967417 | chr7:70406698:G:A | - | 0.0726390300551241 | 0.047484706214446 | KIRC | Female-baised eQTL |
| rs74994417 | chr7:70412859:C:T | - | 0.0726390300551241 | 0.047484706214446 | KIRC | Female-baised eQTL |
| rs10486878 | chr7:70414928:A:G | - | 0.0726390300551241 | 0.047484706214446 | KIRC | Female-baised eQTL |
| rs10277221 | chr7:70424834:G:A | - | 0.0726390300551241 | 0.047484706214446 | KIRC | Female-baised eQTL |
| rs10226520 | chr7:68186489:C:G | - | 0.0801134212790133 | 0.0171776357694185 | LUAD | Female-baised eQTL |
| rs7802701 | chr7:68187030:T:C | - | 0.0815602488308141 | 0.0182411040670231 | LUAD | Female-baised eQTL |
| rs10245854 | chr7:68187531:A:G | - | 0.0815602488308141 | 0.0182411040670231 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10258101 | chr7:68132466:G:C | - | -0.164138209478048 | 0.0288071463946023 | READ | Male-baised eQTL |
| rs2523193 | chr7:80166959:C:T | - | 0.0674739077878941 | 0.035611250218533 | LUSC | Male-baised eQTL |
| rs7788927 | chr7:82093695:C:T | - | 0.0458108223847666 | 0.00112794310883035 | KIRC | Male-baised eQTL |
| rs7787882 | chr7:82093734:G:A | - | 0.0429263599764086 | 0.0126498638493715 | KIRC | Male-baised eQTL |
| rs2057942 | chr7:71124457:C:T | - | -0.0319613984937305 | 0.0191973920737594 | KIRC | Male-baised eQTL |
| rs7783769 | chr7:71130662:G:C | - | -0.031238315949791 | 0.0229054966492322 | KIRC | Male-baised eQTL |
| rs847726 | chr7:71111888:A:G | - | -0.0287003247940557 | 0.0312063592519181 | KIRC | Male-baised eQTL |
| rs11768750 | chr7:69221599:T:C | - | 0.122623639405438 | 0.02321916598313 | LUAD | Male-baised eQTL |
| rs1915973 | chr7:69194893:T:C | - | 0.116872787896498 | 0.0271409254390992 | LUAD | Male-baised eQTL |
| rs62460351 | chr7:69204867:C:T | - | 0.116344295720824 | 0.0289004804490134 | LUAD | Male-baised eQTL |
| rs12333528 | chr7:69210474:T:C | - | 0.116344295720824 | 0.0289004804490134 | LUAD | Male-baised eQTL |
| rs4718867 | chr7:69161788:G:A | - | 0.0945083887431903 | 0.0338269786868442 | LUAD | Male-baised eQTL |
| rs13221078 | chr7:68003438:T:G | - | 0.130045244517473 | 0.0471831066944066 | LUAD | Male-baised eQTL |
| rs2214729 | chr7:82631787:T:A | - | 0.0566917460255384 | 0.00200881888258019 | COAD | Male-baised eQTL |
| rs2906265 | chr7:71415006:G:T | - | 0.0583336252119587 | 0.00549945692737821 | COAD | Male-baised eQTL |
| rs4548103 | chr7:85721353:T:C | - | -0.0560629617217623 | 0.00751628545600076 | COAD | Male-baised eQTL |
| rs4486107 | chr7:85709932:T:G | - | -0.0531398391530212 | 0.0104097535677024 | COAD | Male-baised eQTL |
| rs4329198 | chr7:85676887:T:C | - | -0.0533095669995416 | 0.0107571400374708 | COAD | Male-baised eQTL |
| rs12539713 | chr7:85699334:G:A | - | -0.0555714242980528 | 0.0124619520040364 | COAD | Male-baised eQTL |
| rs4314588 | chr7:85699572:T:A | - | -0.0555714242980528 | 0.0124619520040364 | COAD | Male-baised eQTL |
| rs11765145 | chr7:85705623:C:G | - | -0.0547516023137558 | 0.0159041373617884 | COAD | Male-baised eQTL |
| rs6958207 | chr7:85702713:T:G | - | -0.0538930475826908 | 0.0166938744704911 | COAD | Male-baised eQTL |
| rs7785221 | chr7:85707114:T:C | - | -0.0522088021004235 | 0.0267062014455367 | COAD | Male-baised eQTL |
| rs59626545 | chr7:82333309:A:C | - | 0.0600425526570638 | 0.035799064164042 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000127948 |
| CpG Site: cg01676795 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.13859694537101 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01676795 | chr7:75957030 | gene | -0.13859694537101 | 1.03182340057304e-08 | -0.4073035014973755 | 1.3067688177571518e-11 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of POR |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000127948 | POR | C0001627 | Congenital adrenal hyperplasia | 1 | CTD_human |
| ENSG00000127948 | POR | C0002453 | Amenorrhea | 1 | CTD_human |
| ENSG00000127948 | POR | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| ENSG00000127948 | POR | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| ENSG00000127948 | POR | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| ENSG00000127948 | POR | C0023186 | Learning Disorders | 1 | CTD_human |
| ENSG00000127948 | POR | C0032796 | Postpartum Amenorrhea | 1 | CTD_human |
| ENSG00000127948 | POR | C0206726 | gliosarcoma | 1 | CTD_human |
| ENSG00000127948 | POR | C0751262 | Adult Learning Disorders | 1 | CTD_human |
| ENSG00000127948 | POR | C0751263 | Learning Disturbance | 1 | CTD_human |
| ENSG00000127948 | POR | C0751265 | Learning Disabilities | 1 | CTD_human |
| ENSG00000127948 | POR | C1330966 | Developmental Academic Disorder | 1 | CTD_human |
| ENSG00000127948 | POR | C1860042 | Antley-Bixler Syndrome with Disordered Steroidogenesis | 4 | CTD_human |
| ENSG00000127948 | POR | C2350233 | Antley-Bixler Syndrome Phenotype | 4 | CTD_human |
| ENSG00000127948 | POR | C2936791 | Antley-Bixler Syndrome, Autosomal Dominant | 4 | CTD_human |
| ENSG00000127948 | POR | C3150099 | ANTLEY-BIXLER SYNDROME WITH GENITAL ANOMALIES AND DISORDERED STEROIDOGENESIS | 1 | CTD_human |
